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Gene Music Using Protein Sequence of LHB "LUTEINIZING HORMONE BETA POLYPEPTIDE"
Gene Music Using Protein Sequence of LHB "LUTEINIZING HORMONE BETA POLYPEPTIDE"
Published: 2015/12/04
Channel: Gene Music Studio
Virus Structure and Method of Invasion
Virus Structure and Method of Invasion
Published: 2014/11/24
Channel: Ante Fr
Follicle-stimulating hormone
Follicle-stimulating hormone
Published: 2014/08/31
Channel: Audiopedia
Follicle-stimulating hormone - Video Learning - WizScience.com
Follicle-stimulating hormone - Video Learning - WizScience.com
Published: 2015/09/04
Channel: Wiz Science™
Gonadorelin Peptides UK, Peptides USA, Peptides Cambodia
Gonadorelin Peptides UK, Peptides USA, Peptides Cambodia
Published: 2015/08/02
Channel: Touch Sokhavuth
Fallen enchantress  LH -beta- lets play ep1
Fallen enchantress LH -beta- lets play ep1
Published: 2013/04/27
Channel: Annix Stone
Gene Music Using Protein Sequence of FSHB "FOLLICLE STIMULATING HORMONE, BETA POLYPEPTIDE"
Gene Music Using Protein Sequence of FSHB "FOLLICLE STIMULATING HORMONE, BETA POLYPEPTIDE"
Published: 2015/11/27
Channel: Gene Music Studio
FE LH Beta - Mancers 5
FE LH Beta - Mancers 5
Published: 2013/05/22
Channel: SBFMadDjinn
Narsissss abis ala indiana
Narsissss abis ala indiana
Published: 2012/08/10
Channel: sahat oloan
FE LH Beta - Mancers 4
FE LH Beta - Mancers 4
Published: 2013/05/24
Channel: SBFMadDjinn
FE LH Beta - Mancers 8
FE LH Beta - Mancers 8
Published: 2013/06/03
Channel: SBFMadDjinn
Gene Music Using Protein Sequence of CGA "GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE"
Gene Music Using Protein Sequence of CGA "GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE"
Published: 2015/11/19
Channel: Gene Music Studio
JV LH B 20170516
JV LH B 20170516
Published: 2017/05/20
Channel: Mark McVey
Gene Music Using Protein Sequence of PTH "PARATHYROID HORMONE"
Gene Music Using Protein Sequence of PTH "PARATHYROID HORMONE"
Published: 2015/11/18
Channel: Gene Music Studio
Gene Music Using Protein Sequence of GSTA4 "GLUTATHIONE S-TRANSFERASE ALPHA 4"
Gene Music Using Protein Sequence of GSTA4 "GLUTATHIONE S-TRANSFERASE ALPHA 4"
Published: 2015/12/04
Channel: Gene Music Studio
Bella. Musette. LH B section
Bella. Musette. LH B section
Published: 2017/09/21
Channel: 1234Piano Lessons 1234Piano
Fallen enchantress LH beta- lets play ep5
Fallen enchantress LH beta- lets play ep5
Published: 2013/05/02
Channel: Annix Stone
Fallen enchantress LH beta- lets play ep2
Fallen enchantress LH beta- lets play ep2
Published: 2013/04/28
Channel: Annix Stone
Fallen enchantress LH beta- lets play ep4
Fallen enchantress LH beta- lets play ep4
Published: 2013/04/30
Channel: Annix Stone
Gene Music Using Protein Sequence of GSTA5 "GLUTATHIONE S-TRANSFERASE ALPHA 5"
Gene Music Using Protein Sequence of GSTA5 "GLUTATHIONE S-TRANSFERASE ALPHA 5"
Published: 2015/12/04
Channel: Gene Music Studio
Gene Music Using Protein Sequence of FAM32A "FAMILY WITH SEQUENCE SIMILARITY 32, MEMBER A"
Gene Music Using Protein Sequence of FAM32A "FAMILY WITH SEQUENCE SIMILARITY 32, MEMBER A"
Published: 2015/11/27
Channel: Gene Music Studio
CDL LH B section.MP4
CDL LH B section.MP4
Published: 2012/11/14
Channel: FaithSlakerMusic
Gene Music Using Protein Sequence of PSCA "PROSTATE STEM CELL ANTIGEN"
Gene Music Using Protein Sequence of PSCA "PROSTATE STEM CELL ANTIGEN"
Published: 2015/11/22
Channel: Gene Music Studio
Unit 6 Video 5
Unit 6 Video 5
Published: 2017/02/27
Channel: Manuel Greciano
Complete Solution Is In The Short TUTORIAL
Complete Solution Is In The Short TUTORIAL
Published: 2017/05/24
Channel: Helping Tutors
Primada Barnett 2008
Primada Barnett 2008
Published: 2008/06/24
Channel: Latinodel44
Jan 21, 2011 1:02 PM
Jan 21, 2011 1:02 PM
Published: 2011/01/21
Channel: NiniDatChick
Gene Music Using Protein Sequence of GSTM1 "GLUTATHIONE S-TRANSFERASE MU 1"
Gene Music Using Protein Sequence of GSTM1 "GLUTATHIONE S-TRANSFERASE MU 1"
Published: 2015/12/04
Channel: Gene Music Studio
Gene Music Using Protein Sequence of FKBP1B "FK506 BINDING PROTEIN 1B"
Gene Music Using Protein Sequence of FKBP1B "FK506 BINDING PROTEIN 1B"
Published: 2015/11/27
Channel: Gene Music Studio
Gene Music Using Protein Sequence of ZNF644 "ZINC FINGER PROTEIN 644"
Gene Music Using Protein Sequence of ZNF644 "ZINC FINGER PROTEIN 644"
Published: 2015/11/17
Channel: Gene Music Studio
