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Biogen
Biogen's CEO Is 'Very Excited' About Potential Alzheimer's Drug
Published: 2016/01/12
Channel: Bloomberg
Biogen Breaks Ground on New Manufacturing Facility
Biogen Breaks Ground on New Manufacturing Facility
Published: 2016/02/16
Channel: Biogen
Here
Here's What You Need to Know About Biotech Giant Biogen
Published: 2016/04/21
Channel: TheStreet
Biogen -  Psychic Function [Thule Records]
Biogen - Psychic Function [Thule Records]
Published: 2017/05/02
Channel: Goldcut Crates
U.S. FDA Approves Biogen’s SPINRAZA™ (nusinersen), The First Treatment for Spinal Muscular Atrophy
U.S. FDA Approves Biogen’s SPINRAZA™ (nusinersen), The First Treatment for Spinal Muscular Atrophy
Published: 2016/12/27
Channel: BusinessWire
Thoughts on Vertex and Biogen (11 Apr 2017)
Thoughts on Vertex and Biogen (11 Apr 2017)
Published: 2017/04/21
Channel: Best of Martin Shkreli
Interns at Biogen
Interns at Biogen
Published: 2017/02/08
Channel: Biogen
Red Flag Over Biogen
Red Flag Over Biogen's Expensive Drug For Rare Genetic Disease | Power Lunch | CNBC
Published: 2016/12/29
Channel: CNBC
Biogen -- Caring Deeply, Changing Lives.
Biogen -- Caring Deeply, Changing Lives.
Published: 2014/06/02
Channel: Biogen
Biogen - Autofloat
Biogen - Autofloat
Published: 2011/02/11
Channel: Raftónar
Biogen Idec is Biogen, Once Again
Biogen Idec is Biogen, Once Again
Published: 2015/03/23
Channel: Biogen
Manufacturing Drugs at Large Scale
Manufacturing Drugs at Large Scale
Published: 2012/02/02
Channel: Biogen
Biogen – Borealis | трип
Biogen – Borealis | трип
Published: 2017/06/26
Channel: Inside Techno
The Biotech Brief: Biogen
The Biotech Brief: Biogen's Wonder Drug Could Be the First-Ever Alzheimer's Treatment
Published: 2016/09/07
Channel: Anthony DeThomas
Biogen - Unitled (Official) Trip / TRP006
Biogen - Unitled (Official) Trip / TRP006
Published: 2016/05/25
Channel: Above Board Distribution
U.S. FDA Approves Biogen’s SPINRAZA™ (nusinersen), The First Treatment for Spinal Muscular Atrophy
U.S. FDA Approves Biogen’s SPINRAZA™ (nusinersen), The First Treatment for Spinal Muscular Atrophy
Published: 2016/12/27
Channel: BusinessWire
BIOGEN AGRO
BIOGEN AGRO
Published: 2013/01/17
Channel: El Clanfilms
Visiting Biogen
Visiting Biogen
Published: 2015/04/20
Channel: Brandon Alexander
FDE TV Season 2 Episode 9 - Story of Biogen Investment in Solothurn
FDE TV Season 2 Episode 9 - Story of Biogen Investment in Solothurn
Published: 2016/12/06
Channel: FDE TV
Breaking Wave, kinetic sculpture located in the Biogen Idec lobby
Breaking Wave, kinetic sculpture located in the Biogen Idec lobby
Published: 2014/09/04
Channel: Biogen
Interview with Adriana Bokel, Biogen
Interview with Adriana Bokel, Biogen
Published: 2016/04/07
Channel: Salesforce
Técnica de rejuvenescimento Biogen
Técnica de rejuvenescimento Biogen
Published: 2012/05/31
Channel: Amazon Sat
Biogen - Joe Manjoo
Biogen - Joe Manjoo
Published: 2017/05/05
Channel: Biogen
Biogen - Bliss
Biogen - Bliss
Published: 2017/07/01
Channel: Musical Journey
BIOGEN Rewital Pro +
