Play Video
1
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
::2012/07/17::
Play Video
2
WWE 24/7 - Stylin
WWE 24/7 - Stylin' and Profilin'
::2008/05/05::
Play Video
3
Video # 4 Stylin
Video # 4 Stylin' & Profilin' Part 1
::2014/07/09::
Play Video
4
Let
Let's Play Steamworld Dig - Ep. 1 - Steampunk Minin' & Profilin'
::2014/03/11::
Play Video
5
Mario Kart Wii: Stylin and Profilin - Part 1
Mario Kart Wii: Stylin and Profilin - Part 1
::2013/08/21::
Play Video
6
Ric Flair Stylin and Profilin Episode 1
Ric Flair Stylin and Profilin Episode 1
::2008/07/22::
Play Video
7
GloryDaysTV - Stylin
GloryDaysTV - Stylin' and Profilin'
::2008/01/23::
Play Video
8
Profilin
Profilin
::2012/08/21::
Play Video
9
Firefox - Stylin Profilin
Firefox - Stylin Profilin
::2010/03/05::
Play Video
10
Firefox -- Stylin
Firefox -- Stylin', Profilin' ( Breakdance 2 )
::2013/05/24::
Play Video
11
Deck Profilin Madolches!
Deck Profilin Madolches!
::2012/11/09::
Play Video
12
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
Si te kthejme profilin ne fanpage ne facebook - ArditTutorials
::2011/04/22::
Play Video
13
Shady Nate - Profilin
Shady Nate - Profilin' Ft. Lil B
::2010/07/25::
Play Video
14
DiRT Showdown - Stylin
DiRT Showdown - Stylin' and Profilin' Achievement/Trophy Guide
::2012/06/11::
Play Video
15
Shiko kush ju ka vizituar profilin ne facebook
Shiko kush ju ka vizituar profilin ne facebook
::2014/01/01::
Play Video
16
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
Janette Beckman / The Breaks : Stylin and Profilin 1982-1990
::2008/09/13::
Play Video
17
Stylin
Stylin' and Profilin' - Saints Row 4 PC Co-Op pt.4
::2013/12/01::
Play Video
18
Maria Molina - ATSS 4/25/14 Profilin
Maria Molina - ATSS 4/25/14 Profilin'
::2014/06/14::
Play Video
19
Video #5 Stylin
Video #5 Stylin' & Profilin' Part 2
::2014/07/21::
Play Video
20
1FMC and Ric Flair Stylin and Profilin
1FMC and Ric Flair Stylin and Profilin
::2014/06/19::
Play Video
21
Zbulo kush sheh profilin tend...Scopri chi vedee il tuo profilo di fb...Find out who views your
Zbulo kush sheh profilin tend...Scopri chi vedee il tuo profilo di fb...Find out who views your
::2014/06/14::
Play Video
22
Stylin and Profilin
Stylin and Profilin
::2014/05/04::
Play Video
23
ShadowTrader Video - 02.02.14 - Stylin
ShadowTrader Video - 02.02.14 - Stylin' & Market Profilin
::2014/01/31::
Play Video
24
Tux
Tux's Top 20 Anime Divas Voiced By Wendee Lee: Stylin' & Profilin'
::2014/07/26::
Play Video
25
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin
Schecter Tempest Custom Takes Its Tuxedo Appointments All Stylin' And Profilin' To The Musical Prom
::2009/03/19::
Play Video
26
Official Liker - Perfito 1000 Like ne Profilin Facebook
Official Liker - Perfito 1000 Like ne Profilin Facebook
::2014/05/18::
Play Video
27
Watch Dogs: Profilin
Watch Dogs: Profilin' is Wrong (Super Edit)
::2014/05/27::
Play Video
28
BBCP 1.1 Yuuki Stylin
BBCP 1.1 Yuuki Stylin' N Profilin' Terumi
::2014/07/08::
Play Video
29
Stylin
Stylin' & Profilin'!
::2013/10/29::
Play Video
30
The Whitehead Brothers Stylin
The Whitehead Brothers Stylin' and Profilin'
::2011/06/26::
Play Video
31
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
VRASESI SINANAJ PROKURORIA DO TE REALIZOJE PROFILIN PSIKOLOGJIK TE KILLERIT LAJM
::2014/02/09::
Play Video
32
newLEGACYinc Stylin And Racial Profilin
newLEGACYinc Stylin And Racial Profilin
::2013/11/03::
Play Video
33
Si Te Verifikojm Faqen Ose Profilin Ne FaceBook
Si Te Verifikojm Faqen Ose Profilin Ne FaceBook
::2014/08/13::
Play Video
34
Stylin and profilin. Yep. I
Stylin and profilin. Yep. I'm wearing a dress suit.
::2014/05/01::
Play Video
35
Profilin Remix - Biggie The Kid & Loon The Goon
Profilin Remix - Biggie The Kid & Loon The Goon
::2012/02/25::
Play Video
36
B Hav - Hi Profilin
B Hav - Hi Profilin' (Feat. Allie Baby)
::2013/08/23::
Play Video
37
Midnight Club Los Angeles Walkthrough - High Profilin
Midnight Club Los Angeles Walkthrough - High Profilin'
::2011/08/01::
Play Video
38
DMH 51 NC İLE OKUL SIRALINDA KULLANILAN PROFILIN BÜKÜMÜ VIDEOSU
DMH 51 NC İLE OKUL SIRALINDA KULLANILAN PROFILIN BÜKÜMÜ VIDEOSU
::2013/07/19::
Play Video
39
What
What's Going On! EPA Stylin' & Profilin'
::2013/01/29::
Play Video
40
Clyde
Clyde's Closet: Stylin' & Profilin' in Plaid & Pleats (2/20)
::2013/02/21::
Play Video
41
Si Te Ketheni Profilin Ne Fan Page
Si Te Ketheni Profilin Ne Fan Page
::2011/04/22::
Play Video
42
Touch My Katamari - Episode 4: STYLIN & PROFILIN
Touch My Katamari - Episode 4: STYLIN & PROFILIN
::2014/05/04::
Play Video
43
Styling and profilin By  JayEBeats   Vine
Styling and profilin By JayEBeats Vine
::2013/09/07::
Play Video
44
Tekkit survival island dag 7: Styling
Tekkit survival island dag 7: Styling' and profilin' and red
::2013/01/18::
Play Video
45
Pokemon Y: Episode 13: Stylin
Pokemon Y: Episode 13: Stylin' and Profilin'
::2014/03/02::
Play Video
46
CBS
CBS' John Miller: Stylin' & profilin'.
::2012/12/14::
Play Video
47
Jem and the Holograms - She Makes An Impression (Stylin
Jem and the Holograms - She Makes An Impression (Stylin' and Profilin' Mix)
::2012/11/09::
Play Video
48
Si Te Bejm Verifired Faqen Tuaj Ose Profilin Fallco
Si Te Bejm Verifired Faqen Tuaj Ose Profilin Fallco
::2014/08/26::
Play Video
49
Smackdown vs Raw 2007 | Season Mode - Stylin
Smackdown vs Raw 2007 | Season Mode - Stylin' and Profilin' - EP7
::2013/05/23::
Play Video
50
Stylin
Stylin' & Deck Profilin' Blackwings (September 2013 Format)
::2013/09/05::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Profilin 1
Protein PFN1 PDB 1awi.png
PDB rendering based on 1awi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PFN1 ; ALS18
External IDs OMIM176610 MGI97549 HomoloGene3684 GeneCards: PFN1 Gene
RNA expression pattern
PBB GE PFN1 200634 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5216 18643
Ensembl ENSG00000108518 ENSMUSG00000018293
UniProt P07737 P62962
RefSeq (mRNA) NM_005022 NM_011072
RefSeq (protein) NP_005013 NP_035202
Location (UCSC) Chr 17:
4.85 – 4.85 Mb
Chr 11:
70.65 – 70.65 Mb
PubMed search [1] [2]

