Born on 12 January 1764, Sir Harford Jones-Brydges was the son of Harford Jones of Presteign, Radnorshire by Winifred, daughter of Richard Hooper of the Whittern, Herefordshire. Early in life he entered the service of the East India Company, and, acquiring great proficiency in the oriental languages, he was appointed envoy extraordinary and minister plenipotentiary to the court of Persia, where he remained four years from 1807 to 1811. On 9 October 1807 he was created a baronet. On his return from Persia he was disappointed with the prospects of promotion in the East India Company, and resigned.
In a royal sign manual dated 4 May 1826, in commemoration of his descent through his maternal grandmother from the family of Brydges of Old Colwall, Herefordshire, he assumed the additional name of Brydges.
He died at his seat at Boultibrook, Presteigne on 17 March 1847. Through his marriage with Sarah, eldest daughter of the knight Sir Henry Gott of Newland Park, Buckinghamshire he had one son and two daughters.
Throughout life he a deep interest in the welfare both of the Persians and the natives of India. In 1833 he published The Dynasty of the Kajars, translated from the original Persian manuscript, in the following year An Account of His Majesty's Mission to the Court of Persia in the years 1807–11, to which is added a brief history of the Wahanby, and in 1838 his Letter on the Present State of British Interests and Affairs in Persia, addressed to the Marquis of Wellesley. In 1843 he pleaded the cause of the ameers of Sind in a letter to the court of directors of the East India Company, denouncing the latter's policy of annexation and conquest.
Politically he was a Whig, and took an active interest in the election contests of Radnorshire, where he founded a political association known as the Grey Coat Club. On 15 June 1831 he received the honorary degree of D.C.L. from the University of Oxford. In 1832 he was sworn a privy councillor, and in 1841 was appointed deputy-lieutenant of the county of Hereford.
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