1
Protein folding of src SH3 domain by a Go model
Protein folding of src SH3 domain by a Go model
DATE: 2013/06/06::
2
Regulation of Signaling by the Src Protein
Regulation of Signaling by the Src Protein
DATE: 2015/01/24::
3
SH2 Domain Phosphotyrosine Capture Kits
SH2 Domain Phosphotyrosine Capture Kits
DATE: 2009/04/28::
4
SH3 Dimerization
SH3 Dimerization
DATE: 2014/07/07::
5
SH2 domain
SH2 domain
DATE: 2009/04/10::
6
metadynamics in essential coordinates
metadynamics in essential coordinates
DATE: 2007/12/01::
7
04 Cancer Signalling
04 Cancer Signalling
DATE: 2014/10/30::
8
Henry Chang - The roles of Ack family kinases in Drosophila development
Henry Chang - The roles of Ack family kinases in Drosophila development
DATE: 2013/10/25::
9
PLoS ONE : Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells
PLoS ONE : Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells
DATE: 2015/02/28::
10
Introduction to Chemical Biology 128. Lecture 18. Terpenes and Cell Signaling, Part 2
Introduction to Chemical Biology 128. Lecture 18. Terpenes and Cell Signaling, Part 2
DATE: 2013/03/15::
11
CASK / Lin-2 kinase domain (with sound)
CASK / Lin-2 kinase domain (with sound)
DATE: 2013/02/09::
12
p21 activated protein kinase
p21 activated protein kinase
DATE: 2012/09/23::
13
Tikhnet Show Episode #4 (sh3`let Elly malo sh3`le) برنامج تخنت الحلقة #4 (شغلة اللي مالو شغلة (
Tikhnet Show Episode #4 (sh3`let Elly malo sh3`le) برنامج تخنت الحلقة #4 (شغلة اللي مالو شغلة (
DATE: 2015/03/08::
14
Parkin E3 ubiquitin ligase
Parkin E3 ubiquitin ligase
DATE: 2013/09/19::
15
Let
Let's play Silent Hunter 3 (GWX) patrol 4 part 1
DATE: 2014/12/26::
16
Albania - przejazd drogą SH3. Trasa Elbasan - Librazhd - Qukes - Prrenjas - Qafe Thane.
Albania - przejazd drogą SH3. Trasa Elbasan - Librazhd - Qukes - Prrenjas - Qafe Thane.
DATE: 2013/10/04::
17
Stephanie -Organic Chem class at Wagner college-HIV integrase
Stephanie -Organic Chem class at Wagner college-HIV integrase
DATE: 2014/11/19::
18
SH3 voiceattack
SH3 voiceattack
DATE: 2015/04/27::
19
VIIA Rear torpedo doors SH3
VIIA Rear torpedo doors SH3
DATE: 2015/02/15::
20
Seaking SH3 Biritsh Coast Guard landing at Den Helder Airport
Seaking SH3 Biritsh Coast Guard landing at Den Helder Airport
DATE: 2012/01/06::
21
Sh3 foogy volumetric environment
Sh3 foogy volumetric environment
DATE: 2013/10/02::
22
More Sh3 Problems
More Sh3 Problems
DATE: 2013/07/17::
23
SH3 trimer formation
SH3 trimer formation
DATE: 2014/07/07::
24
Silent Hill Book of Lost Memories - Part1
Silent Hill Book of Lost Memories - Part1
DATE: 2009/09/10::
25
on ap lioa-lioa20kva SH3-lioa nhat linh 20kva 3pha 0913 839 600
on ap lioa-lioa20kva SH3-lioa nhat linh 20kva 3pha 0913 839 600
DATE: 2013/10/25::
26
SH3 Tutorial Part 22
SH3 Tutorial Part 22
DATE: 2015/05/09::
27
on ap lioa -lioa 20kva SH3 - lioa nhat linh 20kva 3pha- 0913 839 600
on ap lioa -lioa 20kva SH3 - lioa nhat linh 20kva 3pha- 0913 839 600
DATE: 2013/10/25::
28
NFkB dimerization domain p65-p50
NFkB dimerization domain p65-p50
DATE: 2014/04/15::
29
vinrar
vinrar
DATE: 2009/07/10::
30
WPSTV - Silent Hunter III gameplay video: sinking merchant ship with deck gun
WPSTV - Silent Hunter III gameplay video: sinking merchant ship with deck gun
DATE: 2009/06/05::
31
Protein Kinase A vs. Kinase Domain in p150
Protein Kinase A vs. Kinase Domain in p150
DATE: 2014/03/19::
32
Breaking Bcr-Abl Resistance
Breaking Bcr-Abl Resistance
DATE: 2011/09/26::
33
Kinase Domain of p150
Kinase Domain of p150
DATE: 2014/03/19::
34
"Immunology", Src Homology 2 and Src Homology 3 Domains
"Immunology", Src Homology 2 and Src Homology 3 Domains
DATE: 2012/08/14::
35
Focal Adhesion Kinase (FAK)
Focal Adhesion Kinase (FAK)
DATE: 2012/08/19::
36
Perplexing scenario as Chinese company wins tender to audit a related company
Perplexing scenario as Chinese company wins tender to audit a related company
DATE: 2014/07/16::
37
Torpedo Bomber Tactics: "Aerial Torpedo Attack High Speed High Altitude" 1945 US Navy Training Film
Torpedo Bomber Tactics: "Aerial Torpedo Attack High Speed High Altitude" 1945 US Navy Training Film
DATE: 2012/08/23::
38
Principles of virus fusion
Principles of virus fusion
DATE: 2014/03/23::
39
Shining OS Version 1.2
Shining OS Version 1.2
DATE: 2008/12/05::
40
2008 Late Night Fright Halloween Fright Fest begins.
2008 Late Night Fright Halloween Fright Fest begins.
DATE: 2008/10/31::
41
AMP activated protein kinase
AMP activated protein kinase
DATE: 2012/11/06::
42
All About - Fuso-class battleship
All About - Fuso-class battleship
DATE: 2014/08/04::
43
Victory at Sea Episode 4 Part 2
Victory at Sea Episode 4 Part 2
DATE: 2007/12/27::
44
All About - Courageous-class aircraft carrier
All About - Courageous-class aircraft carrier
DATE: 2014/08/04::
45
Sinking of HMS Barham 221029-06.mp4
Sinking of HMS Barham 221029-06.mp4
DATE: 2011/09/17::
46
Freighter on fire, low in water, ca1939  221295-04.mp4
Freighter on fire, low in water, ca1939 221295-04.mp4
DATE: 2011/09/26::
47
Over Turned & Wrecked Ships, Others Afire, Pearl Harbor, 12 07 1941 December 7, 1941
Over Turned & Wrecked Ships, Others Afire, Pearl Harbor, 12 07 1941 December 7, 1941
DATE: 2013/12/28::
48
Sea Battle of the Philippines newsreel archival stock footage www.PublicDomainFootage.com
Sea Battle of the Philippines newsreel archival stock footage www.PublicDomainFootage.com
DATE: 2013/02/12::
49
The Fight For Liberty Pt 3/4  221251-06.mp4
The Fight For Liberty Pt 3/4 221251-06.mp4
DATE: 2011/07/02::
50
Introduction to Chemical Biology 128. Lecture 12. Protein Functions.
Introduction to Chemical Biology 128. Lecture 12. Protein Functions.
DATE: 2013/02/19::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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SH3 domain
1shg SH3 domain.png
Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
Identifiers
Symbol SH3_1
Pfam PF00018
Pfam clan CL0010
InterPro IPR001452
SMART SM00326
PROSITE PS50002
SCOP 1shf
SUPERFAMILY 1shf
CDD cd00174

