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1
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
::2011/09/20::
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2
Actin filament assembly
Actin filament assembly
::2012/11/25::
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3
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
::2014/01/23::
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4
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
::2014/01/23::
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5
regulating actin filament formation
regulating actin filament formation
::2010/11/03::
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6
Tilapia spawning by Adi Sucipto
Tilapia spawning by Adi Sucipto
::2008/07/04::
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7
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
::2013/06/22::
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8
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (ZETA'S IMITATE KAPPA'S)
::2008/02/01::
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9
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
::2013/06/22::
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10
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
::2013/06/22::
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11
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2009/06/11::
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12
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
::2015/01/27::
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13
B PHI D ACTIN OUT  AT FROUNT LINE
B PHI D ACTIN OUT AT FROUNT LINE
::2009/12/18::
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14
b phi d actin owt
b phi d actin owt
::2009/06/04::
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15
Destiny Beta Dance show - Michael Jackson / Smooth criminal
Destiny Beta Dance show - Michael Jackson / Smooth criminal
::2014/08/07::
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16
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
::2010/11/22::
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17
Actin a fool wit the frat!
Actin a fool wit the frat!
::2012/04/18::
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18
Myosin is Thick, Actin is Thin
Myosin is Thick, Actin is Thin
::2012/02/15::
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19
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (SIGMA GAMMA RHO IMITATE SIGMAS)
::2008/02/01::
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20
Formin: Another way to regulate Actin Polymerization
Formin: Another way to regulate Actin Polymerization
::2010/11/05::
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21
friday nght actin wild makin a girl smile
friday nght actin wild makin a girl smile
::2013/11/15::
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22
DOLLABILLGATES - ACTIN MY AGE (PROD. BY JOSH FRANKS)
DOLLABILLGATES - ACTIN MY AGE (PROD. BY JOSH FRANKS)
::2011/06/21::
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23
Actin
Actin
::2007/09/04::
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24
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
::2010/10/27::
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25
Afro Samurai/Cowboy Bebop - Don
Afro Samurai/Cowboy Bebop - Don't touch me now
::2008/10/26::
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26
Brotha Lynch Hung & C.o.S. - Actin
Brotha Lynch Hung & C.o.S. - Actin' Up feat. Nicci BlacC
::2007/06/27::
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27
"Hands-on" Actin Polymerization with plaster 3d models
"Hands-on" Actin Polymerization with plaster 3d models
::2013/03/28::
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28
Actin
Actin
::2014/03/14::
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29
Hands-on actin polymerization 2
Hands-on actin polymerization 2
::2013/04/17::
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30
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
::2013/04/24::
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31
Clarksdale actin a ass in wal-mart
Clarksdale actin a ass in wal-mart
::2014/03/24::
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32
memphis chicks actin silly
memphis chicks actin silly
::2011/10/27::
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33
Supplementary movie 7
Supplementary movie 7
::2013/09/23::
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34
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
::2012/06/12::
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35
Actin Myosin 1
Actin Myosin 1
::2012/02/10::
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36
In vitro test of actin polymerization at the cell scale : tension build up
In vitro test of actin polymerization at the cell scale : tension build up
::2013/09/04::
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37
Melanoma cell expressing GFP-actin
Melanoma cell expressing GFP-actin
::2013/05/19::
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38
"Hands-On" dynamic equilibrium of actin polymerization.
"Hands-On" dynamic equilibrium of actin polymerization.
::2013/04/16::
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39
Young hall D wing actin a fool
Young hall D wing actin a fool
::2007/01/20::
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40
Starbound #010 - Ein letzter Sterbemarathon [Let
Starbound #010 - Ein letzter Sterbemarathon [Let's Play][Deutsch/German][HD]
::2014/09/23::
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41
Starbound #001 - Jagen mit Bogen [Let
Starbound #001 - Jagen mit Bogen [Let's Play][Deutsch/German][HD]
::2014/07/08::
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42
[XBOX/WAW] Fyrepit v3.5
[XBOX/WAW] Fyrepit v3.5
::2014/10/04::
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43
Microtubule regulator
Microtubule regulator
::2012/09/03::
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44
Actin a fool @ MVSU
Actin a fool @ MVSU
::2010/04/01::
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45
Polymerization of actin on a liposome membrane
Polymerization of actin on a liposome membrane
::2013/09/04::
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46
Just How Toxic is Mercury? - A Study by University of Calgary
Just How Toxic is Mercury? - A Study by University of Calgary
::2011/04/10::
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47
Jwalk0
Jwalk0's 26th Vid - Ha, This One Is About Alcohol Too
::2009/11/08::
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48
The extraordinary bacterial Type VI secretion machine
The extraordinary bacterial Type VI secretion machine
::2014/12/11::
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49
The Notorious BIG - Big Poppa (HD+Dirty+Lyrics)
The Notorious BIG - Big Poppa (HD+Dirty+Lyrics)
::2011/09/13::
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50
AT The Mall actin stupid
AT The Mall actin stupid
::2010/03/15::
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RESULTS [ .. ]
From Wikipedia, the free encyclopedia
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Actin, beta
Protein ACTB PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTB ; BRWS1; PS1TP5BP1
External IDs OMIM102630 MGI87904 HomoloGene110648 GeneCards: ACTB Gene
RNA expression pattern
PBB GE ACTB 200801 x at tn.png
PBB GE ACTB 213867 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60 11461
Ensembl ENSG00000075624 ENSMUSG00000029580
UniProt P60709 P60710
RefSeq (mRNA) NM_001101 NM_007393
RefSeq (protein) NP_001092 NP_031419
Location (UCSC) Chr 7:
5.57 – 5.57 Mb
Chr 5:
142.9 – 142.91 Mb
PubMed search [1] [2]

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[1] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[2]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[3][4] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[5]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ Hanukoglu I, Tanese N, Fuchs E (February 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". J. Mol. Biol. 163 (4): 673–8. doi:10.1016/0022-2836(83)90117-1. PMID 6842590. 
  2. ^ "Entrez Gene: ACTB actin, beta". 
  3. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  4. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (September 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". J. Biol. Chem. 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  5. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (March 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proc. Natl. Acad. Sci. U.S.A. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]

See also[edit]

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