Playin' HL2 - 6a - Ravenholm :-)

Channel: Isocitration   |   2011/11/20
Play Video
1
Playin
Playin' HL2 - 6a - Ravenholm :-)
::2011/11/20::
Play Video
2
Week 4 of 52 Week Healthy Hair Growth Challenge (Protein Treatment)
Week 4 of 52 Week Healthy Hair Growth Challenge (Protein Treatment)
::2013/06/24::
Play Video
3
CCJbeautydirect Brazilian straight hair Review
CCJbeautydirect Brazilian straight hair Review
::2014/03/12::
Play Video
4
HAIR SPRAY MIX FOR NATURAL 6a HAIR TYPE
HAIR SPRAY MIX FOR NATURAL 6a HAIR TYPE
::2014/03/16::
Play Video
5
Aliexpress Brazilian Straight: Initial Review + Co Wash
Aliexpress Brazilian Straight: Initial Review + Co Wash
::2013/08/28::
Play Video
6
Brazilian straight: aliexpress mocha hair co.
Brazilian straight: aliexpress mocha hair co.
::2013/07/08::
Play Video
7
My First CurlBOX October 11, 2012
My First CurlBOX October 11, 2012
::2012/10/12::
Play Video
8
Queen Weave Beauty Ltd Brazilian Straight
Queen Weave Beauty Ltd Brazilian Straight
::2013/01/31::
Play Video
9
Aliexpress| Mocha Hair Co| Brazillian Staright| First Review!
Aliexpress| Mocha Hair Co| Brazillian Staright| First Review!
::2014/01/11::
Play Video
10
Brazilian straight hair review from aliexpress (Mocha Hair)
Brazilian straight hair review from aliexpress (Mocha Hair)
::2014/02/01::
Play Video
11
Janet Collection Brazilian Bombshell Bundle Hair Review
Janet Collection Brazilian Bombshell Bundle Hair Review
::2013/06/12::
Play Video
12
Wholesale Brazilian Hair
Wholesale Brazilian Hair
::2011/01/03::
Play Video
13
Thailand Hair Extensions Bangkok - Where To Get Quality Hair Extensions -ZENRED
Thailand Hair Extensions Bangkok - Where To Get Quality Hair Extensions -ZENRED
::2012/04/01::
Play Video
14
diy sea salt spray
diy sea salt spray
::2013/09/16::
Play Video
15
GORGEOUS GLAM EXTENSIONS (BEWARE-NIGHTMARE)!
GORGEOUS GLAM EXTENSIONS (BEWARE-NIGHTMARE)!
::2013/12/24::
Play Video
16
Massageador Elétrico - Tech S1
Massageador Elétrico - Tech S1
::2011/03/23::
Play Video
17
access 4c
access 4c
::2014/03/28::
Play Video
18
Virgin Brazilian Natural Wave- Final Review and VOTE
Virgin Brazilian Natural Wave- Final Review and VOTE
::2012/10/31::
Play Video
19
My Current Favs. . .Spring 2K14
My Current Favs. . .Spring 2K14
::2014/03/02::
Play Video
20
RED BY KISS SILICONE STYLER SHOW&&TELL/DEMO
RED BY KISS SILICONE STYLER SHOW&&TELL/DEMO
::2014/03/18::
Play Video
21
33 Cochise Geronimo
33 Cochise Geronimo
::2011/04/27::
Play Video
22
Brazilian Malaysian curly wavy straight kinky curly hair
Brazilian Malaysian curly wavy straight kinky curly hair
::2012/10/20::
Play Video
23
Minecraft Adventure 2 odcinek 6 Gdzie jestem????
Minecraft Adventure 2 odcinek 6 Gdzie jestem????
::2011/10/27::
Play Video
24
Myer shopping
Myer shopping
::2010/05/25::
Play Video
25
Novinhos da 6a
Novinhos da 6a
::2011/11/26::
Play Video
26
6c  Hip Bump
6c Hip Bump
::2014/02/23::
Play Video
27
CLOSED-Makeup and Beauty Product Sale! MAC, Clinique, NYX, Bath & Body Works, China Glaze and more
