Cloo focuses on mystery entertainment, with the majority of the channel's programming borrowed from sister channels NBC and USA Network. However, as of 2014 the network's schedule is made up mostly of repeats of current USA Network series or marathons from the Law and Order franchise, and films either from the NBCUniversal library or acquired as part of USA Network's film rights purchases, meaning films such as Enchanted, The 40 Year-Old Virgin and Bee Movie with nothing to do with crimes or mysteries air on the network.
On August 15, 2011 Cloo was rebranded from its former name of Sleuth, in order to be able to trademark and own the name. NBCUniversal could not do so with the name Clue because Hasbro owns the rights to it with their board game Clue (and in turn owns 40% of its joint venture with Discovery Communications for Discovery Family). NBCUniversal also explained that another reason for the name change was the word "Sleuth" is too common for search engines.
On August 10, 2013, Cloo was dropped by Dish Network, which cited that most of the network's rerun-centric programming was duplicative of that available on other NBCUniversal networks and ION Television. A year later on August 18, 2014, it was removed from Verizon FIOS, also for the same reason. In reverse, the network was added to Charter Communications in December 2013 as a replacement for Cloo's moribund sister network G4.
In January 2009, all shows from the lineup (see past programming) were removed and replaced with mainly NBCUniversal-produced, USA Network original shows, Monk and In Plain Sight to its lineup, running marathons of each program's episodes. CBS military-crime-drama series NCIS were also added to the channel's lineup, both of which are staples on USA Network, as well as another USA Network staple in Walker, Texas Ranger and two Canadian series, Da Vinci's Inquest and Cold Squad, that primarily aired in syndication nationwide. The Law & Order franchise also joined the channel. It recently started airing another Canadian series, The Eleventh Hour. However, it was renamed Bury the Lead, to differentiate it from the since-canceled CBS series of the same name.