1
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
DATE: 2011/09/20::
2
Actin filament assembly
Actin filament assembly
DATE: 2012/11/25::
3
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
DATE: 2014/01/23::
4
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
DATE: 2014/01/23::
5
Stereociliogenesis
Stereociliogenesis
DATE: 2015/06/07::
6
Tilapia spawning by Adi Sucipto
Tilapia spawning by Adi Sucipto
DATE: 2008/07/04::
7
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
DATE: 2013/06/22::
8
regulating actin filament formation
regulating actin filament formation
DATE: 2010/11/03::
9
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (ZETA'S IMITATE KAPPA'S)
DATE: 2008/02/01::
10
B PHI D ACTIN OUT  AT FROUNT LINE
B PHI D ACTIN OUT AT FROUNT LINE
DATE: 2009/12/18::
11
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (3)
DATE: 2013/06/22::
12
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
DATE: 2013/06/22::
13
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
DATE: 2009/06/11::
14
Lightspeed Antibodies Demonstration Live!
Lightspeed Antibodies Demonstration Live!
DATE: 2015/03/21::
15
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
DATE: 2015/01/27::
16
b phi d actin owt
b phi d actin owt
DATE: 2009/06/04::
17
Ciara - I Bet
Ciara - I Bet
DATE: 2015/03/09::
18
Destiny Beta Dance show - Michael Jackson / Smooth criminal
Destiny Beta Dance show - Michael Jackson / Smooth criminal
DATE: 2014/08/07::
19
Actin a fool wit the frat!
Actin a fool wit the frat!
DATE: 2012/04/18::
20
Myosin is Thick, Actin is Thin
Myosin is Thick, Actin is Thin
DATE: 2012/02/15::
21
1ATN Atomic structure of the actin:DNASE I complex. bmaAD
1ATN Atomic structure of the actin:DNASE I complex. bmaAD
DATE: 2015/06/16::
22
Actin/Myosin Movie 2
Actin/Myosin Movie 2
DATE: 2008/11/13::
23
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (SIGMA GAMMA RHO IMITATE SIGMAS)
DATE: 2008/02/01::
24
Actin
Actin
DATE: 2014/03/14::
25
Driving Nonspontaneous Processes
Driving Nonspontaneous Processes
DATE: 2014/01/17::
26
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
DATE: 2010/10/27::
27
Actin polymerization
Actin polymerization
DATE: 2013/08/02::
28
friday nght actin wild makin a girl smile
friday nght actin wild makin a girl smile
DATE: 2013/11/15::
29
"Hands-on" Actin Polymerization with plaster 3d models
"Hands-on" Actin Polymerization with plaster 3d models
DATE: 2013/03/28::
30
Young hall D wing actin a fool
Young hall D wing actin a fool
DATE: 2007/01/20::
31
⋙ Animash ~ ♥ Actin
⋙ Animash ~ ♥ Actin' Outta Control ♥ ||【Minni Project】⋘
DATE: 2011/11/06::
32
"Hands-On" dynamic equilibrium of actin polymerization.
"Hands-On" dynamic equilibrium of actin polymerization.
DATE: 2013/04/16::
33
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
DATE: 2013/04/24::
34
Neuronal migration: Leading process actin flows away from the cell body during nucleokinesis.
Neuronal migration: Leading process actin flows away from the cell body during nucleokinesis.
DATE: 2012/12/05::
35
Hands-on actin polymerization 2
Hands-on actin polymerization 2
DATE: 2013/04/17::
36
Ac-CorE - Actin Like A [Beat Demo]
Ac-CorE - Actin Like A [Beat Demo]
DATE: 2013/05/10::
37
Laser Nanodissection of Actin Cortex at Cell Junctions in an Epithelial Tissue
Laser Nanodissection of Actin Cortex at Cell Junctions in an Epithelial Tissue
DATE: 2013/11/11::
38
Quaylon Actin Like Osceola
Quaylon Actin Like Osceola's Coach Gaten 2 Vj
DATE: 2011/08/04::
39
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
DATE: 2012/06/12::
40
ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast Cancer...
ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast Cancer...
DATE: 2015/03/23::
41
MIles College KK Psi actin a fool
MIles College KK Psi actin a fool
DATE: 2009/12/27::
42
Melanoma cell expressing GFP-actin
Melanoma cell expressing GFP-actin
DATE: 2013/05/19::
43
In vitro test of actin polymerization at the cell scale : tension build up
In vitro test of actin polymerization at the cell scale : tension build up
DATE: 2013/09/04::
44
Starbound #004 - Wir machen auf Multiplayer [Let
Starbound #004 - Wir machen auf Multiplayer [Let's Play][Deutsch/German][HD]
DATE: 2014/07/29::
45
Microtubule regulator
Microtubule regulator
DATE: 2012/09/03::
46
Housekeeping gene
Housekeeping gene
DATE: 2014/11/30::
47
Just How Toxic is Mercury? - A Study by University of Calgary
Just How Toxic is Mercury? - A Study by University of Calgary
DATE: 2011/04/10::
48
Micheal Jackson They Don
Micheal Jackson They Don't Care Sampled Instrumental Rap @akaTheZebra
DATE: 2011/06/29::
49
[XBOX/WAW] Fyrepit v3.5
[XBOX/WAW] Fyrepit v3.5
DATE: 2014/10/04::
50
The king ft Lil Wizzy - King Rapper Number One (Alvin & The chipmunks)
The king ft Lil Wizzy - King Rapper Number One (Alvin & The chipmunks)
DATE: 2010/03/04::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Actin, beta
Protein ACTB PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTB ; BRWS1; PS1TP5BP1
External IDs OMIM102630 MGI87904 HomoloGene110648 GeneCards: ACTB Gene
RNA expression pattern
PBB GE ACTB 200801 x at tn.png
PBB GE ACTB 213867 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60 11461
Ensembl ENSG00000075624 ENSMUSG00000029580
UniProt P60709 P60710
RefSeq (mRNA) NM_001101 NM_007393
RefSeq (protein) NP_001092 NP_031419
Location (UCSC) Chr 7:
5.57 – 5.57 Mb
Chr 5:
142.9 – 142.91 Mb
PubMed search [1] [2]

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[1][2] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[4][5] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[6]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ Gunning, P. W.; Ghoshdastider, U; Whitaker, S; Popp, D; Robinson, R. C. (2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. doi:10.1242/jcs.165563. PMID 25788699.  edit
  2. ^ Hanukoglu I, Tanese N, Fuchs E (Feb 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". Journal of Molecular Biology 163 (4): 673–8. doi:10.1016/0022-2836(83)90117-1. PMID 6842590. 
  3. ^ "Entrez Gene: ACTB actin, beta". 
  4. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A et al. (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  5. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (Sep 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". The Journal of Biological Chemistry 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  6. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C et al. (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]

See also[edit]

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