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Six1 - Used 2 Know (Official Music Video)  @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Six1 - Used 2 Know (Official Music Video) @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Published: 2017/06/04
Channel: Six1Beats
Six1- Caught in the Middle (PROMO SINGLE)
Six1- Caught in the Middle (PROMO SINGLE)
Published: 2017/04/19
Channel: Six1Beats
City of Six1
City of Six1
Published: 2012/08/16
Channel: Jennifer Bakley
SIX Season 1 TRAILER (2017) New History Series
SIX Season 1 TRAILER (2017) New History Series
Published: 2016/12/30
Channel: Series Trailer MP
Six1-I.T. corporate film
Six1-I.T. corporate film
Published: 2013/04/17
Channel: dhruv grover
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
Published: 2017/02/27
Channel: Eze KilläŽ ØG
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
Published: 2017/04/01
Channel: MaxStrazzeRevenge
Year Six1
Year Six1
Published: 2017/07/21
Channel: Parklands Primary
Six1
Six1
Published: 2013/04/18
Channel: Kamron Darakshani
Perry Mason, Silent Six1
Perry Mason, Silent Six1
Published: 2012/03/24
Channel: Mackduff100
six 2 six1+2
six 2 six1+2
Published: 2016/12/04
Channel: Pieter Ettiene
"WHATEVER I WANT" BY VOX FT. SIX1
"WHATEVER I WANT" BY VOX FT. SIX1
Published: 2016/09/03
Channel: Vox Daboss
Got your Six1
Got your Six1
Published: 2017/07/04
Channel: John Catron
SIX1!!!!!11!!
SIX1!!!!!11!!
Published: 2017/07/13
Channel: That girl named Bob
wake six1
wake six1
Published: 2006/07/20
Channel: marcoloo228
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
Published: 2012/08/06
Channel: Thizzler On The Roof
스프릿스礦山six1:22
스프릿스礦山six1:22
Published: 2007/08/01
Channel: Shinn
Roderick Six1
Roderick Six1
Published: 2012/12/31
Channel: MetaForBooks vzw
rainbow six1
rainbow six1
Published: 2016/04/10
Channel: Pedro_Du_38
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
Six1
Six1
Published: 2015/05/01
Channel: University of Rochester Introductory Biochemistry (Bio250H)
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Published: 2017/04/05
Channel: Six1 Racing
스프릿스墓地手指SIX1:34
스프릿스墓地手指SIX1:34
Published: 2007/08/01
Channel: Shinn
Rainbow six1
Rainbow six1
Published: 2016/09/10
Channel: echo 440
six1
six1
Published: 2013/11/08
Channel: Olivier Jost
six1
six1
Published: 2010/05/16
Channel: pablobasa
WARZ SIX TY SIX1-1 กะ เพื่อน เป็นไงไปดูกัน
WARZ SIX TY SIX1-1 กะ เพื่อน เป็นไงไปดูกัน
Published: 2017/06/20
Channel: MILADA CHENO
Janakari six1
Janakari six1
Published: 2014/12/22
Channel: Ajay Nishad
PC Longplay [154] Tom Clancy
PC Longplay [154] Tom Clancy's Rainbow Six (Part 1 of 2)
Published: 2011/08/26
Channel: World of Longplays
Apple six1
Apple six1
Published: 2015/08/17
Channel: zeeshan shaik
Six1 Eya2 movie
Six1 Eya2 movie
Published: 2017/01/27
Channel: ablai2
Big Six1
Big Six1
Published: 2013/09/06
Channel: azvarmint
six1
six1
Published: 2015/01/08
Channel: Selina Bradley
Tom Clancy
Tom Clancy's Rainbow Six1
Published: 2017/05/04
Channel: Exr mad
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
Rainbow six1
Rainbow six1
Published: 2016/10/31
Channel: Krystian G.
今日のrainbow six1
今日のrainbow six1
Published: 2016/12/17
Channel: FA AMAEBI
Rainbow Six1 Intro Deutsch
Rainbow Six1 Intro Deutsch
Published: 2014/05/06
Channel: GeoNeo
Turmfest 2011 SIX1
Turmfest 2011 SIX1
Published: 2011/06/05
Channel: enterprisefm27
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Published: 2014/05/11
Channel: Natalya Panina
Love Crimes of Kabul - Documentary - Afghanistan
Love Crimes of Kabul - Documentary - Afghanistan
Published: 2013/02/16
Channel: IranDocumentary1
six1.ariadnab
six1.ariadnab
Published: 2012/10/14
Channel: ariadna benitez
RNGL x SIx1 TTG vivo
RNGL x SIx1 TTG vivo
Published: 2017/02/25
Channel: Nicolas PSN
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
Published: 2013/02/18
Channel: Verse King Squad TV
friends forever-six1
friends forever-six1
Published: 2010/04/14
Channel: jholenx11
SIX1 - Skivevej 83 - 7830 Vinderup
SIX1 - Skivevej 83 - 7830 Vinderup
Published: 2015/02/05
Channel: NMCPropertyFilms
Sper-six1
Sper-six1
Published: 2014/12/04
Channel: Тетяна Іванюк
SIX1 - Skivevej 83 7830 Vinderup
SIX1 - Skivevej 83 7830 Vinderup
Published: 2015/02/10
Channel: NMCPropertyFilms
team six1
team six1
Published: 2013/04/05
Channel: alejandro gatti
Press Conference (six1) Rivers United versus FUS Rabat (Morocco)
Press Conference (six1) Rivers United versus FUS Rabat (Morocco)
Published: 2017/05/24
Channel: Sam Wejinya
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WIKIPEDIA ARTICLE

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SIX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SIX1, BOS3, DFNA23, TIP39, SIX homeobox 1
External IDs MGI: 102780 HomoloGene: 4360 GeneCards: SIX1
RNA expression pattern
PBB GE SIX1 205817 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005982

NM_009189

RefSeq (protein)

NP_005973

NP_033215

Location (UCSC) Chr 14: 60.64 – 60.66 Mb Chr 12: 73.04 – 73.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[3][4][5]

Function[edit]

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][5]

Interactions[edit]

SIX1 has been shown to interact with EYA1,[6] DACH, GRO and MDFI.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (April 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. PMID 8617500. doi:10.1006/geno.1996.0172. 
  4. ^ Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8090–5. PMC 419562Freely accessible. PMID 15141091. doi:10.1073/pnas.0308475101. 
  5. ^ a b "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 
  6. ^ Buller C, Xu X, Marquis V, Schwanke R, Xu PX (November 2001). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics. 10 (24): 2775–81. PMID 11734542. doi:10.1093/hmg/10.24.2775. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 

Further reading[edit]


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