ATP11B

ATPase, class VI, type 11B

Identifiers

ATP11B; ATPIF; ATPIR

External IDs

OMIM: 605869 MGI: 1923545 HomoloGene: 32919 GeneCards: ATP11B Gene

3.6.3.1

Gene Ontology
Molecular function	• magnesium ion binding • phospholipid-translocating ATPase activity • protein binding • ATP binding • ion transmembrane transporter activity • cation-transporting ATPase activity
Cellular component	• nuclear inner membrane • early endosome • endoplasmic reticulum • plasma membrane • integral to membrane • recycling endosome • recycling endosome membrane
Biological process	• ion transport • aminophospholipid transport • ion transmembrane transport • phospholipid translocation • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
182.51 – 182.64 Mb

Chr 3:
35.75 – 35.86 Mb

PubMed search

[1]

[2]

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.^[1]^[2]^[3]

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM]^[3]

References [edit]

^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Oct 2000). "Differential expression of putative transbilayer amphipath transporters". Physiol Genomics 1 (3): 139–50. PMID 11015572.
^ ^a ^b "Entrez Gene: ATP11B ATPase, Class VI, type 11B".

References [edit]

Further reading [edit]