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1
acta1
acta1
::2013/01/30::
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2
ACTA1/VILL.K
ACTA1/VILL.K
::2012/02/12::
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acta1
acta1
::2010/12/23::
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Actin filament assembly
Actin filament assembly
::2012/11/26::
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5
Actin Bad Click Posted Up In Da Car B4 The Alpha Mansion Party
Actin Bad Click Posted Up In Da Car B4 The Alpha Mansion Party
::2010/01/25::
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6
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
::2010/10/27::
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7
Below - FULL ACTION MOVIE
Below - FULL ACTION MOVIE
::2013/08/13::
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8
TNF-alpha Activated Macrophages
TNF-alpha Activated Macrophages
::2011/12/01::
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9
Jj actin crazy morehead swagg pt.1
Jj actin crazy morehead swagg pt.1
::2010/11/20::
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10
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2010/11/22::
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11
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
::2010/10/27::
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12
Ghost Recon: ALPHA - Full Live-Action Movie (2012) | HD
Ghost Recon: ALPHA - Full Live-Action Movie (2012) | HD
::2012/05/15::
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13
Rho Kappa Chapter of Alpha Phi Alpha Fraternity Inc SUNY Old Wesbury - Meet The Greeks 2013
Rho Kappa Chapter of Alpha Phi Alpha Fraternity Inc SUNY Old Wesbury - Meet The Greeks 2013
::2013/12/25::
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14
Cross Bridge Cycle
Cross Bridge Cycle
::2012/11/16::
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15
Movie7
Movie7
::2012/09/02::
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16
ZOO BOYZ+SHE ACTIN BAD=MONKEY BARS VOL 1
ZOO BOYZ+SHE ACTIN BAD=MONKEY BARS VOL 1
::2009/05/10::
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17
Actin depolymerizing factor
Actin depolymerizing factor
::2012/06/22::
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18
Actin-rich filopodia
Actin-rich filopodia
::2012/10/02::
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19
1 lo que la polla da
1 lo que la polla da
::2013/01/10::
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20
Pikachu in a tree actin like a real piece of work god damn mother fucker
Pikachu in a tree actin like a real piece of work god damn mother fucker
::2014/02/03::
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21
BFP-lamin B1, GFP-α-tubulin 1b, and RFP-β-actin in triple tagged U2OS cells
BFP-lamin B1, GFP-α-tubulin 1b, and RFP-β-actin in triple tagged U2OS cells
::2013/05/23::
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22
Video of actin strand and vinulin made with SketchBio
Video of actin strand and vinulin made with SketchBio
::2013/06/11::
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23
ZE Chapter of Kappa Alpha  Psi Stroll Off Winners 2011
ZE Chapter of Kappa Alpha Psi Stroll Off Winners 2011
::2011/12/10::
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24
Roc actin shady/drama
Roc actin shady/drama
::2013/07/27::
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25
CLASS OF 09
CLASS OF 09' FROM BOLIVAR CENTRAL HIGH ACTIN A DONKEY PART 1
::2009/02/05::
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26
Alpha-actinin incorporation in paxillin complexes in WT cells
Alpha-actinin incorporation in paxillin complexes in WT cells
::2013/06/26::
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27
Muscle Stimulation by Motor Neuron and Muscle Contraction
Muscle Stimulation by Motor Neuron and Muscle Contraction
::2010/08/09::
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28
Arp2/3, actin nucleation & branching
Arp2/3, actin nucleation & branching
::2012/07/12::
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29
BCU tuba section actin a fool
BCU tuba section actin a fool
::2013/01/29::
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30
FSU NPHC Fall 2012- Stroll Off- Alpha Phi Alpha- Round 3
FSU NPHC Fall 2012- Stroll Off- Alpha Phi Alpha- Round 3
::2012/12/12::
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31
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2009/06/11::
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32
Primary Human Macrophages with Actin Cytoskeleton
Primary Human Macrophages with Actin Cytoskeleton
::2011/12/02::
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33
Alpha-catenin, Vinculin
Alpha-catenin, Vinculin
::2012/06/22::
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34
Primary Human Macrophages With Actin Cytoskeleton
Primary Human Macrophages With Actin Cytoskeleton
::2011/12/02::
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35
me and my boys actin a fool in kroger
me and my boys actin a fool in kroger
::2013/04/09::
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36
jordan 1 hares and us actin stupid outside waiting for ups to get there
jordan 1 hares and us actin stupid outside waiting for ups to get there
::2009/05/08::
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37
Kinesin-1 gliding motility assay, alpha casein passivation.avi
Kinesin-1 gliding motility assay, alpha casein passivation.avi
::2010/05/14::
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38
Kappa Alpha Psi Fraternity Inc. at USC Yard Show
Kappa Alpha Psi Fraternity Inc. at USC Yard Show
::2012/09/05::
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39
UCLA Alpha Phi Alpha Fraternity, Inc.
UCLA Alpha Phi Alpha Fraternity, Inc.
::2012/03/30::
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40
TWERKIN N ACTIN BAD! DAYYUM
TWERKIN N ACTIN BAD! DAYYUM
::2013/07/23::
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41
jEsSE™ Actin Stupid One More Tyme
jEsSE™ Actin Stupid One More Tyme
::2008/08/15::
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42
Actin Filament Growth from star-shaped micropatterns
Actin Filament Growth from star-shaped micropatterns
::2011/06/09::
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43
Wale Buffalo State College Spring Fest 2013 "Actin Up" pt.14
Wale Buffalo State College Spring Fest 2013 "Actin Up" pt.14
::2013/05/12::
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44
Carlos nd the bros actin gay
Carlos nd the bros actin gay
::2014/01/05::
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45
Abby Actin White pt.1 LMAO
Abby Actin White pt.1 LMAO
::2008/09/26::
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46
ZEISS ELYRA: Live cell SR-SIM imaging (1)
ZEISS ELYRA: Live cell SR-SIM imaging (1)
::2013/09/12::
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47
Profilin
Profilin
::2012/08/21::
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48
Phi Kappa Chapter of Alpha Phi Omega SPR 2010 Presentation: We Are One (Part One)
Phi Kappa Chapter of Alpha Phi Omega SPR 2010 Presentation: We Are One (Part One)
::2010/10/07::
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49
Supplementary movie 2
Supplementary movie 2
::2013/09/23::
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50
actin up in class part 1
actin up in class part 1
::2008/09/13::
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RESULTS [51 .. 101]
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Actin, alpha 1, skeletal muscle

PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTA1 ; ACTA; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
External IDs OMIM102610 MGI87902 HomoloGene121702 GeneCards: ACTA1 Gene
RNA expression pattern
PBB GE ACTA1 203872 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 58 11459
Ensembl ENSG00000143632 ENSMUSG00000031972
UniProt P68133 P68134
RefSeq (mRNA) NM_001100 NM_001272041
RefSeq (protein) NP_001091 NP_001258970
Location (UCSC) Chr 1:
229.57 – 229.57 Mb
Chr 8:
123.89 – 123.89 Mb
PubMed search [1] [2]

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.[1][2]

Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]

Skeletal actin gene expression[edit]

Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation.[4] Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation.[5] One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene.[6] SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.[7]

Interactions[edit]

Actin, alpha 1 has been shown to interact with TMSB4X,[8][9] MIB2[10] and PRKCE.[11]

See also[edit]

References[edit]

  1. ^ Mogensen J, Kruse TA, Borglum (March 1999). "Assignment of the human skeletal muscle [FC12]a-actin gene (ACTA1) to chromosome 1q42.13-->q42.2 by radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 224–5. doi:10.1159/000015184. PMID 10072583. 
  2. ^ Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L (August 1983). "Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed". Mol Cell Biol 3 (5): 787–95. PMC 368601. PMID 6865942. 
  3. ^ "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle". 
  4. ^ Bandman, E (1992). "Contractile protein isoforms in muscle development.". Developmental biology 154 (2): 273–83. doi:10.1016/0012-1606(92)90067-Q. PMID 1358730. 
  5. ^ Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of Cell Science 114 (Pt 3): 513–24. PMID 11171321. 
  6. ^ Belaguli, NS; Zhou, W; Trinh, TH; Majesky, MW; Schwartz, RJ (1999). "Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets.". Molecular and Cellular Biology 19 (7): 4582–91. PMC 84256. PMID 10373507. 
  7. ^ Vlahopoulos, S; Zimmer, WE; Jenster, G; Belaguli, NS; Balk, SP; Brinkmann, AO; Lanz, RB; Zoumpourlis, VC; Schwartz, RJ (2005). "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.". The Journal of Biological Chemistry 280 (9): 7786–92. doi:10.1074/jbc.M413992200. PMID 15623502. 
  8. ^ Ballweber, Edda; Hannappel Ewald, Huff Thomas, Stephan Harald, Haener Markus, Taschner Nicole, Stoffler Daniel, Aebi Ueli, Mannherz Hans Georg (January 2002). "Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin". J. Mol. Biol. (England) 315 (4): 613–25. doi:10.1006/jmbi.2001.5281. ISSN 0022-2836. PMID 11812134. 
  9. ^ Safer, D; Sosnick T R; Elzinga M (May 1997). "Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends". Biochemistry (UNITED STATES) 36 (19): 5806–16. doi:10.1021/bi970185v. ISSN 0006-2960. PMID 9153421. 
  10. ^ Takeuchi, Tamotsu; Heng Henry H Q, Ye Christine J, Liang Sheng-Ben, Iwata Jun, Sonobe Hiroshi, Ohtsuki Yuji (October 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. (United States) 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647. 
  11. ^ England, Karen; Ashford David; Kidd Daniel; Rumsby Martin (June 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. (England) 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. ISSN 0898-6568. PMID 11897493. 

External links[edit]

Further reading[edit]



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