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Actin filament assembly
Actin filament assembly
Published: 2012/11/26
Channel: Shomu's Biology
What is ACTIN? ACTIN meaning - ACTING definition - ACTIN explanation - ACTIN pronunciation
What is ACTIN? ACTIN meaning - ACTING definition - ACTIN explanation - ACTIN pronunciation
Published: 2016/10/04
Channel: The Audiopedia
GFP beta actin labelled stress fibers (timelapse)
GFP beta actin labelled stress fibers (timelapse)
Published: 2015/10/20
Channel: Howard Vindin
regulating actin filament formation
regulating actin filament formation
Published: 2010/11/03
Channel: af07e
My lil cuz she b actin crae
My lil cuz she b actin crae
Published: 2013/02/01
Channel: haterzmakinmehfamous
Microtubule Microfilament and Intermediate Filament
Microtubule Microfilament and Intermediate Filament
Published: 2016/04/29
Channel: Shomu's Biology
We B Actin!!!
We B Actin!!!
Published: 2006/07/04
Channel: mzgabrielle
B ACTiN SiLLY
B ACTiN SiLLY
Published: 2007/07/01
Channel: xxdangerouscurvesXX
Johnny B actin a foo
Johnny B actin a foo
Published: 2012/02/02
Channel: Stephanie Aguilar
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
Published: 2014/01/23
Channel: Albert Einstein College of Medicine
Cellular barriers to actin nucleation
Cellular barriers to actin nucleation
Published: 2015/12/15
Channel: Julian Eskin Scientific Animation
TWiiN A &B ACTiN H0M0! KEYW0RD [ACTiN] L0L
TWiiN A &B ACTiN H0M0! KEYW0RD [ACTiN] L0L
Published: 2008/05/30
Channel: newnu24
B actin stupid lol
B actin stupid lol
Published: 2007/09/16
Channel: LoveableRedz
TWiN B ACTiN DUM LYKE ALWAYZ!L0L
TWiN B ACTiN DUM LYKE ALWAYZ!L0L
Published: 2008/05/31
Channel: newnu24
Formin mediated actin nucleation and filament assembly
Formin mediated actin nucleation and filament assembly
Published: 2014/10/01
Channel: Mechanobiology Institute, Singapore
i jus b actin retarded 4real
i jus b actin retarded 4real
Published: 2009/03/07
Channel: seaniceboo101
Western blot protocol video
Western blot protocol video
Published: 2015/10/15
Channel: Abcam
C.dAVIS & Chelsea B Actin Stupid
C.dAVIS & Chelsea B Actin Stupid
Published: 2010/07/22
Channel: Clarissa Davis
Moh B Actin Up
Moh B Actin Up
Published: 2012/08/26
Channel: legallyflyalexia
iz-b actin dummmm
iz-b actin dummmm
Published: 2007/08/14
Channel: lachucky
stud b actin a fooooooooo  DEC.1 2010
stud b actin a fooooooooo DEC.1 2010
Published: 2010/12/02
Channel: getemgurl28
TWiN A & TWiN B ACTiN STUPiD!L0L
TWiN A & TWiN B ACTiN STUPiD!L0L
Published: 2008/05/31
Channel: newnu24
Actb boy
Actb boy
Published: 2017/05/31
Channel: Funny Baba
Nac b actin ahh fool
Nac b actin ahh fool
Published: 2011/06/01
Channel: deltonS1
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
Published: 2011/09/21
Channel: EMD Millipore Bioscience
Nac b actin ahh fool pt.2
Nac b actin ahh fool pt.2
Published: 2011/06/01
Channel: deltonS1
B actin a fuckn looney
B actin a fuckn looney
Published: 2011/12/28
Channel: QTSTUD4U Sanchez
Gene Music using Protein Sequence of ACTB "ACTIN, BETA"
Gene Music using Protein Sequence of ACTB "ACTIN, BETA"
Published: 2016/03/30
Channel: Gene Music Studio
dese hoes b actin up
dese hoes b actin up
Published: 2014/07/20
Channel: Lateariona Franklin
dumbasses
dumbasses
Published: 2008/06/20
Channel: haterzbettarecognize
Stereociliogenesis
Stereociliogenesis
Published: 2015/06/07
Channel: NIHOD
Housekeeping gene
Housekeeping gene
Published: 2014/12/01
Channel: Audiopedia
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
Published: 2014/01/23
Channel: Quantum Day
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (ZETA'S IMITATE KAPPA'S)
Published: 2008/02/01
Channel: Brent Y.
Gene Music using Protein Sequence of ACTBL2 "ACTIN, BETA-LIKE 2"
Gene Music using Protein Sequence of ACTBL2 "ACTIN, BETA-LIKE 2"
Published: 2016/03/30
