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ALPL-Bergrennen 1984
ALPL-Bergrennen 1984
Published: 2013/04/14
Channel: Wolfgang Zuntner
ALPL-Bergrennen 70er Jahre
ALPL-Bergrennen 70er Jahre
Published: 2013/04/15
Channel: Wolfgang Zuntner
Alpl 2015
Alpl 2015
Published: 2015/08/22
Channel: turbobert
Waldheimat Alpl
Waldheimat Alpl
Published: 2012/09/19
Channel: AlplWaldheimathof
Schitag Alpl
Schitag Alpl
Published: 2011/02/25
Channel: mailmokka
Kawasakiz1000 Alpl
Kawasakiz1000 Alpl
Published: 2015/08/09
Channel: Heinz Angerer
Alpl
Alpl
Published: 2017/08/17
Channel: günther russel
alpl 2010.avi
alpl 2010.avi
Published: 2010/08/23
Channel: elricoat
Alpl  2011
Alpl 2011
Published: 2011/02/16
Channel: ArminHf10
CRAZY SINGER ALPL
CRAZY SINGER ALPL
Published: 2015/01/18
Channel: pilarpanuska
Alpl   Drohne
Alpl Drohne
Published: 2016/11/08
Channel: Bernd Huber
ALPL Live Stream Chick Hatching
ALPL Live Stream Chick Hatching
Published: 2016/06/21
Channel: Avon Lake Public Library
Bruggraber"s Familienurlaub für sommer und winter Waldheimathof Alpl getestet
Bruggraber"s Familienurlaub für sommer und winter Waldheimathof Alpl getestet
Published: 2011/08/16
Channel: thepampers6
Lloyd alpl
Lloyd alpl
Published: 2017/06/13
Channel: boobal sbs
Hofer Alpl Südtirol
Hofer Alpl Südtirol
Published: 2012/06/17
Channel: hoferalpl
von Krieglach auf
von Krieglach auf's Alpl :) #wandern
Published: 2017/08/28
Channel: jasmin kubat
Alpl Pvt Ltd
Alpl Pvt Ltd
Published: 2017/07/01
Channel: Mahadeb Lohar
Alpl 30. und 31.1.2016
Alpl 30. und 31.1.2016
Published: 2016/02/03
Channel: Markus W.
S6 Autobahn Krieglach nach Waldheimat Alpl (Zinkhaus FEWO)
S6 Autobahn Krieglach nach Waldheimat Alpl (Zinkhaus FEWO)
Published: 2013/12/09
Channel: Zinkhaus Alpl
GoldWing/Alpl ab St. Kathrein, September 2017
GoldWing/Alpl ab St. Kathrein, September 2017
Published: 2017/09/09
Channel: C. H.
Sturmtief "Andrea" fegt übers Alpl
Sturmtief "Andrea" fegt übers Alpl
Published: 2012/01/14
Channel: ArminHf10
Faschingssitzung der Faschingsgilde Alpl 2014
Faschingssitzung der Faschingsgilde Alpl 2014
Published: 2014/01/15
Channel: Medien Verein
Harrys liabste Hütt
Harrys liabste Hütt'n Alpl Joglland
Published: 2012/09/19
Channel: AlplWaldheimathof
Motorradausflug Alpl 29 06 2013
Motorradausflug Alpl 29 06 2013
Published: 2013/06/29
Channel: TomCaspa
Roseggerhof TV -  Christmettenweg in Peter Rosegger´s Waldheimat - Alpl
Roseggerhof TV - Christmettenweg in Peter Rosegger´s Waldheimat - Alpl
Published: 2009/01/10
Channel: roseggerhof
Christmettenweg in Peter Rosegger´s Waldheimat - Alpl
Christmettenweg in Peter Rosegger´s Waldheimat - Alpl
Published: 2010/07/08
Channel: grillprivatzimmer
Hofer Alpl
Hofer Alpl
Published: 2012/06/17
Channel: hoferalpl
1.Rosegger Wirtshaus-Singen auf dem Alpl im GH Roseggerhof
1.Rosegger Wirtshaus-Singen auf dem Alpl im GH Roseggerhof
Published: 2013/10/14
Channel: Medien Verein
ALPL zasklievanie
ALPL zasklievanie
Published: 2016/06/29
Channel: matus ivan
ALPL ( Suara si cantik Aira Yudhoyono )
ALPL ( Suara si cantik Aira Yudhoyono )
Published: 2013/12/05
Channel: Amboun Muaniez'se
ALPL Live Stream Chicken Hatching
ALPL Live Stream Chicken Hatching
Published: 2016/06/21
Channel: Avon Lake Public Library
ALPL Live Stream Chicken Hatching
ALPL Live Stream Chicken Hatching
Published: 2016/06/21
Channel: Avon Lake Public Library
fazer2010 alpl steiermark
fazer2010 alpl steiermark
Published: 2010/10/29
Channel: günther russel
Alpl Wochenende 24.-26.2.2017
Alpl Wochenende 24.-26.2.2017
Published: 2017/03/02
Channel: Markus W.
Conférence de presse de l
