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1
Alpha-catenin, Vinculin
Alpha-catenin, Vinculin
::2012/06/22::
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2
Dictyostelium discoideum - Ddα-catenin (movies2)
Dictyostelium discoideum - Ddα-catenin (movies2)
::2011/03/17::
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3
Insidermedicine In 60 - May 19, 2011
Insidermedicine In 60 - May 19, 2011
::2011/05/24::
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4
A Sticky Wicket: Opposing Functions of p120-Catenin in Development and Cancer
A Sticky Wicket: Opposing Functions of p120-Catenin in Development and Cancer
::2011/10/27::
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5
beta-catenin, armadillo repeats
beta-catenin, armadillo repeats
::2012/05/20::
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6
b-catenin
b-catenin
::2012/04/27::
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7
The Art of Vinculin Activation
The Art of Vinculin Activation
::2009/12/07::
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8
beta catenina fosforilada
beta catenina fosforilada
::2012/03/11::
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9
Painting with cells
Painting with cells
::2012/08/07::
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10
Formin homology domain 2
Formin homology domain 2
::2012/06/24::
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11
The PI3K/AKT signalling pathway
The PI3K/AKT signalling pathway
::2010/02/22::
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12
Talin protein - 3D movie and a song, Rate My Science
Talin protein - 3D movie and a song, Rate My Science
::2008/10/07::
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13
bioinformatics feat. vinculin tail (dnb mix)
bioinformatics feat. vinculin tail (dnb mix)
::2009/01/17::
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14
Dictyostelium d. cells with Ras-GFP - Fluorescence
Dictyostelium d. cells with Ras-GFP - Fluorescence
::2012/07/19::
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15
Elaine Fuchs (Rockefeller) Part 2: Tapping the Potential of Adult Stem Cells, and Summary
Elaine Fuchs (Rockefeller) Part 2: Tapping the Potential of Adult Stem Cells, and Summary
::2010/06/02::
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16
In-Cell Western™ Assay Applications: Cell Proliferation, RNAi Screens, Receptor Traffickingk
In-Cell Western™ Assay Applications: Cell Proliferation, RNAi Screens, Receptor Traffickingk
::2012/06/19::
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17
2D animation of aV-integrin dynamics
2D animation of aV-integrin dynamics
::2011/05/04::
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18
Video of actin strand and vinulin made with SketchBio
Video of actin strand and vinulin made with SketchBio
::2013/06/11::
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19
Ruth Lehmann (NYU) Part 3: Germ Cell Migration
Ruth Lehmann (NYU) Part 3: Germ Cell Migration
::2011/01/10::
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20
vinculin tail movement
vinculin tail movement
::2009/01/16::
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21
cadherin
cadherin
::2013/09/08::
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22
"Candyman" making backflips, jumping off and landing on the same foot.
"Candyman" making backflips, jumping off and landing on the same foot.
::2011/06/06::
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23
Image Studio 3.1 Software for Odyssey Fc Imager - Image Acquisition
Image Studio 3.1 Software for Odyssey Fc Imager - Image Acquisition
::2013/02/19::
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24
biosights: May 13, 2013 - Ventral lamellipodia plug the gaps
biosights: May 13, 2013 - Ventral lamellipodia plug the gaps
::2013/05/15::
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25
Caspase Cellplayer Apoptosis Assay
Caspase Cellplayer Apoptosis Assay
::2011/05/25::
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26
Actin depolymerizing factor
Actin depolymerizing factor
::2012/06/22::
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27
biosights: March 19, 2012 - Vinculin minds the endothelial gap
biosights: March 19, 2012 - Vinculin minds the endothelial gap
::2012/03/20::
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28
biosights October 1, 2012   Cortical dynein puts the spindle in its place
biosights October 1, 2012 Cortical dynein puts the spindle in its place
::2012/12/05::
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29
vinculin_animation
vinculin_animation
::2012/03/15::
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30
Filo transition from patches colored.avi
Filo transition from patches colored.avi
::2010/11/17::
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31
IRP Scientific Imaging Webinar (Part 3) - Clare Waterman, NIH Scientist
IRP Scientific Imaging Webinar (Part 3) - Clare Waterman, NIH Scientist
::2012/11/16::
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32
Morgellons slime mold
Morgellons slime mold
::2012/12/30::
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RESULTS [33 .. 83]
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catenin (cadherin-associated protein), alpha 1, 102kDa
Identifiers
Symbol CTNNA1
Entrez 1495
HUGO 2509
OMIM 116805
RefSeq NM_001903
UniProt P35221
Other data
Locus Chr. 5 q31.2
catenin (cadherin-associated protein), alpha 2
Identifiers
Symbol CTNNA2
Entrez 1496
HUGO 2510
OMIM 114025
RefSeq NM_004389
UniProt P26232
Other data
Locus Chr. 2 p12-p11.1
catenin (cadherin-associated protein), alpha 3
Identifiers
Symbol CTNNA3
Entrez 29119
HUGO 2511
OMIM 607667
RefSeq NM_013266
UniProt Q9UI47
Other data
Locus Chr. 10 q21

Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton.[1] It has been reported that the actin binding proteins vinculin[2] and alpha-actinin[3] can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time.[4] It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.[5]

The amino acid sequence of alpha-catenin has sequence similarity to that of vinculin.[6]

Types[edit]

There are three human alpha-catenin genes:

  • alpha-1-catenin (also called alpha-E-catenin)
  • alpha-2-catenin (also called alpha-N-catenin)
  • alpha-3-catenin (also called alpha-T-catenin)

See also[edit]

External links[edit]

References[edit]

  1. ^ Cooper, Geoffrey M. (2000). "Figure 11.14: Model of attachment of actin filaments to catenin-cadherin complexes". The Cell: A Molecular Approach (2nd ed.). Sinauer Associates. ISBN 0-87893-219-4. 
  2. ^ Watabe-Uchida M, Uchida N, Imamura Y, et al. (August 1998). "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells". J. Cell Biol. 142 (3): 847–57. doi:10.1083/jcb.142.3.847. PMC 2148175. PMID 9700171. 
  3. ^ Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (July 1995). "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin". J. Cell Biol. 130 (1): 67–77. doi:10.1083/jcb.130.1.67. PMC 2120515. PMID 7790378. 
  4. ^ Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ (December 2005). "Deconstructing the cadherin-catenin-actin complex". Cell 123 (5): 889–901. doi:10.1016/j.cell.2005.09.020. PMID 16325582. 
  5. ^ Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI (December 2005). "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly". Cell 123 (5): 903–15. doi:10.1016/j.cell.2005.09.021. PMID 16325583. 
  6. ^ Nagafuchi A, Takeichi M, Tsukita S (May 1991). "The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression". Cell 65 (5): 849–57. doi:10.1016/0092-8674(91)90392-C. PMID 1904011. 


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