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1
PFN2
PFN2
::2013/02/24::
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2
2011 05 Torneio Niveis Acro PFN2 EVS Constança Rafaela
2011 05 Torneio Niveis Acro PFN2 EVS Constança Rafaela
::2011/05/29::
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3
PFN2
PFN2
::2008/02/29::
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4
Willow Hollow PFN-2
Willow Hollow PFN-2
::2013/09/02::
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5
"LET
"LET'S GO" - LIVE m/ PFn #2! - (Call of Duty: Ghost)
::2014/03/14::
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6
PFN 2-4-55 (Lava-Ro)
PFN 2-4-55 (Lava-Ro)
::2012/04/04::
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7
พวกเราคือ PFN 2
พวกเราคือ PFN 2
::2011/11/23::
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8
RN vs PFN 2รอบแล้วนะ PFN
RN vs PFN 2รอบแล้วนะ PFN
::2012/02/07::
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9
PFN 2 ( Primos Felizes News )
PFN 2 ( Primos Felizes News )
::2010/12/09::
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10
PFN 2
PFN 2
::2010/11/28::
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11
Ebo X Gutta- Young Nigga #KlanLyfeMixtape (Shot By. @RaeAccardoSB)
Ebo X Gutta- Young Nigga #KlanLyfeMixtape (Shot By. @RaeAccardoSB)
::2013/07/01::
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12
Akcent - King of Disco (Official Video) (SD).mp4
Akcent - King of Disco (Official Video) (SD).mp4
::2013/11/07::
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13
Salvation Is Here - Ridgefest 2013
Salvation Is Here - Ridgefest 2013
::2013/06/04::
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14
Would You Rather?!
Would You Rather?!
::2014/04/24::
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15
Cena de Accion de Gracias 2010 - Danzare
Cena de Accion de Gracias 2010 - Danzare
::2011/11/19::
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16
Sean being dumb.
Sean being dumb.
::2013/01/01::
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17
TG
TG
::2013/03/23::
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18
SON OF A CRACKER!(sasha and Mary)
SON OF A CRACKER!(sasha and Mary)
::2009/05/26::
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19
Wisin & Yandel   Besos Mojados La Revolucion Official 2009
Wisin & Yandel Besos Mojados La Revolucion Official 2009
::2009/07/03::
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20
Brasada.wmv
Brasada.wmv
::2009/12/29::
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21
團體 156
團體 156
::2011/01/02::
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22
PFN vs SD Tournament Gold-Ro รอบชิงชนะเลิศ (9-2-56)
PFN vs SD Tournament Gold-Ro รอบชิงชนะเลิศ (9-2-56)
::2013/02/10::
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23
PFN vs ESP Tournament Est-Ro (รอบชิงชนะเลิศ)
PFN vs ESP Tournament Est-Ro (รอบชิงชนะเลิศ)
::2012/12/24::
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24
Baby B is for Bear Applique Fleece Blanket - Kiddicare
Baby B is for Bear Applique Fleece Blanket - Kiddicare
::2011/11/08::
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25
Orz  วอเก็บคะแนน SD กาก
Orz วอเก็บคะแนน SD กาก
::2011/11/04::
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26
Ginástica acrobática ARC Azenha - Rita e Soraia (Alfândega da Fé)
Ginástica acrobática ARC Azenha - Rita e Soraia (Alfândega da Fé)
::2013/04/27::
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27
PFN 6-1-56 (Lemon-Ro)
PFN 6-1-56 (Lemon-Ro)
::2013/01/07::
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28
Trio nível 2 ARCA Gimno Júnior 2013 Acro
Trio nível 2 ARCA Gimno Júnior 2013 Acro
::2013/05/26::
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29
2013_02_Distrital_VC_WG_Youth_Comb_SCP_Mafalda_FIlipa_Gabrie
2013_02_Distrital_VC_WG_Youth_Comb_SCP_Mafalda_FIlipa_Gabrie
::2013/03/09::
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30
PFN 11-10-55  (Idol-Ro)
PFN 11-10-55 (Idol-Ro)
::2012/10/12::
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31
Gigi Finizio
Gigi Finizio
::2012/03/02::
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32
MW2: Sick Ts På Rust
MW2: Sick Ts På Rust
::2014/03/15::
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33
yr11 vs yr10
yr11 vs yr10
::2010/10/27::
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34
kro Ragnarok Server War 20100429
kro Ragnarok Server War 20100429
::2011/01/29::
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35
Rn vs เซาะกราว
Rn vs เซาะกราว
::2012/02/06::
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36
$potlight
$potlight
::2011/01/09::
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37
PFN vs TSM Tournament Lava-Ro
PFN vs TSM Tournament Lava-Ro
::2012/04/04::
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38
jornal dos primos ep 3
jornal dos primos ep 3
::2011/12/11::
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39
Pedro Fosas Nasales
Pedro Fosas Nasales
::2010/11/28::
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40
Pleasure of Flavour @ D44
Pleasure of Flavour @ D44
::2008/02/29::
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41
Bad lightening lighting
Bad lightening lighting
::2013/09/01::
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42
RN vs FE.wmv
RN vs FE.wmv
::2012/06/15::
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43
Trickster Online - LadyNoell VS Tenter
Trickster Online - LadyNoell VS Tenter
::2011/11/25::
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44
PFN 21-12-55 (Est-Ro)
PFN 21-12-55 (Est-Ro)
::2012/12/22::
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45
PFN 9-9-55 (Dont-Ro)
PFN 9-9-55 (Dont-Ro)
::2012/09/10::
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46
PFN 27-11-55 (Omo-Ro)
PFN 27-11-55 (Omo-Ro)
::2012/11/28::
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47
2011 05 Sarau EDV Trampolins IV
2011 05 Sarau EDV Trampolins IV
::2011/05/28::
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48
Conjunto 10 maças - Estadual - Nivel 1
Conjunto 10 maças - Estadual - Nivel 1
::2013/12/14::
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49
ESP vs ASC Tournament Skylab-Ro
ESP vs ASC Tournament Skylab-Ro
::2011/12/12::
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50
jornal dos primos ep.1
jornal dos primos ep.1
::2011/11/12::
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RESULTS [51 .. 101]
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Profilin 2

