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Central chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Central chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/02/28
Channel: khanacademymedicine
Central and Peripheral Chemoreceptors (CO2 Detection)
Central and Peripheral Chemoreceptors (CO2 Detection)
Published: 2012/06/07
Channel: Pete Meighan
Respiratory: Regulation of Breathing Part 2: Central & Peripheral Chemoreceptors
Respiratory: Regulation of Breathing Part 2: Central & Peripheral Chemoreceptors
Published: 2017/07/11
Channel: Ninja Nerd Science
Peripheral chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Peripheral chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/03/03
Channel: khanacademymedicine
Control Of Respiration
Control Of Respiration
Published: 2014/09/08
Channel: Armando Hasudungan
03   Breathing control   02   Central chemoreceptors
03 Breathing control 02 Central chemoreceptors
Published: 2014/09/24
Channel: Learn Hub
192 - Aortic and Carotid Baroreceptors, Peripheral and Central Chemoreceptors USMLE STEP 1 ACE
192 - Aortic and Carotid Baroreceptors, Peripheral and Central Chemoreceptors USMLE STEP 1 ACE
Published: 2017/05/06
Channel: USMLE ACE INC
Central chemoreceptors
Central chemoreceptors
Published: 2015/12/26
Channel: WikiAudio
Altitude Adaptation of Central Chemoreceptors
Altitude Adaptation of Central Chemoreceptors
Published: 2013/12/10
Channel: Pete Meighan
The Role of Chemoreceptors in Breathing
The Role of Chemoreceptors in Breathing
Published: 2014/11/09
Channel: Sidney Huber
The Control of Breathing – Part 1
The Control of Breathing – Part 1
Published: 2014/11/06
Channel: Demystifying Medicine
Chemoreceptor Control of Breathing
Chemoreceptor Control of Breathing
Published: 2014/04/12
Channel: llwnr77
The Respiratory System: Control of Breathing
The Respiratory System: Control of Breathing
Published: 2013/04/18
Channel: Orsolya Lapohos
Chemoreceptor Reflex Control of Blood Pressure
Chemoreceptor Reflex Control of Blood Pressure
Published: 2014/06/30
Channel: justatee voo
Chemoreceptors
Chemoreceptors
Published: 2014/11/10
Channel: zwizzle15
Central chemoreceptors (5-2014) by Dr Khaled A Abulfadle
Central chemoreceptors (5-2014) by Dr Khaled A Abulfadle
Published: 2014/05/03
Channel: Dr Khaled A Abulfadle
The respiratory center | Respiratory system physiology | NCLEX-RN | Khan Academy
The respiratory center | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/03/03
Channel: khanacademymedicine
Cardiovascular Physiology : Regulation of Heart Function (Chemoreceptors & Baroreceptors)
Cardiovascular Physiology : Regulation of Heart Function (Chemoreceptors & Baroreceptors)
Published: 2016/06/20
Channel: Royal Christ College
Regulation of respiration -- chemoreceptors -- part 2
Regulation of respiration -- chemoreceptors -- part 2
Published: 2016/04/12
Channel: The Med Hub
RESPIRATORY PHYSIOLOGY; REGULATION OF BREATHING by Professor Fink
RESPIRATORY PHYSIOLOGY; REGULATION OF BREATHING by Professor Fink
Published: 2017/03/05
Channel: professorfink
Central and Peripheral Chemoreceptors (PART2)
Central and Peripheral Chemoreceptors (PART2)
Published: 2012/11/14
Channel: Pete Meighan
[SPEED] Central Chemoreceptors
[SPEED] Central Chemoreceptors
Published: 2015/05/17
Channel: Speed Science
Taste & Smell: Crash Course A&P #16
Taste & Smell: Crash Course A&P #16
Published: 2015/04/27
Channel: CrashCourse
Chemoreceptor Basics
Chemoreceptor Basics
Published: 2017/03/09
Channel: MedPlay
Control of Blood pressure Part 3 (Chemoreceptor Reflex)
Control of Blood pressure Part 3 (Chemoreceptor Reflex)
Published: 2016/11/14
Channel: Concept Clear
Chemoreceptor Reflex
Chemoreceptor Reflex
Published: 2016/11/04
Channel: BYU-Idaho Academic Support
Regulation of blood pressure with baroreceptors | NCLEX-RN | Khan Academy
Regulation of blood pressure with baroreceptors | NCLEX-RN | Khan Academy
Published: 2012/09/13
Channel: khanacademymedicine
Peripheral Nervous System: Crash Course A&P #12
Peripheral Nervous System: Crash Course A&P #12
Published: 2015/03/30
Channel: CrashCourse
Respiratory: Regulation of Breathing Part 1: Respiratory Centers
Respiratory: Regulation of Breathing Part 1: Respiratory Centers
Published: 2017/07/11
Channel: Ninja Nerd Science
Physiology of Vomiting
Physiology of Vomiting
Published: 2013/08/19
Channel: Armando Hasudungan
Autoregulation - Baroreceptors
Autoregulation - Baroreceptors
Published: 2012/09/10
Channel: Khan Academy
The role of chemoreceptors during pathophysiology
The role of chemoreceptors during pathophysiology
Published: 2015/01/26
Channel: The Physiological Society
CO2 Reflex response
CO2 Reflex response
Published: 2017/03/09
Channel: MedPlay
Acid Base Balance, Animation.
Acid Base Balance, Animation.
Published: 2017/10/10
Channel: Alila Medical Media
Chemoreceptor Reflex   Adrenal Medullary Mechanism   CNS Ischemic Response
Chemoreceptor Reflex Adrenal Medullary Mechanism CNS Ischemic Response
Published: 2016/11/04
Channel: BYU-Idaho Academic Support
Центральные хеморецепторы
Центральные хеморецепторы
Published: 2014/12/11
Channel: KhanAcademyRussian
High Altitude Illness (Acute Mountain Sickness) for USMLE
High Altitude Illness (Acute Mountain Sickness) for USMLE
Published: 2015/05/27
Channel: the study spot
03   Breathing control   01   Peripheral chemoreceptors
03 Breathing control 01 Peripheral chemoreceptors
Published: 2014/09/24
Channel: Learn Hub
chemoreceptors control of breathing
chemoreceptors control of breathing
Published: 2014/03/26
Channel: Kamique Hutchinson
Cheyne-Stokes Respiration
Cheyne-Stokes Respiration
Published: 2014/09/12
Channel: Jan Ackermann
chemoreceptor control of breathing
chemoreceptor control of breathing
Published: 2014/03/26
Channel: Chaelin Lee
Baroreflex Regulation of Blood Pressure, Animation.
Baroreflex Regulation of Blood Pressure, Animation.
Published: 2016/10/03
Channel: Alila Medical Media
Chemoreceptor Reflex Control of Blood Pressure HD Animation
Chemoreceptor Reflex Control of Blood Pressure HD Animation
Published: 2017/06/08
Channel: Microbiotic
USMLE Cardiovascular System 9 - Mean Arterial Pressure, Baroreceptors, and Chemoreceptors
USMLE Cardiovascular System 9 - Mean Arterial Pressure, Baroreceptors, and Chemoreceptors
Published: 2016/04/04
Channel: MedXclusive Learning
Baroreceptors mnemonic
Baroreceptors mnemonic
Published: 2014/01/07
Channel: Medicowesome
Chemoreceptor Control of Breathing
Chemoreceptor Control of Breathing
Published: 2014/11/09
Channel: Julia
Chemoreceptor Control of Breathing Final Project
Chemoreceptor Control of Breathing Final Project
Published: 2014/03/28
Channel: Jenna Coates
Breathing and Exchange of Gases for NEET | Part -9 | Regulation of Respiration
Breathing and Exchange of Gases for NEET | Part -9 | Regulation of Respiration
Published: 2017/11/10
Channel: MEDICAL WORLD
BARORECEPTORS AND CHEMORECEPTORS ON HEART FUNCTION BY NIK NIKAM MD
BARORECEPTORS AND CHEMORECEPTORS ON HEART FUNCTION BY NIK NIKAM MD
Published: 2017/04/30
Channel: Nik Nikam
CNS Ischemic Response
CNS Ischemic Response
Published: 2016/11/04
Channel: BYU-Idaho Academic Support
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WIKIPEDIA ARTICLE

