Orient Thai Airlines and its now-defunct wholly owned domestic carrier One-Two-GO Airlines are the only Thai airlines to bear a royal seal, made possible by the owner's, Udom Tantiprasonchai, close relationship with the King of Thailand, based on Mr Tantiprasongchai's history of breaking traditional commercial barriers for Thailand. Prior to their current location, Orient Thai and its subsidiary One-Two-GO were headquartered in Don Mueang District, Bangkok.
On 22 July 2008, shortly after the crash of One-Two-GO Airlines Flight 269 in Phuket which killed 89 people, and after the Internet publication of illegally excessive work hours and check ride fraud, Orient Thai and One-Two-GO were ordered to suspend service for 56 days.
On 22 September 2010, Orient Thai took delivery of its first Boeing 747-400 aircraft, previously registered as N548MD, and arrived at the Orient Thai base as HS-STC.
On September 2004, an Orient Thai 747 mistakenly flew within 200 meters of Japan's Tokyo Tower over the heart of downtown Tokyo.
On 31 July 2013, a chartered Orient Thai 737-400 operating as OX833 made an emergency landing at Surat Thani airport, carrying Chinese passengers from Shenzhen to Phuket. None of the 130 passengers and nine crew was injured.