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IFNK
Identifiers
Aliases IFNK, IFNT1, INFE1, interferon kappa
External IDs MGI: 2683287 HomoloGene: 36384 GeneCards: IFNK
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IFNK
Genomic location for IFNK
Band 9p21.2 Start 27,524,314 bp[1]
End 27,526,498 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020124

NM_199157

RefSeq (protein)

NP_064509

NP_954608

Location (UCSC) Chr 9: 27.52 – 27.53 Mb Chr 4: 35.15 – 35.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[5][6][7]

Function[edit]

IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147896 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042993 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: interferon". 
  6. ^ LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA (October 2001). "Interferon-kappa, a novel type I interferon expressed in human keratinocytes". J. Biol. Chem. 276 (43): 39765–71. doi:10.1074/jbc.M102502200. PMID 11514542. 
  7. ^ Nardelli B, Zaritskaya L, Semenuk M, Cho YH, LaFleur DW, Shah D, Ullrich S, Girolomoni G, Albanesi C, Moore PA (November 2002). "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system". J. Immunol. 169 (9): 4822–30. doi:10.4049/jimmunol.169.9.4822. PMID 12391192. 

3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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