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Central chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Central chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/02/28
Channel: khanacademymedicine
Central and Peripheral Chemoreceptors (CO2 Detection)
Central and Peripheral Chemoreceptors (CO2 Detection)
Published: 2012/06/07
Channel: Pete Meighan
Control Of Respiration
Control Of Respiration
Published: 2014/09/08
Channel: Armando Hasudungan
Peripheral chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Peripheral chemoreceptors | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/03/03
Channel: khanacademymedicine
03   Breathing control   02   Central chemoreceptors
03 Breathing control 02 Central chemoreceptors
Published: 2014/09/24
Channel: Learn Hub
Altitude Adaptation of Central Chemoreceptors
Altitude Adaptation of Central Chemoreceptors
Published: 2013/12/10
Channel: Pete Meighan
Central chemoreceptors
Central chemoreceptors
Published: 2015/12/26
Channel: WikiAudio
192 - Aortic and Carotid Baroreceptors, Peripheral and Central Chemoreceptors USMLE STEP 1 ACE
192 - Aortic and Carotid Baroreceptors, Peripheral and Central Chemoreceptors USMLE STEP 1 ACE
Published: 2017/05/06
Channel: USMLE ACE INC
Chemoreceptor Reflex Control of Blood Pressure
Chemoreceptor Reflex Control of Blood Pressure
Published: 2014/06/30
Channel: justatee voo
The Respiratory System: Control of Breathing
The Respiratory System: Control of Breathing
Published: 2013/04/18
Channel: Orsolya Lapohos
Chemoreceptor Control of Breathing Final Project
Chemoreceptor Control of Breathing Final Project
Published: 2014/03/28
Channel: Jenna Coates
The Role of Chemoreceptors in Breathing
The Role of Chemoreceptors in Breathing
Published: 2014/11/09
Channel: Sidney Huber
Central chemoreceptors (5-2014) by Dr Khaled A Abulfadle
Central chemoreceptors (5-2014) by Dr Khaled A Abulfadle
Published: 2014/05/03
Channel: Dr Khaled A Abulfadle
Central and Peripheral Chemoreceptors (PART2)
Central and Peripheral Chemoreceptors (PART2)
Published: 2012/11/14
Channel: Pete Meighan
RESPIRATORY PHYSIOLOGY; REGULATION OF BREATHING by Professor Fink
RESPIRATORY PHYSIOLOGY; REGULATION OF BREATHING by Professor Fink
Published: 2017/03/05
Channel: professorfink
Chemoreceptor Control of Breathing
Chemoreceptor Control of Breathing
Published: 2014/11/09
Channel: Julia
Regulation of respiration -- chemoreceptors -- part 2
Regulation of respiration -- chemoreceptors -- part 2
Published: 2016/04/12
Channel: The Med Hub
Taste & Smell: Crash Course A&P #16
Taste & Smell: Crash Course A&P #16
Published: 2015/04/27
Channel: CrashCourse
The respiratory center | Respiratory system physiology | NCLEX-RN | Khan Academy
The respiratory center | Respiratory system physiology | NCLEX-RN | Khan Academy
Published: 2013/03/03
Channel: khanacademymedicine
Cardiovascular Physiology : Regulation of Heart Function (Chemoreceptors & Baroreceptors)
Cardiovascular Physiology : Regulation of Heart Function (Chemoreceptors & Baroreceptors)
Published: 2016/06/20
Channel: Royal Christ College
Chemoreceptor Control of Breathing
Chemoreceptor Control of Breathing
Published: 2014/04/12
Channel: llwnr77
Regulation of blood pressure with baroreceptors | NCLEX-RN | Khan Academy
Regulation of blood pressure with baroreceptors | NCLEX-RN | Khan Academy
Published: 2012/09/13
Channel: khanacademymedicine
03   Breathing control   01   Peripheral chemoreceptors
03 Breathing control 01 Peripheral chemoreceptors
Published: 2014/09/24
Channel: Learn Hub
[SPEED] Central Chemoreceptors
[SPEED] Central Chemoreceptors
Published: 2015/05/17
Channel: Speed Science
Chemoreceptors
Chemoreceptors
Published: 2016/12/15
Channel: Majo Leyva
Chemoreceptor Basics
Chemoreceptor Basics
Published: 2017/03/09
Channel: MedPlay
Baroreceptor Control of Blood Pressure
Baroreceptor Control of Blood Pressure
Published: 2014/03/22
Channel: Katiana Van Dyke
Chemoreceptor Reflex
Chemoreceptor Reflex
Published: 2016/11/04
Channel: BYU-Idaho Academic Support
Chemoreceptor Reflex   Adrenal Medullary Mechanism   CNS Ischemic Response
Chemoreceptor Reflex Adrenal Medullary Mechanism CNS Ischemic Response
Published: 2016/11/04
Channel: BYU-Idaho Academic Support
Respiratory: Regulation of Breathing Part 2: Central & Peripheral Chemoreceptors
Respiratory: Regulation of Breathing Part 2: Central & Peripheral Chemoreceptors
Published: 2017/07/11
Channel: Ninja Nerd Science
CO2 Reflex response
CO2 Reflex response
Published: 2017/03/09
Channel: MedPlay
Chemoreceptors
Chemoreceptors
Published: 2014/11/10
Channel: zwizzle15
Arterial Chemoreceptors in Physiology and Pathophysiology Advances in Experimental Medicine and Biol
Arterial Chemoreceptors in Physiology and Pathophysiology Advances in Experimental Medicine and Biol
Published: 2016/06/10
Channel: Craig McKenzie
Baroreflex Regulation of Blood Pressure, Animation.
Baroreflex Regulation of Blood Pressure, Animation.
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Channel: Alila Medical Media
The Control of Breathing – Part 1
The Control of Breathing – Part 1
Published: 2014/11/06
Channel: Demystifying Medicine
Cheyne-Stokes Respiration
Cheyne-Stokes Respiration
Published: 2014/09/12
Channel: Jan Ackermann
Physiology of Vomiting
Physiology of Vomiting
Published: 2013/08/19
Channel: Armando Hasudungan
2016 11 30 Bio30E Lesson 7 8 Unit 4 Reception Chemoreceptors
2016 11 30 Bio30E Lesson 7 8 Unit 4 Reception Chemoreceptors
Published: 2016/11/30
Channel: Melissa Baxter
Peripheral Nervous System: Crash Course A&P #12
Peripheral Nervous System: Crash Course A&P #12
Published: 2015/03/30
Channel: CrashCourse
Shock 14, Neurological compensations in developing shock
Shock 14, Neurological compensations in developing shock
Published: 2013/05/23
Channel: Dr. John Campbell
chemoreceptor control of breathing
chemoreceptor control of breathing
Published: 2014/03/26
Channel: Chaelin Lee
Chemoreceptors and copd
Chemoreceptors and copd
Published: 2012/12/07
Channel: Docterindotcom
How to say "chemoreceptors"! (High Quality Voices)
How to say "chemoreceptors"! (High Quality Voices)
Published: 2017/01/21
Channel: WordBox
Центральные хеморецепторы
Центральные хеморецепторы
Published: 2014/12/11
Channel: KhanAcademyRussian
Chemoreceptor Reflex Control of Blood Pressure HD Animation
Chemoreceptor Reflex Control of Blood Pressure HD Animation
Published: 2017/06/08
Channel: Microbiotic
USMLE Cardiovascular System 9 - Mean Arterial Pressure, Baroreceptors, and Chemoreceptors
USMLE Cardiovascular System 9 - Mean Arterial Pressure, Baroreceptors, and Chemoreceptors
Published: 2016/04/04
Channel: MedXclusive Learning
Baroreceptors & Chemoreceptors of Heart
Baroreceptors & Chemoreceptors of Heart
Published: 2013/02/18
Channel: USMLEFastTrack
High Altitude Illness (Acute Mountain Sickness) for USMLE
High Altitude Illness (Acute Mountain Sickness) for USMLE
Published: 2015/05/27
Channel: the study spot
Breathing and Exchange of Gases - Nervous and Chemical Control of Respiration
Breathing and Exchange of Gases - Nervous and Chemical Control of Respiration
Published: 2016/10/31
Channel: Neela Bakore Tutorials
Peripheral chemoreceptors (4-2013) by Dr Khaled A Abulfadle
Peripheral chemoreceptors (4-2013) by Dr Khaled A Abulfadle
Published: 2013/04/25
Channel: Dr Khaled A Abulfadle
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WIKIPEDIA ARTICLE

