1
Protein folding of src SH3 domain by a Go model
Protein folding of src SH3 domain by a Go model
DATE: 2013/06/06::
2
SH3 Dimerization
SH3 Dimerization
DATE: 2014/07/07::
3
SH2 Domain Phosphotyrosine Capture Kits
SH2 Domain Phosphotyrosine Capture Kits
DATE: 2009/04/28::
4
metadynamics in essential coordinates
metadynamics in essential coordinates
DATE: 2007/12/01::
5
Sts-1
Sts-1
DATE: 2013/03/28::
6
Henry Chang - The roles of Ack family kinases in Drosophila development
Henry Chang - The roles of Ack family kinases in Drosophila development
DATE: 2013/10/25::
7
04 Cancer Signalling
04 Cancer Signalling
DATE: 2014/10/30::
8
MBoC : Crucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ...
MBoC : Crucial role for the LSP1-myosin1e bimolecular complex in the regulation of Fcγ...
DATE: 2015/03/12::
9
PLoS ONE : Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells
PLoS ONE : Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells
DATE: 2015/02/28::
10
Introduction to Chemical Biology 128. Lecture 18. Terpenes and Cell Signaling, Part 2
Introduction to Chemical Biology 128. Lecture 18. Terpenes and Cell Signaling, Part 2
DATE: 2013/03/15::
11
Parkin E3 ubiquitin ligase
Parkin E3 ubiquitin ligase
DATE: 2013/09/19::
12
CASK / Lin-2 kinase domain (with sound)
CASK / Lin-2 kinase domain (with sound)
DATE: 2013/02/09::
13
Albania - przejazd drogą SH3. Trasa Elbasan - Librazhd - Qukes - Prrenjas - Qafe Thane.
Albania - przejazd drogą SH3. Trasa Elbasan - Librazhd - Qukes - Prrenjas - Qafe Thane.
DATE: 2013/10/04::
14
Let
Let's play Silent Hunter 3 (GWX) patrol 4 part 1
DATE: 2014/12/26::
15
p21 activated protein kinase
p21 activated protein kinase
DATE: 2012/09/23::
16
Tikhnet Show Episode #4 (sh3`let Elly malo sh3`le) برنامج تخنت الحلقة #4 (شغلة اللي مالو شغلة (
Tikhnet Show Episode #4 (sh3`let Elly malo sh3`le) برنامج تخنت الحلقة #4 (شغلة اللي مالو شغلة (
DATE: 2015/03/08::
17
Stephanie -Organic Chem class at Wagner college-HIV integrase
Stephanie -Organic Chem class at Wagner college-HIV integrase
DATE: 2014/11/19::
18
CCoM SH3 Cmdr MOD Tunes
CCoM SH3 Cmdr MOD Tunes
DATE: 2015/03/15::
19
SH3 voiceattack
SH3 voiceattack
DATE: 2015/04/27::
20
VIIA Rear torpedo doors SH3
VIIA Rear torpedo doors SH3
DATE: 2015/02/15::
21
Seaking SH3 Biritsh Coast Guard landing at Den Helder Airport
Seaking SH3 Biritsh Coast Guard landing at Den Helder Airport
DATE: 2012/01/06::
22
SH3
SH3
DATE: 2012/11/28::
23
SH3 Tutorial Part 10
SH3 Tutorial Part 10
DATE: 2015/04/15::
24
SH3 Tutorial Part 22
SH3 Tutorial Part 22
DATE: 2015/05/09::
25
SH3 Tutorial Part 11
SH3 Tutorial Part 11
DATE: 2015/04/15::
26
SH3 Tutorial Part 21
SH3 Tutorial Part 21
DATE: 2015/04/15::
27
SH3 Tutorial Part 08
SH3 Tutorial Part 08
DATE: 2015/04/15::
28
SH3 Tutorial Part 18
SH3 Tutorial Part 18
DATE: 2015/04/15::
29
SH3 Tutorial Part 03
SH3 Tutorial Part 03
DATE: 2015/04/12::
30
SH3 Tutorial Part 12
SH3 Tutorial Part 12
DATE: 2015/04/15::
31
SH3 Tutorial Part 20
SH3 Tutorial Part 20
DATE: 2015/04/15::
32
SH3 Tutorial Part 13
SH3 Tutorial Part 13
DATE: 2015/04/15::
33
SH3 Tutorial Part 01
SH3 Tutorial Part 01
DATE: 2015/04/12::
34
SH3 Tutorial Part 16
SH3 Tutorial Part 16
DATE: 2015/04/15::
35
SH3 Tutorial Part 09
SH3 Tutorial Part 09
DATE: 2015/04/15::
36
SH3 Tutorial Part 06
SH3 Tutorial Part 06
DATE: 2015/04/15::
37
ALEX MAYER Монтаж SH3: Секреты
ALEX MAYER Монтаж SH3: Секреты
DATE: 2013/09/17::
38
Serie um medroso jogando sh3  Parte 1
Serie um medroso jogando sh3 Parte 1
DATE: 2014/11/29::
39
¡DESTRIPANDO PORTAVIONES! - Episodio 1 - SH3 - Biel40
¡DESTRIPANDO PORTAVIONES! - Episodio 1 - SH3 - Biel40
DATE: 2013/12/05::
40
Um medroso jogando sh3  Parte 2
Um medroso jogando sh3 Parte 2
DATE: 2014/11/29::
41
on ap lioa 100kva- ổn áp 100kva SH3- ổn áp 100kva-lioa nhat linh 100kva 0913 839 600
on ap lioa 100kva- ổn áp 100kva SH3- ổn áp 100kva-lioa nhat linh 100kva 0913 839 600
DATE: 2013/10/25::
42
ODM reps to pay Sh3,000 a month each
ODM reps to pay Sh3,000 a month each
DATE: 2015/04/09::
43
SH3 Part 1
SH3 Part 1
DATE: 2014/10/12::
44
Microphone Test for SH3
Microphone Test for SH3
DATE: 2014/10/12::
45
SH3 Part 4
SH3 Part 4
DATE: 2014/10/13::
46
SH3 Part 6
SH3 Part 6
DATE: 2014/10/13::
47
SH3 Part 5
SH3 Part 5
DATE: 2014/10/13::
48
Silent Hill Book of Lost Memories - Part1
Silent Hill Book of Lost Memories - Part1
DATE: 2009/09/10::
49
SH3 Tutorial Part 19
SH3 Tutorial Part 19
DATE: 2015/04/15::
50
SH3 Tutorial Part 14
SH3 Tutorial Part 14
DATE: 2015/04/15::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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SH3 domain
1shg SH3 domain.png
Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
Identifiers
Symbol SH3_1
Pfam PF00018
Pfam clan CL0010
InterPro IPR001452
SMART SM00326
PROSITE PS50002
SCOP 1shf
SUPERFAMILY 1shf
CDD cd00174

