Play Video
1
Actin filament assembly
Actin filament assembly
::2012/11/25::
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2
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
::2011/09/20::
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3
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
::2013/04/24::
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4
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
::2014/01/23::
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5
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
::2014/01/23::
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6
Tilapia spawning by Adi Sucipto
Tilapia spawning by Adi Sucipto
::2008/07/04::
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7
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
::2013/06/22::
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8
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
::2013/06/22::
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9
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
::2013/06/22::
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10
b phi d actin owt
b phi d actin owt
::2009/06/04::
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11
B PHI D ACTIN OUT  AT FROUNT LINE
B PHI D ACTIN OUT AT FROUNT LINE
::2009/12/18::
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12
Actin
Actin
::2014/03/14::
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13
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2010/11/22::
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14
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2009/06/11::
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15
"Hands-on" Actin Polymerization with plaster 3d models
"Hands-on" Actin Polymerization with plaster 3d models
::2013/03/28::
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16
Actin a fool wit the frat!
Actin a fool wit the frat!
::2012/04/18::
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17
Polymerization of actin on a liposome membrane
Polymerization of actin on a liposome membrane
::2013/09/04::
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18
Melanoma cell expressing GFP-actin
Melanoma cell expressing GFP-actin
::2013/05/19::
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19
Cross Bridge Cycle
Cross Bridge Cycle
::2012/11/15::
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20
"Hands-On" dynamic equilibrium of actin polymerization.
"Hands-On" dynamic equilibrium of actin polymerization.
::2013/04/16::
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21
Actin Beads Experiment
Actin Beads Experiment
::2013/09/04::
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22
Adrianna Actin A Foo
Adrianna Actin A Foo
::2010/06/07::
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23
Actin
Actin' Up - Harvey Soto (Official Music Video)
::2013/04/02::
Play Video
24
Hands-on actin polymerization 2
Hands-on actin polymerization 2
::2013/04/17::
Play Video
25
hipchat in actin
hipchat in actin
::2013/05/24::
Play Video
26
Brotha Lynch Hung & C.o.S. - Actin
Brotha Lynch Hung & C.o.S. - Actin' Up feat. Nicci BlacC
::2007/06/27::
Play Video
27
LWA and PowerCube Collision Avoidance with Actin
LWA and PowerCube Collision Avoidance with Actin
::2012/07/02::
Play Video
28
memphis chicks actin silly
memphis chicks actin silly
::2011/10/27::
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29
jane crocker voice actin
jane crocker voice actin
::2013/01/26::
Play Video
30
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
::2012/06/12::
Play Video
31
Girl  Actin
Girl Actin' A Fool at Exxon near Baylor July 5, 2012
::2012/07/10::
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32
katrina ruby actin weird
katrina ruby actin weird
::2012/01/09::
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33
SU Actin
SU Actin' Up
::2012/03/08::
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34
Scarecrow and Mike P! Sigmas actin foolish!
Scarecrow and Mike P! Sigmas actin foolish!
::2011/01/06::
Play Video
35
Lil Rell - Actin Up Feat.Bear Head & Trap City
Lil Rell - Actin Up Feat.Bear Head & Trap City
::2012/10/08::
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36
Sigma RhoMeo
Sigma RhoMeo's actin OWT
::2010/03/08::
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37
Actin Black in Walmart pt 1
Actin Black in Walmart pt 1
::2010/10/20::
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38
kenew actin a azz
kenew actin a azz
::2009/02/02::
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39
Young hall D wing actin a fool
Young hall D wing actin a fool
::2007/01/20::
Play Video
40
YOUNG ROW AND CHAMARQUS ACTIN STUPID AS HELL
YOUNG ROW AND CHAMARQUS ACTIN STUPID AS HELL
::2009/03/08::
Play Video
41
US RIDIN ACTIN A FOOL
US RIDIN ACTIN A FOOL
::2008/12/30::
Play Video
42
SSCHS KID ACtIN STUPID
SSCHS KID ACtIN STUPID
::2008/09/13::
Play Video
43
KALIMA ACTIN STUPID!
KALIMA ACTIN STUPID!
::2011/11/13::
Play Video
44
AT The Mall actin stupid
AT The Mall actin stupid
::2010/03/15::
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45
Actin
Actin' upppp.
::2012/12/07::
Play Video
46
J nanny and pooks actin crazy
J nanny and pooks actin crazy
::2007/06/24::
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47
actin a fool at UAPB
actin a fool at UAPB
::2011/07/12::
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48
When SOBER girls Around ME//THEY BE ACTIN LIKE THEY DRUNK~ [IC vs. DeathLorelei]
When SOBER girls Around ME//THEY BE ACTIN LIKE THEY DRUNK~ [IC vs. DeathLorelei]
::2010/11/06::
Play Video
49
Plantation high actin stupid yea yea
Plantation high actin stupid yea yea
::2011/02/08::
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50
Actin a fool @ MVSU
Actin a fool @ MVSU
::2010/04/01::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Actin, beta
Protein ACTB PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTB ; BRWS1; PS1TP5BP1
External IDs OMIM102630 MGI87904 HomoloGene110648 GeneCards: ACTB Gene
RNA expression pattern
PBB GE ACTB 200801 x at tn.png
PBB GE ACTB 213867 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60 11461
Ensembl ENSG00000075624 ENSMUSG00000029580
UniProt P60709 P60710
RefSeq (mRNA) NM_001101 NM_007393
RefSeq (protein) NP_001092 NP_031419
Location (UCSC) Chr 7:
5.57 – 5.57 Mb
Chr 5:
142.9 – 142.91 Mb
PubMed search [1] [2]

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[1] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[2]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[3][4] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[5]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ Hanukoglu I, Tanese N, Fuchs E (February 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". J. Mol. Biol. 163 (4): 673–8. PMID 6842590. 
  2. ^ "Entrez Gene: ACTB actin, beta". 
  3. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  4. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (September 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". J. Biol. Chem. 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  5. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (March 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proc. Natl. Acad. Sci. U.S.A. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]

See also[edit]

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