The show revolves around "re-awakened Monster DNA called Monsuno" that finds its way into the unsuspecting hands of adventure-seeking teenagers Chase, Vicky, and Bren. Accompanied by their Monsuno, Lock, Charger, and Quickforce, they are searching for Chase's father Jeredy Suno, the creator of the Monsuno. They are soon joined by Noah, a monk from the Himalayas along with his Monsuno Glowblade. Noah often speaks of five people that with the help of their Monsuno, could change the world. It just so happens that they are that five, along with Ash, a teenager who along with his Monsuno Airswitch, opposes the team and is disliked among most people. The team has yet to befriend him and persuade him to join their cause. They are also on the run from a HAMMER-type agency called "STORM" (Strategic Tactical Operatives for Recovery of Monsuno) whose plans are still in question and Dr. Emanuel Klipse, a malevolent scientist who has his own nefarious plans.
The 5 adventure-seeking teenagers are once again in the battle of monsunos, now, however, with Jeredy Suno officially back from being missing or kidnapped. But along with old foes, come new, with The Forge Resistance, a manufacture bent on destroying the world with Wild Core Bombs, The STORM Strike Force, a team which could be considered the anti version of Team Core-Tech handpicked by Charlemagne, the Hand of Destiny, a team of century-old tribes who have hidden from the world underground long ago, and Six, a teenager clone of Dr. Eklipse, now on Team Core-Tech's tail, Chase and his friends are ready to take the heat. But as the battle becomes tougher, the team must face new problems and must come to connect to their monsunos than ever before.
The characters are accompanied by Monsunos (giant high-tech and/or armored hybrid monsters of one or more animal species), which are contained in cylinder regeneration chamber capsules known as "cores".
Chase(チェイス?) (voiced by KENN in the Japanese dub, Cam Clarke in the original English) - One of the main protagonists. A brave and adventurous boy, Chase is the leader of Team Core-Tech. In First Season "World Masters," Chase engages on a journey to find his father Jeredy Suno, a research scientist who disappeared while experimenting with the mysterious power source called Monsuno Essence which brought him into conflict with both the corrupt government agency STORM and the rouge scientist Dr Klipse. In the Second Season "Combat Chaos" Chase is repeatedly having visions of this mother Sophia who was believed to be deceased which leaves him to confront The Hand of Destiny which might have a hand at Sophia's disappearance.
Lock(ロック?) - One of Chase's monsters.Chase's first partner. He is a hybrid of a polar bear, a gorilla, and a tiger. He was later combined with Evo to form Lock 2.0.
Evo(イーボ?) - One of Chase's monsters. He is a hybrid of a condor and a swan. He was later combined with Lock to form Lock 2.0.
Nightjackal(ナイトジャッカル?) - One of Chase's monsters. He is a hybrid of a jackal and a panther.
Baryon(バリオン?) - One of Chase's monsters. She is a hybrid of a mandrill and a rat.
Deep-six(ディープシックス?) - one of Chase's new monsters in season 2. This monsuno is a hybrid of a shark and a wolf.
Batteram(バッテラム?) - another of Chase's new monsters for season 2. He resembles a ram.
Bren(ブレン?) (voiced by Chihiro Suzuki in the Japanese dub, Christopher Corey Smith in the original English) - One of the main protagonists. A timid but inquisitive boy whose an adept computer programer and hacker. Bren is one of Chase's closes friends and is usually the one to master or decode any piece of Technology or Monsuno Equipment that Team Core-Tech comes across. Bren has a bit of a playfully antagonistic relationship with Jinja.
Quickforce(クイックフォース?) - One of Bren's monsters. He is a hybrid of an antelope and a raven that resembles a hippogriff. In the Season 2 Premiere Quickforce was destroyed by a wild core bomb.
Longfang(ロングファング,Rongufangu?) - One of Bren's monsters. He is a hybrid of a sabertooth tiger with mineral diamond.
Shellshot(シェルショット?) - One of Bren's monsters. He has a chelonian appearance.
Neo-Quickforce(ネオクイックフォース?) - One of Bren's new monsters in season 2 to replace Quickforce. While his general appearance is the same as Quickforce's, he has different abilities.
Vicky(ビッキー?) (voiced by Asami Tano in the Japanese dub, Karen Strassman in the original English) - One of the main protagonists, Jinja is the self-proclaimed "sassy" and genuinely outspoken tomboy member of Team Core-Tech whose often the first one into battle. Jinja is a strong supporter to Chase in his journeys and is known to playfully tease Bren on occasion. Jinja might posses an attraction with Ash even though she might not admit it aloud.