Gene Music Using Protein Sequence of NPFF "NEUROPEPTIDE FF-AMIDE PEPTIDE PRECURSOR"
Gene Music Using Protein Sequence of NPFF "NEUROPEPTIDE FF-AMIDE PEPTIDE PRECURSOR"
Published: 2015/11/21
Channel: Gene Music Studio
Можно ли бегать после силовой тренировки? Правда ли, что бег сжигает мышечную массу?
Можно ли бегать после силовой тренировки? Правда ли, что бег сжигает мышечную массу?
Published: 2015/07/17
Channel: ПРОКАЧКА
Можно ли заниматься сексом перед силовой тренировкой?
Можно ли заниматься сексом перед силовой тренировкой?
Published: 2015/06/04
Channel: ПРОКАЧКА
Gene Music Using Protein Sequence of AVPI1 "ARGININE VASOPRESSIN-INDUCED 1"
Gene Music Using Protein Sequence of AVPI1 "ARGININE VASOPRESSIN-INDUCED 1"
Published: 2015/12/12
Channel: Gene Music Studio
Gene Music Using Protein Sequence of S100A7L2 "S100 CALCIUM BINDING PROTEIN A7-LIKE 2"
Gene Music Using Protein Sequence of S100A7L2 "S100 CALCIUM BINDING PROTEIN A7-LIKE 2"
Published: 2015/11/18
Channel: Gene Music Studio
Gene Music Using Protein Sequence of GSTM3 "GLUTATHIONE S-TRANSFERASE MU 3 (BRAIN)"
Gene Music Using Protein Sequence of GSTM3 "GLUTATHIONE S-TRANSFERASE MU 3 (BRAIN)"
Published: 2015/12/04
Channel: Gene Music Studio
Gene Music Using Protein Sequence of GSTM2 "GLUTATHIONE S-TRANSFERASE MU 2 (MUSCLE)"
Gene Music Using Protein Sequence of GSTM2 "GLUTATHIONE S-TRANSFERASE MU 2 (MUSCLE)"
Published: 2015/12/04
Channel: Gene Music Studio
NY State Fair
NY State Fair
Published: 2015/08/29
Channel: joerobijr
Как увеличить рост (подрасти)? Упражнения для увеличения роста
Как увеличить рост (подрасти)? Упражнения для увеличения роста
Published: 2015/07/02
Channel: ПРОКАЧКА
Gene Music Using Protein Sequence of SPAG11A "SPERM ASSOCIATED ANTIGEN 11A"
Gene Music Using Protein Sequence of SPAG11A "SPERM ASSOCIATED ANTIGEN 11A"
Published: 2015/11/20
Channel: Gene Music Studio
Gene Music Using Protein Sequence of CORTISTATIN(CORT)
Gene Music Using Protein Sequence of CORTISTATIN(CORT)
Published: 2015/11/16
Channel: Gene Music Studio
Как быстро накачаться без протеинов? Как быстро накачать без стероидов
Как быстро накачаться без протеинов? Как быстро накачать без стероидов
Published: 2015/05/26
Channel: ПРОКАЧКА
Как быстро набрать вес, нарастить мышечную массу. Суровый массонабор в домашних условиях
Как быстро набрать вес, нарастить мышечную массу. Суровый массонабор в домашних условиях
Published: 2016/11/05
Channel: ПРОКАЧКА
#Рост_мышц и боль. Биохимия роста мышц, дома, питание, на турнике, галилео без жира
#Рост_мышц и боль. Биохимия роста мышц, дома, питание, на турнике, галилео без жира
Published: 2016/01/09
Channel: ПРОКАЧКА
Gene Music Using Protein Sequence of RPP14 "RIBONUCLEASE P/MRP 14KDA SUBUNIT"
Gene Music Using Protein Sequence of RPP14 "RIBONUCLEASE P/MRP 14KDA SUBUNIT"
Published: 2015/11/22
Channel: Gene Music Studio
Алкоголь и рост мышц. Влияние алкоголя на спортивные показатели и набор мышечной массы
Алкоголь и рост мышц. Влияние алкоголя на спортивные показатели и набор мышечной массы
Published: 2016/11/05
Channel: ПРОКАЧКА
Gene Music Using Protein Sequence of FAM19A5 "FAMILY WITH SEQUENCE SIMILARITY 19 (CHEMOKINE (C-C MO"
Gene Music Using Protein Sequence of FAM19A5 "FAMILY WITH SEQUENCE SIMILARITY 19 (CHEMOKINE (C-C MO"
Published: 2015/11/27
Channel: Gene Music Studio
Трансформация Эндоморфа на кето диете (кетогенной). Реальный опыт сушки эндоморфа часть 2
Трансформация Эндоморфа на кето диете (кетогенной). Реальный опыт сушки эндоморфа часть 2
Published: 2015/06/15
Channel: ПРОКАЧКА
Что означает статика? Статические и динамические упражнения
Что означает статика? Статические и динамические упражнения
Published: 2015/07/13
Channel: ПРОКАЧКА
Почему качки пузатые? Почему у бодибилдеров выпирающие животы?
Почему качки пузатые? Почему у бодибилдеров выпирающие животы?
Published: 2015/07/22
Channel: ПРОКАЧКА
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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LHB
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LHB, CGB4, LSH-B, hHH23, Luteinizing hormone beta polypeptide, LSH-beta, Luteinizing hormone subunit beta
External IDs MGI: 96782 HomoloGene: 81806 GeneCards: LHB
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LHB
Genomic location for LHB
Band 19q13.33 Start 49,015,980 bp[1]
End 49,017,081 bp[1]
RNA expression pattern
PBB GE LHB 214471 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000894

