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1
VJ Ank1 Alchemy spacing
VJ Ank1 Alchemy spacing
::2010/04/10::
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2
NOISIA - VJ ANK1 @ Victorie
NOISIA - VJ ANK1 @ Victorie
::2010/03/07::
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3
VJ Ank1: Showreel 2012
VJ Ank1: Showreel 2012
::2013/01/10::
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4
VJ Ank1 ADE 2012
VJ Ank1 ADE 2012
::2012/10/29::
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5
VJ Ank1 & VJ Void @ SPOOF   Patronaat
VJ Ank1 & VJ Void @ SPOOF Patronaat
::2011/10/04::
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6
VJ Ank1
VJ Ank1's 3d Videomapping stage @ BKJN Bassacadamy
::2013/01/28::
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7
VJ Ank1 & VJ Judocus- Trentemoller Melkweg
VJ Ank1 & VJ Judocus- Trentemoller Melkweg
::2011/10/02::
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8
VJ Ank1
VJ Ank1's new project
::2013/11/05::
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9
VJ Ank1, Work in progress, LED vs Mapping Workshop
VJ Ank1, Work in progress, LED vs Mapping Workshop
::2013/10/21::
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10
VJ Ank1 @ ADE Visual Conference, Pakhuis de Zwijger
VJ Ank1 @ ADE Visual Conference, Pakhuis de Zwijger
::2013/10/20::
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11
VJ Ank1 : Kraakvj Contest
VJ Ank1 : Kraakvj Contest
::2010/03/25::
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12
VJ Ank1 @ Noodlanding Paradiso VJ academy
VJ Ank1 @ Noodlanding Paradiso VJ academy
::2010/04/15::
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13
VJ Ank1 : Mashup
VJ Ank1 : Mashup
::2009/09/16::
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14
ank1 ace + DEF
ank1 ace + DEF
::2010/08/10::
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15
VJ Ank1 @ STRAF_WERK, Melkweg
VJ Ank1 @ STRAF_WERK, Melkweg
::2011/12/10::
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16
VJ Ank1 - Videomapping Magneet Festival 2013
VJ Ank1 - Videomapping Magneet Festival 2013
::2013/09/30::
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17
Sound of Stereo - ApenZooi NYE 2012 : VJ Ank1
Sound of Stereo - ApenZooi NYE 2012 : VJ Ank1
::2012/01/09::
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18
9-20-09 Dulles South Eagles Ank1 vs Vienna Warhogs Part 1
9-20-09 Dulles South Eagles Ank1 vs Vienna Warhogs Part 1
::2009/09/21::
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19
VJ Ank1 @ Free Your Mind Festival 2010 met Joost van Bellen en Mightyfools
VJ Ank1 @ Free Your Mind Festival 2010 met Joost van Bellen en Mightyfools
::2010/06/09::
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20
ANK1
ANK1
::2010/11/22::
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21
10-4 Dulles South Eagles Ank1 vs South County Colts Part 1
10-4 Dulles South Eagles Ank1 vs South County Colts Part 1
::2009/10/05::
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22
9-20-09 Dulles South Eagles Ank1 vs Vienna Warhogs Part 2
9-20-09 Dulles South Eagles Ank1 vs Vienna Warhogs Part 2
::2009/09/21::
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23
ApenZooi Unie - Laatste Momentje - VJ Ank1
ApenZooi Unie - Laatste Momentje - VJ Ank1
::2012/01/09::
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24
VJ Ank1 : Kraakvj Contest
VJ Ank1 : Kraakvj Contest
::2010/03/25::
Play Video
25
VJ Ank1 Videomapping @ ADE Iamtechno - De Balie
VJ Ank1 Videomapping @ ADE Iamtechno - De Balie
::2011/11/13::
