Play Video
1
Mod-06 Lec-22 Regulation of gene expression by type II nuclear receptors
Mod-06 Lec-22 Regulation of gene expression by type II nuclear receptors
::2011/09/27::
Play Video
2
The FXR LIVES AGAIN!
The FXR LIVES AGAIN!
::2014/08/03::
Play Video
3
廣鼎雷光獵狐光學電競滑鼠 FXR-SM-03 玩具開箱文
廣鼎雷光獵狐光學電競滑鼠 FXR-SM-03 玩具開箱文
::2013/09/12::
NEXT >>
RESULTS [4 .. 54]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Nuclear receptor subfamily 1, group H, member 4
Protein NR1H4 PDB 1osh.png
PDB rendering based on 1osh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NR1H4 ; BAR; FXR; HRR-1; HRR1; RIP14
External IDs OMIM603826 MGI1352464 HomoloGene3760 IUPHAR: NR1H4 ChEMBL: 2047 GeneCards: NR1H4 Gene
RNA expression pattern
PBB GE NR1H4 206340 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9971 20186
Ensembl ENSG00000012504 ENSMUSG00000047638
UniProt Q96RI1 Q60641
RefSeq (mRNA) NM_001206977 NM_001163504
RefSeq (protein) NP_001193906 NP_001156976
Location (UCSC) Chr 12:
100.87 – 100.96 Mb
Chr 10:
89.45 – 89.53 Mb
PubMed search [1] [2]

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.[1][2]

Function[edit]

FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.[2]

One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis from cholesterol. FXR does not directly bind to the CYP7A1 promoter. Rather, FXR induces expression of small heterodimer partner (SHP), which then functions to inhibit transcription of the CYP7A1 gene. In this way a negative feedback pathway is established in which synthesis of bile acids is inhibited when cellular levels are already high.

Interactions[edit]

Farnesoid X receptor has been shown to interact with:

References[edit]

  1. ^ "Entrez Gene: NR1H4 nuclear receptor subfamily 1, group H, member 4". 
  2. ^ a b Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C (June 1995). "Identification of a nuclear receptor that is activated by farnesol metabolites". Cell 81 (5): 687–93. doi:10.1016/0092-8674(95)90530-8. PMID 7774010. 
  3. ^ Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA (January 2004). "Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR". Genes Dev. 18 (2): 157–69. doi:10.1101/gad.1138104. PMC 324422. PMID 14729567. 
  4. ^ Seol W, Choi HS, Moore DD (January 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. 9 (1): 72–85. doi:10.1210/mend.9.1.7760852. PMID 7760852. 

Further reading[edit]

  • Ryan, Karen K.; Tremaroli, Valentina; Clemmensen, Christoffer; Kovatcheva-Datchary, Petia; Myronovych, Andriy; Karns, Rebekah; Wilson-Perez, Hilary E.; Sandoval, Darleen A.; Kohli, Rohit; Backhed, Fredrik; Seeley, Randy J. (2014/05/08/print). "FXR is a molecular target for the effects of vertical sleeve gastrectomy" 509. Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. p. 183.  Check date values in: |date= (help)

External links[edit]


Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014