Safwat Ghayur joined the Police Service of Pakistan in 1981(9th CTP) and worked initially as an Assistant Superintendent of Police (ASP), at various stations of Peshawar, and then as Senior Superintendent of Police (SSP) of Peshawar. He became Deputy Commandant in the National Police Academy of Pakistan and later on Capital City Police Officer of Peshawar. Since December 2009, he served as Commandant of the Frontier Constabulary, which acts as a policing force in the semi-autonomous tribal areas of Pakistan. He had gained a reputation for being actively involved in police work, having been shot in the shoulder in 1997 in a shootout with a criminal, and was widely praised as a hero and became a respected police officer, and a leader in the fight against terrorism.
Safwat Ghayur was killed by a targeted suicide bomb blast at the Frontier Constabulary Chowk on the evening of 4 August 2010, when he was driving away from his office. A pedestrian was killed on the scene and two others later died in the hospital. Eight kilograms of explosives were used; "the severed head of the suspected bomber, who appeared to be in his teens, was found some 20 feet from the gutted vehicle of Mr Ghayur." Responsibility was claimed by Tehrik-i-Taliban Pakistan.