Today, several NGOs and government organizations operate here for the prevention of sexually transmitted diseases (STD) including AIDS. The book Guilty Without Trial by the founders of the NGO Sanlaap based much of their research into human trafficking in India on this area.
The Sonagachi project is a sex workers' cooperative that operates in the area and empowers sex workers to insist on condom use and to stand up against abuse. Run by the Durbar Mahila Samanwaya Committee It was founded by public health scientist Smarajit Jana in 1992 but is now largely run by the prostitutes themselves. While some are crediting DMSC with keeping a relatively low rate of HIV infection among prostitutes in Sonagachi—5.17% of the 13,000 prostitutes in Sonagachi are estimated to be HIV positive —this HIV rate is in fact no different than the average HIV rate for female prostitutes in India, which is estimated to be 5.1%  (the HIV rate infection among prostitutes as well as among the general population varies widely by region in India).
According to some sources, prostitutes from Sonagachi who test HIV positive are not told about the results, and live with the disease without knowing about it "because the DMSC is worried that HIV positive women will be ostracized." Some prostitutes in Sonagachi have stated that "the clients, at least three quarters of them" refuse to use condoms and "if we force them to use the condom, they will just go next door. There are so many women working here, and in the end, everyone is prepared to work without protection for fear of losing trade.”
Besides the Sonagachi project, (DMSC) also runs several similar projects in West Bengal, organizing some 65,000 prostitutes and their children. The organization lobbies for the recognition of sex workers' rights and full legalization, runs literacy and vocational programs, and provides micro loans. The DMSC hosted India's first national convention of sex workers on November 14, 1997 in Kolkata, titled 'Sex Work is Real Work: We Demand Workers Rights'. The book Half the Sky: Turning Oppression into Opportunity for Women Worldwide reports investigations revealing that, contrary to stated policy, the DMSC allows sex slavery, trafficking, and underage girls in Sonagachi project brothels.
The documentary Born into Brothels: Calcutta's Red Light Kids won the Oscar for best documentary feature in the year 2005. It depicts the lives of children born to prostitutes in Sonagachi. "Born into Brothels" is a documentary that takes the viewer beyond the well-known prostitute-clogged streets and into the homes of the children who live in the so-called worst place on earth. If the film has one success story, it's the discovery of ten-year old Avijit whose natural affinity for creating exciting compositions through the lens earned him an invitation to the World Press Photo Foundation in Amsterdam.
There is also a documentary titled Tales of The Night Fairies by Prof. Shohini Ghosh and Dr. Sabeena Ghadioke from Asia's leading Media institute AJK, Mass Communication Research Centre, about the Sonagachi area. It has won the Jeevika Award for the best documentary feature on livelihood in India.
In his documentary The Five Obstructions, renowned Danish filmmaker Lars von Trier asks poet and experimental filmmaker Jorgen Leth to name the worst place in the world he's ever visited, and immediately Leth responds with "The Red Light District of Calcutta."
The Malayalam Film Calcutta News depicts the story of women being trafficked and forced to become sex worker in Sonagachi.