BIOGEN Rewital Pro +
Published: 2016/03/25
Channel: PROCAM Polska Sp. z o.o.
Spatenstich Biogen in Luterbach
Spatenstich Biogen in Luterbach
Published: 2016/02/23
Channel: jumpTelevision
Moving Biogen Forward
Moving Biogen Forward
Published: 2017/05/23
Channel: Biogen
Investing In Biogen
Investing In Biogen
Published: 2016/07/18
Channel: Dukascopy TV (EN)
Biogen - Autofloat
Biogen - Autofloat
Published: 2017/07/01
Channel: Musical Journey
GURI V/S BIOGEN  FULL UNCUT GAMEPLAY + FUNNY TEAMING MOMENTS
GURI V/S BIOGEN FULL UNCUT GAMEPLAY + FUNNY TEAMING MOMENTS
Published: 2016/12/27
Channel: GURI
I Like Regeneron, Celgene and Gilead More Than Biogen Now: Cramer
I Like Regeneron, Celgene and Gilead More Than Biogen Now: Cramer
Published: 2015/07/24
Channel: TheStreet
Biogen - Lag 24
Biogen - Lag 24
Published: 2017/07/01
Channel: Musical Journey
Biogen Idec Tapping into Denmark
Biogen Idec Tapping into Denmark's Strong Biotech Cluster
Published: 2013/04/25
Channel: Invest in Denmark
Biogen at MS Climb to the Top NYC and Boston 2016
Biogen at MS Climb to the Top NYC and Boston 2016
Published: 2016/03/28
Channel: Biogen
Biogen
Biogen
Published: 2016/05/18
Channel: Larry Plotter
Biogen Aktie – Trading Idee gestartet!
Biogen Aktie – Trading Idee gestartet!
Published: 2015/08/23
Channel: GeVestor Finanz Experten
Cazan peleti-porumb-lemn Biogen Plus
Cazan peleti-porumb-lemn Biogen Plus
Published: 2014/04/16
Channel: TRUST EXPERT
Biogen Idec
Biogen Idec's TECFIDERA™ (Dimethyl Fumarate) Approved in US for Multiple Sclerosis
Published: 2013/03/28
Channel: BusinessWire
Biogen - Afloat
Biogen - Afloat
Published: 2015/02/20
Channel: Sedo 86
Biogen - Bliss
Biogen - Bliss
Published: 2013/04/06
Channel: zxcvbn m
Biogen - Raising the Bar: Advancing Women on Boards
Biogen - Raising the Bar: Advancing Women on Boards
Published: 2015/02/20
Channel: Biogen
Tech at Biogen pushes boundaries for patients.
Tech at Biogen pushes boundaries for patients.
Published: 2017/02/08
Channel: Biogen
Spinraza (Nusinersen) Approved by FDA for SMA Patients - Ionis Pharmaceuticals / Biogen
Spinraza (Nusinersen) Approved by FDA for SMA Patients - Ionis Pharmaceuticals / Biogen
Published: 2016/12/30
Channel: Muscle Owl
Biogen
Biogen
Published: 2017/03/14
Channel: Udruženje Biogen
Biogen Food Waste Management
Biogen Food Waste Management
Published: 2014/12/19
Channel: Biogen
Biogen Inc. Chart Analysis – Explosive Options
Biogen Inc. Chart Analysis – Explosive Options
Published: 2017/06/20
Channel: Explosive Options
Biogen
Biogen
Published: 2013/12/20
Channel: Dra. Maribel Santa Cruz
Trendfolger Proffe: Biogen, Amazon & Microsoft im Check
Trendfolger Proffe: Biogen, Amazon & Microsoft im Check
Published: 2013/09/05
Channel: DER AKTIONÄR TV
The Next Big Thing In Biotech: Biogen Idec
The Next Big Thing In Biotech: Biogen Idec
Published: 2011/10/22
Channel: TheStreet
NBC News Report on Nrf2 vs MS - BioGen Idec
NBC News Report on Nrf2 vs MS - BioGen Idec's BG12 Drug vs Protandim
Published: 2013/11/20
Channel: The Kaizen Group
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WIKIPEDIA ARTICLE

