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Six1 - Used 2 Know (Official Music Video)  @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Six1 - Used 2 Know (Official Music Video) @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Published: 2017/06/04
Channel: Six1Beats
City of Six1
City of Six1
Published: 2012/08/16
Channel: Jennifer Bakley
Six1- Caught in the Middle (PROMO SINGLE)
Six1- Caught in the Middle (PROMO SINGLE)
Published: 2017/04/19
Channel: Six1Beats
MÚSICAS E FT. DA FERNANDA BRUM QUE TALVEZ VOCÊ NÃO CONHEÇA | #SIX1
MÚSICAS E FT. DA FERNANDA BRUM QUE TALVEZ VOCÊ NÃO CONHEÇA | #SIX1
Published: 2017/08/31
Channel: Tall Nandes
Six1-I.T. corporate film
Six1-I.T. corporate film
Published: 2013/04/17
Channel: dhruv grover
Perry Mason, Silent Six1
Perry Mason, Silent Six1
Published: 2012/03/24
Channel: Mackduff100
six 2 six1+2
six 2 six1+2
Published: 2016/12/04
Channel: Pieter Ettiene
Six1
Six1
Published: 2013/04/18
Channel: Kamron Darakshani
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
ASSURDO HO SCHIAVIZZATO TUTTO!!1! 1! 11! TOM RAINBOW SEIGE SIX1! 1! cit.Simo33 (sto scherzando)
Published: 2017/04/01
Channel: MaxStrazzeRevenge
PC Longplay [154] Tom Clancy
PC Longplay [154] Tom Clancy's Rainbow Six (Part 1 of 2)
Published: 2011/08/26
Channel: World of Longplays
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
Published: 2017/02/27
Channel: Eze KilläŽ ØG
stream raimbow six1
stream raimbow six1
Published: 2016/08/05
Channel: Zabflo 76
Year Six1
Year Six1
Published: 2017/07/21
Channel: Parklands Primary
Got your Six1
Got your Six1
Published: 2017/07/04
Channel: John Catron
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
Published: 2012/08/06
Channel: Thizzler On The Roof
Six1
Six1
Published: 2015/05/01
Channel: University of Rochester Introductory Biochemistry (Bio250H)
wake six1
wake six1
Published: 2006/07/20
Channel: marcoloo228
Six1 rage
Six1 rage
Published: 2017/08/28
Channel: JuicyBros
Roderick Six1
Roderick Six1
Published: 2012/12/31
Channel: MetaForBooks vzw
스프릿스城鎮手指SIX1:36
스프릿스城鎮手指SIX1:36
Published: 2007/08/01
Channel: Shinn
six1
six1
Published: 2010/05/16
Channel: pablobasa
스프릿스礦山six1:22
스프릿스礦山six1:22
Published: 2007/08/01
Channel: Shinn
"WHATEVER I WANT" BY VOX FT. SIX1
"WHATEVER I WANT" BY VOX FT. SIX1
Published: 2016/09/03
Channel: Vox Daboss
WARZ SIX TY SIX1-1 กะ เพื่อน เป็นไงไปดูกัน
WARZ SIX TY SIX1-1 กะ เพื่อน เป็นไงไปดูกัน
Published: 2017/06/20
Channel: DORAEMON TH
rainbow six1
rainbow six1
Published: 2016/04/10
Channel: Pedro_Du_38
Rainbow six1
Rainbow six1
Published: 2016/10/31
Channel: Krystian G.
스프릿스墓地手指SIX1:34
스프릿스墓地手指SIX1:34
Published: 2007/08/01
Channel: Shinn
six1
six1
Published: 2013/11/08
Channel: Olivier Jost
babydoggfree akecimento verbal antes do concerto!!! aniversario guetto six1!!
babydoggfree akecimento verbal antes do concerto!!! aniversario guetto six1!!
Published: 2011/09/11
Channel: maskias
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
Janakari six1
Janakari six1
Published: 2014/12/22
Channel: Ajay Nishad
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Six1 Racing - 2011 GT500 - 199.6 MPH - Standing Mile
Published: 2017/04/05
Channel: Six1 Racing
Apple six1
Apple six1
Published: 2015/08/17
Channel: zeeshan shaik
[일여섯] 일여섯 부천!! 씨아이팩토리 인사드립니다. ^^ Six1 unit Network for Bu-Cheon CI-Factory
