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Proteins with SH2 or PTB domains that interact with Receptor Tyrosine Kinases
Proteins with SH2 or PTB domains that interact with Receptor Tyrosine Kinases
Published: 2017/04/19
Channel: Life Science Help
Protein folding of src SH3 domain by a Go model
Protein folding of src SH3 domain by a Go model
Published: 2013/06/06
Channel: Takada Lab @ Kyoto U
4.4 Mechanism of receptor tyrosine kinase (RTK) action
4.4 Mechanism of receptor tyrosine kinase (RTK) action
Published: 2017/08/22
Channel: Mark Temple
AMP or PEDAL or BOTH?  Taurus SH3 Stomp-Head
AMP or PEDAL or BOTH? Taurus SH3 Stomp-Head
Published: 2017/11/17
Channel: The Tone King
Sh3 c0me f1rst
Sh3 c0me f1rst
Published: 2017/12/13
Channel: Nash Hoffman
SH3 torpedo solution demonstration
SH3 torpedo solution demonstration
Published: 2010/01/11
Channel: C I
Gene Music using Protein Sequence of SH3KBP1 "SH3-DOMAIN KINASE BINDING PROTEIN 1"
Gene Music using Protein Sequence of SH3KBP1 "SH3-DOMAIN KINASE BINDING PROTEIN 1"
Published: 2016/11/13
Channel: Gene Music Studio
DO SH3
DO SH3
Published: 2017/10/31
Channel: Gina King
Gene Music using Protein Sequence of SH3BP2 "SH3-DOMAIN BINDING PROTEIN 2"
Gene Music using Protein Sequence of SH3BP2 "SH3-DOMAIN BINDING PROTEIN 2"
Published: 2016/10/15
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3BP1 "SH3-DOMAIN BINDING PROTEIN 1"
Gene Music using Protein Sequence of SH3BP1 "SH3-DOMAIN BINDING PROTEIN 1"
Published: 2016/11/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GL3 "SH3-DOMAIN GRB2-LIKE 3"
Gene Music using Protein Sequence of SH3GL3 "SH3-DOMAIN GRB2-LIKE 3"
Published: 2016/03/02
Channel: Gene Music Studio
Let
Let's Play Splatterhouse Classics - SH3 Stage 3
Published: 2014/05/18
Channel: Fiendly
Gene Music using Protein Sequence of G3BP1 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Gene Music using Protein Sequence of G3BP1 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Published: 2016/07/05
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3BP5 "SH3-DOMAIN BINDING PROTEIN 5 (BTK-ASSOCIATED)"
Gene Music using Protein Sequence of SH3BP5 "SH3-DOMAIN BINDING PROTEIN 5 (BTK-ASSOCIATED)"
Published: 2016/05/18
Channel: Gene Music Studio
SH3 Multiple Manual Targeting with Navmap contacts
SH3 Multiple Manual Targeting with Navmap contacts
Published: 2015/10/27
Channel: magnitogorski
Kwaisey Pee - Sh3 Ahw3n33  ft. Fresh Prince
Kwaisey Pee - Sh3 Ahw3n33 ft. Fresh Prince
Published: 2012/01/10
Channel: GhanaPromo TV
SH3-Can a ratio help me solve problems?
SH3-Can a ratio help me solve problems?
Published: 2018/02/16
Channel: Gina King
Gene Music using Protein Sequence of SH3GL1 "SH3-DOMAIN GRB2-LIKE 1"
Gene Music using Protein Sequence of SH3GL1 "SH3-DOMAIN GRB2-LIKE 1"
Published: 2016/04/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GL2 "SH3-DOMAIN GRB2-LIKE 2"
Gene Music using Protein Sequence of SH3GL2 "SH3-DOMAIN GRB2-LIKE 2"
Published: 2016/03/02
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 3"
Gene Music using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 3"
Published: 2017/02/07
Channel: Gene Music Studio
Gene Music using Protein Sequence of UBASH3A "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING A"
Gene Music using Protein Sequence of UBASH3A "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING A"
Published: 2016/11/21
Channel: Gene Music Studio
Gene Music using Protein Sequence of SBK2 "SH3 DOMAIN BINDING KINASE FAMILY, MEMBER 2"
Gene Music using Protein Sequence of SBK2 "SH3 DOMAIN BINDING KINASE FAMILY, MEMBER 2"
Published: 2016/03/01
Channel: Gene Music Studio
Gene Music using Protein Sequence of G3BP2 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Gene Music using Protein Sequence of G3BP2 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Published: 2016/09/12
Channel: Gene Music Studio
Gene Music using Protein Sequence of SORBS2 "SORBIN AND SH3 DOMAIN CONTAINING 2"
Gene Music using Protein Sequence of SORBS2 "SORBIN AND SH3 DOMAIN CONTAINING 2"
Published: 2016/11/21
Channel: Gene Music Studio
Gene Music Using Protein Sequence of SH3BGRL "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN LIKE"
Gene Music Using Protein Sequence of SH3BGRL "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN LIKE"
Published: 2015/11/19
Channel: Gene Music Studio
Gene Music using Protein Sequence of UBASH3B "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING B"