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26
ank1
ank1
::2008/07/13::
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27
9-12-09 Scrimmage Dulles South Ank1 vs Reston at Stone Ridge pt 2
9-12-09 Scrimmage Dulles South Ank1 vs Reston at Stone Ridge pt 2
::2009/09/13::
Play Video
28
VJ Ank1 : Kraakvj Contest
VJ Ank1 : Kraakvj Contest
::2010/03/25::
Play Video
29
ANK1 5b KARÁCSONY 2012
ANK1 5b KARÁCSONY 2012
::2012/12/17::
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30
doi khang(trung ank1)
doi khang(trung ank1)
::2011/06/09::
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31
9-12-09 Scrimmage Dulles South Ank1 vs Reston at Stone Ridge pt 1
9-12-09 Scrimmage Dulles South Ank1 vs Reston at Stone Ridge pt 1
::2009/09/13::
Play Video
32
VJ Ank1 @ Campina Innovation Centre Opening
VJ Ank1 @ Campina Innovation Centre Opening
::2013/10/23::
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33
VJ Ank1, VJ Academy reel
VJ Ank1, VJ Academy reel
::2010/03/30::
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34
9-26 Dulles South Eagles Ank1 vs Gainesville Grizzlies Part 1
9-26 Dulles South Eagles Ank1 vs Gainesville Grizzlies Part 1
::2009/10/04::
Play Video
35
VJ Ank1 @ klinch Melkweg 15-05-9
VJ Ank1 @ klinch Melkweg 15-05-9
::2009/05/19::
Play Video
36
9-26 Dulles South Eagles Ank1 vs Gainesville Grizzlies Part 2
9-26 Dulles South Eagles Ank1 vs Gainesville Grizzlies Part 2
::2009/10/04::
Play Video
37
20 CEAGEN PAGRAM ANK1.mpg
20 CEAGEN PAGRAM ANK1.mpg
::2012/04/18::
Play Video
38
5min of St. Paul & VJ Ank1 @ popfiction
5min of St. Paul & VJ Ank1 @ popfiction
::2010/04/04::
Play Video
39
VJ Ank1 @ Straf_Werk
VJ Ank1 @ Straf_Werk
::2013/04/15::
Play Video
40
OS ank1.wmv
OS ank1.wmv
::2010/12/04::
Play Video
41
VJ Ank1 @ Club Air, Midnight Freaks Tattoo Edition
VJ Ank1 @ Club Air, Midnight Freaks Tattoo Edition
::2010/12/04::
Play Video
42
ANK1 Marcius_15_i_unnepseg 2013
ANK1 Marcius_15_i_unnepseg 2013
::2013/03/31::
Play Video
43
HOCKY EJ AB ANK1 29 DEC
HOCKY EJ AB ANK1 29 DEC
::2013/12/30::
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44
8.D táncosok, ank1
8.D táncosok, ank1
::2010/06/21::
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45
ank1
ank1
::2011/12/18::
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46
Karácsony 2012 5.b ANK1
Karácsony 2012 5.b ANK1
::2012/12/17::
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47
SMKN 6 MKS,,, lomba kasida ank1 AK.1DAN 1AK2
SMKN 6 MKS,,, lomba kasida ank1 AK.1DAN 1AK2
::2012/08/11::
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48
NewsX Ank1
NewsX Ank1
::2011/07/08::
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49
VJ Ank1   Electric Picknic   Ireland   Impressie
VJ Ank1 Electric Picknic Ireland Impressie
::2011/09/06::
Play Video
50
VJ Ank1 DEMOreel oktober 2010
VJ Ank1 DEMOreel oktober 2010
::2010/12/08::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Ankyrin 1, erythrocytic
Protein ANK1 PDB 1n11.png
PDB rendering based on 1n11.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANK1 ; ANK; SPH1; SPH2
External IDs OMIM612641 MGI88024 HomoloGene55427 GeneCards: ANK1 Gene
RNA expression pattern
PBB GE ANK1 205389 s at tn.png
PBB GE ANK1 205390 s at tn.png
PBB GE ANK1 205391 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 286 11733
Ensembl ENSG00000029534 ENSMUSG00000031543
UniProt P16157 Q02357
RefSeq (mRNA) NM_000037 NM_001110783
RefSeq (protein) NP_000028 NP_001104253
Location (UCSC) Chr 8:
41.51 – 41.75 Mb
Chr 8:
22.97 – 23.15 Mb
PubMed search [1] [2]

Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1 gene.[1][2]

Tissue distribution[edit]

The protein encoded by this gene, Ankyrin 1, is the prototype of the ankyrin family, was first discovered in erythrocytes, but since has also been found in brain and muscles.[2]

Genetics[edit]

Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.[2]

Disease linkage[edit]

Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis.[2]

Function[edit]

The ANK1 protein belongs to the ankyrin family that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin-binding domain; and a carboxy-terminal regulatory domain, which is the least conserved and subject to variation.[2]

The small ANK1 (sAnk1) protein splice variants makes contacts with obscurin, a giant protein surrounding the contractile apparatus in striated muscle.[3]

Interactions[edit]

ANK1 has been shown to interact with T-cell lymphoma invasion and metastasis-inducing protein 1,[4] Titin,[5] RHAG[6] and OBSCN.[7]

See also[edit]

References[edit]

  1. ^ Lambert S, Yu H, Prchal JT, et al. (March 1990). "cDNA sequence for human erythrocyte ankyrin". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1730–4. doi:10.1073/pnas.87.5.1730. PMC 53556. PMID 1689849. 
  2. ^ a b c d e "Entrez Gene: ANK1 ankyrin 1, erythrocytic". 
  3. ^ Borzok MA, Catino DH, Nicholson JD, Kontrogianni-Konstantopoulos A, Bloch RJ (November 2007). "Mapping the binding site on small ankyrin 1 for obscurin". J. Biol. Chem. 282 (44): 32384–96. doi:10.1074/jbc.M704089200. PMID 17720975. 
  4. ^ Bourguignon, L Y; Zhu H; Shao L; Chen Y W (July 2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". J. Cell Biol. (UNITED STATES) 150 (1): 177–91. doi:10.1083/jcb.150.1.177. ISSN 0021-9525. PMC 2185563. PMID 10893266. 
  5. ^ Kontrogianni-Konstantopoulos, Aikaterini; Bloch Robert J (February 2003). "The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin". J. Biol. Chem. (United States) 278 (6): 3985–91. doi:10.1074/jbc.M209012200. ISSN 0021-9258. PMID 12444090. 
  6. ^ Nicolas, Virginie; Le Van Kim Caroline, Gane Pierre, Birkenmeier Connie, Cartron Jean-Pierre, Colin Yves, Mouro-Chanteloup Isabelle (July 2003). "Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation". J. Biol. Chem. (United States) 278 (28): 25526–33. doi:10.1074/jbc.M302816200. ISSN 0021-9258. PMID 12719424. 
  7. ^ Kontrogianni-Konstantopoulos, Aikaterini; Jones Ellene M; Van Rossum Damian B; Bloch Robert J (March 2003). "Obscurin is a ligand for small ankyrin 1 in skeletal muscle". Mol. Biol. Cell (United States) 14 (3): 1138–48. doi:10.1091/mbc.E02-07-0411. ISSN 1059-1524. PMC 151585. PMID 12631729. 


Further reading[edit]

  • Bennett V, Baines AJ (2001). "Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.". Physiol. Rev. 81 (3): 1353–92. PMID 11427698. 
  • Bennett V (1979). "Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues.". Nature 281 (5732): 597–9. doi:10.1038/281597a0. PMID 492324. 
  • Lambert S, Yu H, Prchal JT, et al. (1990). "cDNA sequence for human erythrocyte ankyrin.". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1730–4. doi:10.1073/pnas.87.5.1730. PMC 53556. PMID 1689849. 
  • Fujimoto T, Lee K, Miwa S, Ogawa K (1991). "Immunocytochemical localization of fodrin and ankyrin in bovine chromaffin cells in vitro.". J. Histochem. Cytochem. 39 (11): 1485–93. doi:10.1177/39.11.1833445. PMID 1833445. 
  • Lux SE, John KM, Bennett V (1990). "Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.". Nature 344 (6261): 36–42. doi:10.1038/344036a0. PMID 2137557. 
  • Davis LH, Bennett V (1990). "Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.". J. Biol. Chem. 265 (18): 10589–96. PMID 2141335. 
  • Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981. 
  • Cianci CD, Giorgi M, Morrow JS (1988). "Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3.". J. Cell. Biochem. 37 (3): 301–15. doi:10.1002/jcb.240370305. PMID 2970468. 
  • Steiner JP, Bennett V (1988). "Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.". J. Biol. Chem. 263 (28): 14417–25. PMID 2971657. 
  • Hargreaves WR, Giedd KN, Verkleij A, Branton D (1981). "Reassociation of ankyrin with band 3 in erythrocyte membranes and in lipid vesicles.". J. Biol. Chem. 255 (24): 11965–72. PMID 6449514. 
  • Bourguignon LY, Lokeshwar VB, Chen X, Kerrick WG (1994). "Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction.". J. Immunol. 151 (12): 6634–44. PMID 7505012. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Morgans CW, Kopito RR (1993). "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin.". J. Cell. Sci. 105. ( Pt 4): 1137–42. PMID 8227202. 
  • Bourguignon LY, Jin H, Iida N, et al. (1993). "The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells.". J. Biol. Chem. 268 (10): 7290–7. PMID 8385102. 
  • Eber SW, Gonzalez JM, Lux ML, et al. (1996). "Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis.". Nat. Genet. 13 (2): 214–8. doi:10.1038/ng0696-214. PMID 8640229. 
  • Lanfranchi G, Muraro T, Caldara F, et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.". Genome Res. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137. 
  • del Giudice EM, Hayette S, Bozon M, et al. (1996). "Ankyrin Napoli: a de novo deletional frameshift mutation in exon 16 ankyrin gene (ANK1) associated with spherocytosis.". Br. J. Haematol. 93 (4): 828–34. doi:10.1046/j.1365-2141.1996.d01-1746.x. PMID 8703812. 
  • Zhou D, Birkenmeier CS, Williams MW, et al. (1997). "Small, membrane-bound, alternatively spliced forms of ankyrin 1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle.". J. Cell Biol. 136 (3): 621–31. doi:10.1083/jcb.136.3.621. PMC 2134284. PMID 9024692. 
  • Gallagher PG, Tse WT, Scarpa AL, et al. (1997). "Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing.". J. Biol. Chem. 272 (31): 19220–8. doi:10.1074/jbc.272.31.19220. PMID 9235914. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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