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1
Live Cell Imaging of Pseudorabies Virus Particles and KIF1A in Neurons
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::2014/02/11::
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2
KIF1A conformational changes
KIF1A conformational changes
::2014/02/12::
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3
KIF1A single molecule movement
KIF1A single molecule movement
::2014/02/12::
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4
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::2013/01/20::
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5
Axonal transport (軸索輸送)
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::2010/10/05::
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6
Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons
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::2014/02/11::
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[GM Swim]
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::2014/06/11::
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::2013/04/30::
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9
Cells - Live at the 12 bar Club
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::2014/05/23::
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10
Kinesin molecules moving in cell
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::2014/02/12::
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11
Dynamics of Virus-Induced Stress Granules
Dynamics of Virus-Induced Stress Granules
::2014/02/11::
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12
Peter Baas (1) - Microtubule organization in neurons, neuron development and disease
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::2013/06/07::
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13
Intravital imaging of mouse liver
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::2014/03/17::
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14
Bead Movement by Kinesin
Bead Movement by Kinesin
::2014/04/29::
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15
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::2014/02/11::
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Dissociated Axoplasm - Transport of membranes inside of a squid giant axon
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::2014/04/15::
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17
Microdevices to study axonal degeneration
Microdevices to study axonal degeneration
::2013/04/12::
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18
CaMKII translocation in neurons
CaMKII translocation in neurons
::2011/05/23::
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19
Shigella Spreads via Tricellular Junctions
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::2014/02/11::
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20
180 virus.
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Intravital Molecular Imaging
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::2013/10/10::
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3D Distribution of Calgranulin A in Kidney Abscesses of a Staphylococcus aureus-Infected Mouse
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::2014/02/11::
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23
Spine dynamics of control neurons
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::2012/04/04::
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24
Visualization of Bacterial Toxin Induced Responses Using Live Cell Fluorescence Microscopy
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::2014/02/27::
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25
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::2009/05/26::
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26
Imaging Place Second Life, 2008
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::2011/05/18::
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27
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::2014/02/11::
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28
Fluorescence Nanodiamond: probe of vesicle traffic in dendrite of primary neurons
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::2013/09/17::
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29
Navigating the Cellular Landscape with New Optical Probes
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::2013/07/16::
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1st 2-Photon time lapse of neurons connecting
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::2013/01/06::
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31
Unidirectional Transport of Internalized BACE1 in Dendrites - Buggia-Prevot et al. Cell Reports 2013
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::2014/01/12::
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F-actin accumulation in dendritic spines
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::2012/10/01::
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33
Intravital Imaging of the Mouse Popliteal Lymph Node
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::2014/02/27::
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34
Innate Cells Rapidly Infiltrate Vaccinia Virus Lesions
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::2014/02/11::
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35
Intravital microscopy Neisseria meningitidis
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::2013/08/20::
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Three-Dimensional Imaging of Viral Infections: Video 3
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::2014/07/09::
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37
F actin
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::2014/02/12::
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38
Peter Baas (2) - Microtubule organization in neurons, neuron development and disease
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::2013/06/07::
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03   Neuronal Growth and Organization
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::2013/09/28::
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40
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::2013/08/08::
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41
Bidirectional Transport of Internalized BACE1 in Axons -Buggia-Prevot et al Cell Reports 2013
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::2014/01/12::
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42
Particles by infected gallery
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::2014/05/19::
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43
How virus particles are assembled ☆ Virology Course ☆ Virus Lecture #11
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::2014/05/11::
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44
Salmonella Motility in the Gut
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::2014/02/10::
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45
Microtubule dynamics STED
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::2014/02/12::
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46
Imaging: lymphocytes
Imaging: lymphocytes
::2014/06/17::
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47
Designing Probes to Image Proteins Inside Living Cells 20
Designing Probes to Image Proteins Inside Living Cells 20
::2013/05/13::
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48
Whole Axoplasm - Transport of membranes inside of a squid giant axon
Whole Axoplasm - Transport of membranes inside of a squid giant axon
::2014/04/15::
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49
Microscope: Longitude Cut of Nerve
Microscope: Longitude Cut of Nerve
::2011/10/05::
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50
3D view of confocal Z stack zebrafish
3D view of confocal Z stack zebrafish
::2013/07/31::
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RESULTS [51 .. 101]
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Kinesin family member 1A
PDB 1i6i EBI.jpg
PDB rendering based on 1i6i.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIF1A ; ATSV; C2orf20; HSN2C; MRD9; SPG30; UNC104
External IDs OMIM601255 MGI108391 HomoloGene99729 GeneCards: KIF1A Gene
Orthologs
Species Human Mouse
Entrez 547 16560
Ensembl ENSG00000130294 ENSMUSG00000014602
UniProt Q12756 E9Q9G6
RefSeq (mRNA) NM_001244008 NM_001110315
RefSeq (protein) NP_001230937 NP_001103785
Location (UCSC) Chr 2:
241.65 – 241.76 Mb
Chr 1:
93.02 – 93.1 Mb
PubMed search [1] [2]

Kinesin-like protein KIF1A, also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A, is a protein that in humans is encoded by the KIF1A gene.[1][2][3]

Function[edit]

KIF1A is a member of the kinesin family. This protein is highly similar to mouse heavy-chain kinesin member 1A protein, which is an anterograde motor protein that transports membranous organelles along axonal microtubules. It is thought that this protein may play a critical role in the development of axonal neuropathies resulting from impaired axonal transport. There are multiple polyadenylation sites found in this gene.[1]

Clinical significance[edit]

KIF1A is associated with hereditary spastic paraparesis.[4]

References[edit]

  1. ^ a b "Entrez Gene: kinesin family member 1A". 
  2. ^ Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N (June 1995). "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors". Cell 81 (5): 769–80. doi:10.1016/0092-8674(95)90538-3. PMID 7539720. 
  3. ^ Keller MP, Seifried BA, Rabin BA, Chance PF (March 1999). "Mapping of the kinesin-related gene ATSV to chromosome 2q37". Hum. Genet. 104 (3): 254–6. doi:10.1007/s004390050944. PMID 10323250. 
  4. ^ Erlich Y, Edvardson S, Hodges E, Zenvirt S, Thekkat P, Shaag A, Dor T, Hannon GJ, Elpeleg O (April 2011). "Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis". Genome Res 21 (5): 658–64. doi:10.1101/gr.117143.110. PMID 21487076. 


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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