Play Video
1
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
::2012/07/17::
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2
WWE 24/7 - Stylin
WWE 24/7 - Stylin' and Profilin'
::2008/05/05::
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3
Let
Let's Play Steamworld Dig - Ep. 1 - Steampunk Minin' & Profilin'
::2014/03/11::
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4
Ric Flair Stylin and Profilin Episode 1
Ric Flair Stylin and Profilin Episode 1
::2008/07/22::
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5
Mario Kart Wii: Stylin and Profilin - Part 1
Mario Kart Wii: Stylin and Profilin - Part 1
::2013/08/21::
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6
Profilin
Profilin
::2012/08/21::
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7
GloryDaysTV - Stylin
GloryDaysTV - Stylin' and Profilin'
::2008/01/24::
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8
The Whitehead Brothers 1986 Stylin & Profilin
The Whitehead Brothers 1986 Stylin & Profilin
::2013/06/03::
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9
WYND CHYMES - stylin
WYND CHYMES - stylin', smylin' & profilin' - 1982
::2012/09/19::
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10
Shady Nate - Profilin
Shady Nate - Profilin' Ft. Lil B
::2010/07/25::
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11
Firefox -- Stylin
Firefox -- Stylin', Profilin' ( Breakdance 2 )
::2013/05/24::
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12
DiRT Showdown - Stylin
DiRT Showdown - Stylin' and Profilin' Achievement/Trophy Guide
::2012/06/12::
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13
ShadowTrader Video - 02.02.14 - Stylin
ShadowTrader Video - 02.02.14 - Stylin' & Market Profilin
::2014/02/01::
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14
Stylin
Stylin' and Profilin' - Saints Row 4 PC Co-Op pt.4
::2013/12/01::
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15
facebook profilin ilin kohneltmey
facebook profilin ilin kohneltmey
::2013/12/22::
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16
Deck Profilin Madolches!
Deck Profilin Madolches!
::2012/11/09::
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17
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
::2008/09/13::
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18
What
What's Going On! EPA Stylin' & Profilin'
::2013/01/29::
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19
Shiko kush ju ka vizituar profilin ne facebook
Shiko kush ju ka vizituar profilin ne facebook
::2014/01/02::
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20
newLEGACYinc Stylin And Racial Profilin
newLEGACYinc Stylin And Racial Profilin
::2013/11/03::
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21
DiRT Showdown - Stylin and Profilin Achievement Guide
DiRT Showdown - Stylin and Profilin Achievement Guide
::2012/05/28::
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22
Dilatasyon Derz Kesimi Eski Profilin Sökülmesi
Dilatasyon Derz Kesimi Eski Profilin Sökülmesi
::2014/03/21::
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23
Dirt Showdown Achievement Guide - Stylin
Dirt Showdown Achievement Guide - Stylin' and Profilin'
::2012/05/27::
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24
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
::2014/02/09::
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25
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
::2011/04/22::
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26
Stylin
Stylin' & Profilin'!
::2013/10/29::
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27
Pokemon Y: Episode 13: Stylin
Pokemon Y: Episode 13: Stylin' and Profilin'
::2014/03/02::
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28
H8!Machine - Evil Travels Even By Bus EP - Profilin
H8!Machine - Evil Travels Even By Bus EP - Profilin' (Fleshwound 01)
::2014/04/04::
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29
B Hav - Hi Profilin
B Hav - Hi Profilin' (Feat. Allie Baby)
::2013/08/23::
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30
Si Te Bejme Profilin e Ri ne Facebook.com
Si Te Bejme Profilin e Ri ne Facebook.com
::2011/12/22::
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31
DMH 51 NC İLE OKUL SIRALINDA KULLANILAN PROFILIN BÜKÜMÜ VIDEOSU
DMH 51 NC İLE OKUL SIRALINDA KULLANILAN PROFILIN BÜKÜMÜ VIDEOSU
::2013/07/19::
Play Video
32
Dirt ShowDown Stylin And Profilin Achievement
Dirt ShowDown Stylin And Profilin Achievement
::2012/08/07::
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33
Clyde
Clyde's Closet: Stylin' & Profilin' in Plaid & Pleats (2/20)
::2013/02/21::
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34
Profilin
Profilin' - Wade Baker Trio
::2013/09/03::
Play Video
35
How to remove facebook timeline 100% Works. (Si te rikthejme Profilin e vjeter)
How to remove facebook timeline 100% Works. (Si te rikthejme Profilin e vjeter)
::2012/08/02::
Play Video
36
Stylin and Profilin - Rock The Locks
Stylin and Profilin - Rock The Locks
::2013/12/03::
Play Video
37
De Blasio on stop and frisk; too many Dems against profilin
De Blasio on stop and frisk; too many Dems against profilin
::2013/08/07::
Play Video
38
Yugioh Stylin
Yugioh Stylin' and Profilin': GaGaGa's
::2013/10/19::
Play Video
39
Smackdown vs Raw 2007 | Season Mode - Stylin
Smackdown vs Raw 2007 | Season Mode - Stylin' and Profilin' - EP7
::2013/05/23::
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40
APB Reloaded: Stylin
APB Reloaded: Stylin' & Profilin'
::2012/07/08::
Play Video
41
Si te aktivizosh profilin ri ne Facebook - Timeline
Si te aktivizosh profilin ri ne Facebook - Timeline
::2011/11/20::
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42
JAYDAD THE GRATE (SPENDING) RACIAL PROFILIN.. LOYALTY FAMILY..
JAYDAD THE GRATE (SPENDING) RACIAL PROFILIN.. LOYALTY FAMILY..
::2013/11/01::
Play Video
43
Jem and the Holograms - She Makes An Impression (Stylin
Jem and the Holograms - She Makes An Impression (Stylin' and Profilin' Mix)
::2012/11/09::
Play Video
44
Stylin
Stylin' & Deck Profilin' Blackwings (September 2013 Format)
::2013/09/06::
Play Video
45
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin' And Profilin' To The Musical Prom
::2009/03/19::
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46
♡Stylin & Profilin: Summer Neon Crop Top OOTD♡
♡Stylin & Profilin: Summer Neon Crop Top OOTD♡
::2013/07/17::
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47
Stylin
Stylin' and Profilin'
::2008/01/28::
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48
regulating actin filament formation
regulating actin filament formation
::2010/11/03::
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49
Wade Baker Jazz Collaboration performing "Profilin
Wade Baker Jazz Collaboration performing "Profilin'" @ Redmoor Theater
::2011/02/20::
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50
Midnight Club Los Angeles Walkthrough - High Profilin
Midnight Club Los Angeles Walkthrough - High Profilin'
::2011/08/01::
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RESULTS [51 .. 101]
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Profilin 1