Whipper(ホイッパー?) - One of Vicky's monsters. He resembles of a frilled lizard.
Skyfall(スカイフォール?) - One of Vicky's monsters in season 2. She is a hybrid of a hawk, a butterfly and a bat.
Noah (ノア?) (voiced by Sachi Kokuryu in the Japanese dub, Kirk Thornton in the original English) - A supporting protagonist. An introspective and spiritual young man, Noae was introduced in the episode "Knowledge" as a monk who possesses "The Monsuno Sight" ; A special ability that allows one to see into the future. Noah aided Chase, Bren, and Jinja escape from The Booksman's evil clutches and joined Team Core-Tech afterwards.
Glowblade(グローブレイド?) - One of Noah's monsters. He is a hybrid of a three-headed snake and a spider.
Axeblade(アックスブレイド?) - One of Noah's monsters. He is a hybrid of a spider.
Mistyblade(ミスティブレイド?) - One of Noah's monsters in season 2. He is a hybrid of a wolf, a boa constrictor and an eagle. He resembles the mythical Aztec creature Quetzalcoatl.
Ash(アッシュ?) (voiced by Hiroshi Shimozaki in the Japanese dub, Keith Silverstein in the original English) - A cocky young drifter that joined Team Core-Tech in the episode R.S.P.V Dax has a mysterious past that might tie into Dr Klipse illegal Monsuno research. In the original English version, he has a bit of an Australian accent.
Airswitch(エアスイッチ?) - One of Ash's monsters. He is a hybrid of a hawk, a vulture and a lizard.
Boostsaber(ブーストサーベル?) - One of Ash's monsters. He is a hybrid of a wolf and a wildcat.
Charlemagne(シャルルマーニュ?) (voiced by Aki Kanada in the Japanese dub, Karen Strassman in the original English) - The stern and ruthless head of STORM agency. She was behind Master Ey's death in season two.
Kingblade(キングブレイド?) - One of Charlemagne's monsters. It resembles an armored lion. Kingblade was later combined with Sonicbird to form Driftblade 20.
Trey(トレイ?) (voiced by Yoshihito Sasaki in the Japanese dub, Keith Silverstein in the original English) - STORM's second-in-command general.
Heavypanzer(ヘビーパンツァー?) - One of Trey's monsters. It resembles an armored Hercules beetle.
Clipper(クリッパー?) - One of Trey's monsters. It resembles a hybrid of an bird.
Ghillienoyd(ギリーノイド?) - One of Trey's monsters. It resembles an armored chameleon.
Beeponad(ビーポネード?) - one of Trey's monsters. it resembles a bird.
Jon Ace(ジョン・エース?) (voiced by Daisuke Matsuoka in the Japanese version, Christopher Corey Smith in the English dub) - Jeredy's assistant. After he had been captured by Eklipse, he was turned into a Half-Monsuno creature called Toxic Ace. He returns to human form late into season 2, and at the end, becomes the new head of STORM.
Sonicbird(ソニックバード?) - One of Ace's monsters. He is a hybrid of a falcon and a crow. Later used by Charlemagne who combined him with Kingblade to form Driftblade 20.
Goldhorn(ゴールドホーン?) - One of Ace's monsters. She is a hybrid of a wild boar and a rabbit.
Captain(大佐?) (voiced by Christopher Corey Smith in the English dub) - A high-ranking agent of STORM After Captain's Monsuno were defeated by Bren's Longfang, Charlemagne demoted him to lieutenant.
Hydrosword(ハイドロソード?) - One of Captain's monsters. It has the head of a hammerhead shark and the body of an unknown animal. Later used by the STORM Elite.
STORM Soldiers(STORM 兵士?) - The foot soldiers of STORM.
STORM Elite(STORM エリート?) - The elite agents of STORM who are skilled in the use of monsuno.
Crossbolt(クロスボルト?) - One of the STORM Elite's monsters. It looks like an armored wildebeast with enormous tusks.
Skysite(スカイサイト?) - One of the STORM Elite's monsters. It is a four-headed serpentine monsuno with saw-like wings that spin in a circle. From below, it looks like an UFO.
Dr. Emmanuel Klipse(エマニュエル・クリプス博士?) (voiced by Masami Iwasaki in the Japanese version, Cam Clarke in the English dub) - A former member of STORM who is the primary antagonist of "Monsuno: World Masters." A brilliant but amoral scientist who was a former partner of Dr Jeredy Suno on Monsuno Essence. Dr. Klipse is determined to capture Chase and his Monsuno Lock whom he believes could be “the linchpin” in his master plans. Dr Klipse is also the creator of The Monsuno Fighting Underground and DarkSpin, a ruthless group of mercenaries.
