Go bo nhi dnai1

Channel:   |   2014/01/12
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Go bo nhi dnai1
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From Wikipedia, the free encyclopedia
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Dynein, axonemal, intermediate chain 1
Identifiers
Symbols DNAI1 ; CILD1; DIC1; ICS; ICS1; PCD
External IDs OMIM604366 MGI1916172 HomoloGene8122 GeneCards: DNAI1 Gene
RNA expression pattern
PBB GE DNAI1 220125 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27019 68922
Ensembl ENSG00000122735 ENSMUSG00000061322
UniProt Q9UI46 Q8C0M8
RefSeq (mRNA) NM_012144 NM_175138
RefSeq (protein) NP_036276 NP_780347
Location (UCSC) Chr 9:
34.46 – 34.52 Mb
Chr 4:
41.57 – 41.64 Mb
PubMed search [1] [2]

Dynein intermediate chain 1, axonemal is a protein that in humans is encoded by the DNAI1 gene.[1][2]

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.[2]

References[edit]

  1. ^ Pennarun G, Escudier E, Chapelin C, Bridoux AM, Cacheux V, Roger G, Clement A, Goossens M, Amselem S, Duriez B (Jan 2000). "Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia". Am J Hum Genet 65 (6): 1508–19. doi:10.1086/302683. PMC 1288361. PMID 10577904. 
  2. ^ a b "Entrez Gene: DNAI1 dynein, axonemal, intermediate chain 1". 

External links[edit]

Further reading[edit]



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