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.[1][2]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.[3]

Interactions[edit]

Profilin 1 has been shown to interact with WASF1,[4] FMNL1,[5] WASL,[6][7] MLLT4[8] and Vasodilator-stimulated phosphoprotein.[9]

References[edit]

  1. ^ Kwiatkowski DJ, Bruns GA (May 1988). "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis". J Biol Chem 263 (12): 5910–5. PMID 3356709. 
  2. ^ Kwiatkowski DJ, Aklog L, Ledbetter DH, Morton CC (April 1990). "Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome". Am J Hum Genet 46 (3): 559–67. PMC 1683621. PMID 1968707. 
  3. ^ "Entrez Gene: PFN1 profilin 1". 
  4. ^ Miki, H; Suetsugu S; Takenawa T (December 1998). "WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac". EMBO J. (ENGLAND) 17 (23): 6932–41. doi:10.1093/emboj/17.23.6932. ISSN 0261-4189. PMC 1171041. PMID 9843499. 
  5. ^ Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6872–81. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683. 
  6. ^ Mimuro, H; Suzuki T; Suetsugu S; Miki H; Takenawa T; Sasakawa C (September 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. (UNITED STATES) 275 (37): 28893–901. doi:10.1074/jbc.M003882200. ISSN 0021-9258. PMID 10867004. 
  7. ^ Suetsugu, S; Miki H; Takenawa T (November 1998). "The essential role of profilin in the assembly of actin for microspike formation". EMBO J. (ENGLAND) 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. ISSN 0261-4189. PMC 1170999. PMID 9822597. 
  8. ^ Boettner, B; Govek E E; Cross J; Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9064–9. doi:10.1073/pnas.97.16.9064. ISSN 0027-8424. PMC 16822. PMID 10922060. 
  9. ^ Harbeck, B; Hüttelmaier S; Schluter K; Jockusch B M; Illenberger S (October 2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. (UNITED STATES) 275 (40): 30817–25. doi:10.1074/jbc.M005066200. ISSN 0021-9258. PMID 10882740. 

Further reading[edit]



Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014