GJC1

GJC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SHW
Identifiers
Aliases	GJC1, CX45, GJA7, gap junction protein gamma 1
External IDs	MGI: 95718 HomoloGene: 4016 GeneCards: GJC1
Gene ontology
Molecular function	• ion channel activity; • gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling; • gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • membrane; • intercalated disc; • plasma membrane; • cell junction; • gap junction; • connexin complex;
Biological process	• muscle contraction; • cell development; • cardiac muscle tissue development; • cell-cell signaling; • vasculogenesis; • cell communication; • heart development; • ion transmembrane transport; • atrial cardiac muscle cell action potential; • cell-cell junction assembly; • visual perception; • chemical synaptic transmission; • gap junction assembly; • SA node cell to atrial cardiac muscle cell communication by electrical coupling; • AV node cell to bundle of His cell communication by electrical coupling; • transport;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	10052
	14615
	ENSG00000182963
	ENSMUSG00000034520
	P36383
	P28229
	NM_001080383; NM_005497
	NM_001159382; NM_001159383; NM_008122
	NP_001073852; NP_005488
	NP_001152854; NP_001152855; NP_032148
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.^[3]^[4]

Function[edit]

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.^[4]

References[edit]

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Kanter HL, Saffitz JE, Beyer EC (Dec 1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J Mol Cell Cardiol. 26 (7): 861–8. PMID 7966354. doi:10.1006/jmcc.1994.1103.
^ ^a ^b "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa".

Further reading[edit]

Andrew L Harris; Darren Locke (2009). Connexins, A Guide. New York: Springer. p. 574. ISBN 978-1-934115-46-6.
Kilarski WM, Dupont E, Coppen S, et al. (1998). "Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term.". Eur. J. Cell Biol. 75 (1): 1–8. PMID 9523149. doi:10.1016/S0171-9335(98)80040-X.
Vozzi C, Dupont E, Coppen SR, et al. (1999). "Chamber-related differences in connexin expression in the human heart.". J. Mol. Cell. Cardiol. 31 (5): 991–1003. PMID 10336839. doi:10.1006/jmcc.1999.0937.
Chanson M, Scerri I, Suter S (1999). "Defective regulation of gap junctional coupling in cystic fibrosis pancreatic duct cells.". J. Clin. Invest. 103 (12): 1677–84. PMC 408381 . PMID 10377174. doi:10.1172/JCI5645.
Kausalya PJ, Reichert M, Hunziker W (2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells.". FEBS Lett. 505 (1): 92–6. PMID 11557048. doi:10.1016/S0014-5793(01)02786-7.
Laing JG, Manley-Markowski RN, Koval M, et al. (2003). "Connexin45 interacts with zonula occludens-1 in osteoblastic cells.". Cell Commun. Adhes. 8 (4-6): 209–12. PMID 12064590. doi:10.3109/15419060109080725.
Kaba RA, Coppen SR, Dupont E, et al. (2003). "Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts.". Cell Commun. Adhes. 8 (4-6): 339–43. PMID 12064615. doi:10.3109/15419060109080750.
Xiang Q, Fan SQ, Li J, et al. (2003). "[Expression of connexin43 and connexin45 in nasopharyngeal carcinoma]". Ai Zheng. 21 (6): 593–6. PMID 12452056.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Tsai MY, Lan KC, Huang KE, et al. (2004). "Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles.". Fertil. Steril. 80 (6): 1437–43. PMID 14667880. doi:10.1016/j.fertnstert.2003.05.015.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Valiunas V, Doronin S, Valiuniene L, et al. (2004). "Human mesenchymal stem cells make cardiac connexins and form functional gap junctions.". J. Physiol. (Lond.). 555 (Pt 3): 617–26. PMC 1664864 . PMID 14766937. doi:10.1113/jphysiol.2003.058719.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Laing JG, Koval M, Steinberg TH (2007). "Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants.". J. Membr. Biol. 207 (1): 45–53. PMID 16463142. doi:10.1007/s00232-005-0803-2.
Rackauskas M, Kreuzberg MM, Pranevicius M, et al. (2007). "Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45.". Biophys. J. 92 (6): 1952–65. PMC 1861779 . PMID 17189315. doi:10.1529/biophysj.106.099358.
Kotsias BA, Salim M, Peracchia LL, Peracchia C (2007). "Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes.". J. Membr. Biol. 214 (1): 1–8. PMID 17546509. doi:10.1007/s00232-006-0064-8.

External links[edit]

GJC1 human gene location in the UCSC Genome Browser.
GJC1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[pmid7966354-3] Kanter HL, Saffitz JE, Beyer EC (Dec 1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45". J Mol Cell Cardiol. 26 (7): 861–8. PMID 7966354. doi:10.1006/jmcc.1994.1103.

[entrez-4] "Entrez Gene: GJA7 gap junction protein, alpha 7, 45kDa".

[1]

[2]

[3]

[4]

GJC1

WIKIPEDIA ARTICLE

Contents

Function[edit]

References[edit]

Further reading[edit]

External links[edit]

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