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acids residues first identified as a conserved sequence in the viral adaptor protein v-Crk and the non-catalytic parts of enzymes such as phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.[1][2] It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25.[3][4][5] SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. They also regulate the activity state of adaptor proteins and other tyrosine kinases and are thought to increase the substrate specificity of some tyrosine kinases by binding far away from the active site of the kinase. Approximately 300 SH3 domains are found in proteins encoded in the human genome.

Structure[edit]

The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.[6]

Peptide binding[edit]

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold.

Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif:

-X-P-p-X-P-
 1 2 3 4 5

with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.

Proteins with SH3 domain[edit]

See also[edit]

References[edit]

  1. ^ Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Curr. Biol. 3 (7): 434–42. doi:10.1016/0960-9822(93)90350-W. PMID 15335710. 
  2. ^ Mayer BJ (April 2001). "SH3 domains: complexity in moderation". J. Cell. Sci. 114 (Pt 7): 1253–63. PMID 11256992. 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M (July 1992). "SH3--an abundant protein domain in search of a function". FEBS Lett. 307 (1): 55–61. doi:10.1016/0014-5793(92)80901-R. PMID 1639195. 
  4. ^ Mayer BJ, Baltimore D (January 1993). "Signalling through SH2 and SH3 domains". Trends Cell Biol. 3 (1): 8–13. doi:10.1016/0962-8924(93)90194-6. PMID 14731533. 
  5. ^ Pawson T (February 1995). "Protein modules and signalling networks". Nature 373 (6515): 573–80. doi:10.1038/373573a0. PMID 7531822. 
  6. ^ Whisstock JC, Lesk AM (April 1999). "SH3 domains in prokaryotes". Trends Biochem. Sci. 24 (4): 132–3. doi:10.1016/s0968-0004(99)01366-3. PMID 10322416. 

External links[edit]

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