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Aliases INSRR, IRR, insulin receptor related receptor
External IDs MGI: 1346037 HomoloGene: 56539 GeneCards: INSRR
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for INSRR
Genomic location for INSRR
Band 1q23.1 Start 156,840,063 bp[1]
End 156,859,018 bp[1]
RNA expression pattern
PBB GE INSRR 215776 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 156.84 – 156.86 Mb Chr 3: 87.8 – 87.82 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.[5][6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000027644 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005640 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. PMID 2768234. 
  6. ^ Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481. 
  7. ^ "Entrez Gene: INSRR insulin receptor-related receptor". 

Further reading[edit]

  • Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521. 
  • Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology. 136 (9): 4125–32. doi:10.1210/en.136.9.4125. PMID 7649121. 
  • Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525. 
  • Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry. 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919. 
  • Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785. 
  • Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736. 
  • Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406. 
  • Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820. 
  • Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552. 
  • Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149. 
  • Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology. 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402. 


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