Beta-actin

Actin, beta
PDB rendering based on 1atn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BYH, 3D2U, 3LUE
Identifiers
Symbols	ACTB; BRWS1; PS1TP5BP1
External IDs	OMIM: 102630 MGI: 87904 HomoloGene: 110648 GeneCards: ACTB Gene
Gene Ontology Molecular function • structural constituent of cytoskeleton • protein binding • ATP binding • kinesin binding • protein kinase binding • Tat protein binding • nitric-oxide synthase binding Cellular component • cytoplasm • cytosol • cytoskeleton • postsynaptic density • axon • ribonucleoprotein complex • cortical cytoskeleton • NuA4 histone acetyltransferase complex • extracellular vesicular exosome • MLL5-L complex Biological process • protein folding • cellular component movement • axon guidance • blood coagulation • cellular membrane organization • cell junction assembly • adherens junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • cellular protein metabolic process • innate immune response • cell-cell junction organization • 'de novo' posttranslational protein folding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60	11461
Ensembl	ENSG00000075624	ENSMUSG00000029580
UniProt	P60709	P60710
RefSeq (mRNA)	NM_001101	NM_007393
RefSeq (protein)	NP_001092	NP_031419
Location (UCSC)	Chr 7: 5.57 – 5.6 Mb	Chr 5: 142.9 – 142.91 Mb
PubMed search	[1]	[2]
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Beta-actin (gene name ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins^[1] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.^[2]

Interactions [edit]

Beta-actin has been shown to interact with SPTBN2.^[3][4] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Clinical relevance [edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.^[5]

Applications [edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kD.

References [edit]

Further reading [edit]

See also [edit]

• Actin
• ACTA1

v t e PDB gallery 1atn: Atomic structure of the actin:DNASE I complex  1c0f: CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1  1c0g: CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H)  1d4x: Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.  1dej: CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1  1eqy: COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1  1esv: COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1  1h1v: GELSOLIN G4-G6/ACTIN COMPLEX  1hlu: STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE  1ijj: THE X-RAY CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RABBIT SKELETAL MUSCLE ACTIN AND LATRUNCULIN A AT 2.85 A RESOLUTION  1j6z: UNCOMPLEXED ACTIN  1kxp: CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN  1lcu: Polylysine Induces an Antiparallel Actin Dimer that Nucleates Filament Assembly: Crystal Structure at 3.5 A Resolution  1lot: CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN  1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle  1ma9: Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin  1mdu: Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)  1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1nlv: Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1  1nm1: Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution  1nmd: Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP  1nwk: CRYSTAL STRUCTURE OF MONOMERIC ACTIN IN THE ATP STATE  1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE  1p8z: Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156  1qz5: Structure of rabbit actin in complex with kabiramide C  1qz6: Structure of rabbit actin in complex with jaspisamide A  1rdw: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer  1rfq: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer  1rgi: Crystal structure of gelsolin domains G1-G3 bound to actin  1s22: Absolute Stereochemistry of Ulapualide A  1sqk: CRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN  1t44: Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation  1wua: The structure of Aplyronine A-actin complex  1y64: Bni1p Formin Homology 2 Domain complexed with ATP-actin  1yxq: Crystal structure of actin in complex with swinholide A  2a3z: Ternary complex of the WH2 domain of WASP with Actin-DNAse I  2a40: Ternary complex of the WH2 domain of WAVE with Actin-DNAse I  2a41: Ternary complex of the WH2 Domain of WIP with Actin-DNAse I  2a42: Actin-DNAse I Complex  2a5x: Crystal Structure of a Cross-linked Actin Dimer  2asm: Structure of Rabbit Actin In Complex With Reidispongiolide A  2aso: Structure of Rabbit Actin In Complex With Sphinxolide B  2asp: Structure of Rabbit Actin In Complex With Reidispongiolide C  2btf: THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN  2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I  2ff3: Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin  2ff6: Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin  2fxu: X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.  2gwj: SpvB ADP-ribosylated actin: hexagonal crystal form  2gwk: SpvB ADP-ribosylated actin: orthorhombic crystal form  2hf3: Crystal structure of monomeric Actin in the ADP bound state  2hf4: Crystal structure of Monomeric Actin in its ATP-bound state  2hmp: Uncomplexed actin cleaved with protease ECP32  2oan: Structure of oxidized beta-actin  2q1n: Actin Dimer Cross-linked Between Residues 41 and 374  2q31: Actin Dimer Cross-linked Between Residues 41 and 374 and proteolytically cleaved by subtilisin between residues 47 and 48.  2q36: Actin Dimer Cross-linked between Residues 191 and 374 and complexed with Kabiramide C

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