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1
Deny & Destrin birthday on 3rd4rd Dec
Deny & Destrin birthday on 3rd4rd Dec'13
::2013/12/11::
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auneur a un ami paul destrin
auneur a un ami paul destrin
::2013/08/04::
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ouverture de la page facebook de paul destrin est moi
ouverture de la page facebook de paul destrin est moi
::2013/08/10::
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Destrin ando.3gp
Destrin ando.3gp
::2011/05/22::
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5
[cover] Super Junior - HARU
[cover] Super Junior - HARU
::2013/08/30::
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Static Tremor - Stakka Metus
Static Tremor - Stakka Metus
::2012/05/08::
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The Missadventures Of Wadjet 10- Toa Wadjet (Part 2)
The Missadventures Of Wadjet 10- Toa Wadjet (Part 2)
::2011/12/29::
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video gta ou aller pour passer au monde 2
video gta ou aller pour passer au monde 2
::2013/05/25::
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ouverture d une page facebook de math kileur et moi
ouverture d une page facebook de math kileur et moi
::2013/08/07::
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10
presentation de ma chaine
presentation de ma chaine
::2013/05/24::
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11
Static Tremor - UFO 2
Static Tremor - UFO 2
::2012/05/08::
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12
7 ou 8 blague en compagnie de mon amis nicolas ahahah j avais pas les mots
7 ou 8 blague en compagnie de mon amis nicolas ahahah j avais pas les mots
::2013/08/30::
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13
Static Tremor - Destroyer
Static Tremor - Destroyer
::2012/05/08::
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14
Super Junior-Line Up [ENG SUB]
Super Junior-Line Up [ENG SUB]
::2010/10/16::
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presentation de dungeon rampage
presentation de dungeon rampage
::2013/05/24::
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Niki Tobogganning
Niki Tobogganning
::2012/03/21::
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tious tout le monde je vous montre pourquoi je fais des mauvais srore
tious tout le monde je vous montre pourquoi je fais des mauvais srore
::2013/06/28::
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inoguration a la chaine de math kileur
inoguration a la chaine de math kileur
::2013/08/05::
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Super Junior-W3 G0t M@rr!3d part.1 [ENG SUB]
Super Junior-W3 G0t M@rr!3d part.1 [ENG SUB]
::2010/11/05::
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video  campagne sur battlefied 3
video campagne sur battlefied 3
::2013/06/18::
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Super Junior Sungmin As a Guest At $uK!R@ [ENG SUB]
Super Junior Sungmin As a Guest At $uK!R@ [ENG SUB]
::2010/11/16::
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gameplay call of duty black ops 2
::2013/06/13::
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video de minecraft
video de minecraft
::2013/06/10::
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arriver dans une partie dans standoff
arriver dans une partie dans standoff
::2013/06/19::
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25
Star Trek In Future-U.S.S Vortex Opening
Star Trek In Future-U.S.S Vortex Opening
::2011/07/26::
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26
Super Junior-D@ddY f0R A D^Y (KYUMIN) Part.2 [ENG SUB]
Super Junior-D@ddY f0R A D^Y (KYUMIN) Part.2 [ENG SUB]
::2010/10/28::
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desternable
desternable's webcam video September 15, 2010, 02:53 AM
::2010/09/15::
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28
ANTRASS FEAT PARADOX DESTIN TRAGIQUE
ANTRASS FEAT PARADOX DESTIN TRAGIQUE
::2010/05/25::
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Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 3/4
Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 3/4
::2010/11/18::
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Super Junior-Leeteuk & Eunhyuk as Baby Sitter [ENG SUB]
Super Junior-Leeteuk & Eunhyuk as Baby Sitter [ENG SUB]
::2010/11/13::
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Super Junior-After $cH00l 0f R0cK part.2 [ENG SUB]
Super Junior-After $cH00l 0f R0cK part.2 [ENG SUB]
::2010/09/20::
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Super Junior-After $cH00l 0f R0cK part.3 [ENG SUB]
Super Junior-After $cH00l 0f R0cK part.3 [ENG SUB]
::2010/09/20::
