Share
VIDEOS 1 TO 50
Cold agglutinin disease
Cold agglutinin disease
Published: 2014/12/03
Channel: Audiopedia
Cold Agglutinin Disease (autoimmune hemolytic anemia: Mycoplasma Pneumoniae & Mononucleosis)
Cold Agglutinin Disease (autoimmune hemolytic anemia: Mycoplasma Pneumoniae & Mononucleosis)
Published: 2013/06/05
Channel: USMLEFastTrack
Cold Agglutinin
Cold Agglutinin
Published: 2013/08/27
Channel: swicmltvideos
Cold agglutinin disease (Medical Condition)
Cold agglutinin disease (Medical Condition)
Published: 2015/06/03
Channel: Medical Condition Information
Autoimmune Hemolytic Anemia - Warm & Cold Agglutinin
Autoimmune Hemolytic Anemia - Warm & Cold Agglutinin
Published: 2013/10/24
Channel: USMLEFastTrack
Cold Agglutinin
Cold Agglutinin
Published: 2016/07/17
Channel: Chonnapat S.
Autoimmune hemolytic anemia (types "warm & cold", treament, diagnostic tests)
Autoimmune hemolytic anemia (types "warm & cold", treament, diagnostic tests)
Published: 2017/02/21
Channel: MediStude Pediatrics
Cold Algutenin Disease
Cold Algutenin Disease
Published: 2009/10/20
Channel: 3dnamedical
WAHA Warm Autoimmune Hemolytic Anemia  AIHA
WAHA Warm Autoimmune Hemolytic Anemia AIHA
Published: 2013/04/22
Channel: anim otions
Coombs Test Made Simple
Coombs Test Made Simple
Published: 2015/10/26
Channel: MEDSimplified
Autoimmune Hemolytic Anemia
Autoimmune Hemolytic Anemia
Published: 2012/05/23
Channel: MercolaHealthyPets
The Body Against Itself: Immune-Mediated
The Body Against Itself: Immune-Mediated
Published: 2014/02/13
Channel: Morris Animal Foundation
Cold Reactive Antibody Workup SOP
Cold Reactive Antibody Workup SOP
Published: 2017/04/11
Channel: Kayla Hansen
2 Autoimmune haemolytic anemia (cold type 2)
2 Autoimmune haemolytic anemia (cold type 2)
Published: 2017/07/12
Channel: forat adli
436: Cold Agglutinins or Warm Agglutinins
436: Cold Agglutinins or Warm Agglutinins
Published: 2016/09/28
Channel: latisom
1 Autoimmune haemolytic anemia (cold type 1)
1 Autoimmune haemolytic anemia (cold type 1)
Published: 2017/07/12
Channel: forat adli
What Is Autoimmune Hemolytic Anemia?
What Is Autoimmune Hemolytic Anemia?
Published: 2017/08/28
Channel: A Big Question
Paroxysmal nocturnal hemoglobinuria  -animated quick review
Paroxysmal nocturnal hemoglobinuria -animated quick review
Published: 2016/05/15
Channel: Rewise MD
Shwachman - Diamond Syndrome (SDS)
Shwachman - Diamond Syndrome (SDS)
Published: 2014/02/03
Channel: Documentary
Autoimmune Hemolytic Anemia & Coombs Test #USMLE #COMLEX
Autoimmune Hemolytic Anemia & Coombs Test #USMLE #COMLEX
Published: 2017/05/30
Channel: medeasy
1885: Cold Agglutinins or Treponemal Antibody Absorption Test
1885: Cold Agglutinins or Treponemal Antibody Absorption Test
Published: 2016/09/28
Channel: latisom
Cure Any Autoimmune Disease     Crohn
Cure Any Autoimmune Disease Crohn's, TYPE 2 Diabetes, MS, Lupus, Arthritis, Fibromyalgia!!
Published: 2017/05/23
Channel: ReformerThePerformer
****Cure Any Autoimmune Disease *** Crohn
****Cure Any Autoimmune Disease *** Crohn's, TYPE 2 Diabetes, MS, Lupus, Arthritis, Fibromyalgia!!
Published: 2013/04/25
Channel: HealAllDiseases
Autoimmune Hemolytic Anemia
Autoimmune Hemolytic Anemia
Published: 2013/03/12
Channel: Cara Cook
04 Hemolytic Anemia
04 Hemolytic Anemia
