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1
Profilin
Profilin
::2012/08/21::
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2
WWE 24/7 - Stylin
WWE 24/7 - Stylin' and Profilin'
::2008/05/05::
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3
GloryDaysTV - Stylin
GloryDaysTV - Stylin' and Profilin'
::2008/01/24::
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4
Firefox - Stylin Profilin
Firefox - Stylin Profilin
::2010/03/05::
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5
The Whitehead Brothers 1986 Stylin & Profilin
The Whitehead Brothers 1986 Stylin & Profilin
::2013/06/03::
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6
Firefox -- Stylin
Firefox -- Stylin', Profilin' ( Breakdance 2 )
::2013/05/24::
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7
WYND CHYMES - stylin
WYND CHYMES - stylin', smylin' & profilin' - 1982
::2012/09/19::
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8
Shady Nate - Profilin
Shady Nate - Profilin' Ft. Lil B
::2010/07/25::
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9
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
::2012/07/17::
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10
DiRT Showdown - Stylin
DiRT Showdown - Stylin' and Profilin' Achievement/Trophy Guide
::2012/06/12::
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11
Shiko kush ju ka vizituar profilin ne facebook
Shiko kush ju ka vizituar profilin ne facebook
::2014/01/02::
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12
Stylin
Stylin' and Profilin' - Saints Row 4 PC Co-Op pt.4
::2013/12/01::
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13
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
::2008/09/13::
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14
The Whitehead Brothers Stylin
The Whitehead Brothers Stylin' and Profilin'
::2011/06/26::
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15
Stylin and Profilin
Stylin and Profilin
::2014/05/04::
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16
FACEBOOK DA LIMITI DOLMUW PROFILIN ADINI DEYIWMEK
FACEBOOK DA LIMITI DOLMUW PROFILIN ADINI DEYIWMEK
::2013/07/02::
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17
ShadowTrader Video - 02.02.14 - Stylin
ShadowTrader Video - 02.02.14 - Stylin' & Market Profilin
::2014/02/01::
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18
Maria Molina - ATSS 4/25/14 Profilin
Maria Molina - ATSS 4/25/14 Profilin'
::2014/06/14::
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19
Si Te Ketheni Profilin Ne Fan Page
Si Te Ketheni Profilin Ne Fan Page
::2011/04/22::
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20
The Whitehead Brothers(Kenny And Johnny) - Stylin And Profilin
The Whitehead Brothers(Kenny And Johnny) - Stylin And Profilin
::2010/04/03::
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21
LASD/ Union Station Public Servants Walking Around Profilin
LASD/ Union Station Public Servants Walking Around Profilin
::2013/12/06::
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22
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin' And Profilin' To The Musical Prom
::2009/03/19::
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23
SHPERNDAJE EZANIN NE PROFILIN TEND
SHPERNDAJE EZANIN NE PROFILIN TEND
::2014/02/02::
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24
Tux
Tux's Top 20 Anime Divas Voiced By Wendee Lee: Stylin' & Profilin'
::2014/07/26::
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25
1FMC and Ric Flair Stylin and Profilin
1FMC and Ric Flair Stylin and Profilin
::2014/06/19::
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26
JAYDAD THE GRATE (SPENDING) RACIAL PROFILIN.. LOYALTY FAMILY..
JAYDAD THE GRATE (SPENDING) RACIAL PROFILIN.. LOYALTY FAMILY..
::2013/11/01::
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27
Stylin
Stylin' & Profilin'!
::2013/10/29::
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28
SI te caktivizojm profilin fb .......
SI te caktivizojm profilin fb .......
::2014/04/30::
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29
Video #5 Stylin
Video #5 Stylin' & Profilin' Part 2
::2014/07/21::
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30
JAYDAD THE GRATE(LIVE ON STAGE) RACIAL PROFILIN. LOYALTY FAMILY.
JAYDAD THE GRATE(LIVE ON STAGE) RACIAL PROFILIN. LOYALTY FAMILY.
::2013/07/25::
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31
Video # 4 Stylin
Video # 4 Stylin' & Profilin' Part 1
::2014/07/09::
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32
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
::2014/02/09::
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33
The Lyricists - Profilin
The Lyricists - Profilin'
::2009/06/20::
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34
Profilin Remix - Biggie The Kid & Loon The Goon
Profilin Remix - Biggie The Kid & Loon The Goon
::2012/02/25::
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35
Watch Dogs: Profilin
Watch Dogs: Profilin' is Wrong (Super Edit)
::2014/05/27::
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36
Ric Flair Stylin and Profilin Episode 1
Ric Flair Stylin and Profilin Episode 1
::2008/07/22::
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37
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
::2011/04/22::
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38
Jem and the Holograms - She Makes An Impression (Stylin
Jem and the Holograms - She Makes An Impression (Stylin' and Profilin' Mix)
::2012/11/09::
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39
BBCP 1.1 Yuuki Stylin
BBCP 1.1 Yuuki Stylin' N Profilin' Terumi
::2014/07/09::
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40
newLEGACYinc Stylin And Racial Profilin
newLEGACYinc Stylin And Racial Profilin
::2013/11/03::
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41
DiRT Showdown - Stylin and Profilin Achievement Guide
DiRT Showdown - Stylin and Profilin Achievement Guide
::2012/05/28::
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42
Bulls
Bulls 'PROFILIN' Red-Black Fitted Hat by New Era
::2014/06/11::
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43
What
What's Going On! EPA Stylin' & Profilin'
::2013/01/29::
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44
Profilin
Profilin' - HOward MOody
::2008/10/18::
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45
Knicks
Knicks 'PROFILIN' Orange-Royal Fitted Hat by New Era
::2014/06/11::
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46
Vendos Music Player ne Profilin e Facebook
Vendos Music Player ne Profilin e Facebook
::2010/04/17::
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47
Edgar "Baby Gervin" Sosa: Stylin
Edgar "Baby Gervin" Sosa: Stylin' and Profilin'... para las Mujeres!
::2009/03/28::
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48
Lakers
Lakers 'PROFILIN' Gold-Purple Fitted Hat by New Era
::2014/06/11::
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49
Smackdown vs Raw 2007 | Season Mode - Stylin
Smackdown vs Raw 2007 | Season Mode - Stylin' and Profilin' - EP7
::2013/05/23::
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50
Clyde
Clyde's Closet: Stylin' & Profilin' in Plaid & Pleats (2/20)
::2013/02/21::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Profilin
Profilin actin complex.png
Profilin (blue) in complex with actin (green). (PDB code: 2BTF)
Identifiers
Symbol Profilin
Pfam PF00235
InterPro IPR002097
SMART PROF
PROSITE PS00414
SCOP 2btf
SUPERFAMILY 2btf

Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton. It is found in all eukaryotic organisms in most cells. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. This restructuring of the actin cytoskeleton is essential for processes such as organ development, wound healing, and the hunting down of infectious intruders by cells of the immune system.

Profilin also binds sequences rich in the amino acid proline in diverse proteins. While most profilin in the cell is bound to actin, profilins have over 50 different binding partners. Many of those are related to actin regulation, but profilin also seems to be involved in activities in the nucleus such as mRNA splicing.[1]

Profilin binds some variants of membrane phospholipids (Phosphatidylinositol (4,5)-bisphosphate and Inositol triphosphate). The function of this interaction is the sequestration of profilin in an "inactive" form, from where it can be released by action of the enzyme phospholipase C.

Profilin is the major allergen present in birch, grass, and other pollen.

Profilin sources and distribution[edit]

Profilins are proteins of molecular weights of roughly 14–16 kDa. They are present as single genes in yeast, insects, and worms, and as multiple genes in many other organisms including plants. In mammalian cells, four profilin isoforms have been discovered; profilin-I is expressed in most tissues while profilin-II is predominant in brain and kidney.[2]

Profilin in the regulation of actin dynamics[edit]

Profilin enhances actin growth in two ways:

  • Profilin binds to monomeric actin thereby occupying an actin-actin contact site; in effect, profilin sequesters actin from the pool of polymerizable actin monomers. However, profilin also catalyzes the exchange of actin-bound ADP to ATP thereby converting poorly polymerizing ADP-actin monomers into readily polymerizing ATP-actin monomers. On top of that, profilin has a higher affinity for ATP- than for ADP-actin monomers. Thus in a mixture of actin, profilin, and nucleotides (ADP and ATP), actin will polymerize to a certain extent, which may be estimated by the law of mass action.
  • Profilin-actin complexes are fed into growing actin polymers by proteins such as formin, WASP and VASP (that contain proline-rich FH2-domains). This mode of stimulated actin polymerization is much faster than unaided polymerization. Profilin is essential for this mode of polymerization because it recruits the actin monomers to the proline-rich proteins.

Profilin also negatively regulates PI(3,4)P2 limiting recruitment of lamellipodin to the leading edge of the cell

Profilin is one of the most abundant actin monomer binders, but proteins such as CAP and (in mammals) thymosin β4 have some functional overlaps with profilin. In contrast, ADF/cofilin has some properties that antagonize profilin action.

History of profilin discovery[edit]

Profilin was first described by Uno Lindberg and co-workers in the early 1970s as the first actin monomer binding protein.[3] It followed the realization that not only muscle, but also non-muscle cells, contained high concentrations of actin, albeit in part in an unpolymerized form. Profilin was then believed to sequester actin monomers (keep them in a pro-filamentous form), and release them upon a signal to make them accessible for fast actin polymer growth.

Genes[edit]

References[edit]

  1. ^ Di Nardo A, Gareus R, Kwiatkowski D, Witke W (November 2000). "Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms". J. Cell. Sci. 113 (Pt 21): 3795–803. PMID 11034907. 
  2. ^ Witke W, Podtelejnikov AV, Di Nardo A, et al. (February 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". EMBO J. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375. 
  3. ^ Carlsson L, Nyström LE, Sundkvist I, Markey F, Lindberg U (September 1977). "Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells". J. Mol. Biol. 115 (3): 465–83. doi:10.1016/0022-2836(77)90166-8. PMID 563468. 

Bae YH, Ding Z, Das T, Wells A, Gertler F, Roy P (November 2010). "Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells". Proc. Natl. Acad. Sci. U.S.A. 107 (50): 21547–21552. doi:10.1073/pnas.1002309107. PMC 3003040. PMID 21115820. 

External links[edit]

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