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Biogen
Public
Traded as
Industry Biotechnology
Founded 1978 (from merger)
Founders Kenneth Murray
Phillip Allen Sharp
Walter Gilbert
Heinz Schaller
Charles Weissmann
Headquarters Cambridge, Massachusetts, U.S.
Key people
Stelios Papadopoulos, Chairman
Michel Vounatsos, CEO
Products Alprolix, Avonex, Eloctate, Fampyra, Gazyva*, Plegridy, Rituxan*, Tecfidera, Tysabri, Spinraza
Revenue Increase US$ 10.76 billion (2015) <
Increase US$ 4.89 billion (2015) [1]
Increase US$ 3.55 billion (2015)
Total assets Increase US$ 19.505 billion (2015)
Total equity Decrease US$ 9.37 billion (2014)
Number of employees
7,350 (December 2015)[1]
Website www.biogen.com

Biogen, Inc. (previously known as Biogen Idec) is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurodegenerative, hematologic, and autoimmune diseases to patients worldwide.

History[edit]

Biogen was founded in 1978 in Geneva[2] by several prominent biologists, including Kenneth Murray of the University of Edinburgh, Phillip Allen Sharp of the Massachusetts Institute of Technology, Walter Gilbert of Harvard (who served as CEO during the start-up phase), Heinz Schaller, University of Heidelberg and Charles Weissmann, University of Zurich (who contributed the first product interferon alpha). Gilbert and Sharp were subsequently honored with Nobel Prizes: Gilbert was recognized in 1980 with the Nobel Prize in Chemistry for his work in understanding DNA sequencing, while Sharp received the Nobel Prize in Physiology or Medicine in 1993 for his discovery of split genes.

In 2003, Biogen merged with San Diego, California-based IDEC Pharmaceuticals (formed in 1986 by biotech pioneers Ivor Royston and Howard Birndorf) and adopted the name Biogen Idec. After the merger, Biogen Idec became the 3rd largest Biotechnology company in the world.[3] Following shifts in research core areas, the company has since shortened its name, reverting to simply Biogen.[4] Biogen stock is a component of several stock indices such as the S&P 100, S&P 500, S&P 1500, and NASDAQ-100 and the company is listed on the NASDAQ stock exchange under the ticker symbol, BIIB.[5]

In May 2006, the company announced it would acquire cancer specialist, Conforma Therapeutics for $250 million.[6] Later in the same month, the company announced its intention to acquire Fumapharm AG, consolidating ownership of Fumaderm and BG-12, an oral fumarate, which is being studied for the treatment of multiple sclerosis and psoriasis.[7]

In January 2007, the company announced it would acquire Syntonix Pharmaceuticals for up to $120 million, gaining Syntonix's lead product for hemophilia B as well as the technology for developing inhalable treatments.[8][9]

In February 2013, Bloomberg broke the news that Biogen was planning the pay Elan $3.25 billion for the full rights to Tysabri, used to treat multiple sclerosis.[10]

In January 2015 the company announced it will acquire Convergence Pharmaceuticals for up to $675 million, with the acquisition aiming to accelerate the development of Convergence's pipeline, in-particular CNV1014802 – a Phase II small molecule sodium channel blocking candidate.[11] In October 2015 the company announced it will lay off 11% of its workforce, effective immediately.[12]

Bioverativ[edit]

In May 2016 the company announced that it will spin off its hemophilia drug business (Eloctate and Alprolix) into a public company.[13] In August, the company announced that the spun off company would be called Bioverativ, in order to show heritage with Biogen.[14] The company will trade on the NASDAQ exchange under the ticker symbol BIVV[15][16] and will look to be spun off in early 2017.[17]

Acquisition history[edit]

The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):

Biogen



Biogen IDEC


Biogen
(Founded 1978)





IDEC Pharmaceuticals






Conforma Therapeutics
(Acq 2006)






Fumapharm AG
(Acq 2006)






Syntonix Pharmaceuticals
(Acq 2007)