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Super Junior-After $cH00l 0f R0cK part.1 [ENG SUB]
Super Junior-After $cH00l 0f R0cK part.1 [ENG SUB]
::2010/09/20::
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Super Junior-Hidden Camera [ENG SUB]
Super Junior-Hidden Camera [ENG SUB]
::2010/11/05::
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Super Junior & Son Dam Bi-Ch0C0L^T3 Part.1 [ENG SUB]
Super Junior & Son Dam Bi-Ch0C0L^T3 Part.1 [ENG SUB]
::2010/09/14::
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Cho
Cho'gall 10 Normal (Tank PoV)
::2011/01/30::
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Super Junior LT,EH,SW,DH,SD,RW at G^g C0nc3rT [ENG SUB]
Super Junior LT,EH,SW,DH,SD,RW at G^g C0nc3rT [ENG SUB]
::2010/11/16::
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38
Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 2/4
Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 2/4
::2010/11/17::
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Super Junior Sungmin As a Guest At $uK!R@ [ENG SUB]
Super Junior Sungmin As a Guest At $uK!R@ [ENG SUB]
::2010/11/16::
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40
Omnotron Hard Mode 10 (Tank PoV)
Omnotron Hard Mode 10 (Tank PoV)
::2011/03/19::
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41
Super Junior-GU3R!ll@ D@t3 (Sorry Sorry Comeback) [ENG SUB]
Super Junior-GU3R!ll@ D@t3 (Sorry Sorry Comeback) [ENG SUB]
::2010/10/02::
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GWJ Rock Band - Total Eclipse of the Heart - PAX East 2011
GWJ Rock Band - Total Eclipse of the Heart - PAX East 2011
::2011/03/15::
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Super Junior & Son Dam Bi-Ch0C0L^T3 Part.3 [ENG SUB]
Super Junior & Son Dam Bi-Ch0C0L^T3 Part.3 [ENG SUB]
::2010/09/14::
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Nerd Glasses Max : Revenge of the Geek Volume III
Nerd Glasses Max : Revenge of the Geek Volume III
::2011/04/30::
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45
Super Junior-GU3R!ll@ D@t3 (Bonamana Comeback) [ENG SUB]
Super Junior-GU3R!ll@ D@t3 (Bonamana Comeback) [ENG SUB]
::2010/10/02::
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Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 4/4
Super Junior-$t^r K!n9 M^9!c $p3c!^L [ENG SUB] 4/4
::2010/11/18::
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Sunny & Sungmin Dancing Ooh La La.FLV
Sunny & Sungmin Dancing Ooh La La.FLV
::2010/09/14::
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120520 SMTOWN LA (Anaheim) Sungmin - Ending [RE-UPLOAD]
120520 SMTOWN LA (Anaheim) Sungmin - Ending [RE-UPLOAD]
::2012/05/29::
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Super Junior Sungmin Cut @ F^NT^5Y C0UPL3 [ENG SUB]
Super Junior Sungmin Cut @ F^NT^5Y C0UPL3 [ENG SUB]
::2010/09/03::
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Super Junior-D@ddY f0R A D^Y (KYUMIN) Part.1 [ENG SUB]
Super Junior-D@ddY f0R A D^Y (KYUMIN) Part.1 [ENG SUB]
::2010/10/28::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Destrin (actin binding protein)
Destrin.png
Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.[1]
Identifiers
Symbol DSTN
Alt. symbols ADF
Entrez 11034
HUGO 15750
OMIM 609114
RefSeq NM_006870
UniProt P60981
Other data
Locus Chr. 20 p12.1

Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene.[2][3][4] Destrin is a component protein in microfilaments.

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

Structure[edit]

The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, NMR.[1] The secondary and tertiary structures of destrin are similar to the gelsolin family which is another actin-regulating protein family.

There are three ordered layers to destrin which is a globular protein. There is a central β sheet that is composed of one parallel strand and three antiparallel strands. This β sheet is between a long α helix along with a shorter one and two shorter helices on the opposite side. The four helices are parallel to the β strands.[1]

Function[edit]

In a variety of eukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments. [1]

References[edit]

  1. ^ a b c d PDB 1AK6; Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F (June 1996). "Tertiary structure of destrin and structural similarity between two actin-regulating protein families". Cell 85 (7): 1047–55. doi:10.1016/S0092-8674(00)81305-7. PMID 8674111. 
  2. ^ a b "Entrez Gene: Destrin". 
  3. ^ Hawkins M, Pope B, Maciver SK, Weeds AG (September 1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry 32 (38): 9985–93. doi:10.1021/bi00089a014. PMID 8399167. 
  4. ^ Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Wikipedia content is licensed under the GFDL License
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