Clonal deletion - Mashpedia All-in-One Encyclopedia

Clonal deletion is a process by which B cells and T cells are deactivated after they have expressed receptors for self-antigens and before they develop into fully immunocompetent lymphocytes.^[1]

It is one method of immune tolerance.

References [edit]

^ Lecture 15

External links [edit]

Clonal deletion at the US National Library of Medicine Medical Subject Headings (MeSH)

Immunology: Lymphocytic adaptive immune system and complement

Lymphoid

Antigens	Antigen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Antigen presentation/Professional APCs: Dendritic cell Macrophage B cell Immunogen

Antibodies	Antibody Monoclonal antibodies Polyclonal antibodies Autoantibody Microantibody Polyclonal B cell response Allotype Isotype Idiotype Immune complex Paratope

Immunity vs. tolerance	action: Immunity Autoimmunity Alloimmunity Allergy Hypersensitivity Inflammation Cross-reactivity inaction: Tolerance Central Peripheral Clonal anergy Clonal deletion Tolerance in pregnancy Immunodeficiency

Immunogenetics	Affinity maturation (Somatic hypermutation Clonal selection) V(D)J recombination Junctional diversity Immunoglobulin class switching MHC/HLA

Lymphocytes

Substances

Complement

Anaphylatoxins

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug (L3/4)

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