Share
VIDEOS 1 TO 50
Granuloma inguinale (Medical Condition)
Granuloma inguinale (Medical Condition)
Published: 2015/04/14
Channel: Medical Condition Information
Symptoms of Donovanosis or Granuloma inguinale: Treatment and Transmission
Symptoms of Donovanosis or Granuloma inguinale: Treatment and Transmission
Published: 2016/05/04
Channel: Health Web Videos
Lymphogranuloma Venereum, Granuloma Inguinale & Chancroid (Causes, Clinical Feature, Treatment)
Lymphogranuloma Venereum, Granuloma Inguinale & Chancroid (Causes, Clinical Feature, Treatment)
Published: 2013/01/18
Channel: USMLEFastTrack.com
92. What is granuloma inguinale?
92. What is granuloma inguinale?
Published: 2012/06/26
Channel: AmericanMedicalExams
Pseudomonas, Chancroid, Donovanosis, TB, MAC and Leprosy
Pseudomonas, Chancroid, Donovanosis, TB, MAC and Leprosy
Published: 2014/08/25
Channel: Khaleesi Hubsch
Info about Donovanosis: Symptoms and Signs, Treatment and Pictures
Info about Donovanosis: Symptoms and Signs, Treatment and Pictures
Published: 2016/05/05
Channel: Health Web Videos
Herpes Simplex : Causes, Symptoms & Diagnosis | Granuloma Inguinale | Sex science | CVR Health
Herpes Simplex : Causes, Symptoms & Diagnosis | Granuloma Inguinale | Sex science | CVR Health
Published: 2015/11/28
Channel: CVR Health TV
Síntomas de la Granuloma Inguinal
Síntomas de la Granuloma Inguinal
Published: 2017/04/15
Channel: ¡Compartir es Bueno!
What is chancroid? | Infectious diseases | NCLEX-RN | Khan Academy
What is chancroid? | Infectious diseases | NCLEX-RN | Khan Academy
Published: 2015/06/19
Channel: khanacademymedicine
Donovanosis, Granuloma Inguinale
Donovanosis, Granuloma Inguinale
Published: 2017/02/22
Channel: RachelJMurphy Murphy
granuloma annulare treatment
granuloma annulare treatment
Published: 2015/10/18
Channel: Humbas Guyer
Donovanosis Granuloma Inguinale STD Diagnostic Tests
Donovanosis Granuloma Inguinale STD Diagnostic Tests
Published: 2017/05/15
Channel: Dermnet.com Skin Disease Treatment
¿El granuloma inguinal es una infección de transmisión sexual?
¿El granuloma inguinal es una infección de transmisión sexual?
Published: 2016/04/24
Channel: Rexpuestas
Getting into my skin - Granuloma annulare
Getting into my skin - Granuloma annulare
Published: 2016/11/22
Channel: skindeep barbados
Granuloma inguinale or Donovanosis
Granuloma inguinale or Donovanosis
Published: 2017/07/22
Channel: See Hear Say Learn
190) What is Knowing Transmission of a STD? ~ Michael A Haber Miami Criminal Defense DUI BUI Lawyer
190) What is Knowing Transmission of a STD? ~ Michael A Haber Miami Criminal Defense DUI BUI Lawyer
Published: 2017/06/20
Channel: Michael Haber
Donovanosis Test
Donovanosis Test
Published: 2016/12/12
Channel: Samantha Tieng
Sexually Transmitted Infections UCSF Urology Ben Breyer, MD, MAS
Sexually Transmitted Infections UCSF Urology Ben Breyer, MD, MAS
Published: 2017/06/19
Channel: UCSF Urology
Medical vocabulary: What does Granuloma Inguinale mean
Medical vocabulary: What does Granuloma Inguinale mean
Published: 2016/01/17
Channel: botcaster inc. bot
Medical Zone -  Differential Diagnosis of Granuloma inguinale
Medical Zone - Differential Diagnosis of Granuloma inguinale
Published: 2015/08/29
Channel: Medical Zone
Granuloma Inguinal (ETS)
Granuloma Inguinal (ETS)
Published: 2017/02/14
Channel: Alexandro Lopez Chanez
Donovanosis
Donovanosis
Published: 2015/11/05
Channel: Tara Miller
Donovanosis Granuloma Inguinale STD Introduction
Donovanosis Granuloma Inguinale STD Introduction
Published: 2017/05/16
