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ALPL-Bergrennen 70er Jahre
ALPL-Bergrennen 70er Jahre
Published: 2013/04/15
Channel: Wolfgang Zuntner
ALPL-Bergrennen 1984
ALPL-Bergrennen 1984
Published: 2013/04/14
Channel: Wolfgang Zuntner
Alpl 2015
Alpl 2015
Published: 2015/08/22
Channel: turbobert
Waldheimat Alpl
Waldheimat Alpl
Published: 2012/09/19
Channel: AlplWaldheimathof
Schitag Alpl
Schitag Alpl
Published: 2011/02/25
Channel: mailmokka
Kawasakiz1000 Alpl
Kawasakiz1000 Alpl
Published: 2015/08/09
Channel: Heinz Angerer
Alpl   Drohne
Alpl Drohne
Published: 2016/11/08
Channel: Bernd Huber
2016 Sí móka | ALPL
2016 Sí móka | ALPL
Published: 2016/11/29
Channel: András Szerelem
Faschingssitzung der Faschingsgilde Alpl 2014
Faschingssitzung der Faschingsgilde Alpl 2014
Published: 2014/01/15
Channel: Medien Verein
Bruggraber"s Familienurlaub für sommer und winter Waldheimathof Alpl getestet
Bruggraber"s Familienurlaub für sommer und winter Waldheimathof Alpl getestet
Published: 2011/08/16
Channel: thepampers6
Alpl  2011
Alpl 2011
Published: 2011/02/16
Channel: ArminHf10
Lloyd alpl
Lloyd alpl
Published: 2017/06/13
Channel: boobal sbs
ALPL Live Stream Chick Hatching
ALPL Live Stream Chick Hatching
Published: 2016/06/21
Channel: Avon Lake Public Library
Alpl Pvt Ltd
Alpl Pvt Ltd
Published: 2017/07/01
Channel: Mahadeb Lohar
Knottenkonzert mit Heidi Pixner beim Tierser Alpl
Knottenkonzert mit Heidi Pixner beim Tierser Alpl
Published: 2011/08/10
Channel: Seiser Alm
Gasthof Alpl - Sirnitz Hotels, Austria
Gasthof Alpl - Sirnitz Hotels, Austria
Published: 2017/01/22
Channel: Best World Hotels
ALPL zasklievanie
ALPL zasklievanie
Published: 2016/06/29
Channel: matus ivan
Harrys liabste Hütt
Harrys liabste Hütt'n Alpl Joglland
Published: 2012/09/19
Channel: AlplWaldheimathof
Alpl Steiermark - Hill Climb 1984
Alpl Steiermark - Hill Climb 1984
Published: 2017/06/28
Channel: New Switch182
Südtirol Venedig Istrien   Zur Seiser Alm und Tierser Alpl
Südtirol Venedig Istrien Zur Seiser Alm und Tierser Alpl
Published: 2016/07/03
Channel: Video Art-ig
S6 Autobahn Krieglach nach Waldheimat Alpl (Zinkhaus FEWO)
S6 Autobahn Krieglach nach Waldheimat Alpl (Zinkhaus FEWO)
Published: 2013/12/09
Channel: Zinkhaus Alpl
ALPL zaslievanie panorama 3-sklo
ALPL zaslievanie panorama 3-sklo
Published: 2016/08/23
Channel: matus ivan
Schitour Inzinger Alpl - Brechten
Schitour Inzinger Alpl - Brechten
Published: 2015/02/12
Channel: Alexander Egger
Alpl-Schi-1.avi
Alpl-Schi-1.avi
Published: 2012/03/10
Channel: weichsel1
From te balcony Gasthof ALPL
From te balcony Gasthof ALPL
Published: 2010/01/23
Channel: JonnyW57
Sturmtief "Andrea" fegt übers Alpl
Sturmtief "Andrea" fegt übers Alpl
Published: 2012/01/14
Channel: ArminHf10
alpl 2010.avi
alpl 2010.avi
Published: 2010/08/23
Channel: elricoat
ALPL vysklievanie
ALPL vysklievanie
Published: 2016/11/23
Channel: matus ivan
Gene Music using Protein Sequence of ALPL "ALKALINE PHOSPHATASE, LIVER/BONE/KIDNEY"
Gene Music using Protein Sequence of ALPL "ALKALINE PHOSPHATASE, LIVER/BONE/KIDNEY"
Published: 2016/09/24
Channel: Gene Music Studio
Motorradausflug Alpl 29 06 2013
Motorradausflug Alpl 29 06 2013
Published: 2013/06/29
Channel: TomCaspa
Snowboard on Alpl
Snowboard on Alpl
Published: 2008/02/05
Channel: Andreas Dobias
Ranger Spacecraft ALPL hecha en Japón
Ranger Spacecraft ALPL hecha en Japón
Published: 2017/01/20
Channel: mardomagu
Nieder Alpl - Seeberg - Pgusch
Nieder Alpl - Seeberg - Pgusch
Published: 2011/07/24
Channel: michaelklbg
Krampen Neuberg an der Mürz Alpl Lechen Dietlergraben Kapellen Österreich Austria 12.4.2015
Krampen Neuberg an der Mürz Alpl Lechen Dietlergraben Kapellen Österreich Austria 12.4.2015
Published: 2015/07/29
