acta1

Channel: tombaltest   |   2013/01/30
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1
acta1
acta1
::2013/01/30::
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ACTA1/VILL.K
ACTA1/VILL.K
::2012/02/12::
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Actin filament assembly
Actin filament assembly
::2012/11/26::
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acta1
acta1
::2010/12/23::
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Actin Bad Click Posted Up In Da Car B4 The Alpha Mansion Party
Actin Bad Click Posted Up In Da Car B4 The Alpha Mansion Party
::2010/01/25::
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DMACK Actin STUPID....(very RANDOM)
DMACK Actin STUPID....(very RANDOM)
::2007/04/22::
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Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
::2010/10/27::
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alpha actinin assay simus
alpha actinin assay simus
::2014/02/14::
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9
TNF-alpha Activated Macrophages
TNF-alpha Activated Macrophages
::2011/12/01::
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10
ACTIN THE FOOL..PT2
ACTIN THE FOOL..PT2
::2009/04/26::
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11
SU Actin
SU Actin' Up
::2012/03/09::
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12
Below - FULL ACTION MOVIE
Below - FULL ACTION MOVIE
::2013/08/13::
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13
Arp2/3, actin nucleation & branching
Arp2/3, actin nucleation & branching
::2012/07/12::
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14
we actin a fool @hssu lol
we actin a fool @hssu lol
::2012/03/13::
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15
MIles College KK Psi actin a fool
MIles College KK Psi actin a fool
::2009/12/27::
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16
How to look like a guy/boy
How to look like a guy/boy
::2014/03/30::
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Neuronal migration: Actin contractions in the leading process.
Neuronal migration: Actin contractions in the leading process.
::2012/12/05::
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Actin Binding Proteins
Actin Binding Proteins
::2013/11/23::
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19
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (ZETA'S IMITATE KAPPA'S)
::2008/02/01::
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20
ME ACTIN A FOOL
ME ACTIN A FOOL
::2008/04/10::
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21
CUZNS ACTIN DUMB
CUZNS ACTIN DUMB
::2010/04/24::
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22
Jj actin crazy morehead swagg pt.1
Jj actin crazy morehead swagg pt.1
::2010/11/20::
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23
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
::2010/10/27::
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24
jEsSE™ C. Actin StÖopiD...the FIRST tyme
jEsSE™ C. Actin StÖopiD...the FIRST tyme
::2009/03/18::
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25
Abby Actin White pt.1 LMAO
Abby Actin White pt.1 LMAO
::2008/09/26::
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26
Scarecrow and Mike P! Sigmas actin foolish!
Scarecrow and Mike P! Sigmas actin foolish!
::2011/01/07::
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27
Jesse C. N Errbody Actin Stupid
Jesse C. N Errbody Actin Stupid
::2010/01/13::
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28
These Hoes Be Actin Up - Western Michigan University Tailgate - 9/8/12
These Hoes Be Actin Up - Western Michigan University Tailgate - 9/8/12
::2012/09/10::
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29
Ghost Recon: ALPHA - Full Live-Action Movie (2012) | HD
Ghost Recon: ALPHA - Full Live-Action Movie (2012) | HD
::2012/05/15::
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30
Muscle Stimulation by Motor Neuron and Muscle Contraction
Muscle Stimulation by Motor Neuron and Muscle Contraction
::2010/08/09::
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31
b phi d actin owt
b phi d actin owt
::2009/06/05::
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32
iTz a Demon
iTz a Demon's Souls! - P3 - Actin Demickey!
::2014/02/11::
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Wale Buffalo State College Spring Fest 2013 "Actin Up" pt.14
Wale Buffalo State College Spring Fest 2013 "Actin Up" pt.14
::2013/05/12::
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34
Pikachu in a tree actin like a real piece of work god damn mother fucker
Pikachu in a tree actin like a real piece of work god damn mother fucker
::2014/02/03::
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35
ACTIN A ASS AT SAVANNAH STATE
ACTIN A ASS AT SAVANNAH STATE
::2007/02/28::
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36
Alpha-actinin incorporation in paxillin complexes in WT cells
Alpha-actinin incorporation in paxillin complexes in WT cells
::2013/06/26::
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37
Jesse C. Actin Stupid
Jesse C. Actin Stupid
::2007/12/20::
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38
A phi q frat boys..jsimms n ceejay actin fooley
A phi q frat boys..jsimms n ceejay actin fooley
::2010/03/23::
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39
iTz a Let
iTz a Let's Play! - Roche Fusion Alpha 0.3
::2014/02/14::
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40
D-Struck and Rell actin a donkey
D-Struck and Rell actin a donkey
::2009/03/21::
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Microtubule regulator
Microtubule regulator
::2012/09/03::
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withrow high school actin
withrow high school actin
::2010/05/02::
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The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2010/11/22::
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actin stupid 1
actin stupid 1
::2010/05/02::
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The Teaser - DJ Gully aka Da Cute 1
The Teaser - DJ Gully aka Da Cute 1
::2012/10/23::
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46
Video of actin strand and vinulin made with SketchBio
Video of actin strand and vinulin made with SketchBio
::2013/06/11::
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47
Alpha-catenin, Vinculin
Alpha-catenin, Vinculin
::2012/06/22::
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JB, Lil Ant & Freddie B. actin silly
JB, Lil Ant & Freddie B. actin silly
::2010/04/19::
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Profilin
Profilin
::2012/08/21::
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G protein alpha subunit
G protein alpha subunit
::2012/07/14::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Actin, alpha 1, skeletal muscle

PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTA1 ; ACTA; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
External IDs OMIM102610 MGI87902 HomoloGene121702 GeneCards: ACTA1 Gene
RNA expression pattern
PBB GE ACTA1 203872 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 58 11459
Ensembl ENSG00000143632 ENSMUSG00000031972
UniProt P68133 P68134
RefSeq (mRNA) NM_001100 NM_001272041
RefSeq (protein) NP_001091 NP_001258970
Location (UCSC) Chr 1:
229.57 – 229.57 Mb
Chr 8:
123.89 – 123.89 Mb
PubMed search [1] [2]

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.[1][2]

Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]

Skeletal actin gene expression[edit]

Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation.[4] Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation.[5] One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene.[6] SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.[7]

Interactions[edit]

Actin, alpha 1 has been shown to interact with TMSB4X,[8][9] MIB2[10] and PRKCE.[11]

See also[edit]

References[edit]

  1. ^ Mogensen J, Kruse TA, Borglum (March 1999). "Assignment of the human skeletal muscle [FC12]a-actin gene (ACTA1) to chromosome 1q42.13-->q42.2 by radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 224–5. doi:10.1159/000015184. PMID 10072583. 
  2. ^ Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L (August 1983). "Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed". Mol Cell Biol 3 (5): 787–95. PMC 368601. PMID 6865942. 
  3. ^ "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle". 
  4. ^ Bandman, E (1992). "Contractile protein isoforms in muscle development.". Developmental biology 154 (2): 273–83. doi:10.1016/0012-1606(92)90067-Q. PMID 1358730. 
  5. ^ Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of Cell Science 114 (Pt 3): 513–24. PMID 11171321. 
  6. ^ Belaguli, NS; Zhou, W; Trinh, TH; Majesky, MW; Schwartz, RJ (1999). "Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets.". Molecular and Cellular Biology 19 (7): 4582–91. PMC 84256. PMID 10373507. 
  7. ^ Vlahopoulos, S; Zimmer, WE; Jenster, G; Belaguli, NS; Balk, SP; Brinkmann, AO; Lanz, RB; Zoumpourlis, VC; Schwartz, RJ (2005). "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.". The Journal of Biological Chemistry 280 (9): 7786–92. doi:10.1074/jbc.M413992200. PMID 15623502. 
  8. ^ Ballweber, Edda; Hannappel Ewald, Huff Thomas, Stephan Harald, Haener Markus, Taschner Nicole, Stoffler Daniel, Aebi Ueli, Mannherz Hans Georg (January 2002). "Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin". J. Mol. Biol. (England) 315 (4): 613–25. doi:10.1006/jmbi.2001.5281. ISSN 0022-2836. PMID 11812134. 
  9. ^ Safer, D; Sosnick T R; Elzinga M (May 1997). "Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends". Biochemistry (UNITED STATES) 36 (19): 5806–16. doi:10.1021/bi970185v. ISSN 0006-2960. PMID 9153421. 
  10. ^ Takeuchi, Tamotsu; Heng Henry H Q, Ye Christine J, Liang Sheng-Ben, Iwata Jun, Sonobe Hiroshi, Ohtsuki Yuji (October 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. (United States) 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647. 
  11. ^ England, Karen; Ashford David; Kidd Daniel; Rumsby Martin (June 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. (England) 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. ISSN 0898-6568. PMID 11897493. 

External links[edit]

Further reading[edit]



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