PDB rendering based on 1d1j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PFN2 ; D3S1319E; PFL
External IDs OMIM176590 MGI97550 HomoloGene130904 GeneCards: PFN2 Gene
RNA expression pattern
PBB GE PFN2 204992 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5217 18645
Ensembl ENSG00000070087 ENSMUSG00000027805
UniProt P35080 Q9JJV2
RefSeq (mRNA) NM_002628 NM_019410.3
RefSeq (protein) NP_002619 NP_062283.1
Location (UCSC) Chr 3:
149.68 – 149.77 Mb
Chr 3:
57.65 – 57.65 Mb
PubMed search [1] [2]

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.[1][2][3]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.[3]

Interactions[edit]

PFN2 has been shown to interact with ROCK1,[4] Vasodilator-stimulated phosphoprotein,[5][6] CCDC113[7] and FMNL1.[8]

References[edit]

  1. ^ Joensuu T, Blanco G, Pakarinen L, Sistonen P, Kaariainen H, Brown S, Chapelle A, Sankila EM (March 1997). "Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region". Genomics 38 (3): 255–63. doi:10.1006/geno.1996.0626. PMID 8975700. 
  2. ^ Honore B, Madsen P, Andersen AH, Leffers H (October 1993). "Cloning and expression of a novel human profilin variant, profilin II". FEBS Lett 330 (2): 151–5. doi:10.1016/0014-5793(93)80262-S. PMID 8365484. 
  3. ^ a b "Entrez Gene: PFN2 profilin 2". 
  4. ^ Da Silva, Jorge Santos; Medina Miguel, Zuliani Cecilia, Di Nardo Alessia, Witke Walter, Dotti Carlos G (September 2003). "RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability". J. Cell Biol. (United States) 162 (7): 1267–79. doi:10.1083/jcb.200304021. ISSN 0021-9525. PMC 2173969. PMID 14517206. 
  5. ^ Reinhard, M; Giehl K, Abel K, Haffner C, Jarchau T, Hoppe V, Jockusch B M, Walter U (April 1995). "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins". EMBO J. (ENGLAND) 14 (8): 1583–9. ISSN 0261-4189. PMC 398250. PMID 7737110. 
  6. ^ Harbeck, B; Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. (UNITED STATES) 275 (40): 30817–25. doi:10.1074/jbc.M005066200. ISSN 0021-9258. PMID 10882740. 
  7. ^ "Coiled-Coil Domain Containing 113". GeneCards. Retrieved 5/8/2013. 
  8. ^ Yayoshi-Yamamoto, S; Taniuchi I, Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6872–81. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683. 

Further reading[edit]



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