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Keratin 85
Identifiers
Symbols KRT85 ; ECTD4; HB5; Hb-5; K85; KRTHB5; hHb5
External IDs OMIM602767 MGI1859268 HomoloGene37603 GeneCards: KRT85 Gene
RNA expression pattern
PBB GE KRT85 207670 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3891 406219
Ensembl ENSG00000135443 ENSMUSG00000047641
UniProt P78386 Q6IMF0
RefSeq (mRNA) NM_001300810 NM_001003668
RefSeq (protein) NP_001287739 NP_001003668
Location (UCSC) Chr 12:
52.75 – 52.76 Mb
Chr 15:
101.43 – 101.44 Mb
PubMed search [1] [2]

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.[3]

References[edit]

  1. ^ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ a b "Entrez Gene: KRT85 keratin 85". 

Further reading[edit]


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