| Cytochrome P450, family 4, subfamily Z, polypeptide 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CYP4Z1; CYP4A20 | ||||||||||||
| External IDs | HomoloGene: 79596 GeneCards: CYP4Z1 Gene | ||||||||||||
| EC number | 1.14.14.1 | ||||||||||||
|
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 199974 | n/a | |||||||||||
| Ensembl | ENSG00000186160 | n/a | |||||||||||
| UniProt | Q86W10 | n/a | |||||||||||
| RefSeq (mRNA) | NM_178134 | n/a | |||||||||||
| RefSeq (protein) | NP_835235 | n/a | |||||||||||
| Location (UCSC) | Chr 1: 47.53 – 47.58 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein that in humans is encoded by the CYP4Z1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]
CYP4Z1 is overexpressed in breast cancer cells.[1] It has also been demonstrated that the expression of the CYP4Z1 gene is upregulated by activated glucocorticoid and progesterone receptors.[3]
References [edit]
- ^ a b Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B (April 2004). "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma". Cancer Res. 64 (7): 2357–64. doi:10.1158/0008-5472.CAN-03-0849. PMID 15059886.
- ^ "Entrez Gene: CYP4Z1".
- ^ Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF (April 2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.
Further reading [edit]
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zöllner A, Dragan CA, Pistorius D, Müller R, Bode HB, Peters FT, Maurer HH, Bureik M (April 2009). "Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid". Biol. Chem. 390 (4): 313–7. doi:10.1515/BC.2009.030. PMID 19090726.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family.". Gen. Pharmacol. 28 (3): 351–9. doi:10.1016/S0306-3623(96)00246-7. PMID 9068972.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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