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Six1 - Used 2 Know (Official Music Video)  @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Six1 - Used 2 Know (Official Music Video) @Six1_Skip x @Imthatdood | | Shot By @Bgiggz
Published: 2017/06/04
Channel: Six1Beats
Six1- Caught in the Middle (PROMO SINGLE)
Six1- Caught in the Middle (PROMO SINGLE)
Published: 2017/04/19
Channel: Six1Beats
City of Six1
City of Six1
Published: 2012/08/16
Channel: Jennifer Bakley
six1
six1
Published: 2015/01/08
Channel: Selina Bradley
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
D-Boi x Symba - All On Me (prod. Six1) [Thizzler.com Exclusive]
Published: 2012/08/06
Channel: Thizzler On The Roof
Got your Six1
Got your Six1
Published: 2017/07/04
Channel: John Catron
Fluttershy
Fluttershy's funny video and her main six1
Published: 2017/09/23
Channel: Khemjira Yachaimun
Big Six1
Big Six1
Published: 2013/09/06
Channel: azvarmint
"WHATEVER I WANT" BY VOX FT. SIX1
"WHATEVER I WANT" BY VOX FT. SIX1
Published: 2016/09/03
Channel: Vox Daboss
Six1-I.T. corporate film
Six1-I.T. corporate film
Published: 2013/04/17
Channel: dhruv grover
Rainbow six1
Rainbow six1
Published: 2016/09/10
Channel: echo 440
Perry Mason, Silent Six1
Perry Mason, Silent Six1
Published: 2012/03/24
Channel: Mackduff100
Year Six1
Year Six1
Published: 2017/07/21
Channel: Parklands Primary
rainbow six1
rainbow six1
Published: 2016/04/10
Channel: Pedro_Du_38
friends forever-six1
friends forever-six1
Published: 2010/04/14
Channel: jholenx11
SIX1!!!!!11!!
SIX1!!!!!11!!
Published: 2017/07/13
Channel: Lance McClain
Apple six1
Apple six1
Published: 2015/08/17
Channel: zeeshan shaik
six 2 six1+2
six 2 six1+2
Published: 2016/12/04
Channel: Pieter Ettiene
six1
six1
Published: 2013/11/08
Channel: Olivier Jost
PC Longplay [154] Tom Clancy
PC Longplay [154] Tom Clancy's Rainbow Six (Part 1 of 2)
Published: 2011/08/26
Channel: World of Longplays
six1
six1
Published: 2010/05/16
Channel: pablobasa
Audible (feat. Jt the 4th & DtaeLaron)
Audible (feat. Jt the 4th & DtaeLaron)
Published: 2017/11/02
Channel: Various Artists - Topic
MÚSICAS E FT. DA FERNANDA BRUM QUE TALVEZ VOCÊ NÃO CONHEÇA | #SIX1
MÚSICAS E FT. DA FERNANDA BRUM QUE TALVEZ VOCÊ NÃO CONHEÇA | #SIX1
Published: 2017/08/31
Channel: Tall Nandes
stream raimbow six1
stream raimbow six1
Published: 2016/08/05
Channel: Zabflo 76
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
I wanna be, "Shata ft Six1" island hop mixtape "KING SQUAD TV"
Published: 2013/02/18
Channel: Verse King Squad TV
Six1 rage
Six1 rage
Published: 2017/08/28
Channel: JuicyBros
History of - Rainbow Six (1998-2016)
History of - Rainbow Six (1998-2016)
Published: 2016/01/16
Channel: Tofig Shamkhalov
wake six1
wake six1
Published: 2006/07/20
Channel: marcoloo228
Rainbow six1
Rainbow six1
Published: 2016/10/31
Channel: Krystian G.
Tae x Skip x J Wild - Shake (Prod. Six1) [New 2015] (BestInTheWestRap)
Tae x Skip x J Wild - Shake (Prod. Six1) [New 2015] (BestInTheWestRap)
Published: 2015/03/13
Channel: THEBITWEST
Tom Clancy
Tom Clancy's Rainbow Six1
Published: 2017/05/04
Channel: Exr mad
six1.ariadnab
six1.ariadnab
Published: 2012/10/14
Channel: ariadna benitez
21   PERRY SIX1
21 PERRY SIX1
Published: 2015/10/17
Channel: CHS Leilões
