Play Video
1
A Mazzanti   A mutation site approach helps predicting the phenotype expression of MYH7 mutations
A Mazzanti A mutation site approach helps predicting the phenotype expression of MYH7 mutations
::2012/10/04::
Play Video
2
Mavi Collection 2014
Mavi Collection 2014
::2014/03/24::
Play Video
3
SCOPRIAMO I SERVER!!EP 5
SCOPRIAMO I SERVER!!EP 5
::2014/02/02::
Play Video
4
Integrated Pest Management: Grape Root Borer
Integrated Pest Management: Grape Root Borer
::2012/02/10::
Play Video
5
20 years celebrations -  GOA 2011 -2012 Review
20 years celebrations - GOA 2011 -2012 Review
::2012/05/09::
Play Video
6
Jaziekat
Jaziekat's Feb Favs
::2013/03/01::
Play Video
7
ラッセル 016.AVI
ラッセル 016.AVI
::2012/02/01::
Play Video
8
Little - my beauty boy
Little - my beauty boy
::2009/10/20::
Play Video
9
Because Of You
Because Of You
::2008/01/07::
Play Video
10
Jolly
Jolly's Gallon Challenge night
::2008/09/07::
Play Video
11
Filosofia Speciolenyana
Filosofia Speciolenyana
::2011/06/07::
Play Video
12
N Frey   Role of protein degragation pathways in the pathogenesis of cardiomyopathy
N Frey Role of protein degragation pathways in the pathogenesis of cardiomyopathy
::2012/10/04::
Play Video
13
G Thiene   Lesson from History, Galileo as a patient
G Thiene Lesson from History, Galileo as a patient
::2012/10/07::
Play Video
14
F Girolami   Changing Scenarios with next generation sequencing
F Girolami Changing Scenarios with next generation sequencing
::2012/10/03::
Play Video
15
L Monserrat   Next generation genotyping, from diagnosis to prognosis
L Monserrat Next generation genotyping, from diagnosis to prognosis
::2012/10/03::
Play Video
16
R Bonow   USA, Europe and the Rest of the World, differences and similarities
R Bonow USA, Europe and the Rest of the World, differences and similarities
::2012/10/07::
Play Video
17
M G  Bongiorni   Individualised choice, prevention and managementof ICD   related to complication
M G Bongiorni Individualised choice, prevention and managementof ICD related to complication
::2012/10/03::
Play Video
18
L Mestroni   Genotyping and clinical management of DCM
L Mestroni Genotyping and clinical management of DCM
::2012/10/04::
Play Video
19
E Biagini   Genetic profile of HCM patients with LV systolic dysfunction, a multicenter study
E Biagini Genetic profile of HCM patients with LV systolic dysfunction, a multicenter study
::2012/10/03::
Play Video
20
I Olivotto   Ranolazine in chronic ischemic cardiomyopathy, benifits for the quality of life
I Olivotto Ranolazine in chronic ischemic cardiomyopathy, benifits for the quality of life
::2012/10/03::
Play Video
21
No baby gate can hold this guy
No baby gate can hold this guy
::2011/07/08::
Play Video
22
I Olivotto   Pharmacological Treatment  High Time for Evidence
I Olivotto Pharmacological Treatment High Time for Evidence
::2012/10/07::
Play Video
23
K  van Spaendonck Zwarts   Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy
K van Spaendonck Zwarts Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy
::2012/10/04::
Play Video
24
I Olivotto - Management of HCM: the case for disease staging
I Olivotto - Management of HCM: the case for disease staging
::2012/10/05::
Play Video
25
L Choudhury   Association of LV wall thickness and myocardial fibrosis scar with adverse events in HCM
L Choudhury Association of LV wall thickness and myocardial fibrosis scar with adverse events in HCM
::2012/10/03::
Play Video
26
C Ferrara - The HCM-associated cardiac Troponin T mutation K280N
C Ferrara - The HCM-associated cardiac Troponin T mutation K280N
::2012/10/05::
Play Video
27
ALEJANDRO LIMIA (ATAJADA ANTE BOCA)
ALEJANDRO LIMIA (ATAJADA ANTE BOCA)
::2012/08/28::
Play Video
28
PROTOTYPE ENT. 2013 NEW YEAR
PROTOTYPE ENT. 2013 NEW YEAR'S PARTY @ THE FACTORY
::2013/01/03::
Play Video
29
mastiksoul - moche festival
mastiksoul - moche festival
::2012/10/26::
Play Video
30
Flutterwonder Music Video
Flutterwonder Music Video
::2012/11/10::
Play Video
31
private ash3
private ash3
::2010/03/31::
Play Video
32
MPD VID (Music Video)
MPD VID (Music Video)
::2011/10/10::
Play Video
33
Clip Video Nikki
Clip Video Nikki
::2012/06/25::
NEXT >>
RESULTS [34 .. 84]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Myosin, heavy chain 7, cardiac muscle, beta

PDB rendering based on 2fxm.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MYH7 ; CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM
External IDs OMIM160760 MGI2155600 HomoloGene68044 GeneCards: MYH7 Gene
RNA expression pattern
PBB GE MYH7 204737 s at tn.png
PBB GE MYH7 216265 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4625 140781
Ensembl ENSG00000092054 ENSMUSG00000053093
UniProt P12883 Q91Z83
RefSeq (mRNA) NM_000257 NM_080728
RefSeq (protein) NP_000248 NP_542766
Location (UCSC) Chr 14:
23.88 – 23.9 Mb
Chr 14:
54.97 – 54.99 Mb
PubMed search [1] [2]

MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers).[1]

Changes in the relative abundance of MHC-β and MHC-α (MYH6, the fast isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle.[2] In early fetal development, MHC-β is predominately expressed in the ventricles, while MHC-α is predominantly expressed in the atria. In healthy adult hearts, MHC-α is predominantly expressed in the atria (>90%), while MHC-β (~50%) is expressed in the atria of failing adult hearts. In vitro studies have demonstrated that newly formed cardiac myocytes express MHC-β, and after prolonged (1-5 weeks) contractile activity MHC-α becomes detectable. An allelic variant of this gene is associated with approximately 40% of the cases of Hypertrophic cardiomyopathy (HCM). This condition is an autosomal-dominant disease, in which a single copy of the variant gene causes enlargement of the left ventricle of the heart. Disease onset usually occurs later in life, perhaps triggered by changes in thyroid hormone function and/or physical stress.

Another condition associated to mutations in this gene is paraspinal and proximal muscle atrophy (doi: 10.1016/j.nmd.2013.04.003).

A myopathy caused by a MYH7 mutation in pigs.

References[edit]

Further reading[edit]

  • Jääskeläinen P, Miettinen R, Kärkkäinen P et al. (2004). "Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes". Ann. Med. 36 (1): 23–32. doi:10.1080/07853890310017161. PMID 15000344. 
  • Kamisago M, Schmitt JP, McNamara D et al. (2007). "Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure". Novartis Found. Symp. 274: 176–89; discussion 189–95, 272–6. PMID 17019812. 

External links[edit]


Wikipedia content is licensed under the GFDL License

Mashpedia enables any individual or company to promote their own Youtube-hosted videos or Youtube Channels, offering a simple and effective plan to get them in front of our engaged audience.

Want to learn more? Please contact us at: hello@mashpedia.com

Powered by YouTube
LEGAL
  • Mashpedia © 2014