Convergence Pharmaceuticals
(Acq 2015)




Leadership[edit]

Biogen is managed by an executive group composed of ten officers:[18]

  • Michel Vounatsos, Chief Executive Officer and Member, Board of Directors
  • Susan H. Alexander, Executive Vice President, Chief Legal Officer and Corporate Secretary
  • Spyros Artavanis-Tsakonas, Ph.D., Chief Scientific Officer
  • Paul J. Clancy, Executive Vice President and Chief Financial Officer
  • Paul McKenzie, Ph.D., Executive Vice President of Pharmaceutical Operations & Technology,[19]
  • Kenneth DiPietro, Executive Vice President of Human Resources
  • Alfred W. Sandrock, Jr., M.D., Ph.D.,Executive Vice President, Head of Development and Worldwide Medical and Chief Medical Officer
  • Michael Ehlers, M.D., Ph.D. Executive Vice President, Head of R&D

As is customary for a publicly traded company, Biogen is also overseen by a board of directors. The Executive Chairman and Chief Executive Officer both hold positions on the board of directors. The directors are Stelios Papadopoulos (chairman), Michel Vounatsos (CEO), Alexander J. Denner, Ph.D., Caroline Dorsa, Nancy L. Leaming, Richard C. Mulligan, Robert W. Pangia, Brian S. Posner, Eric K. Rowinsky, M.D., The Honorable Lynn Schenk, and Stephen A. Sherwin, M.D.[20]

Products[edit]

Therapy Indication (In United States unless otherwise noted) Year Approved (US) Year Approved (EU) Additional Information
ALPROLIX™ [Coagulation Factor IX (Recombinant), Fc Fusion Protein] Control and prevention of bleeding episodes, perioperative management and routine prophylaxis in adults and children with hemophilia B 2014 1993 Also approved in Canada and Australia.

Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization of ALPROLIX. [21]

AVONEX® (interferon beta-1a) Relapsing forms of multiple sclerosis 1996 1997 Includes the AVONEX PEN auto-injector and the AVOSTARTGRIP titration kit approved in the U.S. in 2012.[22]
ELOCTATE™ [Antihemophilic Factor (Recombinant), Fc Fusion Protein] Control and prevention of bleeding episodes, perioperative (surgical) management and routine prophylaxis in adults and children with hemophilia A 2014 1999 Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization of ELOCTATE.[23]
FAMPYRA® (prolonged-release fampridine tablets) Multiple sclerosis (Walking ability) 2010 2011 Marketed by Biogen in markets outside of the United States.

Commercialized in the United States as AMPYRA (dalfampridine) Extended Release Tablets, by Acorda Therapeutics.[24]

FUMADERM™ (fumaric acid esters) Psoriasis German use 1994 (Germany only) Approved in Germany.

Acquired in acquisition of Fumapharm AG in 2006.[25]

GAZYVA® (obinutuzumab) Chronic lymphocytic leukemia 2013 2014 The first medicine approved with the FDA’s Breakthrough Therapy Designation and is also currently in Phase 3 trials for NHL and diffuse large B-cell lymphoma.

Currently commercialized in the United States by Genentech, a wholly owned subsidiary of Roche.[26]

SPINRAZA™ (nusinersen) Spinal muscular atrophy 2016 The first drug approved for the treatment of spinal muscular atrophy, developed in collaboration with Ionis Pharmaceuticals. EU approval process under way.[27][28]
PLEGRIDY™ (peginterferon beta-1a) Relapsing forms of multiple sclerosis 2014[29] 2014[30]
RITUXAN® (rituximab) Non-Hodgkin's Lymphoma (NHL)

Anti-TNF Refractory Rheumatoid Arthritis

ANCA-Associated Vasculitis

Chronic lymphocytic leukemia

1997[31]

2006[32]

2011[33]

1998 (as MabThera) The first monoclonal antibody for cancer developed by IDEC, prior to merging with Biogen.

Currently commercialized by Roche and its subsidiary, Genentech.

