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Keratin 78
Identifiers
Symbols KRT78 ; K5B; Kb40
External IDs OMIM611159 MGI1917529 HomoloGene65261 GeneCards: KRT78 Gene
Orthologs
Species Human Mouse
Entrez 196374 332131
Ensembl ENSG00000170423 ENSMUSG00000050463
UniProt Q8N1N4 E9Q0F0
RefSeq (mRNA) NM_173352 NM_212487
RefSeq (protein) NP_775487 NP_997652
Location (UCSC) Chr 12:
53.23 – 53.24 Mb
Chr 15:
101.95 – 101.95 Mb
PubMed search [1] [2]

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.[1][2]

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.[2]

References[edit]

  1. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  2. ^ a b "Entrez Gene: KRT78 keratin 78". 

Further reading[edit]



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