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Six1 - "Audible" feat. JT the 4th & Dtaelaron (Official Music Video) @Six1_Skip @Dtaelaron @jtthe4th
Six1 - "Audible" feat. JT the 4th & Dtaelaron (Official Music Video) @Six1_Skip @Dtaelaron @jtthe4th
Published: 2017/12/29
Channel: Six1Beats
Six1 - Used 2 Know (Official Music Video)  @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Six1 - Used 2 Know (Official Music Video) @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Published: 2017/06/04
Channel: Six1Beats
City of Six1
City of Six1
Published: 2012/08/16
Channel: Jennifer Bakley
Six1- Caught in the Middle (PROMO SINGLE)
Six1- Caught in the Middle (PROMO SINGLE)
Published: 2017/04/19
Channel: Six1Beats
Double six1 Live Stream
Double six1 Live Stream
Published: 2017/12/17
Channel: Double six1
six1
six1
Published: 2015/01/08
Channel: Selina Bradley
Roderick Six1
Roderick Six1
Published: 2012/12/31
Channel: MetaForBooks vzw
six 2 six1+2
six 2 six1+2
Published: 2016/12/04
Channel: Pieter Ettiene
스프릿스墓地手指SIX1:34
스프릿스墓地手指SIX1:34
Published: 2007/08/01
Channel: Shinn
Big Six1
Big Six1
Published: 2013/09/06
Channel: azvarmint
"WHATEVER I WANT" BY VOX FT. SIX1
"WHATEVER I WANT" BY VOX FT. SIX1
Published: 2016/09/03
Channel: Vox Daboss
Got your Six1
Got your Six1
Published: 2017/07/04
Channel: John Catron
Year Six1
Year Six1
Published: 2017/07/21
Channel: Parklands Primary
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
Published: 2017/04/01
Channel: MaxStrazzeRevenge
Six1
Six1
Published: 2013/04/18
Channel: Kamron Darakshani
Double six1 Live Stream
Double six1 Live Stream
Published: 2017/12/16
Channel: Double six1
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
Published: 2012/08/06
Channel: Thizzler On The Roof
stream raimbow six1
stream raimbow six1
Published: 2016/08/05
Channel: Zabflo 76
Tae x Skip x J Wild - Shake (Prod. Six1) [New 2015] (BestInTheWestRap)
Tae x Skip x J Wild - Shake (Prod. Six1) [New 2015] (BestInTheWestRap)
Published: 2015/03/13
Channel: THEBITWEST
PC Longplay [154] Tom Clancy
PC Longplay [154] Tom Clancy's Rainbow Six (Part 1 of 2)
Published: 2011/08/26
Channel: World of Longplays
Double six1 Live Stream
Double six1 Live Stream
Published: 2017/12/15
Channel: Double six1
스프릿스礦山six1:22
스프릿스礦山six1:22
Published: 2007/08/01
Channel: Shinn
Double six1 Live Stream
Double six1 Live Stream
Published: 2017/12/16
Channel: Double six1
Patron At Six1
Patron At Six1
Published: 2018/01/07
Channel: deenamic11
SIX1!!!!!11!!
SIX1!!!!!11!!
Published: 2017/07/13
Channel: That girl named Bob
Six1-I.T. corporate film
Six1-I.T. corporate film
Published: 2013/04/17
Channel: dhruv grover
스프릿스城鎮手指SIX1:36
스프릿스城鎮手指SIX1:36
Published: 2007/08/01
Channel: Shinn
wake six1
wake six1
Published: 2006/07/20
Channel: marcoloo228
Rainbow six1
Rainbow six1
Published: 2018/01/18
Channel: Squidz 906
six1
six1
Published: 2013/11/08
Channel: Olivier Jost
스프릿스高速公路SIX1:59
스프릿스高速公路SIX1:59
Published: 2007/08/01
Channel: Shinn
rainbow six1
rainbow six1
Published: 2016/04/10
Channel: Pedro_Du_38
babydoggfree akecimento verbal antes do concerto!!! aniversario guetto six1!!
babydoggfree akecimento verbal antes do concerto!!! aniversario guetto six1!!
Published: 2011/09/11
Channel: maskias
Fluttershy
Fluttershy's funny video and her main six1
Published: 2017/09/23
Channel: Khemjira Yachaimun
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
1 6 X 6 Six by Six1
1 6 X 6 Six by Six1
Published: 2017/09/30
Channel: Roland Salazar Rose
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Published: 2017/04/05
Channel: Six1 Racing
six1.wmv
six1.wmv
Published: 2012/05/02
Channel: Chetna Dabral
Rainbow six1
Rainbow six1
Published: 2017/11/19
Channel: Ml dj Lewis
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
Published: 2013/02/18
Channel: Verse King Squad TV
스프릿스城鎮公路SIX1:23
스프릿스城鎮公路SIX1:23
Published: 2007/08/01
Channel: Shinn
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Published: 2014/05/11
Channel: Natalya Panina
스프릿스冰封烈谷SIX1:55
스프릿스冰封烈谷SIX1:55
Published: 2007/08/01
Channel: Shinn
Six1 Eya2 movie
Six1 Eya2 movie
Published: 2017/01/27
Channel: ablai2
[일여섯] 일여섯 부천!! 씨아이팩토리 인사드립니다. ^^ Six1 unit Network for Bu-Cheon CI-Factory
[일여섯] 일여섯 부천!! 씨아이팩토리 인사드립니다. ^^ Six1 unit Network for Bu-Cheon CI-Factory
Published: 2014/06/18
Channel: 한우진
Turmfest 2011 SIX1
Turmfest 2011 SIX1
Published: 2011/06/05
Channel: enterprisefm27
Rainbow Six1 Siege Higlight #3 Antes Tarde Do Que Nunca
Rainbow Six1 Siege Higlight #3 Antes Tarde Do Que Nunca
Published: 2017/11/02
Channel: GustaGhoul _
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
Perry Mason, Silent Six1
Perry Mason, Silent Six1
Published: 2012/03/24
Channel: Mackduff100
friends forever-six1
friends forever-six1
Published: 2010/04/14
Channel: jholenx11
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WIKIPEDIA ARTICLE

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SIX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SIX1, BOS3, DFNA23, TIP39, SIX homeobox 1
External IDs MGI: 102780 HomoloGene: 4360 GeneCards: SIX1
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIX1
Genomic location for SIX1
Band 14q23.1 Start 60,643,415 bp[1]
End 60,658,259 bp[1]
RNA expression pattern
PBB GE SIX1 205817 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005982

NM_009189

RefSeq (protein)

NP_005973

NP_033215

Location (UCSC) Chr 14: 60.64 – 60.66 Mb Chr 14: 73.04 – 73.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[5][6][7]

Function[edit]

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][7]

Interactions[edit]

SIX1 has been shown to interact with EYA1,[8] DACH, GRO and MDFI.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126778 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051367 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (April 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. doi:10.1006/geno.1996.0172. PMID 8617500. 
  6. ^ Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8090–5. doi:10.1073/pnas.0308475101. PMC 419562Freely accessible. PMID 15141091. 
  7. ^ a b "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 
  8. ^ Buller C, Xu X, Marquis V, Schwanke R, Xu PX (November 2001). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542. 
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]


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