Hellbreaker(ヘルブレイカー?) - One of Klipse's monsters. It is a hybrid of a Gray wolf and a grizzly bear that resembles a werewolf. Hellbreaker was later combined with Shadowhornet to form Backslash 20.
Hargrave(ハーグレイブ?) (voiced by Kirk Thornton in the English dub) - Klipse's loyal butler. He has the Monsuno sight, but has not realised this, which is why he suddenly collapses in season 2's finale.
Shadowhornet(シャドーホーネット?) - One of Hargrave's monsters. It is a hybrid of a bat and a scorpion. Later combined with Hellbreaker to form Hellbreaker 20.
Flamechoppar(フレイムチョッパー?) - One of Hargrave's monsters. It is a hybrid of a tarantula and a wasp.
Twinsting(ツインスティング?) - One of Hargrave's monsters. It resembles a hybrid of a spider with two scorpion tails.
Dom Pyro (voiced by Keith Ferguson in the English dub) - A mercenary and demented collector of rare antiques who possesses Monsuno visions and is hunting Chase Suno and his friends to add in his collection.
Killerzaurer(キラーザウラー?) - Dragonburn is one of Dom's monsters. It is a hybrid of a dragon and a Velociraptor.
Number Six(ナンバー・シックス?) (voiced by Keith Silverstein in the English dub) - The sixth clone of Dr. Emmanuel Klipse.
The Darkspin Gang are a group of mercenaries who have worked for Eklipse and S.T.O.R.M. Among its members are:
Medea(メディーア?) (voiced by Karen Strassman in the English dub) - The beautiful yet wicked leader of the Darkspin Gang and one of Klipse's spies sent to hunt down Chase Suno. Medea is undeniably cunning yet dangerously unstable, and commands absolute loyalty from her subordinates. Medea is obsessed with Chase and forcing him to engage her in the perfect Monsuno battle.
wingviper(ウィングバイパー?) - One of Medea's monsters. It is a hybrid of a dragonfly and a cobra. It was renamed Wingviper(ウィングバイパー,Wingubaipā?) in the Japanese version.
Doxiclaw(ドクシックロー?) - One of Medea's monsters. It resembles a hybrid of a mantis and a beetle.
Dragonwolf(ドラゴンウルフ?) - One of Medea's monsters. It resembles a hybrid of a dragon and a wolf.
The Desert Wolves are a group of people who go around preaching the freedom of Monsuno. Among its members are:
Joker(ジョーカー?) (voiced by Kirk Thornton in the English dub) - The leader of the Desert Wolves. He was once a STORM Elite because he had the power to communicate with Monsuno. Charlemagne put him with a Monsuno who broke his right leg, hand, and eye. After that, he wanted to free all the Monsunos.
Meteostriker(メテオストライカー?) -One of Joker's monsters. It resembles a red panther. A former Eklipse.
Geo(ジオ?) (voiced by Keith Silverstein in the English dub) - The hammer-wielding member of the Desert Wolf.
Stingworm(スティングウォーム?) - One of NA Man's monsters. It is a hybrid of a dragonfly and a centipede.
Becca(ベッカ?) (voiced by Karen Strassman in the English dub) - Member of the Desert Wolf. Mute Woman is the unofficial name of this female operative and is sister of Noah,and adoptive daughter of Master Ey
Beofulton(ベオフルトン?) - One of Mute Woman's monsters. It resembles a three-horned rhinoceros with claw-tipped arms coming out of its shoulders.
Forge (フォージ) is a team of orange core users introduced in the second season. Its motto is "Destruction be our calling card, mayhem be our hands."
Professor Tallis(タリス教授?) (voiced by Keith Ferguson in the English dub) - The leader of Forge. He once worked for STORM before leaving for unknown reasons. He has a cybernetic eye and a metal plate covering his mouth. He stutters when he speaks. After Chase thwarts his plan to destroy Westward City, he swears revenge against him.
Shadowclaw - One of Tallis's monsters. It resemples a hybrid of a hawk. It is shown in episode 40 for first time.
Drezz(ドレッズ?) (voiced by Keith Silverstein in the English dub) - The leader of the Punk Monks posing as an informant for Core-Tech in episode 27.
X-100(X-100?) - One of Drezz's monsters. It resembles a cyborg tiger with antelope-like antlers.
Tryvulcan(トライバルカン?) - One of Drezz's monsters. It looks like a cyborg hydra with three heads.
Biohound(バイオハウンド?) - One of Drezz's monsters. It resembles a cyborg bull with antelope-like antlers.
