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Actin filament assembly
Actin filament assembly
Published: 2012/11/26
Channel: Shomu's Biology
What is ACTIN? ACTIN meaning - ACTING definition - ACTIN explanation - ACTIN pronunciation
What is ACTIN? ACTIN meaning - ACTING definition - ACTIN explanation - ACTIN pronunciation
Published: 2016/10/04
Channel: The Audiopedia
GFP beta actin labelled stress fibers (timelapse)
GFP beta actin labelled stress fibers (timelapse)
Published: 2015/10/20
Channel: Howard Vindin
Microtubule Microfilament and Intermediate Filament
Microtubule Microfilament and Intermediate Filament
Published: 2016/04/29
Channel: Shomu's Biology
Bunna B "Actin"[Prod.2k]
Bunna B "Actin"[Prod.2k]
Published: 2017/08/21
Channel: Bunna B
Formin mediated actin nucleation and filament assembly
Formin mediated actin nucleation and filament assembly
Published: 2014/10/01
Channel: Mechanobiology Institute, Singapore
Cellular barriers to actin nucleation
Cellular barriers to actin nucleation
Published: 2015/12/15
Channel: Julian Eskin Scientific Animation
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
Published: 2013/06/22
Channel: JTingMIT
regulating actin filament formation
regulating actin filament formation
Published: 2010/11/03
Channel: af07e
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
Published: 2014/01/23
Channel: Albert Einstein College of Medicine
Housekeeping gene
Housekeeping gene
Published: 2014/12/01
Channel: Audiopedia
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
Published: 2013/06/22
Channel: JTingMIT
Railbed
Railbed
Published: 2016/05/24
Channel: Dave Mac
Western blot protocol video
Western blot protocol video
Published: 2015/10/15
Channel: Abcam
What is a Tubulin
What is a Tubulin
Published: 2017/10/24
Channel: local calture
Nac b actin ahh fool
Nac b actin ahh fool
Published: 2011/06/01
Channel: deltonS1
rod b actin
rod b actin
Published: 2012/01/09
Channel: 84rodb
We B Actin!!!
We B Actin!!!
Published: 2006/07/04
Channel: mzgabrielle
TWiN A & TWiN B ACTiN STUPiD!L0L
TWiN A & TWiN B ACTiN STUPiD!L0L
Published: 2008/05/31
Channel: newnu24
ACTB_1263
ACTB_1263
Published: 2015/01/07
Channel: Tapasi Bhattacharjee
TWiN B ACTiN DUM LYKE ALWAYZ!L0L
TWiN B ACTiN DUM LYKE ALWAYZ!L0L
Published: 2008/05/31
Channel: newnu24
Nac b actin ahh fool pt.2
Nac b actin ahh fool pt.2
Published: 2011/06/01
Channel: deltonS1
Preach and Goofy B actin out
Preach and Goofy B actin out
Published: 2013/03/20
Channel: preach2me
C.dAVIS & Chelsea B Actin Stupid
C.dAVIS & Chelsea B Actin Stupid
Published: 2010/07/22
Channel: Clarissa Davis
iz-b actin dummmm
iz-b actin dummmm
Published: 2007/08/14
Channel: lachucky
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
Published: 2013/06/22
Channel: JTingMIT
My lil cuz she b actin crae
My lil cuz she b actin crae
Published: 2013/02/01
Channel: haterzmakinmehfamous
me and b actin crazy
me and b actin crazy
Published: 2007/06/05
Channel: brittneyg5525
ACTIN AN AZZ
ACTIN AN AZZ
Published: 2009/05/23
Channel: 511-Falco
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Published: 2013/06/22
Channel: JTingMIT
Gene Music using Protein Sequence of ACTBL2 "ACTIN, BETA-LIKE 2"
Gene Music using Protein Sequence of ACTBL2 "ACTIN, BETA-LIKE 2"
Published: 2016/03/30
Channel: Gene Music Studio
B actin stupid lol
B actin stupid lol
Published: 2007/09/16
Channel: LoveableRedz
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
Published: 2011/09/21
Channel: EMD Millipore Bioscience
Stereociliogenesis
Stereociliogenesis
Published: 2015/06/07
Channel: NIHOD
ACTB  MICRO FINANCE SME HD 1080p
ACTB MICRO FINANCE SME HD 1080p
Published: 2017/06/21
Channel: Alex Proxy
go do another line
go do another line
