|Lateral plate mesoderm|
|Transverse section of a chick embryo of forty-five hours’ incubation.
* Chordamesoderm: yellow, at notochord.
* Paraxial mesoderm: red, at somite.
* Intermediate mesoderm: purple, near Wolffian duct.
* Lateral plate mesoderm: purple, near "Somatic mesoderm" and "Splanchic mesoderm".
|Model of human embryo 1.3 mm. long.. (Splanchic mesoderm labeled at left, somatic mesoderm at top right.)|
|Latin||mesoderma laminae lateralis|
|Gray's||subject #6 50|
|Gives rise to||somatopleure, splanchnopleure|
It will split into two layers, the somatic layer/mesoderm and the splanchnic layer/mesoderm
Spaces within the lateral plate are enclosed and forms the intraembryonic coelom.
Lateral plate mesoderm gives rise to the serosal mesoderms.
Cells from the lateral plate mesoderm and the myotome migrate to the limb field and proliferate to create the limb bud. The lateral plate cells produce the cartilaginous and skeletal portions of the limb while the myotome cells produce the muscle components. The lateral plate mesodermal cells secrete a fibroblast growth factor (FGF7 and FGF10, presumably) to induce the overlying ectoderm to form an important organizing structure called the apical ectodermal ridge (AER).The AER reciprocatively secretes FGF8 and FGF4 which maintains the FGF10 signal and induces proliferation in the mesoderm. The position of FGF10 expression is regulated by Wnt8c in the hindlimb and Wnt2b in the forelimb. The forelimb and the hindlimb are specified by their position along the anterior/posterior axis and possibly by two T-box containing transcription factors: Tbx5 and Tbx4, respectively.
See http://en.wikipedia.orgLimb_development for more information
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