Conférence de presse de l'ALPL et du LCGB-SEA "Lutte contre la fatigue des pilotes (3 octobre 2012)
Published: 2012/10/04
Channel: lcgblux
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 8/12
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 8/12
Published: 2015/05/09
Channel: Wolfgang Pototschnik
Nieder Alpl - Seeberg - Pgusch
Nieder Alpl - Seeberg - Pgusch
Published: 2011/07/24
Channel: michaelklbg
Alpl Schikurs 2013
Alpl Schikurs 2013
Published: 2013/01/17
Channel: renatestr
Skitour Weekend Alpl 24-26.02.2017
Skitour Weekend Alpl 24-26.02.2017
Published: 2017/04/02
Channel: Matthias Schnoater
Kopie von Kawasakiz1000 Alpl
Kopie von Kawasakiz1000 Alpl
Published: 2015/08/09
Channel: Heinz Angerer
Pilgerweg vom Alpl bis Gh. Postmühle  Teil 3
Pilgerweg vom Alpl bis Gh. Postmühle Teil 3
Published: 2013/07/28
Channel: Robert Rosskogler
Angelos Touren: Schneeschuh Alpl - Stanglalm
Angelos Touren: Schneeschuh Alpl - Stanglalm
Published: 2014/02/23
Channel: Franz ANGELO Gruber
Alpl-Schi-1.avi
Alpl-Schi-1.avi
Published: 2012/03/10
Channel: weichsel1
100725 Alpl
100725 Alpl
Published: 2010/08/03
Channel: feherkingus
Hofer Alpl nach Völs... alleeene...
Hofer Alpl nach Völs... alleeene...
Published: 2017/07/27
Channel: Felix Kluge
Dolomite Alphorn Concert at Tierser Alpl Alpine Refuge
Dolomite Alphorn Concert at Tierser Alpl Alpine Refuge
Published: 2010/07/29
Channel: rosengrenerik
Gasthof Alpl, Sirnitz, Austria - Cheap Hotel Deals & Rates 2017
Gasthof Alpl, Sirnitz, Austria - Cheap Hotel Deals & Rates 2017
Published: 2017/07/06
Channel: Cheap Hotels Austria
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 5/12
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 5/12
Published: 2015/05/09
Channel: Wolfgang Pototschnik
Alpl 03012009 0003
Alpl 03012009 0003
Published: 2009/01/04
Channel: a2boei
Volvo V40 vs  Alpl
Volvo V40 vs Alpl
Published: 2014/12/27
Channel: Gottfried Masutti
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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ALPL
Identifiers
Aliases ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, alkaline phosphatase, liver/bone/kidney
External IDs MGI: 87983 HomoloGene: 37314 GeneCards: ALPL
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ALPL
Genomic location for ALPL
Band 1p36.12 Start 21,509,372 bp[1]
End 21,578,412 bp[1]
RNA expression pattern
PBB GE ALPL 215783 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000478
NM_001127501
NM_001177520

NM_001287172
NM_001287176
NM_007431

RefSeq (protein)

NP_000469
NP_001120973
NP_001170991

NP_001274101
NP_031457

Location (UCSC) Chr 1: 21.51 – 21.58 Mb Chr 1: 137.74 – 137.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene.[5][6]

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization. However, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation, since this determines age of onset and severity of symptoms.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162551 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028766 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986). "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase". Proc Natl Acad Sci U S A. 83 (19): 7182–6. PMC 386679Freely accessible. PMID 3532105. doi:10.1073/pnas.83.19.7182. 
  6. ^ Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, Goodfellow P (May 1988). "Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1". Ann Hum Genet. 50 (Pt 3): 229–35. PMID 3446011. doi:10.1111/j.1469-1809.1986.tb01043.x. 
  7. ^ "Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney". 

External links[edit]

Further reading[edit]


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