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Protocadherin 1
Identifiers
Symbols PCDH1 ; PC42; PCDH42
External IDs OMIM603626 MGI104692 HomoloGene12613 GeneCards: PCDH1 Gene
RNA expression pattern
PBB GE PCDH1 215277 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5097 75599
Ensembl ENSG00000156453 ENSMUSG00000051375
UniProt Q08174 Q8CFX3
RefSeq (mRNA) NM_002587 NM_029357
RefSeq (protein) NP_002578 NP_083633
Location (UCSC) Chr 5:
141.23 – 141.26 Mb
Chr 18:
38.19 – 38.21 Mb
PubMed search [1] [2]

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.[1][2]

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.[2]

References[edit]

  1. ^ Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J 12 (6): 2249–56. PMC 413453. PMID 8508762. 
  2. ^ a b "Entrez Gene: PCDH1 protocadherin 1". 

Further reading[edit]

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