TECFIDERA® (dimethyl fumarate) Relapsing forms of multiple sclerosis 2013[34] 2014[35]
TYSABRI® (natalizumab) Relapsing-remitting multiple sclerosis 2004 Re-introduced in 2006 2006 Full rights purchased from partner Elan in 2013.[36]

Pipeline[edit]

Biogen has focused its R&D efforts on the discovery and development of treatments for patients with high unmet medical needs in the areas of neurology, hematology and immunology.

Investigational MS medicines:

  • Daclizumab High-Yield Process (DAC HYP): is being developed as a potential once-monthly subcutaneous injection in the treatment of relapsing-remitting multiple sclerosis (RRMS). DAC HYP is being developed in collaboration with Abbvie, Inc. In June 2014, the companies announced positive top-line results from the Phase III DECIDE clinical trial, where DAC HYP demonstrated superiority over interferon beta-1a in annualized relapse rate.[37]
  • Anti-LINGO-1 (BIIB033) (Opicinumab): is the first candidate being investigated for its potential to remyelinate and repair neurons damaged by MS, currently in Phase 2 trials.[38]

Biogen has several candidates in Phase 1 and 2 clinical trials in neurodegenerative and immunological diseases including MS, Alzheimer’s disease, neuropathic pain, spinal muscular atrophy and lupus nephritis:

  • Phase 2a: anti-LINGO-1 molecule (Opicinumab) in acute optic neuritis
  • Phase 2b: anti-TWEAK monoclonal antibody in lupus nephritis
  • Phase 2a: STX-100 in patients with idiopathic pulmonary fibrosis
  • Phase 2: Neublastin for neuropathic pain in 2013
  • Phase 3:[39] BIIB037 (Aducanumab), Biogen’s first clinical study in Alzheimer’s disease
  • Phase 1/2: BIIB067 (ISIS-SOD1Rx) for Amyotrophic Lateral Sclerosis (ALS), in collaboration with Ionis

Biogen also has several development agreements in place with Ionis Pharmaceuticals to collaborate to leverage antisense technology in advancing the treatment of neurological disorders.[40]

In February 2012, Biogen formalized a joint venture with Samsung, creating Samsung Bioepis. This joint venture brings Biogen’s expertise and capabilities in protein engineering, cell line development, and recombinant biologics manufacturing to position the joint venture so Biogen can participate in the emerging market for biosimilars.[41]

In early 2014, Biogen entered into an agreement with Eisai, Inc., to jointly develop and commercialize two of their candidates for Alzheimer’s disease, which have the potential to reduce Aβ plaques that form in the brains of patients, as well as to slow the formation of new plaques, potentially improving symptoms and suppressing disease progression.[42]

References[edit]

