Fluclorolone acetonide - Mashpedia All-in-One Encyclopedia

Fluclorolone acetonide


Clinical data
Trade names	Cutanit, Topicon
Pregnancy cat.	?
Legal status	?
Routes	Topical
Identifiers
CAS number	3693-39-8
ATC code	D07AC02
PubChem	CID 20054914
UNII	MG258KTA37^Y
Chemical data
Formula	C₂₄H₂₉Cl₂F O₅
Mol. mass	487.388 g/mol
Y (what is this?) (verify)

Fluclorolone acetonide (INN, or flucloronide, USAN, trade names Cutanit, Topicon) is a corticosteroid for topical use on the skin.^[1]

Free fluclorolone, without the acetonide (C₂₁H₂₅Cl₂FO₅, PubChem 60900)

References [edit]

^ Cunliffe, W. J. (1976). "Long-term treatment with 0-01% fluclorolone acetonide in children". British Medical Journal 1 (6010): 627. PMC 1639042. PMID 1252855. edit

Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)

Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)

Pregnene	CORTISONE

Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate Hydrocortisone buteprate Hydrocortisone butyrate) Budesonide Ciclesonide Deflazacort Medrysone Tixocortol HALOGENATED AT 6: Cloprednol HALOGENATED, WITH FG AT 16: Halcinonide

Pregnadiene (+1-ene)	Rimexolone HALOGENATED, WITH FG AT 16: Flunisolide Triamcinolone Amcinonide Fluocinolone acetonide (Fluocinonide)

Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) HALOGENATED AT 9: Fluorometholone HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone Diflucortolone Fluocortin) Desoximetasone

Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone Methylprednisolone aceponate Prednicarbate Prednylidene) Desonide HALOGENATED: Fluprednisolone (Difluprednate Fluperolone) HALOGENATED, WITH FG AT 16: Dexamethasone^# Betamethasone (Clobetasol Clobetasone Diflorasone Halometasone Ulobetasol) Beclometasone Paramethasone Alclometasone Fluclorolone acetonide Flumetasone Fluprednidene

Pregnatriene (+2-ene)	Cortivazol

Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate Fluticasone furoate)

Other/ungrouped	HALOGENATED: Loteprednol HALOGENATED, WITH FG AT 16: Fludroxycortide Formocortal Mometasone furoate

Aldosterone antagonists

Synthesis modifiers

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: END

anat/phys/devp/horm

noco (d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

Glucocorticoids

Receptor

Mixed (SEGRAs): Mapracorat

Enzyme
(inhibitors)

20,22-Desmolase	22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Mitotane Trilostane

17α-Hydroxylase, 17,20-Lyase	22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone Danazol Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 TGF-β Tioconazole Troglitazone VN/87-1 YM116

3β-HSD	4-MA Azastene Cyanoketone Danazol Epostane Genistein Gestrinone Metyrapone Norethisterone Oxymetholone Pioglitazone Rosiglitazone Trilostane Troglitazone

21-Hydroxylase	Aminoglutethimide Amphenone B Bifonazole Clotrimazole Diazepam Econazole Genistein Isoconazole Ketoconazole Metyrapone Miconazole Midazolam Tioconazole

11β-Hydroxylase	Aminoglutethimide Canrenone Etomidate Fadrozole FETO Ketoconazole Metomidate Metyrapone Mitotane Potassium canrenoate Spironolactone Trilostane

18-Hydroxylase	Aminoglutethimide Canrenone FAD286 Fadrozole Ketoconazole LCI699 Metyrapone Mespirenone Potassium canrenoate Spironolactone

Other

Endogenous	Glucocorticoids: Corticosterone Cortisone Cortodoxone/Deoxycortisol Hydrocortisone/Cortisol Antiglucocorticoids: 17-Hydroxyprogesterone Deoxycorticosterone Pregnenolone Progesterone Precursors: Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone 17-Hydroxypregnenolone 17-Hydroxyprogesterone Progesterone Deoxycorticosterone

Indirect	ACTH/Corticotropin CRH DHEA DHEA sulfate Plasma proteins (Transcortin, Albumin) Vasopressin

Procedures	Adrenalectomy Hypophysectomy

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