Channel: Dermnet.com Skin Disease Treatment
How to Pronounce Granuloma Inguinale
How to Pronounce Granuloma Inguinale
Published: 2016/12/05
Channel: Dictionary Voice
Shitfuckingshit - 11 - Wounds Of Solitude
Shitfuckingshit - 11 - Wounds Of Solitude
Published: 2012/02/26
Channel: ShitFuckingShiTS
Donovanosis
Donovanosis
Published: 2016/03/04
Channel: May Larregui.
Granuloma Inguinal
Granuloma Inguinal
Published: 2013/09/07
Channel: Anggie Lorena Espitia Bermudez
Shitfuckingshit - 12 - Medikal Mistake
Shitfuckingshit - 12 - Medikal Mistake
Published: 2012/02/26
Channel: ShitFuckingShiTS
Krueger  Granuloma Inguinal   Venezuela
Krueger Granuloma Inguinal Venezuela
Published: 2014/11/19
Channel: Gloria Al Metal
Sexually Transmitted Infections, Ben Breyer, MD, MAS
Sexually Transmitted Infections, Ben Breyer, MD, MAS
Published: 2017/06/19
Channel: Urology Residents
Shitfuckingshit - 07 - Eating The Dead
Shitfuckingshit - 07 - Eating The Dead
Published: 2012/02/26
Channel: ShitFuckingShiTS
500 hz Relief Granuloma - Isochronic [Brainwave Entrainment]
500 hz Relief Granuloma - Isochronic [Brainwave Entrainment]
Published: 2015/01/22
Channel: Harry Fyntal
Stitch Granuloma Sonograohy
Stitch Granuloma Sonograohy
Published: 2017/04/27
Channel: Dr.Jamil Hawramy
Chronic Granulomatous Disease – Raising Awareness
Chronic Granulomatous Disease – Raising Awareness
Published: 2015/06/25
Channel: TheBalancingAct
Universobio- Metodo Ruffini e l
Universobio- Metodo Ruffini e l'ipoclorito di Sodio
Published: 2015/11/03
Channel: Prodotti biologici online
Pseudomonas Aeruginosa - Liquid Performance (Full)
Pseudomonas Aeruginosa - Liquid Performance (Full)
Published: 2017/02/22
Channel: MAI GORENOISE
Karl McCann - Donovanosis (2008)
Karl McCann - Donovanosis (2008)
Published: 2016/01/31
Channel: Karl McCann
How to Pronounce Apical Granuloma
How to Pronounce Apical Granuloma
Published: 2016/11/20
Channel: Dictionary Voice
How to Pronounce Periapical Granuloma
How to Pronounce Periapical Granuloma
Published: 2016/12/24
Channel: Dictionary Voice
Complete Solution Is In The Short TUTORIAL
Complete Solution Is In The Short TUTORIAL
Published: 2017/05/11
Channel: Helping Tutors
Granuloma annulare treatment
Granuloma annulare treatment
Published: 2015/12/29
Channel: Md Sujaan
How to Pronounce Granuloma
How to Pronounce Granuloma
Published: 2016/12/05
Channel: Dictionary Voice
How to Pronounce Eosinophilic Granuloma
How to Pronounce Eosinophilic Granuloma
Published: 2016/11/26
Channel: Dictionary Voice
Granuloma-Danni da Filler-Rimedi e Cura-Dott.Raffaele Siniscalco
Granuloma-Danni da Filler-Rimedi e Cura-Dott.Raffaele Siniscalco
Published: 2017/06/08
Channel: Chirurgo Estetico-Plastico-Raffaele Siniscalco-Roma-SIMED-Medicina e Chirurgia-Danni-da Filler
Manic (Jamie Bettis) is infact homosexual.
Manic (Jamie Bettis) is infact homosexual.
Published: 2011/10/25
Channel: Jay Rider
Shitfuckingshit - 04 - Donald Duck Has Passed Away
Shitfuckingshit - 04 - Donald Duck Has Passed Away
Published: 2012/02/26
Channel: ShitFuckingShiTS
Gutted Donovanoz PC
Gutted Donovanoz PC
Published: 2009/05/20
Channel: Адский Лук
Complete Solution Is In The Short TUTORIAL
Complete Solution Is In The Short TUTORIAL
Published: 2017/05/11
Channel: Helping Tutors
Shitfuckingshit - 02 - Gender
Shitfuckingshit - 02 - Gender
Published: 2012/02/26
Channel: ShitFuckingShiTS
Shitfuckingshit - 08 - Human Beings To Slaughterhouse
Shitfuckingshit - 08 - Human Beings To Slaughterhouse
Published: 2012/02/26
Channel: ShitFuckingShiTS
NEXT
GO TO RESULTS [51 .. 100]

WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Granuloma inguinale
SOA-Donovanosis.jpg
Donovanosis
Classification and external resources
Specialty infectious disease
ICD-10 A58
ICD-9-CM 099.2
DiseasesDB 3888
MedlinePlus 000636
eMedicine derm/172
MeSH D006100

Granuloma inguinale (also known as donovanosis) is a bacterial disease caused by Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis)[1] characterized by ulcerative genital lesions. It is endemic in many less developed regions. It is also known as donovanosis,[2] granuloma genitoinguinale,[2] granuloma inguinale tropicum,[2] granuloma venereum,[3] granuloma venereum genitoinguinale,[2] lupoid form of groin ulceration,[2] serpiginous ulceration of the groin,[2] ulcerating granuloma of the pudendum,[2] and ulcerating sclerosing granuloma.

The disease often goes untreated because of the scarcity of medical treatment in the countries in which it is found. In addition, the painless genital ulcers can be mistaken for syphilis.[4] The ulcers ultimately progress to destruction of internal and external tissue, with extensive leakage of mucus and blood from the highly vascular lesions. The destructive nature of donovanosis also increases the risk of superinfection by other pathogenic microbes.

Symptoms[edit]

Small, painless nodules appear after about 10–40 days of the contact with the bacteria. Later, the nodules burst, creating open, fleshy, oozing lesions. The infection spreads, mutilating the infected tissue. The infection will continue to destroy the tissue until treated. The lesions occur at the region of contact typically found on the shaft of the penis, the labia, or the perineum. Rarely, the vaginal wall or cervix is the site of the lesion. At least one case in India led to partial autoamputation of the penis. The patient tested positive for HIV-2 and had been infected for six years.[5]

Mechanism[edit]

The microorganism spreads from one host to another through contact with the open sores.

Diagnosis[edit]

The diagnosis is based on the patient's sexual history and on physical examination revealing a painless, "beefy-red ulcer" with a characteristic rolled edge of granulation tissue. In contrast to syphilitic ulcers, inguinal lymphadenopathy is generally mild or absent. Tissue biopsy and Wright-Giemsa stain are used to aid in the diagnosis. The presence of Donovan bodies in the tissue sample confirms donovanosis. Donovan bodies are rod-shaped, oval organisms that can be seen in the cytoplasm of mononuclear phagocytes or histiocytes in tissue samples from patients with granuloma inguinale.[6]

They appear deep purple when stained with Wright's stain.[6] These intracellular inclusions are the encapsulated Gram-negative rods of the causative organisms.[6] They were discovered by Charles Donovan.[7]

Classification[edit]

The first known name for this condition was "serpiginous ulcer", which dates to 1882.[8][9] The proper clinical designation for donovanosis is now "granuloma inguinale".[4] A granuloma is a nodular type of inflammatory reaction, and inguinale refers to the inguinal region, which is commonly involved in this infection. The disease is commonly known as donovanosis, after the Donovan bodies which are a diagnostic sign.

The causative organism, Klebsiella granulomatis, was called Calymmatobacterium granulomatis, and some sources still use this classification,[10][11] from the Greek kalymma (a hood or veil), referring to the lesions that contain the bacteria. Prior to this, it was called Donovania granulomatis, named after the Donovan bodies.[4]

The specific name granulomatis refers to the granulomatous lesions. The organism was recently reclassified under the genus Klebsiella,[12] a drastic taxonomic change since it involved changing the organism's phylum. However, polymerase chain reaction techniques using a colorimetric detection system showed a 99% similarity with other species in the Klebsiella genus.[13]

Prevention[edit]

The disease is effectively treated with antibiotics, therefore, developed countries have a very low incidence of donovanosis; about 100 cases reported each year in the United States. However, sexual contacts with individuals in endemic regions dramatically increases the risk of contracting the disease. Avoidance of these sexual contacts, and sexually transmitted disease testing before beginning a sexual relationship, are effective preventative measures for donovanosis.