Channel: WirWollen EuchNicht
Kopie von Kawasakiz1000 Alpl
Kopie von Kawasakiz1000 Alpl
Published: 2015/08/09
Channel: Heinz Angerer
fazer2010 alpl steiermark
fazer2010 alpl steiermark
Published: 2010/10/29
Channel: günther russel
Volvo V40 vs  Alpl
Volvo V40 vs Alpl
Published: 2014/12/27
Channel: Gottfried Masutti
Airtel Lanka | ALPL Logo Launch (Internal Event) by D STUDIO CMB
Airtel Lanka | ALPL Logo Launch (Internal Event) by D STUDIO CMB
Published: 2012/07/06
Channel: dstudiocmb
UWB Wankspitze/Alpl 2016
UWB Wankspitze/Alpl 2016
Published: 2016/11/29
Channel: Astrobert
HIPOFOSFATASIA SEQUENCIAMENTO DO GENE ALPL
HIPOFOSFATASIA SEQUENCIAMENTO DO GENE ALPL
Published: 2016/10/18
Channel: Centro de Genomas
Zinkhaus - Waldheimat Alpl, Sankt Kathrein, Austria - Cheap Hotel Deals & Rates 2017
Zinkhaus - Waldheimat Alpl, Sankt Kathrein, Austria - Cheap Hotel Deals & Rates 2017
Published: 2017/03/31
Channel: Austria Hotels - See Reviews, Choose, Book
Gasthof Alpl, Sirnitz, Austria - Cheap Hotel Deals & Rates 2017
Gasthof Alpl, Sirnitz, Austria - Cheap Hotel Deals & Rates 2017
Published: 2017/07/06
Channel: Cheap Hotels Austria
mematvo.at - KW 31 - Jakob der Letzte am Alpl
mematvo.at - KW 31 - Jakob der Letzte am Alpl
Published: 2013/08/06
Channel: Fritz Linner
ALPL Live Stream Chicken Hatching
ALPL Live Stream Chicken Hatching
Published: 2016/06/21
Channel: Avon Lake Public Library
Alpl 03012009 0003
Alpl 03012009 0003
Published: 2009/01/04
Channel: a2boei
Dolomite Alphorn Concert at Tierser Alpl Alpine Refuge
Dolomite Alphorn Concert at Tierser Alpl Alpine Refuge
Published: 2010/07/29
Channel: rosengrenerik
Pilgerweg vom Alpl bis Gh. Postmühle  Teil 3
Pilgerweg vom Alpl bis Gh. Postmühle Teil 3
Published: 2013/07/28
Channel: Robert Rosskogler
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 5/12
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 5/12
Published: 2015/05/09
Channel: Wolfgang Pototschnik
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 1/12
2015-04-21 Vespa GTS 300 ie - Alpl - Höllental 1/12
Published: 2015/05/09
Channel: Wolfgang Pototschnik
COMEMORAÇÃO DA FESTA DO DIA DAS MÃES DA ALPL
COMEMORAÇÃO DA FESTA DO DIA DAS MÃES DA ALPL
Published: 2012/05/18
Channel: josivan Gomes
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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ALPL
Identifiers
Aliases ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, alkaline phosphatase, liver/bone/kidney
External IDs MGI: 87983 HomoloGene: 37314 GeneCards: ALPL
RNA expression pattern
PBB GE ALPL 215783 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000478
NM_001127501
NM_001177520

NM_001287172
NM_001287176
NM_007431

RefSeq (protein)

NP_000469
NP_001120973
NP_001170991

NP_001274101
NP_031457

Location (UCSC) Chr 1: 21.51 – 21.58 Mb Chr 4: 137.74 – 137.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene.[3][4]

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization. However, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation, since this determines age of onset and severity of symptoms.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986). "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase". Proc Natl Acad Sci U S A. 83 (19): 7182–6. PMC 386679Freely accessible. PMID 3532105. doi:10.1073/pnas.83.19.7182. 
  4. ^ Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, Goodfellow P (May 1988). "Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1". Ann Hum Genet. 50 (Pt 3): 229–35. PMID 3446011. doi:10.1111/j.1469-1809.1986.tb01043.x. 
  5. ^ "Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney". 

External links[edit]

Further reading[edit]


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