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Insulin receptor-related receptor
Symbols INSRR ; IRR
External IDs OMIM147671 MGI1346037 HomoloGene56539 ChEMBL: 5483 GeneCards: INSRR Gene
EC number
RNA expression pattern
PBB GE INSRR 215776 at tn.png
More reference expression data
Species Human Mouse
Entrez 3645 23920
Ensembl ENSG00000027644 ENSMUSG00000005640
UniProt P14616 Q9WTL4
RefSeq (mRNA) NM_014215 NM_011832
RefSeq (protein) NP_055030 NP_035962
Location (UCSC) Chr 1:
156.84 – 156.86 Mb
Chr 3:
87.8 – 87.82 Mb
PubMed search [1] [2]

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.[1][2][3]


  1. ^ Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem 264 (25): 14605–8. PMID 2768234. 
  2. ^ Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481. 
  3. ^ "Entrez Gene: INSRR insulin receptor-related receptor". 

Further reading[edit]

  • Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521. 
  • Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology 136 (9): 4125–32. doi:10.1210/en.136.9.4125. PMID 7649121. 
  • Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525. 
  • Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919. 
  • Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785. 
  • Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736. 
  • Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406. 
  • Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820. 
  • Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552. 
  • Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149. 
  • Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402. 

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