Treatment[edit]

Recommended regimen is doxycycline 100 mg orally twice a day, alternatively azithromycin 1 g orally once per week or ciprofloxacin 750 mg orally twice a day or erythromycin base 500 mg orally four times a day or trimethoprim-sulfamethoxazole one double-strength (160 mg/800 mg) tablet orally twice a day. All antibiotic regimens should last for at least 3 weeks and until all lesions have completely healed. Normally, the infection will begin to subside within a week of treatment, but the full treatment period must be followed to minimize the possibility of relapse.

According to the CDC 2015 guidelines Azithromycin is the antibiotics of choice.

See also[edit]

References[edit]

  1. ^ O’Farrell, N (2002). "Donovanosis" (PDF). Sexually Transmitted Infections. 78: 452–7. PMC 1758360Freely accessible. PMID 12473810. doi:10.1136/sti.78.6.452. 
  2. ^ a b c d e f g Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  3. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 275. ISBN 0-7216-2921-0. 
  4. ^ a b c Murray, Patrick R; Rosenthal, Ken S; Pfaller, Michael A (2005). Medical Microbiology (5th ed.). Philadelphia: Elsevier Mosby. p. 336. ISBN 0-323-03303-2. 
  5. ^ Chandra Gupta TS, Rayudu T, Murthy SV (2008). "Donovanosis with auto-amputation of penis in a HIV-2 infected person". Indian J Dermatol Venereol Leprol. 74 (5): 490–2. PMID 19052412. doi:10.4103/0378-6323.44308. 
  6. ^ a b c thefreedictionary.com > Donovan bodies Retrieved on Nov 29, 2009
  7. ^ Donovan, C. (1905). "Ulcerating Granuloma of the Pudenda". Ind Med Gaz. 40: 414. 
  8. ^ Rashid RM, Janjua SA, Khachemoune A (2006). "Granuloma inguinale: a case report". Dermatol. Online J. 12 (7): 14. PMID 17459300. 
  9. ^ McLeod K. (1882). "Precis of operations performed in the wards of the first surgeon, Medical College Hospital, during the year 1881". Ind Med Gaz. 11: 113. 
  10. ^ "granuloma inguinale" at Dorland's Medical Dictionary
  11. ^ O'Farrell N (December 2002). "Donovanosis". Sex Transm Infect. 78 (6): 452–7. PMC 1758360Freely accessible. PMID 12473810. doi:10.1136/sti.78.6.452. 
  12. ^ * Boye K, Hansen DS (February 2003). "Sequencing of 16S rDNA of Klebsiella: taxonomic relations within the genus and to other Enterobacteriaceae". Int. J. Med. Microbiol. 292 (7-8): 495–503. PMID 12635932. doi:10.1078/1438-4221-00228. 
  13. ^ Carter JS, Bowden FJ, Bastian I, Myers GM, Sriprakash KS, Kemp DJ (October 1999). "Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb. nov". Int. J. Syst. Bacteriol. 49 (Pt 4): 1695–700. PMID 10555350. doi:10.1099/00207713-49-4-1695. 

Further reading[edit]

  • Gavin Hart MD, MPH Transcript of the lecture given at the Australian Society for Infectious Diseases/Australasian College of Tropical Medicine Conference at Palm Cove (Cairns), Queensland on 19 April 1999.

External links[edit]

Disclaimer

None of the audio/visual content is hosted on this site. All media is embedded from other sites such as GoogleVideo, Wikipedia, YouTube etc. Therefore, this site has no control over the copyright issues of the streaming media.

All issues concerning copyright violations should be aimed at the sites hosting the material. This site does not host any of the streaming media and the owner has not uploaded any of the material to the video hosting servers. Anyone can find the same content on Google Video or YouTube by themselves.

The owner of this site cannot know which documentaries are in public domain, which has been uploaded to e.g. YouTube by the owner and which has been uploaded without permission. The copyright owner must contact the source if he wants his material off the Internet completely.

Powered by YouTube
Wikipedia content is licensed under the GFDL and (CC) license