She is known most for her marriage to Donald Trump, the current President of the United States. She met Trump in 1989 and had a highly publicized relationship, with at least one breakup. The press coverage – the New York Post would have Trump appear on its cover for eight days in a row – amazed Trump, and it distinguished Maples from the many other women rumored to be dating him. The relationship produced one child, Tiffany Ariana Trump, born October 13, 1993.
On March 8, 2016, Maples was announced as one of the celebrities who would compete on season 22 of Dancing with the Stars alongside her Switching Lanes co-star, Kim Fields. She was partnered with professional dancer Tony Dovolani. Maples and Dovolani were eliminated on Week 4 of competition and finished in 10th place.
Maples also joined the women of ABC's morning talk show, The View, as a guest co-host on March 11, 2016.
Maples is committed to supporting charities and non-profit organizations, and is a long time and vocal advocate of Kids Creating Peace, an organization uniting Israeli and Palestinian children. She has shared proceeds of sales with those in need; she shared sales proceeds of her One World of Love album with Success for Kids, and proceeds from her auction with Linda's Stuff went to Spirituality for Kids.
Maples hosted her own talk radio show, Awakening with Marla, on Contact Talk Radio; her guests included naturopathic doctors, authors, and astrologers.
Maples' album The Endless, released in August 2013, is a musical journey of spiritual awakening and transformational energy, featuring thought leaders such as the Dalai Lama, Michael Beckwith, and Deepak Chopra. Each track seeks to evoke a different level of consciousness and connection, designed for deep meditation, prayer circles, or yoga sessions. In December 2012, Maples won a "Hollywood Music in Media Award" for best New Age/Ambient song, for "House of Love", from that album.
Maples is an advocate of health and wellness, with daughter Tiffany Trump confessing she used to make healthy homemade chocolate in Trump Tower; meanwhile her father would sneak her downstairs to the candy store to buy her Almond Joys. She is a self-proclaimed 'mostly-vegan' who avoids dairy, eats organic, and chooses to be gluten free. She told People Magazine that her top three tips for healthy eating are to (a) listen to your body, (b) eat organic, (c) be joyful in all you do/eat.
In 1990, Maples starred in an advertising campaign for No Excuses jeans. In 1993, she designed a line of maternity clothes, sold in several major department stores.
In January 2000, a memoir by Maples, All That Glitters Is Not Gold, was announced by the ReganBooks division of HarperCollins Publishers. In February 2002, a spokeswoman for the publishing company said that ''The author and publisher by mutual consent have agreed not to publish the book.''