NM_008497

RefSeq (protein)

NP_000885

NP_032523

Location (UCSC) Chr 19: 49.02 – 49.02 Mb Chr 19: 45.42 – 45.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Luteinizing hormone subunit beta also known as lutropin subunit beta or LHβ is a polypeptide that in association with an alpha subunit common to all gonadotropin hormones forms the reproductive signaling molecule luteinizing hormone. In humans it is encoded by the LHB gene.[5][6]

Gene[edit]

The luteinizing hormone beta subunit is encoded by a single gene in all mammals. In primates, this gene is located within a cluster that arose through gene duplication, and also includes multiple redundant genes encoding the beta subunit of chorionic gonadotropin as well as several nonfunctional pseudogenes. In humans these are contiguous on chromosome 19q13.3.[6] In equids the beta subunit polypeptides of luteinizing hormone and chorionic gonadotropin are identical in sequence, differing only in their carbohydrate side-chains, and are the product of a single gene.[7]

Function[edit]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit (this protein) which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.[6]

Clinical significance[edit]

Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104826 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100916 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Sairam MR, Li CH (Feb 1976). "Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit". Biochim Biophys Acta. 412 (1): 70–81. PMID 1191677. doi:10.1016/0005-2795(75)90340-2. 
  6. ^ a b c d "Entrez Gene: LHB luteinizing hormone beta polypeptide". 
  7. ^ Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH (June 1992). "A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin". Mol. Endocrinol. 6 (6): 951–9. PMID 1379674. doi:10.1210/me.6.6.951. 