Published: 2006/07/15
Channel: JLyell06
Gene Music using Protein Sequence of ACTB "ACTIN, BETA"
Gene Music using Protein Sequence of ACTB "ACTIN, BETA"
Published: 2016/03/30
Channel: Gene Music Studio
Studs: Don
Studs: Don't Be A Jerk!
Published: 2009/07/24
Channel: StuddedL0ve
Actb boy
Actb boy
Published: 2017/05/31
Channel: Funny Baba
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
Published: 2014/01/23
Channel: Quantum Day
Hirams Brook Culvert
Hirams Brook Culvert
Published: 2013/08/07
Channel: yqm driver
dese hoes b actin up
dese hoes b actin up
Published: 2014/07/20
Channel: Lateariona Franklin
Moh B Actin Up
Moh B Actin Up
Published: 2012/08/26
Channel: legallyflyalexia
RZR ride with Albert County Trail Blazers 12 June 2010
RZR ride with Albert County Trail Blazers 12 June 2010
Published: 2010/06/14
Channel: kempy2233
ACTB - seed to tree video
ACTB - seed to tree video
Published: 2018/02/12
Channel: ACTBUK
Taylor moon walkin....
Taylor moon walkin....
Published: 2009/10/10
Channel: BabyJay155
Regulation of actin during cell migration by nucleotide coding sequence and arginylation
Regulation of actin during cell migration by nucleotide coding sequence and arginylation
Published: 2017/10/12
Channel: LabRoots
Samuel Baidu
Samuel Baidu's thoughts on ACTB
Published: 2014/04/07
Channel: actbactbactb
#ACTB
#ACTB'ers @ Lakefront Brewery
Published: 2009/01/31
Channel: Kevin Spidel
PCCC 2016 ACTB
PCCC 2016 ACTB
Published: 2016/06/05
Channel: A Smith
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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ACTB
Protein ACTB PDB 1atn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
External IDs MGI: 87904 HomoloGene: 110648 GeneCards: ACTB
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ACTB
Genomic location for ACTB
Band 7p22.1 Start 5,527,151 bp[1]
End 5,563,784 bp[1]
RNA expression pattern
PBB GE ACTB 213867 x at fs.png

PBB GE ACTB 200801 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001101

NM_007393

RefSeq (protein)

NP_001092

NP_031419

Location (UCSC) Chr 7: 5.53 – 5.56 Mb Chr 7: 142.9 – 142.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[5][6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[7]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[8][9] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Beta-actin has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS[10]

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[11]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075624 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029580 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (Jun 2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. 128 (11): 2009–2019. doi:10.1242/jcs.165563. PMID 25788699. 
  6. ^ Hanukoglu I, Tanese N, Fuchs E (Feb 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". Journal of Molecular Biology. 163 (4): 673–8. doi:10.1016/0022-2836(83)90117-1. PMID 6842590. 
  7. ^ "Entrez Gene: ACTB actin, beta". 
  8. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  9. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (Sep 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". The Journal of Biological Chemistry. 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  10. ^ Kondrikov D, Fonseca FV, Elms S, Fulton D, Black SM, Block ER, Su Y (Feb 2010). "Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme". The Journal of Biological Chemistry. 285 (7): 4319–27. doi:10.1074/jbc.M109.063172. PMC 2836036Freely accessible. PMID 19946124. 
  11. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757Freely accessible. PMID 22343534. 

External links[edit]

Further reading[edit]

See also[edit]


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