Rainbow Six1 Siege Higlight #3 Antes Tarde Do Que Nunca
Rainbow Six1 Siege Higlight #3 Antes Tarde Do Que Nunca
Published: 2017/11/02
Channel: GustaGhoul _
Agent six1/2 episode:1 (News Flash)
Agent six1/2 episode:1 (News Flash)
Published: 2011/12/22
Channel: TheEmoSkullsXOX
Rainbow six1
Rainbow six1
Published: 2017/11/19
Channel: Ml dj Lewis
One two four six1
One two four six1
Published: 2010/10/20
Channel: marisraful
RNGL x SIx1 TTG vivo
RNGL x SIx1 TTG vivo
Published: 2017/02/25
Channel: Nicolas PSN
[일여섯] 일여섯 전주!!!  카클래스 인사드립니다. ^^ Six1 Unit Network For jeon-ju "Car Class"
[일여섯] 일여섯 전주!!! 카클래스 인사드립니다. ^^ Six1 Unit Network For jeon-ju "Car Class"
Published: 2014/06/18
Channel: 한우진
six1.wmv
six1.wmv
Published: 2012/05/02
Channel: Chetna Dabral
team six1
team six1
Published: 2013/04/05
Channel: alejandro gatti
owais six1
owais six1
Published: 2012/01/14
Channel: Owais Mohd
Funny Moments raimboy six1
Funny Moments raimboy six1
Published: 2017/08/22
Channel: Game squad
SIX1 - Skivevej 83 - 7830 Vinderup
SIX1 - Skivevej 83 - 7830 Vinderup
Published: 2015/02/05
Channel: NMCPropertyFilms
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
SIX1 Vs AKSx/Rngl - Tactic Game - Nr rq
Published: 2017/02/27
Channel: •EzĕėKillåZ•
Tom Clancy
Tom Clancy's Rainbow Six1| weveando en las partidas xddd (con Rod :v HD)
Published: 2017/03/06
Channel: Fa var
tattoo artists history six1
tattoo artists history six1
Published: 2012/03/12
Channel: Anghel Emil
jump val di luce six1 the ssnof
jump val di luce six1 the ssnof
Published: 2007/11/21
Channel: six51284
six1.avi
six1.avi
Published: 2011/04/17
Channel: Stefano Ventura
Sper-six1
Sper-six1
Published: 2014/12/04
Channel: Тетяна Іванюк
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WIKIPEDIA ARTICLE

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SIX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SIX1, BOS3, DFNA23, TIP39, SIX homeobox 1
External IDs MGI: 102780 HomoloGene: 4360 GeneCards: SIX1
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SIX1
Genomic location for SIX1
Band 14q23.1 Start 60,643,415 bp[1]
End 60,658,259 bp[1]
RNA expression pattern
PBB GE SIX1 205817 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005982

NM_009189

RefSeq (protein)

NP_005973

NP_033215

Location (UCSC) Chr 14: 60.64 – 60.66 Mb Chr 14: 73.04 – 73.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[5][6][7]

Function[edit]

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][7]

Interactions[edit]

SIX1 has been shown to interact with EYA1,[8] DACH, GRO and MDFI.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126778 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051367 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (April 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. doi:10.1006/geno.1996.0172. PMID 8617500. 
  6. ^ Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8090–5. doi:10.1073/pnas.0308475101. PMC 419562Freely accessible. PMID 15141091. 
  7. ^ a b "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". 
  8. ^ Buller C, Xu X, Marquis V, Schwanke R, Xu PX (November 2001). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542. 
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]


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