His work spans the science fiction, horror and fantasy genres, sometimes within a single novel: a typical example of Simmons' intermingling of genres is Song of Kali (1985), winner of World Fantasy Award. He also writes mysteries and thrillers, some of which feature the continuing character Joe Kurtz.
Summer of Night (1991) recounts the childhood of a group of pre-teens who band together in the 1960s to defeat a centuries-old evil that terrorizes their hometown of Elm Haven, Illinois. The novel, which was praised by Stephen King, is similar to King's It in its focus on small town life, the corruption of innocence, the return of an ancient evil, and the responsibility for others that emerges with the transition from youth to adulthood.
In the sequel to Summer of Night, A Winter Haunting, Dale Stewart (one of the first book's protagonists, and now an adult), revisits his boyhood home to come to grips with mysteries that have disrupted his adult life. Children of the Night, another loose sequel, features Mike O'Rourke, now much older and a Roman Catholic priest, who is sent on a mission to investigate bizarre events in a European city. Another Summer of Night character, Dale's younger brother, Lawrence Stewart, appears as a minor character in Simmons' thriller Darwin's Blade, while the adult Cordie Cooke appears in Fires of Eden.
The Terror (2007) crosses the bridge between horror and historical fiction. It is a fictionalized account of Captain Sir John Franklin's expedition to find the Northwest Passage. The two ships HMS Erebus and HMS Terror become icebound the first winter, and the captains and crew struggle to survive while being stalked across an Arctic landscape by a monster.
The Abominable (2013) recounts a late 1920's attempt on Mount Everest by five climbers—two English, one French, one Sherpa, and one American, the narrator—to recover the body of the cousin of one of the English characters. What follows is a tale of the early days of mountain climbing, a history of the early assaults on Everest, intrigue, espionage, and human dedication and willpower.
The basic structure of Hyperion is taken from the Middle-English cycle of stories The Canterbury Tales. A varied group of individuals are on a pilgrimage to solicit a kind of demon-god called the Shrike on the planet Hyperion in a universe on the edge of the apocalypse. Each pilgrim tells his or her tale of why they are going to see the Shrike. The Fall of Hyperion is the conclusion to the story of the pilgrims rather than a stand-alone sequel. Hyperion and Fall of Hyperion are essentially one work in two volumes.
His Ilium/Olympos cycle is inspired by Homer's works. Both Shakespeare and Proust are mentioned as well.
The character of Ada and her home Ardis Hall in the Ilium cycle are inspired by Vladimir Nabokov's novel Ada or Ardor, which was one of Nabokov's forays into the science fiction genre and alternate history.
His collection of short stories, Worlds Enough & Time, takes its name from the first line of the poem To His Coy Mistress by British poet Andrew Marvell: 'Had we but world enough, and time,'.
In 2009, Scott Derrickson was set to direct "Hyperion Cantos" for Warner Bros. and GK Films, with Trevor Sands penning the script to blend the first two cantos "Hyperion" and "The Fall of Hyperion" into one film. In 2011, actor Bradley Cooper expressed interest in taking over the adaptation.
Dan Simmons has been nominated on numerous occasions in a range of categories for his fiction, including the Arthur C. Clarke Award, Bram Stoker Award, British Fantasy Society Award, Hugo Award, Nebula Award, and World Fantasy Award.