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Central chemoreceptors of the central nervous system, located on the ventrolateral medullary surface in the vicinity of the exit of the 9th and 10th cranial nerves, are sensitive to the pH of their environment.

These act to detect the changes in pH of nearby cerebrospinal fluid (CSF) that are indicative of altered oxygen or carbon dioxide concentrations available to brain tissues. An increase in carbon dioxide causes tension of the arteries, often resulting from decreased CO2 output (hypercapnia), indirectly causes the blood to become more acidic; the cerebrospinal fluid pH is closely comparable to plasma, as carbon dioxide easily diffuses across the blood–brain barrier.

However, a change in plasma pH alone will not stimulate central chemoreceptors as H+ are not able to diffuse across the blood–brain barrier into the CSF. Only CO2 levels affect this as it can diffuse across, reacting with H2O to form carbonic acid and thus decrease pH. Central chemoreception remains, in this way, distinct from peripheral chemoreceptors.

The central chemoreception system has also been shown experimentally to respond to hypercapnic hypoxia (elevated CO2, decreased O2) and aqueous sodium cyanide injection into the whole animal[1] and in vitro slice preparation. These methods can be used to mimic some forms of hypoxic hypoxia and they are currently being studied including the detection of variation in arterial CO2 tension acting as a quick-response-system for short term (or emergency) regulation.

This system utilizes a negative feedback system, therefore if the pH of the cerebral spinal fluid does not compare to an ideal “set” level, then the receptor will send an error signal to the effectors and appropriate action may be executed.

Peripheral chemoreceptors (carotid and aortic bodies) and central chemoreceptors (medullary neurons) primarily function to regulate respiratory activity. This is an important mechanism for maintaining arterial blood pO2, pCO2, and pH within appropriate physiological ranges. For example, a fall in arterial pO2 (hypoxemia) or an increase in arterial pCO2 (hypercapnia) leads to an increase in the rate and depth of respiration through activation of the chemoreceptor reflex. Chemoreceptor activity, however, also affects cardiovascular function either directly (by interacting with medullary vasomotor centers) or indirectly (via altered pulmonary stretch receptor activity). Respiratory arrest and circulatory shock (these conditions decrease arterial pO2 and pH, and increase arterial pCO2) dramatically increase chemoreceptor activity leading to enhanced sympathetic outflow to the heart and vasculature via activation of the vasomotor center in the medulla.

See also[edit]

References[edit]

  1. ^ Solomon IC, Edelman NH, Neubauer, JA. Pre-Bötzinger complex functions as a central hypoxia chemosensor for respiration in vivo. J Neurophysiol. 83(5):2854-68, 2000.

External links[edit]

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