Further reading[edit]

  • Keutmann HT, Hua QX, Weiss MA (1992). "Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy". Mol. Endocrinol. 6 (6): 904–13. PMID 1495492. doi:10.1210/me.6.6.904. 
  • Weiss J, Axelrod L, Whitcomb RW, et al. (1992). "Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone". N. Engl. J. Med. 326 (3): 179–83. PMID 1727547. doi:10.1056/NEJM199201163260306. 
  • Weisshaar G, Hiyama J, Renwick AG, Nimtz M (1991). "NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin". Eur. J. Biochem. 195 (1): 257–68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x. 
  • Jameson JL, Lindell CM, Habener JF (1986). "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes". DNA. 5 (3): 227–34. PMID 2424697. doi:10.1089/dna.1986.5.227. 
  • Keutmann HT, Charlesworth MC, Mason KA, et al. (1987). "A receptor-binding region in human choriogonadotropin/lutropin beta subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 2038–42. PMC 304579Freely accessible. PMID 3470775. doi:10.1073/pnas.84.7.2038. 
  • Shome B, Parlow AF (1973). "The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH)". J. Clin. Endocrinol. Metab. 36 (3): 618–21. PMID 4685398. doi:10.1210/jcem-36-3-618. 
  • Closset J, Hennen G, Lequin RM (1973). "Human luteinizing hormone. The amino acid sequence of the subunit". FEBS Lett. 29 (2): 97–100. PMID 4719207. doi:10.1016/0014-5793(73)80534-4. 
  • Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone". Nature. 307 (5946): 37–40. PMID 6690982. doi:10.1038/307037a0. 
  • Beitins IZ, Axelrod L, Ostrea T, et al. (1981). "Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone". J. Clin. Endocrinol. Metab. 52 (6): 1143–9. PMID 6785294. doi:10.1210/jcem-52-6-1143. 
  • Berger P, Kranewitter W, Madersbacher S, et al. (1994). "Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis". FEBS Lett. 343 (3): 229–33. PMID 7513655. doi:10.1016/0014-5793(94)80561-X. 
  • Keutmann HT, Rubin DA (1993). "A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking". Endocrinology. 132 (3): 1305–12. PMID 7679977. doi:10.1210/en.132.3.1305. 
  • Herrlich A, Kühn B, Grosse R, et al. (1996). "Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C". J. Biol. Chem. 271 (28): 16764–72. PMID 8663226. doi:10.1074/jbc.271.28.16764. 
  • Muyan M, Furuhashi M, Sugahara T, Boime I (1997). "The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers". Mol. Endocrinol. 10 (12): 1678–87. PMID 8961276. doi:10.1210/me.10.12.1678. 
  • Roy AC, Liao WX, Chen Y, et al. (1997). "Identification of seven novel mutations in LH beta-subunit gene by SSCP". Mol. Cell. Biochem. 165 (2): 151–3. PMID 8979264. doi:10.1007/bf00229477. 
  • Liao WX, Roy AC, Chan C, et al. (1998). "A new molecular variant of luteinizing hormone associated with female infertility". Fertil. Steril. 69 (1): 102–6. PMID 9457942. doi:10.1016/S0015-0282(97)00445-7. 
  • O'Connor JF, Kovalevskaya G, Birken S, et al. (1998). "The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay". Hum. Reprod. 13 (4): 826–35. PMID 9619532. doi:10.1093/humrep/13.4.826. 
  • Takahashi K, Kurioka H, Ozaki T, et al. (1999). "Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients". Hum. Reprod. 13 (12): 3338–44. PMID 9886510. doi:10.1093/humrep/13.12.3338. 
  • Elter K, Erel CT, Cine N, et al. (1999). "Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome". Fertil. Steril. 71 (3): 425–30. PMID 10065776. doi:10.1016/S0015-0282(98)00491-9. 
  • Jiang M, Pakarinen P, Zhang FP, et al. (1999). "A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence". Hum. Mol. Genet. 8 (11): 2037–46. PMID 10484773. doi:10.1093/hmg/8.11.2037. 


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