Inositol-phosphate phosphatase

In enzymology, an inositol-phosphate phosphatase (EC 3.1.3.25) is an enzyme that catalyzes the chemical reaction

myo-inositol phosphate + H₂O myo-inositol + phosphate

Thus, the two substrates of this enzyme are myo-inositol phosphate and H₂O, whereas its two products are myo-inositol and phosphate.

This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.

Nomenclature [edit]

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include:

• myo-inositol-1(or 4)-monophosphatase,
• inositol 1-phosphatase,
• L-myo-inositol-1-phosphate phosphatase,
• myo-inositol 1-phosphatase,
• inositol phosphatase,
• inositol monophosphate phosphatase,
• inositol-1(or 4)-monophosphatase,
• myo-inositol-1(or 4)-phosphate phosphohydrolase,
• myo-inositol monophosphatase, and
• myo-inositol-1-phosphatase.

References [edit]

• Eisenberg F Jr (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis". J. Biol. Chem. 242 (7): 1375–82. PMID 4290245. 
• Shute JK; Ragan, CI; Watling, KJ; Aspley, S; Jackson, RG; Reid, GG; Gani, D; Shute, JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain". Biochem. J. 249 (3): 883–9. PMC 1148789. PMID 2833231. 
• Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896–901. PMID 6253491. 
• Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol. Psychiatry. 2 (5): 393–7. doi:10.1038/sj.mp.4000325. PMID 9322233. 
• Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
• Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism". Biochem. J. 242 (2): 517–24. PMC 1147736. PMID 3036092. 

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