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Protein folding of src SH3 domain by a Go model
Protein folding of src SH3 domain by a Go model
Published: 2013/06/06
Channel: Takada Lab @ Kyoto U
Oncogenic activation receptor tyrosine kinases
Oncogenic activation receptor tyrosine kinases
Published: 2010/02/22
Channel: Onkoview
SH3 Attack on Force H  (GWX Edition)
SH3 Attack on Force H (GWX Edition)
Published: 2017/04/02
Channel: Epiic soniickzz
SH3 6-8-17
SH3 6-8-17
Published: 2017/06/09
Channel: Rob H
SH2 domain
SH2 domain
Published: 2009/04/10
Channel: CR King
SH3 Tutorial Part 01
SH3 Tutorial Part 01
Published: 2015/04/12
Channel: BATTLECATT00
Proteins with SH2 or PTB domains that interact with Receptor Tyrosine Kinases
Proteins with SH2 or PTB domains that interact with Receptor Tyrosine Kinases
Published: 2017/04/19
Channel: Life Science Help
SH3
SH3
Published: 2012/05/03
Channel: Scott Hall
sh3
sh3
Published: 2014/11/29
Channel: AR Arizona
SH3
SH3
Published: 2012/07/17
Channel: kauputa
sh3
sh3
Published: 2013/08/22
Channel: Blair Fisher
sh3 1
sh3 1
Published: 2012/07/16
Channel: xyric23
SH3
SH3
Published: 2015/05/04
Channel: Drew Mags
SH3 Dimerization
SH3 Dimerization
Published: 2014/07/07
Channel: Thirumalai Lab
SH3 1
SH3 1
Published: 2012/06/12
Channel: maniko021
sh3
sh3
Published: 2012/05/28
Channel: mgic29
$sh3
$sh3
Published: 2010/03/22
Channel: jhencado
Sh3
Sh3
Published: 2017/05/27
Channel: Jim Mara
04 Cancer Signalling
04 Cancer Signalling
Published: 2014/10/30
Channel: Mark Temple
SH3
SH3
Published: 2015/07/15
Channel: ptushqa
SH3
SH3
Published: 2007/08/11
Channel: SensesFailxx
sh3
sh3
Published: 2009/10/04
Channel: bdottm
SH3 GAT DA BOOT3 DOH.....
SH3 GAT DA BOOT3 DOH.....
Published: 2016/10/25
Channel: scott franklin
SH3 D3V1L
SH3 D3V1L
Published: 2014/02/13
Channel: Shes Lucifor
sh3
sh3
Published: 2012/06/15
Channel: mianihit12
Sh3
Sh3
Published: 2014/05/02
Channel: Marykosama
Gene Music using Protein Sequence of G3BP1 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Gene Music using Protein Sequence of G3BP1 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Published: 2016/07/05
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GL1 "SH3-DOMAIN GRB2-LIKE 1"
Gene Music using Protein Sequence of SH3GL1 "SH3-DOMAIN GRB2-LIKE 1"
Published: 2016/04/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of SASH1 "SAM AND SH3 DOMAIN CONTAINING 1"
Gene Music using Protein Sequence of SASH1 "SAM AND SH3 DOMAIN CONTAINING 1"
Published: 2017/04/22
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GL3 "SH3-DOMAIN GRB2-LIKE 3"
Gene Music using Protein Sequence of SH3GL3 "SH3-DOMAIN GRB2-LIKE 3"
Published: 2016/03/02
Channel: Gene Music Studio
MBoC : The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated...
MBoC : The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated...
Published: 2015/03/05
Channel: KeSimpulan
Sh3 sucker m6 I
Sh3 sucker m6 I'm
Published: 2017/03/13
Channel: Katawna Jordan
Gene Music using Protein Sequence of SH3D21 "SH3 DOMAIN CONTAINING 21"
Gene Music using Protein Sequence of SH3D21 "SH3 DOMAIN CONTAINING 21"
Published: 2016/11/13
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3KBP1 "SH3-DOMAIN KINASE BINDING PROTEIN 1"
Gene Music using Protein Sequence of SH3KBP1 "SH3-DOMAIN KINASE BINDING PROTEIN 1"
Published: 2016/11/13
Channel: Gene Music Studio
SH3 Tracking a radio contact by Bstanko6
SH3 Tracking a radio contact by Bstanko6
Published: 2017/03/13
Channel: SH3 Bstanko6
Gene Music using Protein Sequence of SORBS2 "SORBIN AND SH3 DOMAIN CONTAINING 2"
Gene Music using Protein Sequence of SORBS2 "SORBIN AND SH3 DOMAIN CONTAINING 2"
Published: 2016/11/21
Channel: Gene Music Studio
Gene Music using Protein Sequence of SORBS3 "SORBIN AND SH3 DOMAIN CONTAINING 3"
Gene Music using Protein Sequence of SORBS3 "SORBIN AND SH3 DOMAIN CONTAINING 3"
Published: 2016/11/21
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3RF2 "SH3 DOMAIN CONTAINING RING FINGER 2"
Gene Music using Protein Sequence of SH3RF2 "SH3 DOMAIN CONTAINING RING FINGER 2"
Published: 2017/01/26
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3BP5 "SH3-DOMAIN BINDING PROTEIN 5 (BTK-ASSOCIATED)"
Gene Music using Protein Sequence of SH3BP5 "SH3-DOMAIN BINDING PROTEIN 5 (BTK-ASSOCIATED)"
Published: 2016/05/18
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3TC2 "SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS 2"
Gene Music using Protein Sequence of SH3TC2 "SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS 2"
Published: 2017/05/09
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP2 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 2"
Gene Music using Protein Sequence of ASAP2 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 2"
Published: 2017/04/15
Channel: Gene Music Studio
Gene Music using Protein Sequence of G3BP2 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Gene Music using Protein Sequence of G3BP2 "GTPASE ACTIVATING PROTEIN (SH3 DOMAIN) BINDING PROTEIN "
Published: 2016/09/12
Channel: Gene Music Studio
Gene Music using Protein Sequence of UBASH3B "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING B"
Gene Music using Protein Sequence of UBASH3B "UBIQUITIN ASSOCIATED AND SH3 DOMAIN CONTAINING B"
Published: 2016/12/10
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3D19 "SH3 DOMAIN CONTAINING 19"
Gene Music using Protein Sequence of SH3D19 "SH3 DOMAIN CONTAINING 19"
Published: 2017/01/26
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3BP1 "SH3-DOMAIN BINDING PROTEIN 1"
Gene Music using Protein Sequence of SH3BP1 "SH3-DOMAIN BINDING PROTEIN 1"
Published: 2016/11/13
Channel: Gene Music Studio
Gene Music Using Protein Sequence of SH3BGRL "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN LIKE"
Gene Music Using Protein Sequence of SH3BGRL "SH3 DOMAIN BINDING GLUTAMATE-RICH PROTEIN LIKE"
Published: 2015/11/19
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 3"
Gene Music using Protein Sequence of ASAP3 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 3"
Published: 2017/02/07
Channel: Gene Music Studio
Gene Music using Protein Sequence of SBK2 "SH3 DOMAIN BINDING KINASE FAMILY, MEMBER 2"
Gene Music using Protein Sequence of SBK2 "SH3 DOMAIN BINDING KINASE FAMILY, MEMBER 2"
Published: 2016/03/01
Channel: Gene Music Studio
Gene Music using Protein Sequence of ASAP1 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 1"
Gene Music using Protein Sequence of ASAP1 "ARFGAP WITH SH3 DOMAIN, ANKYRIN REPEAT AND PH DOMAIN 1"
Published: 2017/04/15
Channel: Gene Music Studio
Gene Music using Protein Sequence of SH3GL2 "SH3-DOMAIN GRB2-LIKE 2"
Gene Music using Protein Sequence of SH3GL2 "SH3-DOMAIN GRB2-LIKE 2"
Published: 2016/03/02
Channel: Gene Music Studio
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WIKIPEDIA ARTICLE