PDB rendering based on 1awi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PFN1 ; ALS18
External IDs OMIM176610 MGI97549 HomoloGene3684 GeneCards: PFN1 Gene
RNA expression pattern
PBB GE PFN1 200634 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5216 18643
Ensembl ENSG00000108518 ENSMUSG00000018293
UniProt P07737 P62962
RefSeq (mRNA) NM_005022 NM_011072
RefSeq (protein) NP_005013 NP_035202
Location (UCSC) Chr 17:
4.85 – 4.85 Mb
Chr 11:
70.65 – 70.65 Mb
PubMed search [1] [2]

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.[1][2]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.[3]

Interactions[edit]

Profilin 1 has been shown to interact with WASF1,[4] FMNL1,[5] WASL,[6][7] MLLT4[8] and Vasodilator-stimulated phosphoprotein.[9]

References[edit]

  1. ^ Kwiatkowski DJ, Bruns GA (May 1988). "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis". J Biol Chem 263 (12): 5910–5. PMID 3356709. 
  2. ^ Kwiatkowski DJ, Aklog L, Ledbetter DH, Morton CC (April 1990). "Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome". Am J Hum Genet 46 (3): 559–67. PMC 1683621. PMID 1968707. 
  3. ^ "Entrez Gene: PFN1 profilin 1". 
  4. ^ Miki, H; Suetsugu S, Takenawa T (December 1998). "WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac". EMBO J. (ENGLAND) 17 (23): 6932–41. doi:10.1093/emboj/17.23.6932. ISSN 0261-4189. PMC 1171041. PMID 9843499. 
  5. ^ Yayoshi-Yamamoto, S; Taniuchi I, Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6872–81. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683. 
  6. ^ Mimuro, H; Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (September 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. (UNITED STATES) 275 (37): 28893–901. doi:10.1074/jbc.M003882200. ISSN 0021-9258. PMID 10867004. 
  7. ^ Suetsugu, S; Miki H, Takenawa T (November 1998). "The essential role of profilin in the assembly of actin for microspike formation". EMBO J. (ENGLAND) 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. ISSN 0261-4189. PMC 1170999. PMID 9822597. 
  8. ^ Boettner, B; Govek E E, Cross J, Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9064–9. doi:10.1073/pnas.97.16.9064. ISSN 0027-8424. PMC 16822. PMID 10922060. 
  9. ^ Harbeck, B; Hüttelmaier S, Schluter K, Jockusch B M, Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. (UNITED STATES) 275 (40): 30817–25. doi:10.1074/jbc.M005066200. ISSN 0021-9258. PMID 10882740. 

Further reading[edit]



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