1
Actin filament assembly
Actin filament assembly
DATE: 2012/11/25::
2
EMD Millipore
EMD Millipore's LentiBrite™ GFP-Beta Actin Lentiviral Biosensor (Catalogue No. 17-10204)
DATE: 2011/09/20::
3
Imaging the Brain While Forming Memories
Imaging the Brain While Forming Memories
DATE: 2014/01/23::
4
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
The Molecular Basis of Memory: Tracking mRNA in Brain Cells in Real Time
DATE: 2014/01/23::
5
regulating actin filament formation
regulating actin filament formation
DATE: 2010/11/03::
6
Tilapia spawning by Adi Sucipto
Tilapia spawning by Adi Sucipto
DATE: 2008/07/04::
7
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (1)
DATE: 2013/06/22::
8
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (ZETA'S IMITATE KAPPA'S)
DATE: 2008/02/01::
9
B PHI D ACTIN OUT  AT FROUNT LINE
B PHI D ACTIN OUT AT FROUNT LINE
DATE: 2009/12/18::
10
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
Monitoring spontaneous synaptic activity in neurons with GCaMP6s (2)
DATE: 2013/06/22::
11
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
Monitoring spontaneous synaptic activity in neurons with GCaMP6f (4)
DATE: 2013/06/22::
12
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
DATE: 2009/06/11::
13
b phi d actin owt
b phi d actin owt
DATE: 2009/06/04::
14
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
Guillaume Durin - Catch and Release - Extraction and Purification of NGS Grade DNA and RNA from FFPE
DATE: 2015/01/27::
15
The Joy of Phylogeny: How To Make Your Own Phylogram
The Joy of Phylogeny: How To Make Your Own Phylogram
DATE: 2010/11/22::
16
Actin a fool wit the frat!
Actin a fool wit the frat!
DATE: 2012/04/18::
17
Myosin is Thick, Actin is Thin
Myosin is Thick, Actin is Thin
DATE: 2012/02/15::
18
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
Diablo 3 Lets Play - Barbarian - Osa 10 - 1 Actin Loppu
DATE: 2012/06/12::
19
Cornell BRC Image Contest 2nd Place: Optical severing of actin filaments
Cornell BRC Image Contest 2nd Place: Optical severing of actin filaments
DATE: 2014/11/25::
20
TUSKEGEE
TUSKEGEE'S GREEK STOMP DA YARD (SIGMA GAMMA RHO IMITATE SIGMAS)
DATE: 2008/02/01::
21
Actin
Actin
DATE: 2014/03/14::
22
Chi Epsilon Beta(XEB)
Chi Epsilon Beta(XEB)
DATE: 2010/06/17::
23
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 1 of 2
DATE: 2010/10/27::
24
Actin
Actin
DATE: 2007/09/04::
25
DOLLABILLGATES - ACTIN MY AGE (PROD. BY JOSH FRANKS)
DOLLABILLGATES - ACTIN MY AGE (PROD. BY JOSH FRANKS)
DATE: 2011/06/21::
26
friday nght actin wild makin a girl smile
friday nght actin wild makin a girl smile
DATE: 2013/11/15::
27
"Hands-on" Actin Polymerization with plaster 3d models
"Hands-on" Actin Polymerization with plaster 3d models
DATE: 2013/03/28::
28
Actin Poly/dePoly movie
Actin Poly/dePoly movie
DATE: 2014/12/04::
29
Brotha Lynch Hung & C.o.S. - Actin
Brotha Lynch Hung & C.o.S. - Actin' Up feat. Nicci BlacC
DATE: 2007/06/27::
30
MU BETA OMEGAS
MU BETA OMEGAS
DATE: 2006/11/30::
31
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
GFP-lamin-B1 and RFP-β-actin: endogenous gene tagging by ZFNs
DATE: 2013/04/24::
32
ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast Cancer...
ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast Cancer...
DATE: 2015/03/23::
33
Young hall D wing actin a fool
Young hall D wing actin a fool
DATE: 2007/01/20::
34
Hands-on actin polymerization 2
Hands-on actin polymerization 2
DATE: 2013/04/17::
35
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