  1. ^ a b "Biogen Inc. 10-K report 2015". Securities and Exchange Commission. Retrieved November 6, 2016.
  2. ^ "Biotech's Comeback Kid". Forbes. Retrieved 2012-12-04. 
  3. ^ "Idec to Merge With Biogen in $6.8 Billion Deal". New York Times. Retrieved 2003-06-24. 
  4. ^ "Biogen Drops Idec From Name". Wall Street Journal. Retrieved 2015-03-23. 
  5. ^ "Biogen Idec Inc. Stock Quote & Summary Data". NASDAQ. 
  6. ^ http://www.pharmatimes.com/news/biogen_idec_agrees_to_buy_swiss_company_fumapharm_996746
  7. ^ http://www.businesswire.com/news/home/20060531005276/en/Biogen-Idec-Acquire-Fumapharm-AG-Consolidates-Ownership
  8. ^ http://www.fiercebiotech.com/biotech/biogen-to-buy-syntonix-120m-deal
  9. ^ http://www.businesswire.com/news/home/20070104005533/en/Biogen-Idec-Acquire-Syntonix
  10. ^ https://www.bloomberg.com/news/articles/2013-02-06/biogen-to-pay-elan-3-25-billion-for-full-tysabri-rights
  11. ^ "Biogen Idec Snaps Up Convergence for Up-to-$675M - GEN News Highlights - GEN". 
  12. ^ "Biogen is cutting 11% of its workforce". 
  13. ^ D'Souza, Savio (May 3, 2016). "Biogen to spin off hemophilia drug business into a public company". Reuters. Retrieved May 3, 2016. 
  14. ^ "Amid takeover chatter, Biogen introduces hemophilia spinoff Bioverativ - FiercePharma". 
  15. ^ http://www.businesswire.com/news/financialpost/20160809005296/en/Biogen-Announces-Bioverativ-Hemophilia-Focused-Company
  16. ^ "Biogen unveils name for hemophilia drug spinoff: Bioverativ - The Boston Globe". 
  17. ^ "Biogen Announces Bioverativ as Name of New Hemophilia-Focused Company - Biogen Media". 
  18. ^ "Biogen Idec Inc (BIIB) Top Compensated Officers". Business Week. Retrieved 2014-04-14. 
  19. ^ "Biogen Announces Departure of Tony Kingsley | Business Wire". www.businesswire.com. Retrieved 2015-10-13. 
  20. ^ "Biogen Idec (BIIB) Chairman Young to Retire". StreetInsider.com. Retrieved 2014-02-18. 
  21. ^ "Does Biogen Idec Inc Have a New Blockbuster Hemophilia Therapy?". The Motley Fool. Retrieved 2014-07-04. 
  22. ^ "Avonex". National MS Society. 
  23. ^ "Biogen Idec’s Eloctate gains FDA approval". The Pharma Letter. Retrieved 2014-09-06. 
  24. ^ "Fampridine (Fampyra)". MS Trust. 
  25. ^ "Biogen Idec enters deal to acquire Fumapharm". First Word Pharma. Retrieved 2006-05-31. 
  26. ^ "FDA approves Gazyva for chronic lymphocytic leukemia". FDA.gov. Retrieved 2013-01-11. 
  27. ^ Wadman, Meredith (23 December 2016). "Updated: FDA approves drug that rescues babies with fatal neurodegenerative disease". Science. 
  28. ^ Grant, Charley (2016-12-27). "Surprise Drug Approval Is Holiday Gift for Biogen". Wall Street Journal. ISSN 0099-9660. Retrieved 2016-12-27. 
  29. ^ "Biogen Idec’s PLEGRIDY™(Peginterferon Beta-1a) Approved in the US for the Treatment of Multiple Sclerosis". Reuters. 
  30. ^ "Biogen Idec’s Plegridy approved in Europe for relapsing-remitting multiple sclerosis". The Pharma Letter. 
  31. ^ "FDA Approval for Rituximab". National Cancer Institute. 
  32. ^ "UPDATE 1-Roche, Biogen end dispute over Rituxan follow-ons". Reuters. Retrieved 2010-10-21. 
  33. ^ "FDA approves Rituxan to treat two rare disorders". FDA.gov. Retrieved 2011-04-19. 
  34. ^ "Cell Therapeutics buys Zevalin from Biogen Idec for $10M, with up to $20M extra plus milestones". The Pharma Letter. Retrieved 2007-09-03. 
  35. ^ "Tecifedra". National MS Society. 
  36. ^ "Tysabri". National MS Society. 
  37. ^ "Once-monthly MS drug from Biogen Idec, AbbVie clears Phase III hurdle". Fierce Biotech. Retrieved 2013-04-08. 
  38. ^ "Lingo: a promising remyelination target in MS". Multiple Sclerosis Research. Retrieved 2014-06-16. 
  39. ^ "Aducanumab Reduces Amyloid Plaques in Early Alzheimer's". PRIME. 
  40. ^ "Isis Pharmaceuticals and Biogen Idec". Fierce Biotech. 
  41. ^ "Biogen Sees Eloctate FDA Delay Pushing Marketing to Mid-2014". BusinessWeek. Retrieved 2013-12-11. 
  42. ^ "Isis Pharmaceuticals and Biogen Idec". Fierce Biotech. 

External links[edit]

Coordinates: 42°21′58.3″N 71°5′13.2″W / 42.366194°N 71.087000°W / 42.366194; -71.087000

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