CLOSED-Makeup and Beauty Product Sale! MAC, Clinique, NYX, Bath & Body Works, China Glaze and more
::2010/07/27::
Play Video
28
Fadianxiu Hair - Virgin Brazilian Straight AAAAA aliexpress
Fadianxiu Hair - Virgin Brazilian Straight AAAAA aliexpress
::2012/09/28::
Play Video
29
Aliexpress Mocha Hair 3 Week Update Review! (Brazilian Straight)
Aliexpress Mocha Hair 3 Week Update Review! (Brazilian Straight)
::2013/08/16::
Play Video
30
Glass house Nieuwe Kwattaweg 5
Glass house Nieuwe Kwattaweg 5
::2014/01/01::
Play Video
31
Get The Look: Cute Wet Messy Bun
Get The Look: Cute Wet Messy Bun
::2011/03/08::
Play Video
32
Home 4b
Home 4b
::2013/11/28::
Play Video
33
Nairobi-UP-DO STYLING SPRAY
Nairobi-UP-DO STYLING SPRAY
::2012/07/31::
Play Video
34
las bellas J8
las bellas J8
::2011/03/01::
Play Video
35
Новогодний проект ʕ·ᴥ·ʔ 7 блогеров. Скоро!
Новогодний проект ʕ·ᴥ·ʔ 7 блогеров. Скоро!
::2013/12/23::
Play Video
36
3B.MOV
3B.MOV
::2012/11/06::
Play Video
37
Manga Rosa Profissional - Passo a Passo: PH Organics
Manga Rosa Profissional - Passo a Passo: PH Organics
::2012/06/03::
Play Video
38
Passo a Passo Tratamento Hair Brazilian Top   YouTube
Passo a Passo Tratamento Hair Brazilian Top YouTube
::2013/01/17::
Play Video
39
Новогодний макияж для карих глаз/ New Year make up
Новогодний макияж для карих глаз/ New Year make up
::2013/12/26::
Play Video
40
ALIEXPRESS GS VIRGIN BRAZILIAN HAIR 2 WEEK REVIEW ! STRAIGHT
ALIEXPRESS GS VIRGIN BRAZILIAN HAIR 2 WEEK REVIEW ! STRAIGHT
::2012/10/16::
Play Video
41
Fall Clothing Haul!
Fall Clothing Haul!
::2013/11/24::
Play Video
42
How to Pronounce Rollers
How to Pronounce Rollers
::2013/11/11::
Play Video
43
pink woman fashion denim style
pink woman fashion denim style
::2012/07/19::
Play Video
44
pink woman fashion denim style
pink woman fashion denim style
::2012/07/18::
Play Video
45
MeuGuiaCarioca.com | 9a Entrevista no Fashion Business 2010
MeuGuiaCarioca.com | 9a Entrevista no Fashion Business 2010
::2010/05/24::
Play Video
46
Loreal Paris Excellence Creme 7BB Review
Loreal Paris Excellence Creme 7BB Review
::2012/01/23::
Play Video
47
[Family Circle] How to Dye Your Hair with Clairol Nice
[Family Circle] How to Dye Your Hair with Clairol Nice 'n Easy Color Blend Foam
::2010/12/03::
Play Video
48
Już wkrótce farba TOPCHIC w nowej odsłonie!
Już wkrótce farba TOPCHIC w nowej odsłonie!
::2013/02/13::
Play Video
49
MeuGuiaCarioca.com | 10a Entrevista no Fashion Business 2010
MeuGuiaCarioca.com | 10a Entrevista no Fashion Business 2010
::2010/05/24::
Play Video
50
2011歌唱比賽6B華麗舞台  (正義必勝) CCCKHSS
2011歌唱比賽6B華麗舞台 (正義必勝) CCCKHSS
::2011/11/09::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Keratin 6A
Identifiers
Symbols KRT6A ; CK6A; CK6C; CK6D; K6A; K6C; K6D; KRT6C; KRT6D
External IDs OMIM148041 MGI1333768 HomoloGene36182 GeneCards: KRT6A Gene
Orthologs
Species Human Mouse
Entrez 3853 16687
Ensembl ENSG00000205420 ENSMUSG00000058354
UniProt P02538 P50446
RefSeq (mRNA) NM_005554 NM_008476
RefSeq (protein) NP_005545 NP_032502
Location (UCSC) Chr 12:
52.88 – 52.89 Mb
Chr 15:
101.69 – 101.69 Mb
PubMed search [1] [2]