Published: 2016/11/05
Channel: Muna Hassan
Why Do I Have Anemia? Symptoms, Treatments and Causes
Why Do I Have Anemia? Symptoms, Treatments and Causes
Published: 2015/07/03
Channel: Dr Lonnie Herman
Why Do Antibodies Attack Red Blood Cells?
Why Do Antibodies Attack Red Blood Cells?
Published: 2017/07/06
Channel: sparky Q
Hemolytic Anemia
Hemolytic Anemia
Published: 2013/08/07
Channel: daf189
Hemolytic Anemia Treatment | Autoimmune Hemolytic anemia symptoms
Hemolytic Anemia Treatment | Autoimmune Hemolytic anemia symptoms
Published: 2016/04/25
Channel: Medical Lectures and Health Tips
Autoimmune Hemolytic Anaemia
Autoimmune Hemolytic Anaemia
Published: 2015/12/31
Channel: Cec Ugc
IgM & AGGLUTINATION
IgM & AGGLUTINATION
Published: 2016/02/18
Channel: Walter Jahn
Hemolytic Anemia
Hemolytic Anemia
Published: 2014/05/22
Channel: oakie88
Usmle Step 1 Hematology 24 video
Usmle Step 1 Hematology 24 video
Published: 2011/10/04
Channel: Riyadh Alrubaye
Blood Bank-Antibody Screen (Prewarm Technique)
Blood Bank-Antibody Screen (Prewarm Technique)
Published: 2015/07/31
Channel: Robert Bounds
Sample Lecture – Hematology Immune Hemolytic Anemia
Sample Lecture – Hematology Immune Hemolytic Anemia
Published: 2014/11/11
Channel: SmarTeach
Hemolytic Anemia
Hemolytic Anemia
Published: 2011/10/25
Channel: DrER.tv
Shwachman - Diamond Syndrome (SDS)
Shwachman - Diamond Syndrome (SDS)
Published: 2015/07/06
Channel: Vahapana Otekidi
Autoimmune Hemolytic Anemia
Autoimmune Hemolytic Anemia
Published: 2012/10/18
Channel: Gretchen Mosiman
Agglutinin Meaning
Agglutinin Meaning
Published: 2015/05/01
Channel: ADictionary
Autoimmune hemolytic anemia (Medical Condition)
Autoimmune hemolytic anemia (Medical Condition)
Published: 2015/05/25
Channel: Medical Condition Information
Warm autoimmune hemolytic anemia (Medical Condition)
Warm autoimmune hemolytic anemia (Medical Condition)
Published: 2015/04/28
Channel: Medical Condition Information
Autoimmune hemolytic anemia demonstration
Autoimmune hemolytic anemia demonstration
Published: 2014/04/17
Channel: Evan Pirog
****Cure Any Autoimmune Disease *** MS, TYPE 2 Diabetes, Crohn
****Cure Any Autoimmune Disease *** MS, TYPE 2 Diabetes, Crohn's, Arthritis, Fibromyalgia, Lupus!!
Published: 2013/12/28
Channel: HealAllDiseases
Agglutination assay to detect antigens - Multi-Lingual Captions
Agglutination assay to detect antigens - Multi-Lingual Captions
Published: 2010/12/23
Channel: openmichigan
Hematology - 4 | U1-L44 | P blood group system
Hematology - 4 | U1-L44 | P blood group system
Published: 2017/10/12
Channel: المقررات المفتوحة
Medical vocabulary: What does Hemoglobinuria, Paroxysmal mean
Medical vocabulary: What does Hemoglobinuria, Paroxysmal mean
Published: 2016/01/17
Channel: botcaster inc. bot
Hemolytic Anemia – Hematology | Medical Education Videos
Hemolytic Anemia – Hematology | Medical Education Videos
Published: 2015/06/25
Channel: Lecturio Medical Videos
An Allergic Reaction to Extreme Cold
An Allergic Reaction to Extreme Cold
Published: 2014/02/01
Channel: keshetrescue
nutrition (anemia disease)
nutrition (anemia disease)
Published: 2011/04/16
Channel: canouch01
Warm Autoantibody Workup SOP Review
Warm Autoantibody Workup SOP Review
Published: 2017/04/11
Channel: Kayla Hansen
NEXT
GO TO RESULTS [51 .. 100]

WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cold agglutinin disease
Coldagglutinin.svg
Cold agglutination - at body temperature, the antibodies do not attach to the red blood cells. At lower temperatures, however, the antibodies react to Ii antigens, bringing the red blood cells together, a process known as agglutination
Classification and external resources
Specialty hematology
ICD-10 D59.1
ICD-9-CM 283.0
DiseasesDB 2949
eMedicine med/408
MeSH D000744

Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells.[1] It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28–31 °C.

Cold agglutinin disease was first described in 1957.[2][3]

Cause[edit]

Cold agglutinin disease can be either primary (arising spontaneously) or secondary (a result of another pathology).

Pathophysiology[edit]

All individuals have circulating antibodies directed against red blood cells, but their concentrations are often too low to trigger disease (titers under 64 at 4 °C). In individuals with cold agglutinin disease, these antibodies are in much higher concentrations (titers over 1000 at 4 °C).

At body temperatures of 28–31 °C, such as those encountered during winter months, and occasionally at body temperatures of 37 °C, antibodies (generally IgM) bind to the polysaccharide region of glycoproteins on the surface of red blood cells (typically the I antigen, i antigen, and Pr antigens). Binding of antibodies to red blood cells activates the classical pathway of the complement system. If the complement response is sufficient, red blood cells are damaged by the membrane attack complex, an effector of the complement cascade. In the formation of the membrane attack complex, several complement proteins are inserted into the red blood cell membrane, forming pores that lead to membrane instability and intravascular hemolysis (destruction of the red blood cell within the blood vessels).

If the complement response is insufficient to form membrane attack complexes, then extravascular lysis will be favored over intravascular red blood cell lysis. In lieu of the membrane attack complex, complement proteins (particularly C3b and C4b) are deposited on red blood cells. This opsonization enhances the clearance of red blood cell by phagocytes in the liver, spleen, and lungs, a process termed extravascular hemolysis.

Individuals with cold agglutinin disease present with signs and symptoms of hemolytic anemia. Those with secondary agglutinin disease may also present with an underlying disease, often autoimmune.

Treatment[edit]

  • Avoid cold weather.
  • Treat the underlying lymphoma.
  • No cold drinks; all drinks should be at room temperature (or above).
  • Requires heater to maintain temperature in cold places.

Treatment with rituximab has been described.[6]

See also[edit]

References[edit]

  1. ^ Cold Agglutinin Disease at eMedicine
  2. ^ Gertz, Moric A (2006). "Cold agglutinin disease". Haematologica. 91 (4): 439–41. PMID 16585009. 
  3. ^ Dacie, J. V.; Crookston, J. H.; Christenson, W. N. (1957). "‘Incomplete’ Cold Antibodies: Role of Complement in Sensitization to Antiglobulin Serum by Potentially Haemolytic Antibodies". British Journal of Haematology. 3 (1): 77–87. PMID 13413095. doi:10.1111/j.1365-2141.1957.tb05773.x. 
  4. ^ Berentsen, Sigbjørn; Tjønnfjord, Geir E. (2012). "Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia". Blood Reviews. 26 (3): 107–15. PMID 22330255. doi:10.1016/j.blre.2012.01.002. 
  5. ^ Berentsen, Sigbjørn; Randen, Ulla; Tjønnfjord, Geir E. (2015). "Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia". Hematology/Oncology Clinics of North America. 29 (3): 455–71. PMID 26043385. doi:10.1016/j.hoc.2015.01.002. 
  6. ^ Berentsen, Sigbjørn; Ulvestad, Elling; Gjertsen, Bjørn Tore; Hjorth-Hansen, Henrik; Langholm, Ruth; Knutsen, Håvar; Ghanima, Waleed; Shammas, Fuad Victor; Tjønnfjord, Geir E. (2004). "Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients". Blood. 103 (8): 2925–8. PMID 15070665. doi:10.1182/blood-2003-10-3597. 

Disclaimer

None of the audio/visual content is hosted on this site. All media is embedded from other sites such as GoogleVideo, Wikipedia, YouTube etc. Therefore, this site has no control over the copyright issues of the streaming media.

All issues concerning copyright violations should be aimed at the sites hosting the material. This site does not host any of the streaming media and the owner has not uploaded any of the material to the video hosting servers. Anyone can find the same content on Google Video or YouTube by themselves.

The owner of this site cannot know which documentaries are in public domain, which has been uploaded to e.g. YouTube by the owner and which has been uploaded without permission. The copyright owner must contact the source if he wants his material off the Internet completely.

Powered by YouTube
Wikipedia content is licensed under the GFDL and (CC) license