Jeredy Suno(ジェレディ・スーノ?) (voiced by Keiji Fujiwara in the Japanese version, Cam Clarke in the English dub) - Chase's father. Originally a researcher working for S.T.O.R.M., he went missing before both S.T.O.R.M. and Chase Suno tried to find him. He was often abducted at the end of season 1.
Sophia Suno(ソフィア・スーノ?) (voiced by Karen Strassman in the English dub) - Chase Suno's mother. During Chase Suno's quest of finding Jeredy Suno, she appeared in Chase's vision. She is the damsel in distress in season two, as it is implied the Hand of Destiny kidnapped her over 10 years ago, and that she had transported Noah to Chase's side during the episode "Insight".
The Bookman(ベクター卿?) (voiced by Christopher Corey Smith in the English dub) - The Bookman is the Bookkeeper for the monks at the Library of Tebab who wants to control an army of monsuno to conquer the world.
Deltahound(デルタハウンド?) - One of The Bookman's monsters. It resembles a red wolf with the back of a turtle.
Dawnmaster(ドーンマスター?) (voiced Kirk Thornton in the English dub) - A professional thief and an ally of Core-Tech. Helped to change all the books in the library to master Ey.
Skyleopard(スカイレパード?) - One of Dawnmaster's monsters. It is a hybrid of a jaguar and an eagle.
Master Ey(マスター・エイ?) (voiced by Keith Silverstein in the English dub) - Beyal's spiritual mentor and head monk of Tebab. He is killed in Season two when Charlemagne takes control of Jack's mind.
Digby Droog(ドルーグ?) (voiced Kirk Thornton in the English dub) - A mysterious character who appears halfway through season one. His generous hospitality for Team Core-Tech is a welcome treat which Bren is more than happy to oblige. Unbeknownst to the kids, he harbors an undying resentment for the Monsunos, and seeing they were not destroyed at the end of season 1, he becomes a villain during season 2, with the sole goal of activating Jeredy's failsafe device, fulfilling his vendetta.
Sid(シド?) - A merchant. He has the Monsuno sight, but is not aware of this.
Kimi(キミ?) (voiced by Karen Strassman in the English dub) - A 12-year-old girl following Dawnmaster.
Although the series had been aired in North America, and across the world, the Japanese version of the series was delayed. Earlier, it was reported that Monsuno was being produced for TV Tokyo on Fremantle Media Kids' website, though was later changed to reflect that the show had begun airing across the world, including in the US. Later on June 14, 2012, it was announced that Japan would get the series, starting in October 2012 at the Bandai booth for the Tokyo Toy Show. Here, it was announced the show would air under the name, Juusen Battle Monsuno and that the toyline would hit Japan in September 2012. Later that same month, it was announced through the launch of TV Tokyo's website and various other outlets, that Monsuno would indeed air on the TV Tokyo Network in October, on an unspecified date. Here the cast and staff were announced, as well as the renaming of certain characters and that the Japanese version would retain the same soundtrack as the English version. Chase Suno, retaining his name in the Japanese version, would be voiced by KENN, a well known actor and singer in Japan who had previously done the voice of Judai from Yu-Gi-Oh! GX and Jil from The Tower of Druaga. Bren and most of the S.T.O.R.M. and Eklipse characters, would retain their original names, however, most of the Core-Tech cast would be renamed. Jinja was renamed Vicky, Beyal to Noah, and Dax to Ash. In a tweet response to when someone asked about the name changes, co-creator Jared Wolfson responded on Twitter, saying "Names were slightly altered in order to better suit the Japanese market". 
The series premiered on October 3, 2012 at 6:00 pm JST on six TXN-affiliated TV stations and ran new episodes on Wednesday evenings in that timeslot until the series finale on September 25, 2013. After a special spin-off series of Inazuma Eleven GO!, which aired on Tuesday mornings at 7:30 am JST, was canceled due to low ratings, reruns of the first 13 episodes were broadcast in its place between January 2, 2013 and March 26, 2013, when they were taken off the schedule to make room for a Japanese dub of My Little Pony: Friendship is Magic.
Jakks Pacific owns exclusive worldwide rights to manufacture Monsuno's toy products. Jakks Pacific is distributing directly in the United States and Canada. Bandai will be the distribution partner in Japan; Giochi Preziosi will distribute in Europe. In Australia and New Zealand, Banter Toys & Collectibles will be the distribution partner.
^Jinja / Medea Production Art - It should be noted that Vicky was originally used as her name in the production art, later getting changed to Vicky for the Japanese release. As a result, there are two different renderings of her name.