Channel: Gene Music Studio
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
Published: 2009/06/11
Channel: C0nc0rdance
sean flips
sean flips
Published: 2006/09/16
Channel: littleqt0924
8th graders outside
8th graders outside
Published: 2012/03/01
Channel: Corneilous Williams
Overwatch : : Beta  Dudes Actin
Overwatch : : Beta Dudes Actin' Like Jay Ain't The Tracer GAWD
Published: 2016/05/10
Channel: JUCK FAY
#ACTB Lunch Cam
#ACTB Lunch Cam
Published: 2009/01/20
Channel: Kevin Spidel
ACTB location 1
ACTB location 1
Published: 2010/05/27
Channel: niallmac81
Samuel Baidu
Samuel Baidu's thoughts on ACTB
Published: 2014/04/07
Channel: actbactbactb
ACTB Breakfast and Multimedia Orgy
ACTB Breakfast and Multimedia Orgy
Published: 2009/01/31
Channel: Kevin Spidel
#ACTB Rockband!
#ACTB Rockband!
Published: 2009/01/31
Channel: Kevin Spidel
ACTB Raven
ACTB Raven's Inn Butter
Published: 2016/06/27
Channel: A Chance To Be
Earth Shaker gameplay. B/\ACTb Dota 2
Earth Shaker gameplay. B/\ACTb Dota 2
Published: 2014/07/15
Channel: Vlad Djavakhadze
witch doctor ultra kill by  B/\ACTb
witch doctor ultra kill by B/\ACTb
Published: 2014/08/16
Channel: Vlad Djavakhadze
Instantaneous fluorescence polarization microscope: Orientation of actin filaments
Instantaneous fluorescence polarization microscope: Orientation of actin filaments
Published: 2016/09/29
Channel: MBL Woods Hole
Deona n joann actb a damn fool
Deona n joann actb a damn fool
Published: 2011/04/25
Channel: Antoinette Wiley
GFP actin FRAP (Photobleaching)
GFP actin FRAP (Photobleaching)
Published: 2015/10/26
Channel: PhotonicInstruments
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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ACTB
Protein ACTB PDB 1atn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
External IDs MGI: 87904 HomoloGene: 110648 GeneCards: ACTB
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ACTB
Genomic location for ACTB
Band 7p22.1 Start 5,527,151 bp[1]
End 5,563,784 bp[1]
RNA expression pattern
PBB GE ACTB 213867 x at fs.png

PBB GE ACTB 200801 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001101

NM_007393

RefSeq (protein)

NP_001092

NP_031419

Location (UCSC) Chr 7: 5.53 – 5.56 Mb Chr 7: 142.9 – 142.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[5][6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[7]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[8][9] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Beta-actin has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS[10]

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[11]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075624 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029580 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (Jun 2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. 128 (11): 2009–2019. doi:10.1242/jcs.165563. PMID 25788699. 
  6. ^ Hanukoglu I, Tanese N, Fuchs E (Feb 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". Journal of Molecular Biology. 163 (4): 673–8. doi:10.1016/0022-2836(83)90117-1. PMID 6842590. 
  7. ^ "Entrez Gene: ACTB actin, beta". 
  8. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  9. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (Sep 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". The Journal of Biological Chemistry. 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  10. ^ Kondrikov D, Fonseca FV, Elms S, Fulton D, Black SM, Block ER, Su Y (Feb 2010). "Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme". The Journal of Biological Chemistry. 285 (7): 4319–27. doi:10.1074/jbc.M109.063172. PMC 2836036Freely accessible. PMID 19946124. 
  11. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757Freely accessible. PMID 22343534. 

External links[edit]

Further reading[edit]

See also[edit]


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