Play Video
1
Lymphogranuloma Venereum, Granuloma Inguinale & Chancroid (Causes, Clinical Feature, Treatment)
Lymphogranuloma Venereum, Granuloma Inguinale & Chancroid (Causes, Clinical Feature, Treatment)
::2013/01/18::
Play Video
2
92. What is granuloma inguinale?
92. What is granuloma inguinale?
::2012/06/26::
Play Video
3
Granuloma Inguinal
Granuloma Inguinal
::2013/09/06::
Play Video
4
Granuloma Inguinale
Granuloma Inguinale
::2014/05/07::
Play Video
5
Shitfuckingshit - 04 - Donald Duck Has Passed Away
Shitfuckingshit - 04 - Donald Duck Has Passed Away
::2012/02/26::
Play Video
6
Shitfuckingshit - 03 - Buio Totale
Shitfuckingshit - 03 - Buio Totale
::2012/02/26::
Play Video
7
Shitfuckingshit - 05 - Violent Fuck Face
Shitfuckingshit - 05 - Violent Fuck Face
::2012/02/26::
Play Video
8
Shitfuckingshit - 06 - Arrosto Di Bambino
Shitfuckingshit - 06 - Arrosto Di Bambino
::2012/02/26::
Play Video
9
Shitfuckingshit - 08 - Human Beings To Slaughterhouse
Shitfuckingshit - 08 - Human Beings To Slaughterhouse
::2012/02/26::
Play Video
10
Shitfuckingshit - 12 - Medikal Mistake
Shitfuckingshit - 12 - Medikal Mistake
::2012/02/26::
Play Video
11
Shitfuckingshit - 02 - Gender
Shitfuckingshit - 02 - Gender
::2012/02/26::
Play Video
12
Shitfuckingshit - 01 - Presentazioni
Shitfuckingshit - 01 - Presentazioni
::2012/02/26::
Play Video
13
Shitfuckingshit - 09 - Orgasmic Wipe
Shitfuckingshit - 09 - Orgasmic Wipe
::2012/02/26::
Play Video
14
Cos
Cos'è l'Ernia Inguinale
::2011/07/05::
Play Video
15
Shitfuckingshit - 07 - Eating The Dead
Shitfuckingshit - 07 - Eating The Dead
::2012/02/26::
Play Video
16
Shitfuckingshit - 10 - Lord
Shitfuckingshit - 10 - Lord
::2012/02/26::
Play Video
17
Shitfuckingshit - 11 - Wounds Of Solitude
Shitfuckingshit - 11 - Wounds Of Solitude
::2012/02/26::
Play Video
18
Manic (Jamie Bettis) is infact homosexual.
Manic (Jamie Bettis) is infact homosexual.
::2011/10/25::
Play Video
19
My Slideshow
My Slideshow
::2013/12/01::
Play Video
20
081391191939-Obat Sipilis ( YIULORATOSUYALI ) Cod Solo,Klaten,Magelang,Purworejo,Semarang
081391191939-Obat Sipilis ( YIULORATOSUYALI ) Cod Solo,Klaten,Magelang,Purworejo,Semarang
::2014/09/28::
Play Video
21
081391191939-Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Solo,Surabaya,Bali,Makassar,Medan
081391191939-Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Solo,Surabaya,Bali,Makassar,Medan
::2014/09/23::
Play Video
22
Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Semarang,Magelang 082220044223
Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Semarang,Magelang 082220044223
::2014/08/07::
Play Video
23
081391191939-Jual Obat Sipilis ( YIULORATOSUYALI ) Cod Jogja,Sleman,Bantul,Wates,Gunungkidul
081391191939-Jual Obat Sipilis ( YIULORATOSUYALI ) Cod Jogja,Sleman,Bantul,Wates,Gunungkidul
::2014/09/28::
Play Video
24
Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Semarang,Magelang 082220044223
Obat Sipilis Ampuh ( YIULORATOSUYALI ) Jogja,Semarang,Magelang 082220044223
::2014/08/03::
Play Video
25
77. Do all civil surgeons follow the same process?
77. Do all civil surgeons follow the same process?