Keratin 6A is one the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined.[1] Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins.[1] In humans Keratin 6A is encoded by the KRT6A gene.[2][3]

Keratins[edit]

Keratins are the intermediate filament proteins that form a dense meshwork of filaments throughout the cytoplasm of epithelial cells. Keratins form heteropolymers consisting of a type I and a type II keratin. Keratins are generally expressed in particular pairs of type I and type II keratin proteins in a tissue-specific and cellular differentiation-specific manner.

The keratin proteins of epithelial tissues are commonly known as "keratins" or are sometimes referred to as "epithelial keratins" or "cytokeratins". The specialized keratins of hair and nail are known as "hard keratins" or "trichocyte keratins". Trichocytes are the specialized epithelial cells from which hair and nail are composed. Trichocyte keratins are similar in their gene and protein structure to keratins except that they are especially rich in the sulfur-containing amino acid cysteine, which facilitates chemical cross-linking of the assembled hard keratins to form a more structurally resilient material.

Both epithelial keratins and hard keratins can be further subdivided into type I (acidic) keratins and type II (neutral-basic) keratins. The genes for the type I keratins are located in a gene cluster on human chromosome 17q, whereas the genes for type II keratins are located in a cluster on human chromosome 12q (the exception being K18, a type I keratin located in the type II gene cluster).

Keratin 6A[edit]

Keratin 6A (protein name K6A; gene name KRT6A), is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. It is found with keratin 16 and/or keratin 17 in the palm and sole epidermis, the epithelial cells of the nail bed, the filiform papillae of the tongue, the epithelial lining of oral mucosa and esophagus, as well as the hair follicles. This keratin 6 isoform is thought to be the most abundant of the K6 isoforms.

The KRT6A gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human chromosome 12q. Keratin 6B and keratin 6C are encoded by the neighbouring genes, which are identical in intron-exon organization to KRT6A and are more than 99% identical in their DNA coding sequences.

Genetic disorders[edit]

Mutations in the genes expressing this protein have been associated with the PC1 variant of pachyonychia congenita, an inherited disorder of the epithelial tissues in which keratin 6A is expressed, particularly leading to structural abnormalities of the nails, the epidermis of the palms and soles, and oral epithelia.[4][5][6]

External links[edit]

References[edit]

  1. ^ a b Hanukoglu, I.; Fuchs, E. (Jul 1983). "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins.". Cell 33 (3): 915–24. doi:10.1016/0092-8674(83)90034-X. PMID 6191871. 
  2. ^ Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenet. Cell Genet. 57 (1): 33–8. doi:10.1159/000133109. PMID 1713141. 
  3. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  4. ^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C (March 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat. Genet. 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. 
  5. ^ Bowden PE, Haley JL, Kansky A, Rothnagel JA, Jones DO, Turner RJ (July 1995). "Mutation of a type II keratin gene (K6a) in pachyonychia congenita". Nat. Genet. 10 (3): 363–5. doi:10.1038/ng0795-363. PMID 7545493. 
  6. ^ Smith FJ, Jonkman MF, van Goor H, Coleman CM, Covello SP, Uitto J, McLean WH (July 1998). "A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2". Hum. Mol. Genet. 7 (7): 1143–8. doi:10.1093/hmg/7.7.1143. PMID 9618173. 
Wikipedia content is licensed under the GFDL License

Mashpedia enables any individual or company to promote their own Youtube-hosted videos or Youtube Channels, offering a simple and effective plan to get them in front of our engaged audience.

Want to learn more? Please contact us at: hello@mashpedia.com

Powered by YouTube
LEGAL
  • Mashpedia © 2014