Gene Music using Protein Sequence of UBASH3B "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING B"
Published: 2016/12/10
Channel: Gene Music Studio
Gene Music using Protein Sequence of SORBS3 "SORBIN AND SH3 DOMAIN CONTAINING 3"
Gene Music using Protein Sequence of SORBS3 "SORBIN AND SH3 DOMAIN CONTAINING 3"
Published: 2016/11/21
Channel: Gene Music Studio
Listen - PacMan Feat. sh3 & Michael Milner 🔥
Listen - PacMan Feat. sh3 & Michael Milner 🔥
Published: 2018/02/08
Channel: G MusicTour
Gene Music using Protein Sequence of SH3BGR "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN"
Gene Music using Protein Sequence of SH3BGR "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN"
Published: 2015/12/28
Channel: Gene Music Studio
Gene Music using Protein Sequence of SASH1 "SAM AND SH3 DOMAIN CONTAINING 1"
Gene Music using Protein Sequence of SASH1 "SAM AND SH3 DOMAIN CONTAINING 1"
Published: 2017/04/22
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP1 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 1"
Gene Music using Protein Sequence of ASAP1 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 1"
Published: 2017/04/15
Channel: Gene Music Studio
Gene Music using Protein Sequence of SGIP1 "SH3-DOMAIN GRB2-LIKE (ENDOPHILIN) INTERACTING PROTEIN 1"
Gene Music using Protein Sequence of SGIP1 "SH3-DOMAIN GRB2-LIKE (ENDOPHILIN) INTERACTING PROTEIN 1"
Published: 2017/01/26
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3BP5L "SH3-BINDING DOMAIN PROTEIN 5-LIKE"
Gene Music using Protein Sequence of SH3BP5L "SH3-BINDING DOMAIN PROTEIN 5-LIKE"
Published: 2016/04/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP2 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 2"
Gene Music using Protein Sequence of ASAP2 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 2"
Published: 2017/04/15
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3D21 "SH3 DOMAIN CONTAINING 21"
Gene Music using Protein Sequence of SH3D21 "SH3 DOMAIN CONTAINING 21"
Published: 2016/11/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3D19 "SH3 DOMAIN CONTAINING 19"
Gene Music using Protein Sequence of SH3D19 "SH3 DOMAIN CONTAINING 19"
Published: 2017/01/26
Channel: Gene Music Studio
sh3
sh3
Published: 2017/12/13
Channel: кинокоптер
Gene Music using Protein Sequence of SASH3 "SAM AND SH3 DOMAIN CONTAINING 3"
Gene Music using Protein Sequence of SASH3 "SAM AND SH3 DOMAIN CONTAINING 3"
Published: 2016/04/07
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3RF2 "SH3 DOMAIN CONTAINING RING FINGER 2"
Gene Music using Protein Sequence of SH3RF2 "SH3 DOMAIN CONTAINING RING FINGER 2"
Published: 2017/01/26
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GLB1 "SH3-DOMAIN GRB2-LIKE ENDOPHILIN B1"
Gene Music using Protein Sequence of SH3GLB1 "SH3-DOMAIN GRB2-LIKE ENDOPHILIN B1"
Published: 2016/03/02
Channel: Gene Music Studio
ON3 ANGRY HUMAN / SH3 WOLF X Favorite Dress
ON3 ANGRY HUMAN / SH3 WOLF X Favorite Dress
Published: 2018/01/26
Channel: ON3 ANGRY HUMAN
Gene Music using Protein Sequence of SH3RF1 "SH3 DOMAIN CONTAINING RING FINGER 1"
Gene Music using Protein Sequence of SH3RF1 "SH3 DOMAIN CONTAINING RING FINGER 1"
Published: 2017/03/10
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3RF3 "SH3 DOMAIN CONTAINING RING FINGER 3"
Gene Music using Protein Sequence of SH3RF3 "SH3 DOMAIN CONTAINING RING FINGER 3"
Published: 2017/03/10
Channel: Gene Music Studio
Gene Music Quartet using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH D"
Gene Music Quartet using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH D"
Published: 2017/05/08
Channel: Gene Music Studio
Sh3 million tools of trade provided to people living with disabilities in Trans Nzoia
Sh3 million tools of trade provided to people living with disabilities in Trans Nzoia
Published: 2017/12/19
Channel: DailyNation
SH3 Dimerization
SH3 Dimerization
Published: 2014/07/07
Channel: Thirumalai Lab
Gene Music using Protein Sequence of STAC "SH3 AND CYSTEINE RICH DOMAIN"
Gene Music using Protein Sequence of STAC "SH3 AND CYSTEINE RICH DOMAIN"
Published: 2016/04/18
Channel: Gene Music Studio
SH3 DROP D3AD
SH3 DROP D3AD
Published: 2017/12/27
Channel: ЅlΙМZΣЄ400ТΝ TƲ
SH3
SH3
Published: 2009/01/15
Channel: mattaeca1024
Gene Music using Protein Sequence of SH3PXD2A "SH3 AND PX DOMAINS 2A"
Gene Music using Protein Sequence of SH3PXD2A "SH3 AND PX DOMAINS 2A"
Published: 2017/05/01
Channel: Gene Music Studio
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WIKIPEDIA ARTICLE