[일여섯] 일여섯 부천!! 씨아이팩토리 인사드립니다. ^^ Six1 unit Network for Bu-Cheon CI-Factory
Published: 2014/06/18
Channel: 한우진
Six1 Eya2 movie
Six1 Eya2 movie
Published: 2017/01/27
Channel: ablai2
[일여섯] 일여섯 전주!!!  카클래스 인사드립니다. ^^ Six1 Unit Network For jeon-ju "Car Class"
[일여섯] 일여섯 전주!!! 카클래스 인사드립니다. ^^ Six1 Unit Network For jeon-ju "Car Class"
Published: 2014/06/18
Channel: 한우진
今日のrainbow six1
今日のrainbow six1
Published: 2016/12/17
Channel: FA AMAEBI
Big Six1
Big Six1
Published: 2013/09/06
Channel: azvarmint
let
let's play : after the flash deep six1!!!!!!!!!
Published: 2017/06/08
Channel: xexe112
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Ganna & Nati vs Deerockz / SIX1 CYPHER Battle
Published: 2014/05/11
Channel: Natalya Panina
SIX Season 1 TRAILER (2017) New History Series
SIX Season 1 TRAILER (2017) New History Series
Published: 2016/12/30
Channel: Series Trailer MP
Raimbox six1
Raimbox six1
Published: 2016/11/18
Channel: Adrian Aguado
RNGL x SIx1 TTG vivo
RNGL x SIx1 TTG vivo
Published: 2017/02/25
Channel: Nicolas PSN
스프릿스高速公路SIX1:59
스프릿스高速公路SIX1:59
Published: 2007/08/01
Channel: Shinn
Turmfest 2011 SIX1
Turmfest 2011 SIX1
Published: 2011/06/05
Channel: enterprisefm27
friends forever-six1
friends forever-six1
Published: 2010/04/14
Channel: jholenx11
SIX1!!!!!11!!
SIX1!!!!!11!!
Published: 2017/07/13
Channel: That girl named Bob
six1.ariadnab
six1.ariadnab
Published: 2012/10/14
Channel: ariadna benitez
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
Published: 2013/02/18
Channel: Verse King Squad TV
FRIENDLY FIRE 🎮 Rainbow Six: Siege #1
FRIENDLY FIRE 🎮 Rainbow Six: Siege #1
Published: 2015/11/26
Channel: PietSmiet
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WIKIPEDIA ARTICLE

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SIX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SIX1, BOS3, DFNA23, TIP39, SIX homeobox 1
External IDs MGI: 102780 HomoloGene: 4360 GeneCards: SIX1
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIX1
Genomic location for SIX1
Band 14q23.1 Start 60,643,415 bp[1]
End 60,658,259 bp[1]
RNA expression pattern
PBB GE SIX1 205817 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005982

NM_009189

RefSeq (protein)

NP_005973

NP_033215

Location (UCSC) Chr 14: 60.64 – 60.66 Mb Chr 14: 73.04 – 73.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[5][6][7]

Function[edit]

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][7]

Interactions[edit]

SIX1 has been shown to interact with EYA1,[8] DACH, GRO and MDFI.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126778 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051367 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (April 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. PMID 8617500. doi:10.1006/geno.1996.0172. 
  6. ^ Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8090–5. PMC 419562Freely accessible. PMID 15141091. doi:10.1073/pnas.0308475101. 
  7. ^ a b "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 
  8. ^ Buller C, Xu X, Marquis V, Schwanke R, Xu PX (November 2001). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics. 10 (24): 2775–81. PMID 11734542. doi:10.1093/hmg/10.24.2775. 
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 

Further reading[edit]


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