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Dynein, light chain, Tctex-type 3
Identifiers
Symbols DYNLT3 ; RP3; TCTE1L; TCTEX1L
External IDs OMIM300302 MGI1914367 HomoloGene21304 GeneCards: DYNLT3 Gene
RNA expression pattern
PBB GE DYNLT3 203303 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6990 67117
Ensembl ENSG00000165169 ENSMUSG00000031176
UniProt P51808 P56387
RefSeq (mRNA) NM_006520 NM_025975
RefSeq (protein) NP_006511 NP_080251
Location (UCSC) Chr X:
37.7 – 37.71 Mb
Chr X:
9.65 – 9.66 Mb
PubMed search [1] [2]

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.[1][2]

Function[edit]

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase.[3] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.[4]

Interactions[edit]

DYNLT3 has been shown to interact with VDAC1.[5]

References[edit]

  1. ^ "Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3". 
  2. ^ Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092. 
  3. ^ Lo KW, Kogoy JM, Pfister KK (April 2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665. 
  4. ^ Yeh TY, Chuang JZ, Sung CH (August 2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell. Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286. 
  5. ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu, Thinnes Friedrich P, Hilschmann Norbert (Sep 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. (England) 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. 

Further reading[edit]



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