Play Video
1
Video Chart ACTC 1/17/14
Video Chart ACTC 1/17/14
::2014/01/17::
Play Video
2
Bloomberg Television Interview with William Caldwell, IV, Chairman and CEO of ACTC - 1-20-07
Bloomberg Television Interview with William Caldwell, IV, Chairman and CEO of ACTC - 1-20-07
::2009/03/10::
Play Video
3
III Campeonato de Aceleración 1/4 Milla "ACTC",1-1.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC",1-1.wmv
::2011/08/12::
Play Video
4
reg VS actc 1
reg VS actc 1
::2009/03/22::
Play Video
5
descargar e instalar actc
descargar e instalar actc
::2013/09/03::
Play Video
6
Bruce Bedrick on Bloomberg Television
Bruce Bedrick on Bloomberg Television
::2014/01/13::
Play Video
7
Hillary In India - Bloomberg
Hillary In India - Bloomberg
::2009/07/20::
Play Video
8
ACTC Advanced Cell Technology Inc.(ACTC.OB) ADVANCED CELL TECH
ACTC Advanced Cell Technology Inc.(ACTC.OB) ADVANCED CELL TECH
::2010/12/08::
Play Video
9
12 Days of Bitcoin: Who Is the Creator?
12 Days of Bitcoin: Who Is the Creator?
::2014/03/06::
Play Video
10
ACTC at the Great Western Bike Rally 2007
ACTC at the Great Western Bike Rally 2007
::2007/06/12::
Play Video
11
Bloomberg TV   Interview with Presdir Newmont Nusa Tenggara
Bloomberg TV Interview with Presdir Newmont Nusa Tenggara
::2014/02/28::
Play Video
12
III Campeonato de Aceleración 1/4 Milla "ACTC",, mini- 124.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC",, mini- 124.wmv
::2011/08/12::
Play Video
13
reg VS sdo 1
reg VS sdo 1
::2009/03/30::
Play Video
14
Bloomberg TV interview
Bloomberg TV interview
::2012/05/14::
Play Video
15
Advanced Cell Technology "ACTC" ON FOX Ticker March 23, 2009
Advanced Cell Technology "ACTC" ON FOX Ticker March 23, 2009
::2009/03/23::
Play Video
16
como descargar e instalar tc 2011 para simu tc
como descargar e instalar tc 2011 para simu tc
::2013/04/16::
Play Video
17
TuToRiaL- Como Descargar E Instalar Actc Full Gratis! [Loquendo]
TuToRiaL- Como Descargar E Instalar Actc Full Gratis! [Loquendo]
::2012/04/21::
Play Video
18
III Campeonato de Aceleración 1/4 Milla "ACTC", c3-124.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC", c3-124.wmv
::2011/08/12::
Play Video
19
PuppetMasteR - Far away at home Disc 2: 09 - Uno Turbo i.e.
PuppetMasteR - Far away at home Disc 2: 09 - Uno Turbo i.e.
::2011/08/12::
Play Video
20
soto de valderrueda  ( león )
soto de valderrueda ( león )
::2011/07/18::
Play Video
21
III Campeonato de Aceleración 1/4 Milla "ACTC", c3-c4.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC", c3-c4.wmv
::2011/08/16::
Play Video
22
reg VS actc 2
reg VS actc 2
::2009/03/22::
Play Video
23
Advanced Cell Tech phase 1 trading volumes remain high in the stem cell company
Advanced Cell Tech phase 1 trading volumes remain high in the stem cell company's stock
::2010/10/14::
Play Video
24
calidaddelaactc1.mp4
calidaddelaactc1.mp4
::2011/11/14::
Play Video
25
Max Connop of Aedas Architects on Bloomberg
Max Connop of Aedas Architects on Bloomberg's Greener Asia.wmv
::2011/05/31::
Play Video
26
descargar y instalar actc 2000
descargar y instalar actc 2000
::2012/12/08::
Play Video
27
Lt. Gen. Williams of the US Marine Corps
Lt. Gen. Williams of the US Marine Corps
::2013/07/10::
Play Video
28
CNN - John King State of the Union - March 8, 2009
CNN - John King State of the Union - March 8, 2009
::2009/03/09::
Play Video
29
Facebook Beats Street: What Analysts Are Missing
Facebook Beats Street: What Analysts Are Missing
::2014/04/23::
Play Video
30
Bloomberg video interview with Bezurk CEO
Bloomberg video interview with Bezurk CEO
::2008/01/15::
Play Video
31
III Campeonato de Aceleración 1/4 Milla "ACTC", c4-mini.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC", c4-mini.wmv
::2011/08/12::
Play Video
32
Recruitment and Retention Strategies for Board: Comment on Board Responsibilities
Recruitment and Retention Strategies for Board: Comment on Board Responsibilities
::2011/04/29::
Play Video
33
Bill Beach on Bloomberg TV
Bill Beach on Bloomberg TV
::2009/01/06::
Play Video
34
Bloomberg Interview with Stephen Cannon
Bloomberg Interview with Stephen Cannon
::2009/02/09::
Play Video
35
Finles CEO Rob van Kuijk on Bloomberg Television
Finles CEO Rob van Kuijk on Bloomberg Television
::2007/10/24::
Play Video
36
Tutorial Como Descargar Loquendo para pc(1 link )
Tutorial Como Descargar Loquendo para pc(1 link )
::2012/12/21::
Play Video
37
Japan
Japan's Temperature And Productivity - Bloomberg
::2009/07/30::
Play Video
38
III Campeonato de Aceleración 1/4 Milla "ACTC", mini - 131.wmv
III Campeonato de Aceleración 1/4 Milla "ACTC", mini - 131.wmv
::2011/08/16::
Play Video
39
ACTC: Nasdaq Listing and Russell 2000 Index
ACTC: Nasdaq Listing and Russell 2000 Index
::2012/05/10::
Play Video
40
Advanced Cell Technology (ACTC.OB) Technical Stock Chart Video
Advanced Cell Technology (ACTC.OB) Technical Stock Chart Video
::2011/04/04::
Play Video
41
Lançamento do  Uno Turbo i.e 1994
Lançamento do Uno Turbo i.e 1994
::2011/08/01::
Play Video
42
como descargar e instalar mod en el actc
como descargar e instalar mod en el actc
::2013/03/08::
Play Video
43
Dr. Robert Lanza from Advanced Cell Technology Inc. with Barbara Walters - Stem Cell Research
Dr. Robert Lanza from Advanced Cell Technology Inc. with Barbara Walters - Stem Cell Research
::2009/03/07::
Play Video
44
Lt Gen William Caldwell speaks to newest Afghan Elite Police Officers
Lt Gen William Caldwell speaks to newest Afghan Elite Police Officers
::2010/05/06::
Play Video
45
CNN News Part 1 - Stem Cell Ban Reversal by Obama- March 9, 2009
CNN News Part 1 - Stem Cell Ban Reversal by Obama- March 9, 2009
::2009/03/10::
Play Video
46
Jeffrey Scott, CIO, on Bloomberg Television
Jeffrey Scott, CIO, on Bloomberg Television's 'Market Makers'
::2012/12/07::
Play Video
47
I Concentración de Vehículos Clásicos La Trinidad.wmv
I Concentración de Vehículos Clásicos La Trinidad.wmv
::2010/08/11::
Play Video
48
Prioro Turístico. Visitar prioro
Prioro Turístico. Visitar prioro
::2013/03/27::
Play Video
49
Bloomberg TV Gets Royce Reaction to GSE Reform
Bloomberg TV Gets Royce Reaction to GSE Reform
::2011/02/11::
Play Video
50
World Wide Sensation William Caldwell
World Wide Sensation William Caldwell
::2011/04/12::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Actin, alpha, cardiac muscle 1
Protein ACTC1 PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTC1 ; ACTC; ASD5; CMD1R; CMH11; LVNC4
External IDs OMIM102540 MGI87905 HomoloGene68446 GeneCards: ACTC1 Gene
RNA expression pattern
PBB GE ACTC1 205132 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 70 11464
Ensembl ENSG00000159251 ENSMUSG00000068614
UniProt P68032 P68033
RefSeq (mRNA) NM_005159 NM_009608
RefSeq (protein) NP_005150 NP_033738
Location (UCSC) Chr 15:
35.08 – 35.09 Mb
Chr 2:
114.05 – 114.05 Mb
PubMed search [1] [2]

