The Bills surrendered only 229 points (14.3 points per game), the lowest total in franchise history in a 16-game season, and second-fewest in the league. Buffalo's 2,675 passing yards and 4,045 total yards allowed were both the fewest totals in the NFL in 1999.
The Bills finished in second place in the AFC East and finished the National Football League's 1999 season with a record of 11 wins and 5 losses. The Bills qualified for the postseason for the seventh time in the decade. They would lose to the Titans in the game called "The Music City Miracle".
As of the 2016 season, this was the last season that Buffalo qualified for the playoffs, making it 17 straight years that the Buffalo Bills have missed the playoffs.
Going into the game, Bills coach Wade Phillips created a stir by starting quarterback Rob Johnson, rather than Doug Flutie, who had started 15 games, and who had led the team to the playoffs. Late in the fourth quarter, the stage was set for an exciting finish. Tennessee received the ball with 6:15 remaining. Titans receiver Isaac Byrd's 16-yard punt return and five carries from Eddie George for 17 yards set up a wobbly 36-yard field goal by Del Greco. The Titans took a 15–13 lead with 1:48 to go. On the ensuing drive, with no timeouts remaining, Bills quarterback Johnson led the Bills on a five-play, 37-yard drive to the Titans' 24-yard line. On the last two plays from scrimmage, Johnson played with only one shoe on, as he had lost one and had no time to put it back on, with the clock running out. With only 16 seconds remaining in the game, Steve Christie, the Bills' kicker, made a 41-yard field goal to put Buffalo in the lead, 16–15.
Moments later, Christie kicked off, and Titans player Lorenzo Neal received. Neal handed the ball off to Titans tight end Frank Wycheck, who then lateraled the ball across the field to another Titans player, Kevin Dyson, who then ran down the sidelines for a 75-yard touchdown. The play was named Home Run Throwback by the Titans and was developed by Special Teams Coordinator Alan Lowry.
Per the instant replay rules, the play was reviewed by referee Phil Luckett since it was uncertain if the ball had been a forward pass, which is illegal on a kickoff return. However, the call on the field was upheld as a touchdown, and the Titans won the game 22–16. After the game, however, many Bills players and fans continued to insist that it was indeed an illegal forward pass.
It could be said that the game served as revenge for the Titans/Oilers franchise for The Comeback, where the Bills came back from a 32-point deficit to defeat the Houston Oilers, 41–38, in overtime. For the Bills, it led to the firing after 13 seasons of special teams coach Bruce DeHaven. One year later, Phillips was fired (partly due to his failure to lead the Bills past the first round of the playoffs during his tenure) and replaced by Titans defensive coordinator Gregg Williams. It was added to the list of infamous moments in Buffalo sports history, joining Wide Right and No Goal.
As of the conclusion of the 2016 NFL Regular Season, Buffalo has not reached the playoffs since the Music City Miracle.