::2012/06/09::
Play Video
26
Vete a la versh,version humanizada xD "Chancro Voraz"
Vete a la versh,version humanizada xD "Chancro Voraz"
::2014/02/23::
Play Video
27
The Rescue
The Rescue
::2012/06/22::
Play Video
28
Granuloma
Granuloma
::2014/05/11::
Play Video
29
Transmastoid Middle Fossa Resection of Giant Cholesterol Granuloma-James K. Liu, MD
Transmastoid Middle Fossa Resection of Giant Cholesterol Granuloma-James K. Liu, MD
::2014/01/30::
Play Video
30
Granuloma Annulare: Best Points for USMLE
Granuloma Annulare: Best Points for USMLE
::2009/09/24::
Play Video
31
Motorized Roller Shades - LGV Project
Motorized Roller Shades - LGV Project
::2012/03/26::
Play Video
32
Linfo granuloma
Linfo granuloma
::2010/07/11::
Play Video
33
Granuloma Annulare
Granuloma Annulare
::2013/02/23::
Play Video
34
Yoko
Yoko's Vet Review - Eosinophilic Granuloma Complex
::2011/10/10::
Play Video
35
Chronic Granulomatous Disease
Chronic Granulomatous Disease
::2013/10/31::
Play Video
36
large CALCIFIED GRANULOMA of liver
large CALCIFIED GRANULOMA of liver
::2013/08/29::
Play Video
37
Questions & Answers 265
Questions & Answers 265
::2014/08/20::
Play Video
38
Granuloma Annulare ¦ Treatment and Symptoms
Granuloma Annulare ¦ Treatment and Symptoms
::2013/03/05::
Play Video
39
Granuloma Tissue - Pathology, by  Dr.Hadeel-(Ninavah Medical College).
Granuloma Tissue - Pathology, by Dr.Hadeel-(Ninavah Medical College).
::2013/11/02::
Play Video
40
Granulomatous Disease - Causes
Granulomatous Disease - Causes
::2013/10/16::
Play Video
41
Petrous Apex Epidermoid & Petrous Apex Cholesterol Granuloma with Subtitles
Petrous Apex Epidermoid & Petrous Apex Cholesterol Granuloma with Subtitles
::2011/09/27::
Play Video
42
Chronic Granulomatous Disease (CGD)
Chronic Granulomatous Disease (CGD)
::2014/05/11::
Play Video
43
Septal pyogenic Granuloma - Management - My technique
Septal pyogenic Granuloma - Management - My technique
::2013/02/01::
Play Video
44
PYOGENIC GRANULOMA AND IMPLANTS .GRANULOMA EN IMPLANTE - Revista MAXILLARIS
PYOGENIC GRANULOMA AND IMPLANTS .GRANULOMA EN IMPLANTE - Revista MAXILLARIS
::2012/10/26::
Play Video
45
Pyogenic Granuloma ¦ Treatment and Symptoms
Pyogenic Granuloma ¦ Treatment and Symptoms
::2013/03/08::
Play Video
46
Sloppy Seconds
Sloppy Seconds
::2010/03/19::
Play Video
47
GRANULOMA INGUINAL
GRANULOMA INGUINAL
::2013/09/04::
Play Video
48
psicopathias sexualis + granuloma inguinal
psicopathias sexualis + granuloma inguinal
::2012/09/23::
Play Video
49
BRAIN ODEMA GRANULOMA PERILESION OEDEMA HOMEOPATHY
BRAIN ODEMA GRANULOMA PERILESION OEDEMA HOMEOPATHY
::2013/07/11::
Play Video
50
Granuloma   Wiki Article
Granuloma Wiki Article
::2013/11/02::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about the ulcerative disease caused by Klebsiella granulomatis. For sexually transmitted disease caused by certain types of chlamydia, see Lymphogranuloma venereum.
Granuloma inguinale
Classification and external resources
Donovanosis.JPG
Donovanosis of the penis.
ICD-10 A58
ICD-9 099.2
DiseasesDB 3888
MedlinePlus 000636
eMedicine derm/172
MeSH D006100

Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis characterized by ulcerative genital lesions. It is endemic in many less developed regions. It is also known as donovanosis,[1] granuloma genitoinguinale,[1] granuloma inguinale tropicum,[1] granuloma venereum,[2] granuloma venereum genitoinguinale,[1] lupoid form of groin ulceration,[1] serpiginous ulceration of the groin,[1] ulcerating granuloma of the pudendum,[1] and ulcerating sclerosing granuloma.

The disease often goes untreated because of the scarcity of medical treatment in the countries in which it is found. In addition, the painless genital ulcers can be mistaken for syphilis.[3] The ulcers ultimately progress to destruction of internal and external tissue, with extensive leakage of mucus and blood from the highly vascular lesions. The destructive nature of donovanosis also increases the risk of superinfection by other pathogenic microbes.

Classification and terminology[edit]

The first known name for this condition was "serpiginous ulcer", which dates to 1882.[4][5] The proper clinical designation for donovanosis is now "granuloma inguinale".[3] A granuloma is a nodular type of inflammatory reaction, and inguinale refers to the inguinal region, which is commonly involved in this infection. The disease is commonly known as donovanosis, after the Donovan bodies which are a diagnostic sign.

The causative organism, Klebsiella granulomatis, was called Calymmatobacterium granulomatis, and some sources still use this classification,[6][7] from the Greek kalymma (a hood or veil), referring to the lesions that contain the bacteria. Prior to this, it was called Donovania granulomatis, named after the Donovan bodies.[3]

The specific name granulomatis refers to the granulomatous lesions. The organism was recently reclassified under the genus Klebsiella,[8] drastic taxonomic change, since it involved changing the organism's phylum. However, polymerase chain reaction techniques using a colorimetric detection system showed a 99% similarity with other species in the Klebsiella genus.[9]

Symptoms[edit]

Small, painless nodules appear after about 10–40 days of the contact with the bacteria. Later, the nodules burst, creating open, fleshy, oozing lesions. The infection spreads, mutilating the infected tissue. The infection will continue to destroy the tissue until treated. The lesions occur at the region of contact typically found on the shaft of the penis, the labia, or the perineum. Rarely, the vaginal wall or cervix is the site of the lesion. At least one case in India led to partial autoamputation of the penis. The patient tested positive for HIV-2 and had been infected for six years.[10]

Transmission[edit]

The microorganism spreads from one host to another through contact with the open sores.

Diagnosis[edit]

The diagnosis is based on the patient's sexual history and on physical examination revealing a painless, "beefy-red ulcer" with a characteristic rolled edge of granulation tissue. In contrast to syphilitic ulcers, inguinal lymphadenopathy is generally mild or absent. Tissue biopsy and Wright-Giemsa stain are used to aid in the diagnosis. The presence of Donovan bodies in the tissue sample confirms donovanosis. Donovan bodies are rod-shaped, oval organisms that can be seen in the cytoplasm of mononuclear phagocytes or histiocytes in tissue samples from patients with granuloma inguinale.[11]

They appear deep purple when stained with Wright's stain.[11] These intracellular inclusions are the encapsulated Gram-negative rods of the causative organisms.[11] They were discovered by Charles Donovan.[12]

Treatment[edit]

Three weeks of treatment with erythromycin, streptomycin, or tetracycline, or 12 weeks of treatment with ampicillin are standard forms of therapy. Normally, the infection will begin to subside within a week of treatment, but the full treatment period must be followed to minimize the possibility of relapse.

Prevention[edit]

The disease is effectively treated with antibiotics, therefore, developed countries, like the United States, have a very low incidence of donovanosis, approximately 100 cases reported each year in the United States. However, sexual contacts with individuals in endemic regions dramatically increases the risk of contracting the disease. Avoidance of these sexual contacts, and sexually transmitted disease testing before beginning a sexual relationship, are effective preventative measures for donovanosis.

Gallery[edit]

See also[edit]

References[edit]

  1. ^ a b c d e f g Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 275. ISBN 0-7216-2921-0. 
  3. ^ a b c Murray, Patrick R; Rosenthal, Ken S; Pfaller, Michael A (2005). Medical Microbiology (5th ed.). Philadelphia: Elsevier Mosby. p. 336. ISBN 0-323-03303-2. 
  4. ^ Rashid RM, Janjua SA, Khachemoune A (2006). "Granuloma inguinale: a case report". Dermatol. Online J. 12 (7): 14. PMID 17459300. 
  5. ^ McLeod K. (1882). "Precis of operations performed in the wards of the first surgeon, Medical College Hospital, during the year 1881". Ind Med Gaz 11: 113. 
  6. ^ "granuloma inguinale" at Dorland's Medical Dictionary
  7. ^ O'Farrell N (December 2002). "Donovanosis". Sex Transm Infect 78 (6): 452–7. doi:10.1136/sti.78.6.452. PMC 1758360. PMID 12473810. 
  8. ^ * Boye K, Hansen DS (February 2003). "Sequencing of 16S rDNA of Klebsiella: taxonomic relations within the genus and to other Enterobacteriaceae". Int. J. Med. Microbiol. 292 (7-8): 495–503. doi:10.1078/1438-4221-00228. PMID 12635932. 
  9. ^ Carter JS, Bowden FJ, Bastian I, Myers GM, Sriprakash KS, Kemp DJ (October 1999). "Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb. nov". Int. J. Syst. Bacteriol. 49 (Pt 4): 1695–700. doi:10.1099/00207713-49-4-1695. PMID 10555350. 
  10. ^ Chandra Gupta TS, Rayudu T, Murthy SV (2008). "Donovanosis with auto-amputation of penis in a HIV-2 infected person". Indian J Dermatol Venereol Leprol 74 (5): 490–2. doi:10.4103/0378-6323.44308. PMID 19052412. 
  11. ^ a b c thefreedictionary.com > Donovan bodies Retrieved on Nov 29, 2009
  12. ^ Donovan, C. (1905). "Ulcerating Granuloma of the Pudenda". Ind Med Gaz 40: 414. 

External links[edit]

Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014