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SH3 domain
1shg SH3 domain.png
Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
Identifiers
Symbol SH3_1
Pfam PF00018
Pfam clan CL0010
InterPro IPR001452
SMART SM00326
PROSITE PS50002
SCOP 1shf
SUPERFAMILY 1shf
CDD cd00174

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.[1][2] It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25.[3][4][5] SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways[6] and regulating the interactions of proteins involved in the cytoplasmic signaling.[7]

Structure[edit]

The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.[8]

Peptide binding[edit]

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold.

Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif:

-X-P-p-X-P-
 1 2 3 4 5

with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.

SH3 interactomes[edit]

SH3 domain mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis.[9][10] Nevertheless, orthologous SH3 domain-mediated interactions are highly rewired between worm and yeast.[9]

Proteins with SH3 domain[edit]

See also[edit]

References[edit]

  1. ^ Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Current Biology. 3 (7): 434–42. doi:10.1016/0960-9822(93)90350-W. PMID 15335710. 
  2. ^ Mayer BJ (April 2001). "SH3 domains: complexity in moderation". Journal of Cell Science. 114 (Pt 7): 1253–63. PMID 11256992. 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M (July 1992). "SH3--an abundant protein domain in search of a function". FEBS Letters. 307 (1): 55–61. doi:10.1016/0014-5793(92)80901-R. PMID 1639195. 
  4. ^ Mayer BJ, Baltimore D (January 1993). "Signalling through SH2 and SH3 domains". Trends in Cell Biology. 3 (1): 8–13. doi:10.1016/0962-8924(93)90194-6. PMID 14731533. 
  5. ^ Pawson T (February 1995). "Protein modules and signalling networks". Nature. 373 (6515): 573–80. doi:10.1038/373573a0. PMID 7531822. 
  6. ^ Schlessinger J (February 1994). "SH2/SH3 signaling proteins". Current Opinion in Genetics & Development. 4 (1): 25–30. doi:10.1016/0959-437X(94)90087-6. PMID 8193536. 
  7. ^ Koch CA, Anderson D, Moran MF, Ellis C, Pawson T (May 1991). "SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins". Science. 252 (5006): 668–74. PMID 1708916. 
  8. ^ Whisstock JC, Lesk AM (April 1999). "SH3 domains in prokaryotes". Trends in Biochemical Sciences. 24 (4): 132–3. doi:10.1016/s0968-0004(99)01366-3. PMID 10322416. 
  9. ^ a b Xin, Xiaofeng; Gfeller, David; Cheng, Jackie; Tonikian, Raffi; Sun, Lin; Guo, Ailan; Lopez, Lianet; Pavlenco, Alevtina; Akintobi, Adenrele (2013-01-01). "SH3 interactome conserves general function over specific form". Molecular Systems Biology. 9: 652. doi:10.1038/msb.2013.9. ISSN 1744-4292. PMC 3658277Freely accessible. PMID 23549480. 
  10. ^ Tonikian, Raffi; Xin, Xiaofeng; Toret, Christopher P.; Gfeller, David; Landgraf, Christiane; Panni, Simona; Paoluzi, Serena; Castagnoli, Luisa; Currell, Bridget (2009-10-01). "Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins". PLOS Biology. 7 (10): e1000218. doi:10.1371/journal.pbio.1000218. ISSN 1545-7885. PMC 2756588Freely accessible. PMID 19841731. 

External links[edit]

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