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From Wikipedia, the free encyclopedia
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Homeobox C4
Identifiers
Symbols HOXC4 ; HOX3; HOX3E; cp19
External IDs OMIM142974 MGI96195 HomoloGene8408 GeneCards: HOXC4 Gene
RNA expression pattern
PBB GE HOXC4 206194 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3221 15423
Ensembl ENSG00000198353 ENSMUSG00000075394
UniProt P09017 Q08624
RefSeq (mRNA) NM_014620 NM_013553
RefSeq (protein) NP_055435 NP_038581
Location (UCSC) Chr 12:
54.41 – 54.45 Mb
Chr 15:
103.02 – 103.04 Mb
PubMed search [1] [2]

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.[3]

See also[edit]

Interactions[edit]

HOXC4 has been shown to interact with Ku70.[4]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXC4 homeobox C4". 
  4. ^ Schild-Poulter, C; Pope L, Giffin W, Kochan J C, Ngsee J K, Traykova-Andonova M, Haché R J (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. (United States) 276 (20): 16848–56. doi:10.1074/jbc.M100768200. ISSN 0021-9258. PMID 11279128. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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