GJC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SHW
Identifiers
Aliases	GJC1, CX45, GJA7, gap junction protein gamma 1
External IDs	MGI: 95718 HomoloGene: 4016 GeneCards: GJC1
Gene ontology Molecular function • ion channel activity • gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling • gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intercalated disc • plasma membrane • cell junction • gap junction • connexin complex Biological process • muscle contraction • cell development • cardiac muscle tissue development • cell-cell signaling • vasculogenesis • cell communication • heart development • ion transmembrane transport • atrial cardiac muscle cell action potential • cell-cell junction assembly • transport • visual perception • chemical synaptic transmission • gap junction assembly • SA node cell to atrial cardiac muscle cell communication by electrical coupling • AV node cell to bundle of His cell communication by electrical coupling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10052	14615
Ensembl	ENSG00000182963	ENSMUSG00000034520
UniProt	P36383	P28229
RefSeq (mRNA)	NM_001080383 NM_005497	NM_001159382 NM_001159383 NM_008122
RefSeq (protein)	NP_001073852 NP_005488	NP_001152854.1 NP_001152855.1 NP_032148.1 NP_001152854 NP_001152855 NP_032148
Location (UCSC)	Chr 17: 44.8 – 44.83 Mb	Chr 11: 102.8 – 102.82 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene.^[3][4]

Function[edit]

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described.^[4]

References[edit]

Further reading[edit]

External links[edit]

• GJC1 human gene location in the UCSC Genome Browser.
• GJC1 human gene details in the UCSC Genome Browser.

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