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1
DYNAMIN in CLATHRIN-mediated endocytosis
DYNAMIN in CLATHRIN-mediated endocytosis
::2012/11/01::
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2
Clathrin mediated endocytosis - cell proccess.flv
Clathrin mediated endocytosis - cell proccess.flv
::2010/12/16::
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3
Endocytosis
Endocytosis
::2012/06/27::
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4
"YAMAHA Dynamin Guitar" & Aria, 岡林による演奏
"YAMAHA Dynamin Guitar" & Aria, 岡林による演奏
::2012/01/08::
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danieliko27-5ª Fail Hunger Games c/ babaro1999 y DYNAMIN -MALDITO LAGG
danieliko27-5ª Fail Hunger Games c/ babaro1999 y DYNAMIN -MALDITO LAGG
::2014/07/23::
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6
DYNAMIN @ Spitz Eisenach 16.01.2010
DYNAMIN @ Spitz Eisenach 16.01.2010
::2010/01/22::
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7
Dynamin Soaring mit 479 km/h, von Needle100 zur Noodle100
Dynamin Soaring mit 479 km/h, von Needle100 zur Noodle100
::2012/03/30::
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8
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
::2012/05/15::
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9
180 [Grad] | DEEPWITHYOU & MARKUS KAVKA | Aftervideo mit u.a. Markus Kavka, Dynamin & Sierra
180 [Grad] | DEEPWITHYOU & MARKUS KAVKA | Aftervideo mit u.a. Markus Kavka, Dynamin & Sierra
::2013/02/24::
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10
QR Business Card / Your Business card with a dynamin video QR code
QR Business Card / Your Business card with a dynamin video QR code
::2012/08/23::
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11
DYNAMIN
DYNAMIN
::2012/07/04::
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12
danieliko27-2ªFail Hunger Games c/ DYNAMIN - Parte 2
danieliko27-2ªFail Hunger Games c/ DYNAMIN - Parte 2
::2014/07/17::
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13
danieliko27-2ª Fail Hunger Games c/ DYNAMIN - Parte 1
danieliko27-2ª Fail Hunger Games c/ DYNAMIN - Parte 1
::2014/07/16::
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14
dynamin palle
dynamin palle
::2013/12/14::
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15
dynamin albero
dynamin albero
::2013/12/14::
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16
dynamin albero 2
dynamin albero 2
::2013/12/14::
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17
DYNAMIN @ Spitz Eisenach 16.01.2010
DYNAMIN @ Spitz Eisenach 16.01.2010
::2010/01/22::
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18
Dynamin - Klangkino Gebesee 02.06.11
Dynamin - Klangkino Gebesee 02.06.11
::2011/06/03::
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Dynamin @ Klangkino Gebesee
Dynamin @ Klangkino Gebesee
::2011/06/03::
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20
Dynamin Paint Test
Dynamin Paint Test
::2012/03/04::
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21
Clathrin Mediated Endocytosis by Janet Iwasa and Tom Kirchhausen 2012
Clathrin Mediated Endocytosis by Janet Iwasa and Tom Kirchhausen 2012
::2013/05/19::
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22
Dynasore From Selleckchem.com
Dynasore From Selleckchem.com
::2014/03/25::
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23
Protecting your Borders: Regulated Entry into the Cell
Protecting your Borders: Regulated Entry into the Cell
::2010/11/15::
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Mdivi-1 From Selleckchem.com
Mdivi-1 From Selleckchem.com
::2014/04/02::
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Clathrin.m4v
Clathrin.m4v
::2010/12/13::
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ADJAM EN LIVE a Decazeville
ADJAM EN LIVE a Decazeville
::2014/06/16::
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IronHeart (original Mix) Dj Dynaminx
IronHeart (original Mix) Dj Dynaminx
::2014/06/14::
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chee - ridin heavy (parental advisory) explicit content
chee - ridin heavy (parental advisory) explicit content
::2014/06/26::
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Milo singe rit
Milo singe rit
::2014/06/04::
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Java Lecture #10
Java Lecture #10
::2013/04/26::
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Inheritance Patterns: Centronuclear Myopathy
Inheritance Patterns: Centronuclear Myopathy
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29.08.2009 Klangkino Gebesee
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::2011/02/23::
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Centronuclear Myopathy: Umbrella term for CNM
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Pounding Techno Floor - 7 Jahre Hard & Smart - Para Siempre Live - Alte Zuckerfabrik Laucha -
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HardTechno Floor - Para Siempre live - Zuckerfabrik Laucha 28.02.09 - Part 2- Rhimin Simon Skit
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Hard Techno Floor - Para Siempre Live @ Alte Zuckerfabrik Laucha 28.02.09 Get ur Freak On Faster
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Brachiale Musikgestalter Live @ Alte Zuckerfabrik Laucha 28.02.09 (Intro_Short)
Brachiale Musikgestalter Live @ Alte Zuckerfabrik Laucha 28.02.09 (Intro_Short)
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Butterflymodels ICandyOnlineTV - Shereece
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2011-06-23 Mr.O flies Needle 100" Full DS at Wu-Fen Mt.
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RESULTS [51 .. 101]
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Dynamin family
PDB 2aka EBI.jpg
Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin I from Rattus norvegicus
Identifiers
Symbol Dynamin_N
Pfam PF00350
Pfam clan CL0023
InterPro IPR001401
PROSITE PDOC00362
Dynamin central region
PDB 2aka EBI.jpg
Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin I from Rattus norvegicus
Identifiers
Symbol Dynamin_M
Pfam PF01031
InterPro IPR000375

Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus.[1][2][3] Dynamin also plays a role in many processes including division of organelles,[4] cytokinesis and microbial pathogen resistance.

Dynamin is part of the "dynamin superfamily," which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA, mitofusins, and GBPs. Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule-based motors from the bovine brain. Dynamin has been extensively studied in the context of clathrin-coated vesicle budding from the cell membrane.[3][5]

Function[edit]

As a vesicle invaginates, dynamin forms a spiral around the neck of the vesicle. Once the spiral is in place, it extends lengthwise and constricts through GTP hydrolysis. This lengthening and tightening of the coil around the vesicle neck causes it to break and results in the pinching off of the vesicle from the parent membrane. An example of a vesicle is a clathrin-coated pit.[2][5]

To view a ‘cartoon’ image of the non-constricted and constricted state of dynamin spirals, please follow this link: http://dynamin.niddk.nih.gov/figure5.html.[2] The first structure on the left is dynamin in its relaxed state. The structure on the right is dynamin in its constricted state. This shows the extent to which dynamin tightens and changes when GTP is converted to GDP.[1]

This constriction is in part the result of the twisting activity of dynamin [6] This twisting required GTP hydrolysis. Dynamin is the only molecular motor known to have a twisting activity. Dynamin is a right-handed helix and has a right-handed twisting activity that explains its tightening and the reduction in the pitch of the helix described above.

Types[edit]

In mammals, three different dynamin genes have been identified:

Disease implications[edit]

Mutations in Dynamin II have been found to cause dominant intermediate Charcot-Marie-Tooth disease.[7]

References[edit]

  1. ^ a b c Henley, J.R., Cao, H., McNicven, M.A. (1999). “Participation of dynamin in the biogenesis of cytoplasmic vesicles”. The FASEB Journal, 13, S243-S247.
  2. ^ a b c Hinshaw, J. “Research statement, Jenny E. Hinshaw, Ph.D.” National Institute of Diabetes & Digestive & Kidney Diseases, Laboratory of Cell Biochemistry and Biology. Accessed 19 March 2013.
  3. ^ a b Urrutia, R.; Henley, J.R.; Cook, T.; McNiven, M.A. (1997). "The dynamins: Redundant or distinct functions for an expanding family of related GTPases?". Proc. Natl Acad. Sci. USA 94 (2): 377–384. doi:10.1073/pnas.94.2.377. 
  4. ^ Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949. 
  5. ^ a b c McMahon. (2004). “Researching Endocytic Mechanisms: Dynamin. Accompaniment to Nature Reviews Molecular Cell Biology, 5, 133-147.
  6. ^ Roux, A; Uyhazi, K; Frost, A; De Camilli, P (2006-04-30). "GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission". Nature 441 (7092): 528–31. doi:10.1038/nature04718. PMID 16648839. 
  7. ^ Stephan Zuchner, Maher Noureddine, Marina Kennerson, Kristien Verhoeven, Kristl Claeys, Peter De Jonghe, John Merory, Sofia A. Oliveira, Marcy C. Speer, Judith E. Stenger, Gina Walizada, Danqing Zhu, Margaret A. Pericak-Vance, Garth Nicholson, Vincent Timmerman & Jeffery M. Vance (March 2005). "Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease". Nature Genetics 37 (3): 289–294. doi:10.1038/ng1514. PMID 15731758. 

External links[edit]

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