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Cyclic lipopeptide antibiotics
Symbol N/A
TCDB 1.D.15
OPM superfamily 172
OPM protein 1t5n

A lipopeptide is a molecule consisting of a lipid connected to a peptide.[1] Bacteria express these molecules. They are able to self-assemble into different structures.[1][2][3] Certain lipopeptides are used as antibiotics.[4][5] Other lipopeptides are toll-like receptor agonists.[3] Certain lipopeptides can have strong antifungal and hemolytic activities.[6] It has been demonstrated that their activity is generally linked to interactions with the plasma membrane,[7] and sterol components of the plasma membrane could play a major role in this interaction.[8][9]


See also[edit]


  1. ^ a b Hamley, I.W. Lipopeptides: From Self-Assembly to Bioactivity. Chem. Comm. 2015, 51, 8574-8583. doi: 10.1039/c5cc01535a
  2. ^ Kirkham, S.; Castelletto, V.; Hamley, I. W.; Inoue, K.; Rambo, R.; Reza, M.; Ruokolainen, J., Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride. Chemphyschem 2016, 17, 2118-2122.doi:10.1002/cphc.201600308
  3. ^ a b Hamley, I. W.; Kirkham, S.; Dehsorkhi, A.; Castelletto, V.; Reza, M.; Ruokolainen, J., Toll-Like Receptor Agonist Lipopeptides Self-Assemble into Distinct Nanostructures.doi:10.1039/c4cc07511k
  4. ^ US Patent 6911525 - Lipopeptides as antibacterial agents
  5. ^ Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections , Judith N. Steenbergen*, Jeff Alder, Grace M. Thorne and Francis P. Tally , Journal of Antimicrobial Chemotherapy 2005 55(3):283-288; doi:10.1093/jac/dkh546
  6. ^ Maget-Dana, R., & Peypoux, F. (1994). Iturins, a special class of pore-forming lipopeptides: biological and physicochemical properties. Toxicology, 87(1-3), 151–74
  7. ^ Nasir, M. N., Besson, F., & Deleu, M. (2013). Interactions des antibiotiques ituriniques avec la membrane plasmique. Apport des systèmes biomimétiques des membranes. Biotechnology, Agronomy and Society and Environment, 17(3), 505–516.
  8. ^ Nasir, M. N., & Besson, F. (2012). Interactions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1302–1308
  9. ^ Nasir, M. N., & Besson, F. F. (2011). Specific Interactions of Mycosubtilin with Cholesterol-Containing Artificial Membranes. Langmuir : The ACS Journal of Surfaces and Colloids, 27(17), 10785–10792.

Further reading[edit]

  • Giuliani A, Pirri G, Nicoletto S (2007). "Antimicrobial peptides: an overview of a promising class of therapeutics". Cent. Eur. J. Biol. 2 (1): 1–33. doi:10.2478/s11535-007-0010-5. 
  • Pirri G, Giuliani A, Nicoletto S, Pizutto L, Rinaldi A (2009). "Lipopeptides as anti-infectives: a practical perspective". Cent. Eur. J. Biol. 4 (3): 258–273. doi:10.2478/s11535-009-0031-3. 


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