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SH3 domain
1shg SH3 domain.png
Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
Identifiers
Symbol SH3_1
Pfam PF00018
Pfam clan CL0010
InterPro IPR001452
SMART SM00326
PROSITE PS50002
SCOP 1shf
SUPERFAMILY 1shf
CDD cd00174

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.[1][2] It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25.[3][4][5] SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways[6] and regulating the interactions of proteins involved in the cytoplasmic signaling.[7]

Structure[edit]

The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.[8]

Peptide binding[edit]

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold.

Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif:

-X-P-p-X-P-
 1 2 3 4 5

with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.

SH3 interactomes[edit]

SH3 domain mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis.[9][10] Nevertheless, orthologous SH3 domain-mediated interactions are highly rewired between worm and yeast.[9]

Proteins with SH3 domain[edit]

See also[edit]

References[edit]

  1. ^ Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Current Biology. 3 (7): 434–42. PMID 15335710. doi:10.1016/0960-9822(93)90350-W. 
  2. ^ Mayer BJ (April 2001). "SH3 domains: complexity in moderation". Journal of Cell Science. 114 (Pt 7): 1253–63. PMID 11256992. 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M (July 1992). "SH3--an abundant protein domain in search of a function". FEBS Letters. 307 (1): 55–61. PMID 1639195. doi:10.1016/0014-5793(92)80901-R. 
  4. ^ Mayer BJ, Baltimore D (January 1993). "Signalling through SH2 and SH3 domains". Trends in Cell Biology. 3 (1): 8–13. PMID 14731533. doi:10.1016/0962-8924(93)90194-6. 
  5. ^ Pawson T (February 1995). "Protein modules and signalling networks". Nature. 373 (6515): 573–80. PMID 7531822. doi:10.1038/373573a0. 
  6. ^ Schlessinger J (February 1994). "SH2/SH3 signaling proteins". Current Opinion in Genetics & Development. 4 (1): 25–30. PMID 8193536. doi:10.1016/0959-437X(94)90087-6. 
  7. ^ Koch CA, Anderson D, Moran MF, Ellis C, Pawson T (May 1991). "SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins". Science. 252 (5006): 668–74. PMID 1708916. 
  8. ^ Whisstock JC, Lesk AM (April 1999). "SH3 domains in prokaryotes". Trends in Biochemical Sciences. 24 (4): 132–3. PMID 10322416. doi:10.1016/s0968-0004(99)01366-3. 
  9. ^ a b Xin, Xiaofeng; Gfeller, David; Cheng, Jackie; Tonikian, Raffi; Sun, Lin; Guo, Ailan; Lopez, Lianet; Pavlenco, Alevtina; Akintobi, Adenrele (2013-01-01). "SH3 interactome conserves general function over specific form". Molecular Systems Biology. 9: 652. ISSN 1744-4292. PMC 3658277Freely accessible. PMID 23549480. doi:10.1038/msb.2013.9. 
  10. ^ Tonikian, Raffi; Xin, Xiaofeng; Toret, Christopher P.; Gfeller, David; Landgraf, Christiane; Panni, Simona; Paoluzi, Serena; Castagnoli, Luisa; Currell, Bridget (2009-10-01). "Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins". PLOS Biology. 7 (10): e1000218. ISSN 1545-7885. PMC 2756588Freely accessible. PMID 19841731. doi:10.1371/journal.pbio.1000218. 

External links[edit]

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