Zeta Phi Beta Sorority, Inc, Rho Alpha Chapter Spring 2010 Step Show Pt. 2 of 2
DATE: 2010/10/27::
36
"Hands-On" dynamic equilibrium of actin polymerization.
"Hands-On" dynamic equilibrium of actin polymerization.
DATE: 2013/04/16::
37
Cribz  (EAstbrooke) Lane College
Cribz (EAstbrooke) Lane College
DATE: 2010/10/27::
38
Clarksdale actin a ass in wal-mart
Clarksdale actin a ass in wal-mart
DATE: 2014/03/24::
39
ENTERACT PERFORMANCE IN MONO ACTIN AT IIT KGP SPRINGFEST 2K13
ENTERACT PERFORMANCE IN MONO ACTIN AT IIT KGP SPRINGFEST 2K13
DATE: 2013/01/28::
40
Hangin owt wit Beta Theta: Aint nothin like it! Part III
Hangin owt wit Beta Theta: Aint nothin like it! Part III
DATE: 2008/02/19::
41
Supplementary movie 7
Supplementary movie 7
DATE: 2013/09/23::
42
Quaylon Actin Like Osceola
Quaylon Actin Like Osceola's Coach Gaten 2 Vj
DATE: 2011/08/04::
43
Actin a fool @ MVSU
Actin a fool @ MVSU
DATE: 2010/04/01::
44
Polymerization of actin on a liposome membrane
Polymerization of actin on a liposome membrane
DATE: 2013/09/04::
45
Starbound #010 - Ein letzter Sterbemarathon [Let
Starbound #010 - Ein letzter Sterbemarathon [Let's Play][Deutsch/German][HD]
DATE: 2014/09/23::
46
Starbound #004 - Wir machen auf Multiplayer [Let
Starbound #004 - Wir machen auf Multiplayer [Let's Play][Deutsch/German][HD]
DATE: 2014/07/29::
47
►Texture Pack Release►Pirate Pack►
►Texture Pack Release►Pirate Pack►
DATE: 2014/09/22::
48
Microtubule regulator
Microtubule regulator
DATE: 2012/09/03::
49
Micheal Jackson They Don
Micheal Jackson They Don't Care Sampled Instrumental Rap @akaTheZebra
DATE: 2011/06/29::
50
Mani Ratnam
Mani Ratnam's Fairytale Movie Hitting the screens today
DATE: 2015/04/16::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Actin, beta
Protein ACTB PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACTB ; BRWS1; PS1TP5BP1
External IDs OMIM102630 MGI87904 HomoloGene110648 GeneCards: ACTB Gene
RNA expression pattern
PBB GE ACTB 200801 x at tn.png
PBB GE ACTB 213867 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 60 11461
Ensembl ENSG00000075624 ENSMUSG00000029580
UniProt P60709 P60710
RefSeq (mRNA) NM_001101 NM_007393
RefSeq (protein) NP_001092 NP_031419
Location (UCSC) Chr 7:
5.57 – 5.57 Mb
Chr 5:
142.9 – 142.91 Mb
PubMed search [1] [2]

Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[1][2] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]

Interactions[edit]

Beta-actin has been shown to interact with SPTBN2.[4][5] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[6]

Applications[edit]

Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.

References[edit]

  1. ^ Gunning, P. W.; Ghoshdastider, U; Whitaker, S; Popp, D; Robinson, R. C. (2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. doi:10.1242/jcs.165563. PMID 25788699.  edit
  2. ^ Hanukoglu I, Tanese N, Fuchs E (Feb 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions". Journal of Molecular Biology 163 (4): 673–8. doi:10.1016/0022-2836(83)90117-1. PMID 6842590. 
  3. ^ "Entrez Gene: ACTB actin, beta". 
  4. ^ Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A et al. (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. 
  5. ^ Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL (Sep 2001). "beta III spectrin binds to the Arp1 subunit of dynactin". The Journal of Biological Chemistry 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920. 
  6. ^ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C et al. (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]

See also[edit]

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