Actin, alpha cardiac muscle 1 is a protein that in humans is encoded by the ACTC1 gene.[1][2]

Function[edit]

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is composed of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).[2]

It has been suggested that the ACTC1 gene has a role during development. Experiments in chick embryos found an association between ACTC1 knockdown and a reduction in the artrial septa.[3]

Role in disease[edit]

Polymorphisms in ACTC1 have been linked to Dilated Cardiomyopathy in a small number of Japanese patients.[4] Further studies in patients from South Africa found no association.[5] The E101K missense mutation has been associated with Hypertrophic Cardiomyopathy[6][7][8][9] and Left Ventricular Noncompaction.[10] Another mutation has in the ACTC1 gene has been associated with atrial septal defects.[3]

References[edit]

  1. ^ Kramer PL, Luty JA, Litt M (Aug 1992). "Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q". Genomics 13 (3): 904–5. doi:10.1016/0888-7543(92)90185-U. PMID 1639426. 
  2. ^ a b "Entrez Gene: ACTC1 actin, alpha, cardiac muscle 1". 
  3. ^ a b Matsson H, et al (Jan 2008). "Alpha-cardiac actin mutations produce atrial septal defects.". Hum Mol Genet. 17 (2): 256–65. doi:10.1093/hmg/ddm302. PMID 17947298. 
  4. ^ Takai E, et al (Oct 1999). "Mutational analysis of the cardiac actin gene in familial and sporadic dilated cardiomyopathy.". Am J Med Genet. 86 (4): 325–7. doi:10.1002/(SICI)1096-8628. 
  5. ^ Mayosi BM, et al (Oct 1999). "Cardiac and skeletal actin gene mutations are not a common cause of dilated cardiomyopathy.". J Med Genet. 36 (10): 796–7. doi:10.1136/jmg.36.10.796. 
  6. ^ Olson TM, et al (Sep 2000). "Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy.". J Mol Cell Cardiol. 32 (9): 1687–94. doi:10.1006/jmcc.2000.1204. PMID 10966831. 
  7. ^ Arad M, et al (Nov 2005). "Gene mutations in apical hypertrophic cardiomyopathy.". Circulation. 112 (18): 2805–11. doi:10.1161/CIRCULATIONAHA.105.547448. 
  8. ^ Monserrat L, et al (Aug 2007). "Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects.". Eur Heart J. 28 (16): 1953–61. doi:10.1093/eurheartj/ehm239. 
  9. ^ Morita H, et al (May 2008). "Shared genetic causes of cardiac hypertrophy in children and adults.". N Engl J Med. 358 (18): 1899–908. doi:10.1056/NEJMoa075463. 
  10. ^ Klaassen S, et al (June 2008). "Mutations in sarcomere protein genes in left ventricular noncompaction.". Circulation. 117 (22): 2893–901. doi:10.1161/CIRCULATIONAHA.107.746164. PMID 1850600. 

Further reading[edit]

External links[edit]



Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014