Play Video
1
REGRET @ Live HNF4 15-03-14
REGRET @ Live HNF4 15-03-14
::2014/03/19::
Play Video
2
hnf4
hnf4
::2012/10/29::
Play Video
3
Billy Boy VS Joe - Trickonometry France
Billy Boy VS Joe - Trickonometry France
::2007/04/22::
Play Video
4
ADEPT take off external
ADEPT take off external
::2012/07/10::
Play Video
5
Evolution of Nuclear Receptor Superfamily
Evolution of Nuclear Receptor Superfamily
::2010/12/30::
Play Video
6
Mercedes-Benz E-Klasse 300 Automaat Bluetec Avantgarde COMAND NAVI-XENON
Mercedes-Benz E-Klasse 300 Automaat Bluetec Avantgarde COMAND NAVI-XENON
::2014/01/29::
Play Video
7
Malema visits Madiba
Malema visits Madiba's Houghton home
::2013/12/12::
Play Video
8
Mercedes-Benz E-Klasse 300 Automaat Bluetec Avantgarde COMAND NAVI-XENON
Mercedes-Benz E-Klasse 300 Automaat Bluetec Avantgarde COMAND NAVI-XENON
::2014/02/04::
Play Video
9
Mod-06 Lec-22 Regulation of gene expression by type II nuclear receptors
Mod-06 Lec-22 Regulation of gene expression by type II nuclear receptors
::2011/09/27::
Play Video
10
LOKI KILLSTREAK!! - COD Ghost w/ SlyFusion
LOKI KILLSTREAK!! - COD Ghost w/ SlyFusion
::2014/04/04::
Play Video
11
/Seafight/ exk szigetlövés 2012.márc
/Seafight/ exk szigetlövés 2012.márc
::2012/03/07::
Play Video
12
Cowichan Day Trip - Day 3
Cowichan Day Trip - Day 3
::2014/04/01::
Play Video
13
Вопрос ответ #1
Вопрос ответ #1
::2014/03/26::
Play Video
14
Marquise Allen Bulford
Marquise Allen Bulford's Pregame Workout Snippet | Shot by @CHDProductions
::2013/09/16::
Play Video
15
new garhwali  jagar live by deepak/ vivek/ kaintura  sarpoli hindow 2012/
new garhwali jagar live by deepak/ vivek/ kaintura sarpoli hindow 2012/
::2012/11/14::
Play Video
16
1998 Mercedes Benz E300 Turbodiesel 2/2
1998 Mercedes Benz E300 Turbodiesel 2/2
::2014/04/23::
Play Video
17
Kilmac Trail Run
Kilmac Trail Run
::2013/05/31::
Play Video
18
Another Year HD Trailer german (2011)
Another Year HD Trailer german (2011)
::2010/12/08::
Play Video
19
TIEMPO NUEVO - El Pobre
TIEMPO NUEVO - El Pobre
::2010/04/04::
Play Video
20
Modern Squidted! - Mario Kart Wii Co-op episode 4 part 4 I WILL win!
Modern Squidted! - Mario Kart Wii Co-op episode 4 part 4 I WILL win!
::2012/08/20::
Play Video
21
Graphs Powerpoint-7/8-3
Graphs Powerpoint-7/8-3
::2012/12/20::
Play Video
22
Rincon de la montaña 2
Rincon de la montaña 2
::2012/10/26::
Play Video
23
Nissan Juke Autohaus Günther Open Day
Nissan Juke Autohaus Günther Open Day
::2012/02/24::
Play Video
24
1486 Cypress Trace, Suntree, FL 32940
1486 Cypress Trace, Suntree, FL 32940
::2014/04/17::
Play Video
25
Alkuillan tunnelmat ipmiehen kanssa
Alkuillan tunnelmat ipmiehen kanssa
::2012/04/13::
Play Video
26
Me ame Bon
Me ame Bon'D Nejo
::2013/03/05::
Play Video
27
The Herobrine Ep: 1
The Herobrine Ep: 1
::2013/07/13::
Play Video
28
14000A1 01
14000A1 01
::2011/10/05::
Play Video
29
bim poşetinin yanış anları
bim poşetinin yanış anları
::2013/10/28::
Play Video
30
Pitch Perfect Appeal Video
Pitch Perfect Appeal Video
::2009/11/17::
Play Video
31
이게 광고지
이게 광고지
::2013/08/06::
Play Video
32
Hussain Aftab Changi at HYD - The Glimpse
Hussain Aftab Changi at HYD - The Glimpse
::2011/10/16::
Play Video
33
BEAT UP Zlín (L. A. Kings) - BUP channel news
BEAT UP Zlín (L. A. Kings) - BUP channel news
::2014/03/16::
Play Video
34
누구도 따로올수 없다
누구도 따로올수 없다
::2013/01/15::
Play Video
35
The Roadhouse Band
The Roadhouse Band
::2012/04/01::
Play Video
36
PROMISSE ME
PROMISSE ME
::2014/03/20::
Play Video
37
ford fiesta titanium 1.5 tdci mileage
ford fiesta titanium 1.5 tdci mileage
::2014/04/18::
Play Video
38
Starcraft Zerg rush
Starcraft Zerg rush
::2012/08/12::
Play Video
39
MAH06574
MAH06574
::2014/04/18::
Play Video
40
Treino De Basquete
Treino De Basquete
::2014/04/07::
Play Video
41
Marik juega Bloodlines - Parte 1 - Mascarada! Sub Español
Marik juega Bloodlines - Parte 1 - Mascarada! Sub Español
::2011/05/08::
Play Video
42
Foster The People Live in KL 13012012 - Pumped Up Kicks (Part 2)
Foster The People Live in KL 13012012 - Pumped Up Kicks (Part 2)
::2012/01/14::
Play Video
43
Haha my mom geting mad at me
Haha my mom geting mad at me
::2012/10/06::
Play Video
44
disneyland surprise
disneyland surprise
::2011/08/24::
Play Video
45
pago libre - fake folk
pago libre - fake folk
::2011/02/24::
Play Video
46
Ледяная вода после сауны
Ледяная вода после сауны
::2013/08/16::
Play Video
47
2011.06.17 CN train 584 east with 8 cars at Casselman
2011.06.17 CN train 584 east with 8 cars at Casselman
::2011/06/18::
Play Video
48
Biggest Loooser - HERO ft Angel, LAtruth
Biggest Loooser - HERO ft Angel, LAtruth
::2011/04/30::
Play Video
49
MANTENHA SEU BALÃO CHEIO!!!!DANIEL GODRI
MANTENHA SEU BALÃO CHEIO!!!!DANIEL GODRI
::2010/08/09::
Play Video
50
Criiiiisssss.MPG
Criiiiisssss.MPG
::2011/04/11::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hepatocyte nuclear factor 4 alpha
Identifiers
Symbol HNF4A
Alt. symbols TCF14, MODY, MODY1
Entrez 3172
HUGO 5024
OMIM 600281
PDB 1M7W (RCSB PDB PDBe PDBj)
RefSeq NM_001030004
UniProt P41235
Other data
Locus Chr. 20 q12-20q13.1
Hepatocyte nuclear factor 4 gamma
Identifiers
Symbol HNF4G
Entrez 3174
HUGO 5026
OMIM 605966
PDB 1LV2 (RCSB PDB PDBe PDBj)
RefSeq NM_004133
UniProt Q14541
Other data
Locus Chr. 8 q21-q22

HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. In humans, there are two isoforms of HNF4, alpha and gamma encoded by two separate genes HNF4A and HNF4G respectively.[1]

Ligands[edit]

HNF4 was originally classified as an orphan receptor that exhibits constitutive transactivation activity apparently by being continuously bound to a variety of fatty acids.[2][3] The existence of a ligand for HNF4 has been somewhat controversial, but linoleic acid (LA) has been identified as the endogenous ligand of native HNF4 expressed in mouse liver; the binding of LA to HNF4 is reversible.[4]

The ligand binding domain of HNF4, as with other nuclear receptors, adopts a canonical alpha helical sandwich fold[5][6] and interacts with co-activator proteins.[7]

HNF4 binds to the consensus sequence AGGTCAaAGGTCA in order to activate transcription.

Pathology[edit]

Mutations in the HNF4A gene have been linked to maturity onset diabetes of the young 1 (MODY1).[8]

See also[edit]

References[edit]

  1. ^ Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (1994). "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver". Gene 147 (2): 269–72. doi:10.1016/0378-1119(94)90079-5. PMID 7926813. 
  2. ^ Sladek F (August 2002). "Desperately seeking...something". Mol. Cell 10 (2): 219–21. doi:10.1016/S1097-2765(02)00605-6. PMID 12191466. 
  3. ^ Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O (November 2005). "Fatty acid regulation of hepatic gene transcription". J. Nutr. 135 (11): 2503–6. PMID 16251601. 
  4. ^ Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM (2009). "Identification of an endogenous ligand bound to a native orphan nuclear receptor". In Laudet, Vincent. PLoS ONE 4 (5): e5609. doi:10.1371/journal.pone.0005609. PMC 2680617. PMID 19440305. 
  5. ^ Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure 10 (9): 1225–34. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494. 
  6. ^ Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE (October 2002). "Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand". J. Biol. Chem. 277 (41): 37973–6. doi:10.1074/jbc.C200420200. PMID 12193589. 
  7. ^ Duda K, Chi YI, Shoelson SE (May 2004). "Structural basis for HNF-4alpha activation by ligand and coactivator binding". J. Biol. Chem. 279 (22): 23311–6. doi:10.1074/jbc.M400864200. PMID 14982928. 
  8. ^ Fajans SS, Bell GI, Polonsky KS (2001). "Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young". N Engl J Med 345 (13): 971–80. doi:10.1056/NEJMra002168. PMID 11575290. 

External links[edit]


Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014