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1
#hacettepe #dişhekfak #dnm2
#hacettepe #dişhekfak #dnm2
::2013/11/11::
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2
Marti Dnm2
Marti Dnm2
::2013/07/22::
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3
dnm2
dnm2
::2012/07/04::
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4
dnm2
dnm2
::2006/10/28::
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5
Ave Maria DNM2
Ave Maria DNM2
::2011/12/12::
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6
dnm2
dnm2
::2009/11/12::
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7
Ennemi - Ennemi ft. Cesar Alfonso
Ennemi - Ennemi ft. Cesar Alfonso
::2014/03/25::
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8
uur_ir-dnm2
uur_ir-dnm2
::2013/08/19::
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9
DETAIL WIEDERERÖFFNUNG // 27.10.2012 24:00
DETAIL WIEDERERÖFFNUNG // 27.10.2012 24:00
::2012/10/23::
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10
3730#11 DNM2-GFP_TIRF01.avi
3730#11 DNM2-GFP_TIRF01.avi
::2009/12/01::
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11
dnm2
dnm2
::2007/10/18::
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12
DnM 2
DnM 2
::2012/03/20::
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13
Dnm 2
Dnm 2
::2013/08/27::
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14
Dnm#2 - Strict Parents
Dnm#2 - Strict Parents
::2012/09/13::
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15
suzuki swift mk1 vs corsa a en Alto vs corsa B
suzuki swift mk1 vs corsa a en Alto vs corsa B
::2008/07/05::
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16
sTM by dNM#2
sTM by dNM#2
::2011/10/14::
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17
dnm 2
dnm 2
::2009/10/04::
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18
Cover Miss A Goodbye baby teaser by Domino (DNM) 2
Cover Miss A Goodbye baby teaser by Domino (DNM) 2
::2011/09/18::
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19
08 DNM 2.wmv
08 DNM 2.wmv
::2010/02/07::
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20
can dnm 2.
can dnm 2.
::2013/01/07::
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21
Permanent Residence in DNM - 2
Permanent Residence in DNM - 2
::2009/05/16::
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22
dnm 2
dnm 2
::2011/08/29::
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23
DNM 2/23/12
DNM 2/23/12
::2012/02/24::
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24
DNM 2/23/12
DNM 2/23/12
::2012/02/24::
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25
SwaggaLikeUs vs D.n.M (2)
SwaggaLikeUs vs D.n.M (2)
::2010/05/21::
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26
nmdstry dnm 2.mpg
nmdstry dnm 2.mpg
::2011/08/31::
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27
06. BRA 1.wmv
06. BRA 1.wmv
::2010/02/07::
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28
Miss A - Goodbye Baby (J One cover).avi
Miss A - Goodbye Baby (J One cover).avi
::2012/03/21::
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29
Get Out
Get Out
::2012/02/24::
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30
neth 1
neth 1
::2009/10/04::
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31
สุดมัน
สุดมัน
::2013/08/29::
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32
bleep original
bleep original
::2011/08/29::
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33
neth 2
neth 2
::2009/10/04::
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34
ew dnm video 3.mpg
ew dnm video 3.mpg
::2011/09/01::
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35
ukr 100
ukr 100
::2009/10/04::
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36
cover "goodbye baby" by miss a
cover "goodbye baby" by miss a
::2012/06/24::
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37
can deneme 5
can deneme 5
::2013/02/03::
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38
menemen park işleri !
menemen park işleri !
::2013/02/03::
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39
nomad story dnm xD.mpg
nomad story dnm xD.mpg
::2011/08/30::
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40
can dnm 1.
can dnm 1.
::2013/01/07::
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41
spik985
spik985's ROBLOX video
::2011/09/26::
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42
face book
face book
::2011/08/29::
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43
全家-電影院篇
全家-電影院篇
::2008/11/13::
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44
SwaggaLikeUs vs D.n.M
SwaggaLikeUs vs D.n.M
::2010/05/21::
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45
Intro to channel
Intro to channel
::2014/08/25::
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46
Admirals future of affiliation unknown
Admirals future of affiliation unknown
::2012/06/05::
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47
VICTOR GUERRERO
VICTOR GUERRERO
::2011/08/23::
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48
Cesar Alfonso - 17
Cesar Alfonso - 17
::2014/05/15::
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49
Cee Lo Green - F*ck You at American University
Cee Lo Green - F*ck You at American University
::2011/01/14::
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50
baby Million, ENNEMI feat MISTA, HÉRICKA (CLIP OFFICIEL)
baby Million, ENNEMI feat MISTA, HÉRICKA (CLIP OFFICIEL)
::2014/07/18::
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RESULTS [51 .. 101]
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Dynamin 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DNM2 ; CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; DYNII; LCCS5
External IDs OMIM602378 MGI109547 HomoloGene90883 ChEMBL: 5812 GeneCards: DNM2 Gene
EC number 3.6.5.5
Orthologs
Species Human Mouse
Entrez 1785 13430
Ensembl ENSG00000079805 ENSMUSG00000033335
UniProt P50570 P39054
RefSeq (mRNA) NM_001005360 NM_001039520
RefSeq (protein) NP_001005360 NP_001034609
Location (UCSC) Chr 19:
10.72 – 10.83 Mb
Chr 9:
21.42 – 21.51 Mb
PubMed search [1] [2]

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.[1][2]

Function[edit]

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.[3]

Interactions[edit]

DNM2 has been shown to interact with:

Clinical relevance[edit]

Mutations in this gene have been associated to cases of acute lymphoblastic leukaemia.[6]

References[edit]

  1. ^ Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G (Nov 1995). "Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family". Gene 163 (2): 301–6. doi:10.1016/0378-1119(95)00275-B. PMID 7590285. 
  2. ^ Klocke R, Augustin A, Ronsiek M, Stief A, van der Putten H, Jockusch H (Jul 1997). "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively". Genomics 41 (2): 290–2. doi:10.1006/geno.1997.4634. PMID 9143510. 
  3. ^ "Entrez Gene: DNM2 dynamin 2". 
  4. ^ a b Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995. 
  5. ^ Lundmark R, Carlsson SR (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47): 46772–81. doi:10.1074/jbc.M307334200. PMID 12952949. 
  6. ^ Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG (2012). "The genetic basis of early T-cell precursor acute lymphoblastic leukaemia". Nature 481 (7380): 157–63. doi:10.1038/nature10725. PMC 3267575. PMID 22237106. 

Further reading[edit]

External links[edit]


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