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acids residues first identified as a conserved sequence in the viral adaptor protein v-Crk and the non-catalytic parts of enzymes such as phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.[1][2] It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25.[3][4][5] SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. They also regulate the activity state of adaptor proteins and other tyrosine kinases and are thought to increase the substrate specificity of some tyrosine kinases by binding far away from the active site of the kinase. Approximately 300 SH3 domains are found in proteins encoded in the human genome.

Structure[edit]

The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.[6]

Peptide binding[edit]

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold.

Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif:

-X-P-p-X-P-
 1 2 3 4 5

with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.

Proteins with SH3 domain[edit]

See also[edit]

References[edit]

  1. ^ Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Curr. Biol. 3 (7): 434–42. doi:10.1016/0960-9822(93)90350-W. PMID 15335710. 
  2. ^ Mayer BJ (April 2001). "SH3 domains: complexity in moderation". J. Cell. Sci. 114 (Pt 7): 1253–63. PMID 11256992. 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M (July 1992). "SH3--an abundant protein domain in search of a function". FEBS Lett. 307 (1): 55–61. doi:10.1016/0014-5793(92)80901-R. PMID 1639195. 
  4. ^ Mayer BJ, Baltimore D (January 1993). "Signalling through SH2 and SH3 domains". Trends Cell Biol. 3 (1): 8–13. doi:10.1016/0962-8924(93)90194-6. PMID 14731533. 
  5. ^ Pawson T (February 1995). "Protein modules and signalling networks". Nature 373 (6515): 573–80. doi:10.1038/373573a0. PMID 7531822. 
  6. ^ Whisstock JC, Lesk AM (April 1999). "SH3 domains in prokaryotes". Trends Biochem. Sci. 24 (4): 132–3. doi:10.1016/s0968-0004(99)01366-3. PMID 10322416. 

External links[edit]

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