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Central chemoreceptors of the central nervous system, located on the ventrolateral medullary surface in the vicinity of the exit of the 9th and 10th cranial nerves, are sensitive to the pH of their environment.

These act to detect the changes in pH of nearby cerebrospinal fluid (CSF) that are indicative of altered oxygen or carbon dioxide concentrations available to brain tissues. An increase in carbon dioxide causes tension of the arteries, often resulting from decreased CO2 output (hypercapnia), indirectly causes the blood to become more acidic; the cerebrospinal fluid pH is closely comparable to plasma, as carbon dioxide easily diffuses across the blood–brain barrier.

However, a change in plasma pH alone will not stimulate central chemoreceptors as H+ are not able to diffuse across the blood–brain barrier into the CSF. Only CO2 levels affect this as it can diffuse across, reacting with H2O to form carbonic acid and thus decrease pH. Central chemoreception remains, in this way, distinct from peripheral chemoreceptors.

The central chemoreception system has also been shown experimentally to respond to hypercapnic hypoxia (elevated CO2, decreased O2) and aqueous sodium cyanide injection into the whole animal[1] and in vitro slice preparation. These methods can be used to mimic some forms of hypoxic hypoxia and they are currently being studied including the detection of variation in arterial CO2 tension acting as a quick-response-system for short term (or emergency) regulation.

This system utilizes a negative feedback system, therefore if the pH of the cerebral spinal fluid does not compare to an ideal “set” level, then the receptor will send an error signal to the effectors and appropriate action may be executed.

Peripheral chemoreceptors (carotid and aortic bodies) and central chemoreceptors (medullary neurons) primarily function to regulate respiratory activity. This is an important mechanism for maintaining arterial blood pO2, pCO2, and pH within appropriate physiological ranges. For example, a fall in arterial pO2 (hypoxemia) or an increase in arterial pCO2 (hypercapnia) leads to an increase in the rate and depth of respiration through activation of the chemoreceptor reflex. Chemoreceptor activity, however, also affects cardiovascular function either directly (by interacting with medullary vasomotor centers) or indirectly (via altered pulmonary stretch receptor activity). Respiratory arrest and circulatory shock (these conditions decrease arterial pO2 and pH, and increase arterial pCO2) dramatically increase chemoreceptor activity leading to enhanced sympathetic outflow to the heart and vasculature via activation of the vasomotor center in the medulla.

See also[edit]

References[edit]

  1. ^ Solomon IC, Edelman NH, Neubauer, JA. Pre-Bötzinger complex functions as a central hypoxia chemosensor for respiration in vivo. J Neurophysiol. 83(5):2854-68, 2000.

External links[edit]

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