Libertarian transhumanists believe that the principle of self-ownership is the most fundamental idea from which both libertarianism and transhumanism stem. They are rational egoists and ethical egoists who embrace the prospect of using emerging technologies to enhance human capacities, which they believe stems from the self-interested application of reason and will in the context of the individual freedom to achieve a posthuman state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. They extend this rational and ethical egoism to advocate a form of "biolibertarianism".
Critiques of the techno-utopianism of libertarian transhumanists from progressive cultural critics include Richard Barbrook and Andy Cameron's 1995 essay The Californian Ideology; Mark Dery's 1996 book Escape Velocity: Cyberculture at the End of the Century; and Paulina Borsook's 2000 book Cyberselfish: A Critical Romp Through the Terribly Libertarian Culture of High-Tech.
Sociologist James Hughes is the most militant critic of libertarian transhumanism. While articulating “democratic transhumanism” as a sociopolitical program in his 2004 book Citizen Cyborg, Hughes sought to convince libertarian transhumanists to embrace social democracy by arguing that:
Klaus-Gerd Giesen, a German political scientist specializing in the philosophy of technology, wrote a critique of the libertarianism he imputes to all transhumanists. While pointing out that the works of Austrian School economist Friedrich Hayek figure in practically all of the recommended reading lists of Extropians, he argues that transhumanists, convinced of the sole virtues of the free market, advocate an unabashed inegalitarianism and merciless meritocracy which can be reduced in reality to a biological fetish. He is especially critical of their promotion of a science-fictional liberal eugenics, virulently opposed to any political regulation of human genetics, where the consumerist model presides over their ideology. Giesen concludes that the despair of finding social and political solutions to today's sociopolitical problems incites transhumanists to reduce everything to the hereditary gene, as a fantasy of omnipotence to be found within the individual, even if it means transforming the subject (human) to a new draft (posthuman).